ATP7B Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ATPase, Cu++ transporting, beta polypeptide|This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 540)
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Genes

351 genes differentially expressed following the ATP7B gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PRSS53 protease, serine, 53 2.50796
VN1R1 vomeronasal 1 receptor 1 2.50796
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 2.50796
GPR26 G protein-coupled receptor 26 2.50796
SDSL serine dehydratase-like 2.50796
RNF113B ring finger protein 113B 2.50796
ADAM7 ADAM metallopeptidase domain 7 2.50796
NPPC natriuretic peptide C 2.50796
KLHL6 kelch-like family member 6 2.50796
MAEL maelstrom spermatogenic transposon silencer 2.50796
SCRT2 scratch family zinc finger 2 2.50796
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 2.50796
CH25H cholesterol 25-hydroxylase 2.50796
GJA4 gap junction protein, alpha 4, 37kDa 2.50796
RLBP1 retinaldehyde binding protein 1 2.50796
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.50796
SLC9C2 solute carrier family 9, member C2 (putative) 2.50796
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 2.50796
ETV3L ets variant 3-like 2.50796
LHX8 LIM homeobox 8 2.50796
LEP leptin 2.50796
CORO6 coronin 6 2.50796
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.47822
ADRB1 adrenoceptor beta 1 2.47822
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 2.47822
SLC16A11 solute carrier family 16, member 11 2.47822
AKR1C2 aldo-keto reductase family 1, member C2 2.47822
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.47822
GPR52 G protein-coupled receptor 52 2.47822
VWA5B2 von Willebrand factor A domain containing 5B2 2.47822
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 2.47822
FAM167A family with sequence similarity 167, member A 2.47822
THEMIS thymocyte selection associated 2.47822
HIC1 hypermethylated in cancer 1 2.47822
ASB15 ankyrin repeat and SOCS box containing 15 2.47822
NECAB2 N-terminal EF-hand calcium binding protein 2 2.47822
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.47822
FABP1 fatty acid binding protein 1, liver 2.47822
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.47822
FHL5 four and a half LIM domains 5 2.47822
GMFG glia maturation factor, gamma 2.47822
TRIM77 tripartite motif containing 77 2.47822
LRRC10B leucine rich repeat containing 10B 2.47822
LCN15 lipocalin 15 2.47822
PECAM1 platelet/endothelial cell adhesion molecule 1 2.47822
GPR20 G protein-coupled receptor 20 2.47822
RGPD3 RANBP2-like and GRIP domain containing 3 2.47822
MEIKIN meiotic kinetochore factor 2.47822
TYRP1 tyrosinase-related protein 1 2.47822
KIF2B kinesin family member 2B 2.47822
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 2.47822
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.47822
LRRC53 leucine rich repeat containing 53 2.47822
VSTM2A V-set and transmembrane domain containing 2A 2.47822
SLC25A41 solute carrier family 25, member 41 2.47822
TMEM151A transmembrane protein 151A 2.47822
CDH5 cadherin 5, type 2 (vascular endothelium) 2.47822
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.47822
TYW2 tRNA wybutosine-synthesizing protein 2 2.47822
H2BC1 H2B clustered histone 1 2.47822
GIPC3 GIPC PDZ domain containing family, member 3 2.47822
ZNF728 zinc finger protein 728 2.47822
C3AR1 complement component 3a receptor 1 2.47822
RAX2 retina and anterior neural fold homeobox 2 2.47822
PNLIPRP3 pancreatic lipase-related protein 3 2.47822
TMIGD1 transmembrane and immunoglobulin domain containing 1 2.47822
HS1BP3 HCLS1 binding protein 3 2.47822
OR1C1 olfactory receptor, family 1, subfamily C, member 1 2.47822
H1-6 H1.6 linker histone, cluster member 2.47822
LOC124901449 uncharacterized LOC124901449 2.47822
TMEM275 transmembrane protein 275 2.47822
FAM240C family with sequence similarity 240 member C 2.47822
LRRC8C-DT LRRC8C divergent transcript 2.47822
SMIM45 small integral membrane protein 45 2.47822
H3C3 H3 clustered histone 3 2.47822
EZHIP EZH inhibitory protein 2.47822
GARIN4 golgi associated RAB2 interactor family member 4 2.47822
TERB1 telomere repeat binding bouquet formation protein 1 2.47822
CFAP20DC CFAP20 domain containing 2.47822
