ATG12 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description autophagy related 12|Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM, Mar 2008] (NCBI Entrez Gene Database, 9140)
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Genes

337 genes differentially expressed following the ATG12 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.86222
ASB4 ankyrin repeat and SOCS box containing 4 2.86222
FABP12 fatty acid binding protein 12 2.86222
CLIC5 chloride intracellular channel 5 2.86222
GCKR glucokinase (hexokinase 4) regulator 2.86222
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.86222
C11ORF87 chromosome 11 open reading frame 87 2.86222
SLC9C2 solute carrier family 9, member C2 (putative) 2.86222
VWC2L von Willebrand factor C domain containing protein 2-like 2.86222
LPA lipoprotein, Lp(a) 2.86222
PADI4 peptidyl arginine deiminase, type IV 2.86222
C6ORF163 chromosome 6 open reading frame 163 2.86222
BTNL8 butyrophilin-like 8 2.86222
CHAD chondroadherin 2.86222
LRRC61 leucine rich repeat containing 61 2.86222
OR11A1 olfactory receptor, family 11, subfamily A, member 1 2.86222
THEMIS thymocyte selection associated 2.86222
GIP gastric inhibitory polypeptide 2.86222
LHX1 LIM homeobox 1 2.86222
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 2.86222
CRYGA crystallin, gamma A 2.86222
TMPRSS11E transmembrane protease, serine 11E 2.86222
TRARG1 trafficking regulator of GLUT4 (SLC2A4) 1 2.86222
CYSRT1 cysteine-rich tail protein 1 2.86222
NECTIN4 nectin cell adhesion molecule 4 2.86222
NANOS3 nanos homolog 3 (Drosophila) 2.76663
IGFL3 IGF-like family member 3 2.76663
PAX2 paired box 2 2.76663
NANOS2 nanos homolog 2 (Drosophila) 2.76663
CSTL1 cystatin-like 1 2.76663
DDN dendrin 2.76663
PRODH2 proline dehydrogenase (oxidase) 2 2.76663
DRICH1 aspartate-rich 1 2.76663
CELF3 CUGBP, Elav-like family member 3 2.76663
RIMBP2 RIMS binding protein 2 2.76663
TRIM15 tripartite motif containing 15 2.76663
OLIG3 oligodendrocyte transcription factor 3 2.76663
RNF39 ring finger protein 39 2.76663
TAS2R19 taste receptor, type 2, member 19 2.76663
HBM hemoglobin, mu 2.76663
TRIM40 tripartite motif containing 40 2.76663
MUC20 mucin 20, cell surface associated 2.76663
NPIPA3 nuclear pore complex interacting protein family, member A3 2.76663
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.76663
CD69 CD69 molecule 2.76663
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.76663
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.76663
ADAMTSL5 ADAMTS-like 5 2.76663
SPINT3 serine peptidase inhibitor, Kunitz type, 3 2.76663
FCRL5 Fc receptor-like 5 2.76663
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.76663
TUBB8 tubulin, beta 8 class VIII 2.76663
BATF basic leucine zipper transcription factor, ATF-like 2.76663
OIT3 oncoprotein induced transcript 3 2.76663
DRC11L dynein regulatory complex subunit 11 like 2.76663
ASB9 ankyrin repeat and SOCS box containing 9 2.76663
GRAP GRB2-related adaptor protein 2.76663
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.76663
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 2.76663
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.76663
LRRN4CL LRRN4 C-terminal like 2.76663
LTF lactotransferrin 2.76663
PTH parathyroid hormone 2.76663
IQUB IQ motif and ubiquitin domain containing 2.76663
PDC phosducin 2.76663
MLN motilin 2.76663
PNMA6F PNMA family member 6F 2.76663
C19ORF85 chromosome 19 open reading frame 85 2.76663
H4C14 H4 clustered histone 14 2.76663
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 2.76663
CFAP276 cilia and flagella associated protein 276 2.76663
SEPTIN12 septin 12 2.76663
CATSPERZ catsper channel auxiliary subunit zeta 2.76663
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 2.76663
LRRC3C leucine rich repeat containing 3C 2.76663
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.76663
C1QTNF1 C1q and tumor necrosis factor related protein 1 2.76663
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.76663
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 2.76663
HBA2 hemoglobin, alpha 2 2.76663
WEE2 WEE1 homolog 2 (S. pombe) 2.76663
TSSK4 testis-specific serine kinase 4 2.76663
