ATF6B Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description activating transcription factor 6 beta|The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 1388)
Similar Terms
Downloads & Tools

Genes

327 genes differentially expressed following the ATF6B gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GARIN1A golgi associated RAB2 interactor 1A 4.16438
GDF9 growth differentiation factor 9 4.16438
IRF8 interferon regulatory factor 8 4.16438
EHBP1L1 EH domain binding protein 1-like 1 4.16438
SH2D6 SH2 domain containing 6 4.16438
BNC1 basonuclin 1 4.16438
HES3 hes family bHLH transcription factor 3 4.16438
NR1I3 nuclear receptor subfamily 1, group I, member 3 4.16438
LEF1 lymphoid enhancer-binding factor 1 4.16438
MUSTN1 musculoskeletal, embryonic nuclear protein 1 4.16438
MIA melanoma inhibitory activity 4.16438
SPMIP11 sperm microtubule inner protein 11 4.16438
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 4.16438
OR2D2 olfactory receptor, family 2, subfamily D, member 2 4.16438
CPLX4 complexin 4 4.16438
TMC2 transmembrane channel-like 2 4.16438
EYA4 EYA transcriptional coactivator and phosphatase 4 4.16438
H4C12 H4 clustered histone 12 4.16438
F2RL2 coagulation factor II (thrombin) receptor-like 2 4.16438
LOXL4 lysyl oxidase-like 4 4.16438
RPS21-DT RPS21 divergent transcript 4.16438
CCNA1 cyclin A1 4.16438
CX3CL1 chemokine (C-X3-C motif) ligand 1 4.16438
ZPLD1 zona pellucida-like domain containing 1 4.16438
OR5P3 olfactory receptor, family 5, subfamily P, member 3 4.15416
CRISP1 cysteine-rich secretory protein 1 4.15416
RRAD Ras-related associated with diabetes 4.15416
COL19A1 collagen, type XIX, alpha 1 4.15416
CCNB3 cyclin B3 4.15416
HCRTR1 hypocretin (orexin) receptor 1 4.15416
INHBC inhibin, beta C 4.15416
TM4SF20 transmembrane 4 L six family member 20 4.15416
SSTR1 somatostatin receptor 1 4.15416
INHBA inhibin, beta A 4.15416
UCN urocortin 4.15416
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 4.15416
CAPNS2 calpain, small subunit 2 4.15416
IL5RA interleukin 5 receptor, alpha 4.15416
S100A2 S100 calcium binding protein A2 4.15416
COL15A1 collagen, type XV, alpha 1 4.15416
CRYGA crystallin, gamma A 4.15416
ETV2 ets variant 2 4.15416
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 4.15416
STAP1 signal transducing adaptor family member 1 4.15416
CLCF1 cardiotrophin-like cytokine factor 1 4.15416
CD180 CD180 molecule 4.15416
METTL21C methyltransferase like 21C 4.15416
KHDC3L KH domain containing 3-like, subcortical maternal complex member 4.15416
F7 coagulation factor VII (serum prothrombin conversion accelerator) 4.15416
PROB1 proline-rich basic protein 1 4.15416
GJB3 gap junction protein, beta 3, 31kDa 4.15416
LRRC55 leucine rich repeat containing 55 4.15416
GDNF glial cell derived neurotrophic factor 4.15416
RSPO3 R-spondin 3 4.15416
CIITA class II, major histocompatibility complex, transactivator 4.15416
TAS2R1 taste receptor, type 2, member 1 4.15416
MYCT1 myc target 1 4.15416
TNIP3 TNFAIP3 interacting protein 3 4.15416
TWIST1 twist family bHLH transcription factor 1 4.15416
RBM33-DT RBM33 divergent transcript 4.15416
SPATS1 spermatogenesis associated, serine-rich 1 4.15416
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 4.15416
ARX aristaless related homeobox 4.15416
PLG plasminogen 4.15416
OTOF otoferlin 4.15416
GPR34 G protein-coupled receptor 34 4.15416
RD3 retinal degeneration 3 4.15416
FIMP1 fertilization-influencing membrane protein 1 4.15416
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 4.15416
PLPP4 phospholipid phosphatase 4 4.15416
ELOA2 elongin A2 4.15416
NOTCH2NLB notch 2 N-terminal like B 4.15416
PRRT1B proline rich transmembrane protein 1B 4.15416
ZNF593OS ZNF593 opposite strand 4.15416
RHEX regulator of hemoglobinization and erythroid cell expansion 4.15416
EZHIP EZH inhibitory protein 4.15416
HOATZ HOATZ cilia and flagella associated protein 4.15416
CFAP299 cilia and flagella associated protein 299 4.15416
CFAP97D1 CFAP97 domain containing 1 4.15416
CFAP99 cilia and flagella associated protein 99 4.15416