FAM237B family with sequence similarity 237 member B 2.47822
TREX2 three prime repair exonuclease 2 2.47822
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.47822
ZIC4 Zic family member 4 2.47822
ULBP1 UL16 binding protein 1 2.47822
CKM creatine kinase, muscle 2.47822
IRF5 interferon regulatory factor 5 2.47822
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.47822
CAPN14 calpain 14 2.47822
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) 2.47822
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.47822
WEE2 WEE1 homolog 2 (S. pombe) 2.47822
DMBX1 diencephalon/mesencephalon homeobox 1 2.47822
IL6 interleukin 6 2.47822
IL5 interleukin 5 2.47822
SYT15 synaptotagmin XV 2.47822
HNF1A HNF1 homeobox A 2.47822
TMEM119 transmembrane protein 119 2.47822
SBSN suprabasin 2.47822
GSC goosecoid homeobox 2.47822
S100B S100 calcium binding protein B 2.47822
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.47822
MYH13 myosin, heavy chain 13, skeletal muscle 2.47822
TLR6 toll-like receptor 6 2.47822
CFHR3 complement factor H-related 3 2.47822
TBC1D28 TBC1 domain family, member 28 2.47822
CDR2L cerebellar degeneration-related protein 2-like 2.47822
AMIGO1 adhesion molecule with Ig-like domain 1 2.47822
CERKL ceramide kinase-like 2.47822
MT2A metallothionein 2A 2.47822
BTNL3 butyrophilin-like 3 2.47822
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 2.47822
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.47822
TDRD10 tudor domain containing 10 2.47822
NIPAL4 NIPA-like domain containing 4 2.47822
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.47822
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.47822
MAPK11 mitogen-activated protein kinase 11 2.47822
ABHD1 abhydrolase domain containing 1 2.47822
ECM1 extracellular matrix protein 1 2.47822
PRND prion protein 2 (dublet) 2.47822
TCF21 transcription factor 21 2.47822
ANKRD62 ankyrin repeat domain 62 2.47822
KPNA5 karyopherin alpha 5 (importin alpha 6) 2.47822
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.47822
KRT16 keratin 16, type I 2.47822
TRIM50 tripartite motif containing 50 2.47822
PCDHGA7 protocadherin gamma subfamily A, 7 2.47822
RGS4 regulator of G-protein signaling 4 2.47822
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.47822
HMGB3 high mobility group box 3 2.47822
GPR149 G protein-coupled receptor 149 2.47822
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.47822
IL25 interleukin 25 2.47822
LMX1B LIM homeobox transcription factor 1, beta 2.47822
LMX1A LIM homeobox transcription factor 1, alpha 2.47822
TEX26 testis expressed 26 2.47822
SYNGR4 synaptogyrin 4 2.47822
LRRC9 leucine rich repeat containing 9 2.47822
PCDHGA2 protocadherin gamma subfamily A, 2 2.47822
C17ORF99 chromosome 17 open reading frame 99 2.47822
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.47822
SLC36A3 solute carrier family 36, member 3 2.47822
SPEF1 sperm flagellar 1 2.47822
TMEM178B transmembrane protein 178B 2.47822
FGA fibrinogen alpha chain 2.47822
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.47822
ZC3H12D zinc finger CCCH-type containing 12D 2.47822
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.47822
PRR15L proline rich 15-like 2.47822
DUOXA1 dual oxidase maturation factor 1 2.47822
GHRH growth hormone releasing hormone 2.47822
C5ORF46 chromosome 5 open reading frame 46 2.47822
ASCL3 achaete-scute family bHLH transcription factor 3 2.47822
NLRP6 NLR family, pyrin domain containing 6 2.47822
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 2.47822
LRRC34 leucine rich repeat containing 34 2.47822
LPA lipoprotein, Lp(a) 2.47822
ARGFX arginine-fifty homeobox 2.47822
OR14A2 olfactory receptor, family 14, subfamily A, member 2 2.47822
POU5F1 POU class 5 homeobox 1 2.47822
LBX2 ladybird homeobox 2 2.47822
LHB luteinizing hormone beta polypeptide 2.47822
TSSK1B testis-specific serine kinase 1B 2.47822
WFDC12 WAP four-disulfide core domain 12 2.47822
HIGD1C HIG1 hypoxia inducible domain family, member 1C 2.47822
ALOX15B arachidonate 15-lipoxygenase, type B 2.47822
ACKR2 atypical chemokine receptor 2 2.47822
GH1 growth hormone 1 2.47822
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.47822
