ATM Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ATM serine/threonine kinase|The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010] (NCBI Entrez Gene Database, 472)
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Genes

326 genes differentially expressed following the ATM gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NRN1 neuritin 1 2.67878
ALOX15 arachidonate 15-lipoxygenase 2.67878
RCL1 RNA terminal phosphate cyclase-like 1 2.67878
SPINK6 serine peptidase inhibitor, Kazal type 6 2.67878
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.67878
PGAM4 phosphoglycerate mutase family member 4 2.67878
PCDHB1 protocadherin beta 1 2.67878
SLC35G6 solute carrier family 35, member G6 2.67878
MILR1 mast cell immunoglobulin-like receptor 1 2.67878
NPPB natriuretic peptide B 2.67878
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.67878
WEE2 WEE1 homolog 2 (S. pombe) 2.67878
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.67878
CFHR3 complement factor H-related 3 2.67878
CCDC116 coiled-coil domain containing 116 2.67878
LAPTM5 lysosomal protein transmembrane 5 2.67878
CST11 cystatin 11 2.67878
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.67878
NPAP1 nuclear pore associated protein 1 2.67878
CCNB3 cyclin B3 2.67878
RRAD Ras-related associated with diabetes 2.67878
DUSP10 dual specificity phosphatase 10 2.67878
OR1L8 olfactory receptor, family 1, subfamily L, member 8 2.67878
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.67878
LATS1 large tumor suppressor kinase 1 2.67878
MISP mitotic spindle positioning 2.67878
MMP20 matrix metallopeptidase 20 2.67878
RNF133 ring finger protein 133 2.67878
GALR2 galanin receptor 2 2.67878
ETV2 ets variant 2 2.67878
FSCN2 fascin actin-bundling protein 2, retinal 2.67878
C1ORF146 chromosome 1 open reading frame 146 2.67878
TMEM191B transmembrane protein 191B 2.67878
PAX8 paired box 8 2.67878
FAM90A1 family with sequence similarity 90, member A1 2.67878
DMRTC1B DMRT-like family C1B 2.67878
FOLR3 folate receptor 3 (gamma) 2.67878
MYOM2 myomesin 2 2.67878
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.67878
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 2.67878
ACY3 aminoacylase 3 2.67878
FPR2 formyl peptide receptor 2 2.67878
LOC107986837 uncharacterized LOC107986837 2.67878
JAML junction adhesion molecule like 2.67878
CCN6 cellular communication network factor 6 2.67878
PLAAT4 phospholipase A and acyltransferase 4 2.67878
HTD2 hydroxyacyl-thioester dehydratase type 2 2.67878
CFAP65 cilia and flagella associated protein 65 2.67878
TLE7 TLE family member 7 2.67878
AVPR1A arginine vasopressin receptor 1A 2.67878
FKBP6 FK506 binding protein 6, 36kDa 2.67878
ELOA2 elongin A2 2.67878
DEFB131B defensin beta 131B 2.67878
CIMIP7 ciliary microtubule inner protein 7 2.67878
LNC-LBCS lncRNA bladder and prostate cancer suppressor, hnRNPK interacting 2.67878
WASL-DT WASL divergent transcript 2.67878
C8ORF90 chromosome 8 open reading frame 90 2.67878
LOC124902436 talanin 2.67878
ARMH2 armadillo like helical domain containing 2 2.67878
MEIOSIN meiosis initiator 2.67878
H1-8 H1.8 linker histone 2.67878
FMO1 flavin containing monooxygenase 1 2.67878
FOXN4 forkhead box N4 2.67878
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.67878
BARHL1 BarH-like homeobox 1 2.67878
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.67878
CKM creatine kinase, muscle 2.67878
MAGEB3 melanoma antigen family B3 2.67878
PCDHB12 protocadherin beta 12 2.67878
CDX2 caudal type homeobox 2 2.67878
ACTL10 actin-like 10 2.67878
OR2A25 olfactory receptor, family 2, subfamily A, member 25 2.67878
C1QTNF1 C1q and tumor necrosis factor related protein 1 2.67878
GJD4 gap junction protein, delta 4, 40.1kDa 2.67878
ACSL5 acyl-CoA synthetase long-chain family member 5 2.67878
ASB9 ankyrin repeat and SOCS box containing 9 2.67878
WNT16 wingless-type MMTV integration site family, member 16 2.67878
IMPG1 interphotoreceptor matrix proteoglycan 1 2.67878
ZNF705A zinc finger protein 705A 2.67878