GJA9 gap junction protein, alpha 9, 59kDa 2.76663
GPR75 G protein-coupled receptor 75 2.76663
HLF hepatic leukemia factor 2.76663
VSX2 visual system homeobox 2 2.76663
WNT11 wingless-type MMTV integration site family, member 11 2.76663
OLAH oleoyl-ACP hydrolase 2.76663
TBX3 T-box 3 2.76663
PGC progastricsin (pepsinogen C) 2.76663
MYH13 myosin, heavy chain 13, skeletal muscle 2.76663
TFEC transcription factor EC 2.76663
TLR4 toll-like receptor 4 2.76663
IL6 interleukin 6 2.76663
ZNF575 zinc finger protein 575 2.76663
TMEM235 transmembrane protein 235 2.76663
ADGRE3 adhesion G protein-coupled receptor E3 2.76663
HIC1 hypermethylated in cancer 1 2.76663
FAM163A family with sequence similarity 163, member A 2.76663
ANKRD33 ankyrin repeat domain 33 2.76663
LST1 leukocyte specific transcript 1 2.76663
POTEF POTE ankyrin domain family, member F 2.76663
ARMCX6 armadillo repeat containing, X-linked 6 2.76663
KCNK9 potassium channel, two pore domain subfamily K, member 9 2.76663
DEFB134 defensin, beta 134 2.76663
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 2.76663
SPEF1 sperm flagellar 1 2.76663
LY96 lymphocyte antigen 96 2.76663
ITGB7 integrin, beta 7 2.76663
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.76663
SYTL5 synaptotagmin-like 5 2.76663
TAPBPL TAP binding protein-like 2.76663
ADAM20 ADAM metallopeptidase domain 20 2.76663
TRAF3IP3 TRAF3 interacting protein 3 2.76663
ASTL astacin-like metallo-endopeptidase (M12 family) 2.76663
FBXO40 F-box protein 40 2.76663
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.76663
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.76663
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.76663
ZNF703 zinc finger protein 703 2.76663
ERICH4 glutamate-rich 4 2.76663
IGFBP7 insulin-like growth factor binding protein 7 2.76663
PAGE4 P antigen family, member 4 (prostate associated) 2.76663
VWA7 von Willebrand factor A domain containing 7 2.76663
CER1 cerberus 1, DAN family BMP antagonist 2.76663
KRT17 keratin 17, type I 2.76663
TMEM150B transmembrane protein 150B 2.76663
CYBB cytochrome b-245, beta polypeptide 2.76663
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 2.76663
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.76663
CATIP ciliogenesis associated TTC17 interacting protein 2.76663
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.76663
GPR68 G protein-coupled receptor 68 2.76663
DNAH8 dynein, axonemal, heavy chain 8 2.76663
R3HDML R3H domain containing-like 2.76663
HIGD1C HIG1 hypoxia inducible domain family, member 1C 2.76663
ORM2 orosomucoid 2 2.76663
NRSN1 neurensin 1 2.76663
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.76663
PRSS22 protease, serine, 22 2.76663
CD34 CD34 molecule 2.76663
TYR tyrosinase 2.76663
EMCN endomucin 2.76663
CCNA1 cyclin A1 2.76663
C22ORF31 chromosome 22 open reading frame 31 2.76663
GOLGA8N golgin A8 family, member N 2.76663
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 2.76663
SPAG6 sperm associated antigen 6 2.76663
TMEM52B transmembrane protein 52B 2.76663
MRGPRX3 MAS-related GPR, member X3 2.76663
PSG3 pregnancy specific beta-1-glycoprotein 3 2.76663
KIF12 kinesin family member 12 2.76663
GCM1 glial cells missing homolog 1 (Drosophila) 2.76663
EFCC1 EF-hand and coiled-coil domain containing 1 2.76663
PHOX2A paired-like homeobox 2a 2.76663
NLRP3 NLR family, pyrin domain containing 3 2.76663
C5ORF46 chromosome 5 open reading frame 46 2.76663
AMPD1 adenosine monophosphate deaminase 1 2.76663
DCST1 DC-STAMP domain containing 1 2.76663
LOXL4 lysyl oxidase-like 4 2.76663
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 2.75295
UQCRC1 ubiquinol-cytochrome c reductase core protein I 2.74208
TSLIG3B tRNA splicing ligase complex subunit 3B 2.68319
IARS1 isoleucyl-tRNA synthetase 1 2.67136
RETREG2 reticulophagy regulator family member 2 2.66665
ZNF574 zinc finger protein 574 2.66665
CTSO cathepsin O 2.65639
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 2.65639
ADAP2 ArfGAP with dual PH domains 2 2.65639
GLIPR1 GLI pathogenesis-related 1 2.65639
PDS5B PDS5 cohesin associated factor B 2.63902
NDC80 NDC80 kinetochore complex component 2.62219