SPATA22 spermatogenesis associated 22 4.15416
CFC1 cripto, FRL-1, cryptic family 1 4.15416
LY6K lymphocyte antigen 6 complex, locus K 4.15416
CATSPER3 cation channel, sperm associated 3 4.15416
CLEC3A C-type lectin domain family 3, member A 4.15416
MAGEB2 melanoma antigen family B2 4.15416
TIMD4 T-cell immunoglobulin and mucin domain containing 4 4.15416
DMP1 dentin matrix acidic phosphoprotein 1 4.15416
PCDHA2 protocadherin alpha 2 4.15416
ACTL10 actin-like 10 4.15416
CD300LG CD300 molecule-like family member g 4.15416
LIPJ lipase, family member J 4.15416
TLR7 toll-like receptor 7 4.15416
CCDC121 coiled-coil domain containing 121 4.15416
GCSAM germinal center-associated, signaling and motility 4.15416
MAGIX MAGI family member, X-linked 4.15416
ZNF705D zinc finger protein 705D 4.15416
SYT15 synaptotagmin XV 4.15416
IL16 interleukin 16 4.15416
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 4.15416
WNT9B wingless-type MMTV integration site family, member 9B 4.15416
GLIPR1L2 GLI pathogenesis-related 1 like 2 4.15416
CDKN2A cyclin-dependent kinase inhibitor 2A 4.15416
WEE2 WEE1 homolog 2 (S. pombe) 4.15416
MBOAT4 membrane bound O-acyltransferase domain containing 4 4.15416
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 4.15416
PSKH2 protein serine kinase H2 4.15416
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 4.15416
DRD2 dopamine receptor D2 4.15416
IL1B interleukin 1, beta 4.15416
RGCC regulator of cell cycle 4.15416
TEX12 testis expressed 12 4.15416
FAM135B family with sequence similarity 135, member B 4.15416
ADAM2 ADAM metallopeptidase domain 2 4.15416
SEBOX SEBOX homeobox 4.15416
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 4.15416
PCDHGB2 protocadherin gamma subfamily B, 2 4.15416
APLNR apelin receptor 4.15416
TEKT2 tektin 2 (testicular) 4.15416
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 4.15416
OR56A4 olfactory receptor, family 56, subfamily A, member 4 4.15416
CXCR5 chemokine (C-X-C motif) receptor 5 4.15416
CTAGE9 CTAGE family, member 9 4.15416
LRRIQ3 leucine-rich repeats and IQ motif containing 3 4.15416
PRPH peripherin 4.15416
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 4.15416
LY96 lymphocyte antigen 96 4.15416
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 4.15416
CPN2 carboxypeptidase N, polypeptide 2 4.15416
GBX2 gastrulation brain homeobox 2 4.15416
PPP1R27 protein phosphatase 1, regulatory subunit 27 4.15416
NPY2R neuropeptide Y receptor Y2 4.15416
PDK4 pyruvate dehydrogenase kinase, isozyme 4 4.15416
LY6G6C lymphocyte antigen 6 complex, locus G6C 4.15416
OR52N5 olfactory receptor, family 52, subfamily N, member 5 4.15416
NKX6-2 NK6 homeobox 2 4.15416
MOG myelin oligodendrocyte glycoprotein 4.15416
CD247 CD247 molecule 4.15416
ITGB4 integrin, beta 4 4.15416
CRYBA1 crystallin, beta A1 4.15416
GFRAL GDNF family receptor alpha like 4.15416
GPR62 G protein-coupled receptor 62 4.15416
PRTN3 proteinase 3 4.15416
SOSTDC1 sclerostin domain containing 1 4.15416
IDI2 isopentenyl-diphosphate delta isomerase 2 4.15416
NCR3 natural cytotoxicity triggering receptor 3 4.15416
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 4.15416
ADIRF adipogenesis regulatory factor 4.15416
FCN3 ficolin (collagen/fibrinogen domain containing) 3 4.15416
TMPRSS13 transmembrane protease, serine 13 4.15416
BOLL boule-like RNA-binding protein 4.15416
TMPRSS12 transmembrane (C-terminal) protease, serine 12 4.15416
CD80 CD80 molecule 4.15416
CETP cholesteryl ester transfer protein, plasma 4.15416
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 4.15416
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 4.15416
PLGLB1 plasminogen-like B1 4.15416
NUTM2F NUT family member 2F 4.15416
CHRM4 cholinergic receptor, muscarinic 4 4.15416
SDSL serine dehydratase-like 4.15416
MSTN myostatin 4.15416
R3HDML R3H domain containing-like 4.15416
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 4.15416
POPDC2 popeye domain containing 2 4.15416
AOC1 amine oxidase, copper containing 1 4.15416