TINAG tubulointerstitial nephritis antigen 2.67878
LRRC71 leucine rich repeat containing 71 2.67878
CLDN22 claudin 22 2.67878
KLF10 Kruppel-like factor 10 2.67878
LVRN laeverin 2.67878
APOL3 apolipoprotein L, 3 2.67878
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2.67878
EBF1 early B-cell factor 1 2.67878
CNPY2 canopy FGF signaling regulator 2 2.67878
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.67878
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10 2.67878
AQP7 aquaporin 7 2.67878
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 2.67878
ERICH6B glutamate-rich 6B 2.67878
GML glycosylphosphatidylinositol anchored molecule like 2.67878
PCDHGB1 protocadherin gamma subfamily B, 1 2.67878
NGB neuroglobin 2.67878
NPAS4 neuronal PAS domain protein 4 2.67878
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 2.67878
MT1M metallothionein 1M 2.67878
STMND1 stathmin domain containing 1 2.67878
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.67878
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2.67878
KRT15 keratin 15, type I 2.67878
ERMN ermin, ERM-like protein 2.67878
IL13RA2 interleukin 13 receptor, alpha 2 2.67878
HSPB9 heat shock protein, alpha-crystallin-related, B9 2.67878
CLEC4D C-type lectin domain family 4, member D 2.67878
PGR progesterone receptor 2.67878
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.67878
ORM2 orosomucoid 2 2.67878
MYADML2 myeloid-associated differentiation marker-like 2 2.67878
SPATA17 spermatogenesis associated 17 2.67878
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.67878
GJC2 gap junction protein, gamma 2, 47kDa 2.67878
GOLGA8R golgin A8 family, member R 2.67878
LRRC24 leucine rich repeat containing 24 2.67878
SOSTDC1 sclerostin domain containing 1 2.67878
LYZ lysozyme 2.67878
CAGE1 cancer antigen 1 2.67878
NUPR1 nuclear protein, transcriptional regulator, 1 2.67878
IL19 interleukin 19 2.67878
CFI complement factor I 2.67878
PLA1A phospholipase A1 member A 2.67878
C8ORF89 chromosome 8 open reading frame 89 2.67878
KLK7 kallikrein-related peptidase 7 2.67878
KLK6 kallikrein-related peptidase 6 2.67878
FSHR follicle stimulating hormone receptor 2.67878
KRTAP11-1 keratin associated protein 11-1 2.67878
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 2.67878
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 2.67878
SNAI2 snail family zinc finger 2 2.67878
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.67878
TAS2R43 taste receptor, type 2, member 43 2.67878
RYR2 ryanodine receptor 2 (cardiac) 2.67878
NPC1L1 NPC1-like 1 2.67878
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2.67878
GPR179 G protein-coupled receptor 179 2.67878
NLRP13 NLR family, pyrin domain containing 13 2.67878
ANPEP alanyl (membrane) aminopeptidase 2.67878
TMEM215 transmembrane protein 215 2.67878
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.67878
TRAF3IP3 TRAF3 interacting protein 3 2.67878
TMEM86B transmembrane protein 86B 2.67878
SERTM1 serine-rich and transmembrane domain containing 1 2.67878
CD33 CD33 molecule 2.67878
H2AZ2 H2A.Z variant histone 2 2.67401
ADD3 adducin 3 (gamma) 2.64685
ETV5 ets variant 5 2.61285
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2.58544
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.57893
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 2.57246
RND2 Rho family GTPase 2 2.51485
N4BP1 NEDD4 binding protein 1 2.49698
CLCNKA chloride channel, voltage-sensitive Ka 2.4576
SYCP3 synaptonemal complex protein 3 2.4576
HIGD1B HIG1 hypoxia inducible domain family, member 1B 2.4576
STARD13 StAR-related lipid transfer (START) domain containing 13 2.43322
UGCG UDP-glucose ceramide glucosyltransferase 2.40699
ODAD1 outer dynein arm docking complex subunit 1 2.36445
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 2.36445
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 2.34321
ORAI3 ORAI calcium release-activated calcium modulator 3 2.34246
C5ORF24 chromosome 5 open reading frame 24 2.32958
IGFBP7 insulin-like growth factor binding protein 7 2.28895
