ATM Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description ATM serine/threonine kinase|The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010] (NCBI Entrez Gene Database, 472)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GCM_ATM
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Genes

56 co-expressed genes for ATM from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
AANAT aralkylamine N-acetyltransferase
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
ADRB3 adrenoceptor beta 3
AQP2 aquaporin 2 (collecting duct)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATM ATM serine/threonine kinase
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BCL3 B-cell CLL/lymphoma 3
BTN3A1 butyrophilin, subfamily 3, member A1
BTN3A2 butyrophilin, subfamily 3, member A2
CASP8 caspase 8, apoptosis-related cysteine peptidase
CDK13 cyclin-dependent kinase 13
CLEC2D C-type lectin domain family 2, member D
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DENND2D DENN/MADD domain containing 2D
DRG2 developmentally regulated GTP binding protein 2
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
DUSP2 dual specificity phosphatase 2
GPER1 G protein-coupled estrogen receptor 1
GPR171 G protein-coupled receptor 171
GVINP1 GTPase, very large interferon inducible pseudogene 1
GZMK granzyme K (granzyme 3; tryptase II)
HECA headcase homolog (Drosophila)
HMHA1 histocompatibility (minor) HA-1
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3
HSF4 heat shock transcription factor 4
HTT huntingtin
ITK IL2-inducible T-cell kinase
KRT35 keratin 35, type I
LAT linker for activation of T cells
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LTK leukocyte receptor tyrosine kinase
MICB MHC class I polypeptide-related sequence B
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MYBPC2 myosin binding protein C, fast type
NEFL neurofilament, light polypeptide
NR1H2 nuclear receptor subfamily 1, group H, member 2
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLK1 polo-like kinase 1
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1
RABGGTA Rab geranylgeranyltransferase, alpha subunit
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RENBP renin binding protein
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SIRPB1 signal-regulatory protein beta 1
SYNRG synergin, gamma
TH tyrosine hydroxylase
TMC6 transmembrane channel-like 6
TRAF3IP3 TRAF3 interacting protein 3
WAS Wiskott-Aldrich syndrome
ZNF266 zinc finger protein 266