ZNF536 zinc finger protein 536 2.52666
ZBTB46 zinc finger and BTB domain containing 46 2.52347
PRTFDC1 phosphoribosyl transferase domain containing 1 2.50105
AKAP19 A-kinase anchoring protein 19 2.48264
C17ORF78 chromosome 17 open reading frame 78 2.4031
GAGE10 G antigen 10 2.4031
COTL1 coactosin-like F-actin binding protein 1 2.39986
FAM217A family with sequence similarity 217, member A 2.39614
LIN28B lin-28 homolog B (C. elegans) 2.36004
GPR108 G protein-coupled receptor 108 2.33833
EBI3 Epstein-Barr virus induced 3 2.33797
ZNF441 zinc finger protein 441 2.33797
TRAPPC8 trafficking protein particle complex 8 2.33671
BLACAT1 bladder cancer associated transcript 1 (non-protein coding) 2.32891
SRP19 signal recognition particle 19kDa 2.32481
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 2.3215
MRPL22 mitochondrial ribosomal protein L22 2.3215
CCHCR1 coiled-coil alpha-helical rod protein 1 2.30196
DGKD diacylglycerol kinase, delta 130kDa 2.28948
TMEM222 transmembrane protein 222 2.28304
ERRFI1 ERBB receptor feedback inhibitor 1 2.28164
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 2.27545
INSYN1 inhibitory synaptic factor 1 2.27234
NBEAL1 neurobeachin-like 1 2.25429
TMED4 transmembrane emp24 protein transport domain containing 4 2.22679
NKAP NFKB activating protein 2.2175
HSPA2 heat shock 70kDa protein 2 2.21052
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 2.18571
RFC3 replication factor C (activator 1) 3, 38kDa 2.18571
SPATA2L spermatogenesis associated 2-like 2.18571
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 2.18077
TM7SF3 transmembrane 7 superfamily member 3 2.17581
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.17103
ZNF529 zinc finger protein 529 2.1446
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 2.11619
NODAL nodal growth differentiation factor 2.0985
ORAI2 ORAI calcium release-activated calcium modulator 2 2.09727
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit 2.08887
TMC7 transmembrane channel-like 7 2.08724
COA7 cytochrome c oxidase assembly factor 7 (putative) 2.07254
RBM5 RNA binding motif protein 5 2.06475
CORO2B coronin, actin binding protein, 2B 2.06475
BAG6 BCL2-associated athanogene 6 2.06475
TRNP1 TMF1-regulated nuclear protein 1 2.06475
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) 2.06475
C15ORF40 chromosome 15 open reading frame 40 2.05515
UROS uroporphyrinogen III synthase 2.04287
VRTN vertebrae development associated 2.04263
NUDCD2 NudC domain containing 2 2.02548
AMPH amphiphysin 2.02492
NKIRAS2 NFKB inhibitor interacting Ras-like 2 2.02465
FASTKD2 FAST kinase domains 2 2.00372

decreased expression

Symbol Name Standardized Value
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) -2.86222
COL8A2 collagen, type VIII, alpha 2 -2.86222
PPP1R42 protein phosphatase 1, regulatory subunit 42 -2.86222
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -2.86222
USP50 ubiquitin specific peptidase 50 -2.86222
ATG12 autophagy related 12 -2.86222
ART3 ADP-ribosyltransferase 3 -2.86222
TMEM151A transmembrane protein 151A -2.76663
FAM161B family with sequence similarity 161, member B -2.76663
MAP3K8 mitogen-activated protein kinase kinase kinase 8 -2.76663
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 -2.76663
CD99 CD99 molecule -2.76663
SOX7 SRY (sex determining region Y)-box 7 -2.76663
STKLD1 serine/threonine kinase-like domain containing 1 -2.76663
PSORS1C2 psoriasis susceptibility 1 candidate 2 -2.76663
HHEX hematopoietically expressed homeobox -2.76663
ACTL8 actin-like 8 -2.76663
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 -2.76663
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C -2.76663
STOML1 stomatin (EPB72)-like 1 -2.76663
HAS2 hyaluronan synthase 2 -2.76663
CIITA class II, major histocompatibility complex, transactivator -2.76663
ZSCAN22 zinc finger and SCAN domain containing 22 -2.76663
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -2.76663
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -2.76663
ZNF324B zinc finger protein 324B -2.76663
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 -2.76663
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -2.76663