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.2867
MINDY4B MINDY family member 4B 2.28522
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 2.27293
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 2.27259
SHTN1 shootin 1 2.26055
C12ORF57 chromosome 12 open reading frame 57 2.25687
ASPH aspartate beta-hydroxylase 2.2306
CCDC141 coiled-coil domain containing 141 2.2306
EXOSC1 exosome component 1 2.2306
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 2.22884
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 2.2274
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 2.2274
COL12A1 collagen, type XII, alpha 1 2.22327
ATG9A autophagy related 9A 2.21382
THTPA thiamine triphosphatase 2.21279
RNPC3 RNA-binding region (RNP1, RRM) containing 3 2.20468
H2BC12 H2B clustered histone 12 2.1409
SGO1 shugoshin 1 2.13417
TPBG trophoblast glycoprotein 2.09115
HMCN2 hemicentin 2 2.09088
OTOG otogelin 2.09088
CCDC106 coiled-coil domain containing 106 2.08626
SRPRA SRP receptor subunit alpha 2.08053
THY1 Thy-1 cell surface antigen 2.06394
SELENOF selenoprotein F 2.05677
SCD stearoyl-CoA desaturase (delta-9-desaturase) 2.04953
AXIN1 axin 1 2.04032
HSPB11 heat shock protein family B (small), member 11 2.03784
E2F7 E2F transcription factor 7 2.03668
SLC38A4 solute carrier family 38, member 4 2.0347
TTC39C tetratricopeptide repeat domain 39C 2.03117
ACAT1 acetyl-CoA acetyltransferase 1 2.03117
SLC39A8 solute carrier family 39 (zinc transporter), member 8 2.02467
ULK1 unc-51 like autophagy activating kinase 1 2.02016
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 2.01199
MAGEE1 melanoma antigen family E1 2.00291
HEBP2 heme binding protein 2 2.00291
CALCB calcitonin-related polypeptide beta 2.00203
SPDYA speedy/RINGO cell cycle regulator family member A 2.00023

decreased expression

Symbol Name Standardized Value
SPHK2 sphingosine kinase 2 -2.67878
AKR1C2 aldo-keto reductase family 1, member C2 -2.67878
PNMA8C PNMA family member 8C -2.67878
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 -2.67878
LACC1 laccase (multicopper oxidoreductase) domain containing 1 -2.67878
DAND5 DAN domain family member 5, BMP antagonist -2.67878
TULP1 tubby like protein 1 -2.67878
MAPK11 mitogen-activated protein kinase 11 -2.67878
LTC4S leukotriene C4 synthase -2.67878
TAS2R4 taste receptor, type 2, member 4 -2.67878
CDX4 caudal type homeobox 4 -2.67878
TOB2 transducer of ERBB2, 2 -2.67878
ZPLD1 zona pellucida-like domain containing 1 -2.67878
GSTM2 glutathione S-transferase mu 2 (muscle) -2.67878
DDX55 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 -2.67878
USP50 ubiquitin specific peptidase 50 -2.67878
CFAP53 cilia and flagella associated protein 53 -2.67878
SPAG8 sperm associated antigen 8 -2.67878
CA7 carbonic anhydrase VII -2.67878
RTL9 retrotransposon Gag like 9 -2.67878
CD22 CD22 molecule -2.67878
GLYATL1B glycine-N-acyltransferase like 1B -2.67878
C11ORF86 chromosome 11 open reading frame 86 -2.67878
ZNF232 zinc finger protein 232 -2.67878
MANSC4 MANSC domain containing 4 -2.67878
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -2.67878
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) -2.67878
KLHL31 kelch-like family member 31 -2.67878
OR2A14 olfactory receptor, family 2, subfamily A, member 14 -2.67878
CIROZ ciliated left-right organizer protein containing ZP-N domains -2.67878
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) -2.67878
SLC15A5 solute carrier family 15, member 5 -2.67878
C1ORF167 chromosome 1 open reading frame 167 -2.67878
FCRLB Fc receptor-like B -2.67878
ZNF572 zinc finger protein 572 -2.67878
LEF1 lymphoid enhancer-binding factor 1 -2.67878
MYOT myotilin -2.67878
NMBR neuromedin B receptor -2.67878
TMED6 transmembrane emp24 protein transport domain containing 6 -2.67878
KLF9 Kruppel-like factor 9 -2.67878
PAMR1 peptidase domain containing associated with muscle regeneration 1 -2.67878
CFAP99 cilia and flagella associated protein 99 -2.67878
PDF peptide deformylase (mitochondrial) -2.67878