PF4V1 platelet factor 4 variant 1 4.15416
ITGA8 integrin, alpha 8 4.15416
PYHIN1 pyrin and HIN domain family, member 1 4.15416
IFI16 interferon, gamma-inducible protein 16 4.07936
RAB3A RAB3A, member RAS oncogene family 3.81151
SKAP1 src kinase associated phosphoprotein 1 3.68474
DBF4B DBF4 zinc finger B 3.36093
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 3.15571
CHL1 cell adhesion molecule L1-like 3.15571
PCDHB16 protocadherin beta 16 3.15571
C2ORF72 chromosome 2 open reading frame 72 3.15571
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) 2.96299
MRPL20 mitochondrial ribosomal protein L20 2.84113
FAM151B family with sequence similarity 151, member B 2.82748
WDR1 WD repeat domain 1 2.76757
DYDC2 DPY30 domain containing 2 2.74092
N4BP2L2 NEDD4 binding protein 2-like 2 2.73177
HSPD1 heat shock 60kDa protein 1 (chaperonin) 2.69109
C1ORF56 chromosome 1 open reading frame 56 2.68962
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 2.63189
RWDD2A RWD domain containing 2A 2.61957
ULK3 unc-51 like kinase 3 2.61474
KLHL9 kelch-like family member 9 2.59965
ILF2 interleukin enhancer binding factor 2 2.54182
TSHR thyroid stimulating hormone receptor 2.54182
NFE2 nuclear factor, erythroid 2 2.54182
MMP20 matrix metallopeptidase 20 2.54182
COQ5 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) 2.47302
TBRG4 transforming growth factor beta regulator 4 2.46056
TMEM132D transmembrane protein 132D 2.44187
IZUMO2 IZUMO family member 2 2.4265
HEMK2 HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine 2.41906
KIF25 kinesin family member 25 2.40993
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 2.3956
MST1 macrophage stimulating 1 2.3956
NPB neuropeptide B 2.3956
RIN1 Ras and Rab interactor 1 2.38104
ZFP69B ZFP69 zinc finger protein B 2.37451
KMT2D lysine (K)-specific methyltransferase 2D 2.35606
GM2A GM2 ganglioside activator 2.3551
COMMD5 COMM domain containing 5 2.33591
SLC29A4 solute carrier family 29 (equilibrative nucleoside transporter), member 4 2.32269
TRAM1 translocation associated membrane protein 1 2.29156
C1ORF159 chromosome 1 open reading frame 159 2.26768
AKAP13 A kinase (PRKA) anchor protein 13 2.26768
RBP1 retinol binding protein 1, cellular 2.2565
DLC1 DLC1 Rho GTPase activating protein 2.23597
SLC25A38 solute carrier family 25, member 38 2.23175
MRPL17 mitochondrial ribosomal protein L17 2.17417
NMT2 N-myristoyltransferase 2 2.16593
ZNF700 zinc finger protein 700 2.1289
GRM5 glutamate receptor, metabotropic 5 2.12879
ERVMER34-1 endogenous retrovirus group MER34, member 1 2.10684
UBE2R2 ubiquitin-conjugating enzyme E2R 2 2.10684
CLDN19 claudin 19 2.09333
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 2.0872
CUL4A cullin 4A 2.07867
NPW neuropeptide W 2.07497
FBXO46 F-box protein 46 2.05995
MANF mesencephalic astrocyte-derived neurotrophic factor 2.05758
EXOSC10 exosome component 10 2.04811
CCDC61 coiled-coil domain containing 61 2.02347
EMC9 ER membrane protein complex subunit 9 2.02167
METTL9 methyltransferase like 9 2.00624

decreased expression

Symbol Name Standardized Value
MAOB monoamine oxidase B -4.16438
TP53TG5 TP53 target 5 -4.16438
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 -4.16438
ALOX12B arachidonate 12-lipoxygenase, 12R type -4.16438
DUSP28 dual specificity phosphatase 28 -4.15416
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 -4.15416
MMP19 matrix metallopeptidase 19 -4.15416
GDF15 growth differentiation factor 15 -4.15416
SFN stratifin -4.15416
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta -4.15416
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) -4.15416
ZFP3 ZFP3 zinc finger protein -4.15416
CRYGS crystallin, gamma S -4.15416
PARP15 poly (ADP-ribose) polymerase family, member 15 -3.92927
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 -3.92927
PCDHGA12 protocadherin gamma subfamily A, 12 -3.92927
CLDN14 claudin 14 -3.92927
MRO maestro -3.92927
YY2 YY2 transcription factor -3.92927
PAX6 paired box 6 -3.92927
FAM131B family with sequence similarity 131, member B -3.92927
