ATM Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description ATM serine/threonine kinase|The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010] (NCBI Entrez Gene Database, 472)
External Link http://www.ncbi.nlm.nih.gov/gene/472
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Genes

108 substrates of the kinase ATM from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
AATF apoptosis antagonizing transcription factor
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
APLF aprataxin and PNKP like factor
ATF2 activating transcription factor 2
ATM ATM serine/threonine kinase
AVEN apoptosis, caspase activation inhibitor
BAG6 BCL2-associated athanogene 6
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QBP complement component 1, q subcomponent binding protein
CCDC6 coiled-coil domain containing 6
CHD4 chromodomain helicase DNA binding protein 4
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
COPS3 COP9 signalosome subunit 3
CREB1 cAMP responsive element binding protein 1
CROCC ciliary rootlet coiled-coil, rootletin
DAXX death-domain associated protein
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DCLRE1C DNA cross-link repair 1C
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
E2F1 E2F transcription factor 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EP300 E1A binding protein p300
EWSR1 EWS RNA-binding protein 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FANCD2 Fanconi anemia, complementation group D2
FANCI Fanconi anemia, complementation group I
FBXO31 F-box protein 31
FUS FUS RNA binding protein
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
H2AFX H2A histone family, member X
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
KDM2A lysine (K)-specific demethylase 2A
KHSRP KH-type splicing regulatory protein
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MCM3 minichromosome maintenance complex component 3
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MED1 mediator complex subunit 1
MEN1 multiple endocrine neoplasia I
MLH1 mutL homolog 1
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NABP2 nucleic acid binding protein 2
NBN nibrin
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NHEJ1 nonhomologous end-joining factor 1
NKX3-1 NK3 homeobox 1
NUSAP1 nucleolar and spindle associated protein 1
PBRM1 polybromo 1
PNKP polynucleotide kinase 3'-phosphatase
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTEN phosphatase and tensin homolog
RAD17 RAD17 homolog (S. pombe)
RAD18 RAD18 E3 ubiquitin protein ligase
RAD50 RAD50 homolog (S. cerevisiae)
RAD9A RAD9 homolog A (S. pombe)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBBP8 retinoblastoma binding protein 8
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RFWD3 ring finger and WD repeat domain 3
RIF1 replication timing regulatory factor 1
RNF20 ring finger protein 20, E3 ubiquitin protein ligase
RNF40 ring finger protein 40, E3 ubiquitin protein ligase
RPA2 replication protein A2, 32kDa
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
SIAH1 siah E3 ubiquitin protein ligase 1
SLX4 SLX4 structure-specific endonuclease subunit
SMAD1 SMAD family member 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
SP1 Sp1 transcription factor
STK11 serine/threonine kinase 11
SYN1 synapsin I
TAOK1 TAO kinase 1
TAOK3 TAO kinase 3
TDP1 tyrosyl-DNA phosphodiesterase 1
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP63 tumor protein p63
TRIM28 tripartite motif containing 28
TTC5 tetratricopeptide repeat domain 5
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UIMC1 ubiquitin interaction motif containing 1
USP10 ubiquitin specific peptidase 10
USP15 ubiquitin specific peptidase 15
USP28 ubiquitin specific peptidase 28
USP34 ubiquitin specific peptidase 34
VCP valosin containing protein
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WRN Werner syndrome, RecQ helicase-like
XPA xeroderma pigmentosum, complementation group A
ZBTB2 zinc finger and BTB domain containing 2
ZNF148 zinc finger protein 148
ZNF420 zinc finger protein 420