C4ORF50 chromosome 4 open reading frame 50 -2.67878
RGS11 regulator of G-protein signaling 11 -2.67878
STAR steroidogenic acute regulatory protein -2.67878
IL1R1 interleukin 1 receptor, type I -2.67878
CLDN5 claudin 5 -2.67878
MEOX2 mesenchyme homeobox 2 -2.67878
MTMR3 myotubularin related protein 3 -2.67878
IDS iduronate 2-sulfatase -2.67878
AGAP5 ArfGAP with GTPase domain, ankyrin repeat and PH domain 5 -2.64886
COMT catechol-O-methyltransferase -2.60736
PIERCE2 piercer of microtubule wall 2 -2.58199
RNF19B ring finger protein 19B -2.57575
SPMIP2 sperm microtubule inner protein 2 -2.5585
CCDC175 coiled-coil domain containing 175 -2.5585
CLTB clathrin, light chain B -2.55309
YPEL1 yippee-like 1 (Drosophila) -2.53637
INHBA inhibin, beta A -2.51668
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit -2.51307
PDS5B PDS5 cohesin associated factor B -2.49547
ARHGAP45 Rho GTPase activating protein 45 -2.47134
EIF3L eukaryotic translation initiation factor 3, subunit L -2.46473
NBN nibrin -2.46297
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 -2.4415
MIPEP mitochondrial intermediate peptidase -2.43572
AMPD3 adenosine monophosphate deaminase 3 -2.43322
CDADC1 cytidine and dCMP deaminase domain containing 1 -2.42244
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -2.42244
SP1 Sp1 transcription factor -2.40699
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19 -2.40699
CCDC150 coiled-coil domain containing 150 -2.40699
KATNAL2 katanin p60 subunit A-like 2 -2.39309
GOLGA8A golgin A8 family, member A -2.36608
SAXO2 stabilizer of axonemal microtubules 2 -2.36608
ZNF112 zinc finger protein 112 -2.32079
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.29149
CARMIL2 capping protein regulator and myosin 1 linker 2 -2.28895
CHIC1 cysteine-rich hydrophobic domain 1 -2.25687
ZNF354A zinc finger protein 354A -2.23917
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) -2.23213
ZNF41 zinc finger protein 41 -2.2274
LDHB lactate dehydrogenase B -2.21641
TIGD2 tigger transposable element derived 2 -2.18146
PLA2R1 phospholipase A2 receptor 1, 180kDa -2.18032
SSTR2 somatostatin receptor 2 -2.1802
RARS2 arginyl-tRNA synthetase 2, mitochondrial -2.17898
ADAR adenosine deaminase, RNA-specific -2.15922
SWAP70 SWAP switching B-cell complex 70kDa subunit -2.15582
BIRC6 baculoviral IAP repeat containing 6 -2.15582
PKD1L1 polycystic kidney disease 1 like 1 -2.15582
SIAE sialic acid acetylesterase -2.15149
CCDC81 coiled-coil domain containing 81 -2.15149
NBEA neurobeachin -2.15149
NDC80 NDC80 kinetochore complex component -2.13048
ICE2 interactor of little elongation complex ELL subunit 2 -2.11731
COL11A2 collagen, type XI, alpha 2 -2.11667
DNAH12 dynein, axonemal, heavy chain 12 -2.11667
GRK5 G protein-coupled receptor kinase 5 -2.09404
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -2.08243
TTC9C tetratricopeptide repeat domain 9C -2.07576
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -2.06394
YDJC YdjC homolog (bacterial) -2.06104
ZNF514 zinc finger protein 514 -2.06086
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.06063
PLXDC1 plexin domain containing 1 -2.0456
ITGA7 integrin, alpha 7 -2.0409
PPP2R5D protein phosphatase 2, regulatory subunit B', delta -2.0398
MSRA methionine sulfoxide reductase A -2.03668
BUB3 BUB3 mitotic checkpoint protein -2.0366
JMY junction mediating and regulatory protein, p53 cofactor -2.0366
RAB25 RAB25, member RAS oncogene family -2.03128
EIF4B eukaryotic translation initiation factor 4B -2.03128
MARCHF8 membrane associated ring-CH-type finger 8 -2.03117
TRIR telomerase RNA component interacting RNase -2.02847
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.02847
CYTIP cytohesin 1 interacting protein -2.02467
UEVLD UEV and lactate/malate dehyrogenase domains -2.02467
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) -2.02467
CCDC158 coiled-coil domain containing 158 -2.02467
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase -2.0044
CKAP2L cytoskeleton associated protein 2-like -2.00023