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 -3.92927
SLC35D3 solute carrier family 35, member D3 -3.92927
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 -3.92927
SAMD11 sterile alpha motif domain containing 11 -3.92927
VSTM5 V-set and transmembrane domain containing 5 -3.92927
IL1A interleukin 1, alpha -3.92927
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -3.92927
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) -3.92927
CATSPERZ catsper channel auxiliary subunit zeta -3.92927
CALHM3 calcium homeostasis modulator 3 -3.92927
MEIS1 Meis homeobox 1 -3.92927
PENK proenkephalin -3.92927
OR4D1 olfactory receptor, family 4, subfamily D, member 1 -3.92927
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) -3.92927
MZB1 marginal zone B and B1 cell-specific protein -3.92927
UCMA upper zone of growth plate and cartilage matrix associated -3.77331
SOX15 SRY (sex determining region Y)-box 15 -3.52054
TRIM69 tripartite motif containing 69 -3.16921
AMOT angiomotin -3.0125
ASTN2 astrotactin 2 -2.99363
ADM2 adrenomedullin 2 -2.88857
GLI2 GLI family zinc finger 2 -2.87173
FKBPL FK506 binding protein like -2.75472
CA2 carbonic anhydrase II -2.74833
QDPR quinoid dihydropteridine reductase -2.73725
RCAN3 RCAN family member 3 -2.68506
SYCE2 synaptonemal complex central element protein 2 -2.67668
ARL15 ADP-ribosylation factor-like 15 -2.65887
THADA thyroid adenoma associated -2.63274
PTEN phosphatase and tensin homolog -2.61957
SLC46A1 solute carrier family 46 (folate transporter), member 1 -2.61957
TRPC6 transient receptor potential cation channel, subfamily C, member 6 -2.61957
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -2.61957
HSF5 heat shock transcription factor family member 5 -2.61957
RPIA ribose 5-phosphate isomerase A -2.61957
PAMR1 peptidase domain containing associated with muscle regeneration 1 -2.61957
ART3 ADP-ribosyltransferase 3 -2.61957
PLA2G10 phospholipase A2, group X -2.61957
IKZF3 IKAROS family zinc finger 3 (Aiolos) -2.61957
MKX mohawk homeobox -2.61957
C2CD4C C2 calcium-dependent domain containing 4C -2.61957
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -2.52496
SLC44A2 solute carrier family 44 (choline transporter), member 2 -2.45518
SANBR SANT and BTB domain regulator of CSR -2.44776
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 -2.4215
TMEM187 transmembrane protein 187 -2.39762
ADGRD2 adhesion G protein-coupled receptor D2 -2.39762
ACMSD aminocarboxymuconate semialdehyde decarboxylase -2.3956
UVRAG UV radiation resistance associated -2.32434
CELF2 CUGBP, Elav-like family member 2 -2.32269
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) -2.32269
PARP8 poly (ADP-ribose) polymerase family, member 8 -2.30868
C20ORF203 chromosome 20 open reading frame 203 -2.30261
NPIPA7 nuclear pore complex interacting protein family, member A7 -2.30261
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -2.29575
GRM8 glutamate receptor, metabotropic 8 -2.27593
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.26237
ATAD3C ATPase family, AAA domain containing 3C -2.2565
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 -2.2565
DEPDC7 DEP domain containing 7 -2.2565
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 -2.25511
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 -2.25403
IGFBP7 insulin-like growth factor binding protein 7 -2.25403
KCP kielin/chordin-like protein -2.16972
PRMT8 protein arginine methyltransferase 8 -2.16972
DCC DCC netrin 1 receptor -2.16972
ACTG2 actin, gamma 2, smooth muscle, enteric -2.16593
NOXO1 NADPH oxidase organizer 1 -2.16593
INSC inscuteable homolog (Drosophila) -2.16593
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 -2.16593
MCOLN2 mucolipin 2 -2.14318
NUMB numb homolog (Drosophila) -2.12879
SPRY4 sprouty homolog 4 (Drosophila) -2.10553
TUBB6 tubulin, beta 6 class V -2.0872
ZFAND2A zinc finger, AN1-type domain 2A -2.02779
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 -2.02347
KHNYN KH and NYN domain containing -2.00061