TNC tenascin C -2.76663
TMEM123 transmembrane protein 123 -2.76663
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 -2.76663
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 -2.76663
CRACR2A calcium release activated channel regulator 2A -2.76663
BTNL2 butyrophilin-like 2 -2.76663
BARX1 BARX homeobox 1 -2.76663
ACE2 angiotensin I converting enzyme 2 -2.76663
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 -2.76663
ARG1 arginase 1 -2.76663
ZNF519 zinc finger protein 519 -2.76663
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) -2.76663
KCNK2 potassium channel, two pore domain subfamily K, member 2 -2.76663
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -2.76663
LDHAL6A lactate dehydrogenase A-like 6A -2.76663
ACOX2 acyl-CoA oxidase 2, branched chain -2.76663
CCDC150 coiled-coil domain containing 150 -2.76663
STAB1 stabilin 1 -2.76663
CA8 carbonic anhydrase VIII -2.72219
TTC7A tetratricopeptide repeat domain 7A -2.68004
MIEF2 mitochondrial elongation factor 2 -2.66665
ECT2L epithelial cell transforming 2 like -2.66665
CSNK1E casein kinase 1, epsilon -2.66665
TBX6 T-box 6 -2.64948
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 -2.64948
DNAH1 dynein, axonemal, heavy chain 1 -2.64948
XG Xg blood group -2.63717
ADAM19 ADAM metallopeptidase domain 19 -2.61033
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -2.58929
HPS6 Hermansky-Pudlak syndrome 6 -2.58024
U2AF2 U2 small nuclear RNA auxiliary factor 2 -2.57119
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -2.50824
CDA cytidine deaminase -2.5026
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -2.47285
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) -2.47285
TRAPPC9 trafficking protein particle complex 9 -2.41742
RPL29 ribosomal protein L29 -2.4127
TRIM2 tripartite motif containing 2 -2.39986
CCNG1 cyclin G1 -2.3982
PAQR9 progestin and adipoQ receptor family member IX -2.39356
MCOLN2 mucolipin 2 -2.3872
WBP2NL WBP2 N-terminal like -2.35924
KDM4B lysine (K)-specific demethylase 4B -2.34864
NCAPG2 non-SMC condensin II complex, subunit G2 -2.34549
CHD2 chromodomain helicase DNA binding protein 2 -2.33854
SEC31B SEC31 homolog B (S. cerevisiae) -2.33445
H1-2 H1.2 linker histone, cluster member -2.32348
TUFM Tu translation elongation factor, mitochondrial -2.27234
CHN2 chimerin 2 -2.25151
H1-1 H1.1 linker histone, cluster member -2.22416
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 -2.22416
TSPOAP1 TSPO associated protein 1 -2.22416
GPSM3 G-protein signaling modulator 3 -2.21575
NKIRAS1 NFKB inhibitor interacting Ras-like 1 -2.20254
ZNF75D zinc finger protein 75D -2.20254
IGF1 insulin-like growth factor 1 (somatomedin C) -2.19254
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -2.19254
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) -2.18616
BRSK1 BR serine/threonine kinase 1 -2.18571
SDCBP syndecan binding protein (syntenin) -2.18513
ZNF730 zinc finger protein 730 -2.18173
KCNK6 potassium channel, two pore domain subfamily K, member 6 -2.17103
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -2.17103
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 -2.16053
RBIS ribosomal biogenesis factor -2.12839
CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 -2.11185
RGN regucalcin -2.11185
RPUSD2 RNA pseudouridylate synthase domain containing 2 -2.10581
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -2.0985
EDIL3 EGF-like repeats and discoidin I-like domains 3 -2.0985
CALML4 calmodulin-like 4 -2.09135
RBM42 RNA binding motif protein 42 -2.08981
TBC1D14 TBC1 domain family, member 14 -2.06475
BRD8 bromodomain containing 8 -2.0575
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.05357
PRR5L proline rich 5 like -2.0459
MCM8 minichromosome maintenance complex component 8 -2.04263
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase -2.04096
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 -2.02465
RELL2 RELT-like 2 -2.02465
ESRRA estrogen-related receptor alpha -2.02465
TRIM25 tripartite motif containing 25 -2.02064
ZNF226 zinc finger protein 226 -2.01162
OMD osteomodulin -2.01074
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.00046