OR56A5 olfactory receptor, family 56, subfamily A, member 5 2.47822
REV1 REV1, polymerase (DNA directed) 2.47822
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.47822
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 2.47822
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 2.47822
ZPLD1 zona pellucida-like domain containing 1 2.47822
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 2.47822
PODN podocan 2.47822
YARS1 tyrosyl-tRNA synthetase 1 2.47536
ELAPOR2 endosome-lysosome associated apoptosis and autophagy regulator family member 2 2.43875
PRCD progressive rod-cone degeneration 2.43493
GOPC golgi-associated PDZ and coiled-coil motif containing 2.43493
ITK IL2-inducible T-cell kinase 2.43493
TTLL10 tubulin tyrosine ligase-like family member 10 2.43493
ZNF862 zinc finger protein 862 2.39709
ZEB2 zinc finger E-box binding homeobox 2 2.35824
PEX5L peroxisomal biogenesis factor 5-like 2.34887
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 2.34585
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 2.33764
VAMP3 vesicle-associated membrane protein 3 2.27041
ZNF385C zinc finger protein 385C 2.27041
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 2.27041
SSR4 signal sequence receptor, delta 2.27041
NOX3 NADPH oxidase 3 2.26505
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.26505
SYT14 synaptotagmin XIV 2.25204
FMN1 formin 1 2.22601
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 2.22434
ZSWIM6 zinc finger, SWIM-type containing 6 2.22434
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 2.21766
STRIP2 striatin interacting protein 2 2.18636
H2BC4 H2B clustered histone 4 2.18422
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 2.16206
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 2.13002
MYO3B myosin IIIB 2.12849
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 2.12692
ACOXL acyl-CoA oxidase-like 2.12692
MEST mesoderm specific transcript 2.12692
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial 2.11809
NCAM1 neural cell adhesion molecule 1 2.10053
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 2.09097
SKA3 spindle and kinetochore associated complex subunit 3 2.08275
RETREG2 reticulophagy regulator family member 2 2.07056
CPE carboxypeptidase E 2.063
CHAMP1 chromosome alignment maintaining phosphoprotein 1 2.05814
AP3D1 adaptor-related protein complex 3, delta 1 subunit 2.04471
CAPN13 calpain 13 2.02149
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 2.01528
PIGV phosphatidylinositol glycan anchor biosynthesis, class V 2.01528
TMEM68 transmembrane protein 68 2.00316
USP2 ubiquitin specific peptidase 2 2.00316

decreased expression

Symbol Name Standardized Value
SLC7A14 solute carrier family 7, member 14 -2.50796
NYAP1 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 -2.50796
ADGRA2 adhesion G protein-coupled receptor A2 -2.50796
MPZL2 myelin protein zero-like 2 -2.50796
TTLL9 tubulin tyrosine ligase-like family member 9 -2.4929
CPZ carboxypeptidase Z -2.4929
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 -2.4929
PLEKHD1 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 -2.4929
PCDH20 protocadherin 20 -2.4929
SHROOM2 shroom family member 2 -2.4929
KIAA1755 KIAA1755 -2.47822
ASB18 ankyrin repeat and SOCS box containing 18 -2.47822
TMEM100 transmembrane protein 100 -2.47822
SFXN3 sideroflexin 3 -2.47822
GPR22 G protein-coupled receptor 22 -2.47822
THRSP thyroid hormone responsive -2.47822
IGSF22 immunoglobulin superfamily, member 22 -2.47822
CLNK cytokine-dependent hematopoietic cell linker -2.47822
TTLL2 tubulin tyrosine ligase-like family member 2 -2.47822
EIF1 eukaryotic translation initiation factor 1 -2.47822
LKAAEAR1 LKAAEAR motif containing 1 -2.47822
FARSA phenylalanyl-tRNA synthetase, alpha subunit -2.47822
TXNDC16 thioredoxin domain containing 16 -2.47822
THSD1 thrombospondin, type I, domain containing 1 -2.47822
TPPP tubulin polymerization promoting protein -2.47822
SPESP1 sperm equatorial segment protein 1 -2.47822
CD160 CD160 molecule -2.47822
MUC6 mucin 6, oligomeric mucus/gel-forming -2.47822
CCDC92 coiled-coil domain containing 92 -2.47822
PIWIL4 piwi-like RNA-mediated gene silencing 4 -2.47822
ZMYND8 zinc finger, MYND-type containing 8 -2.47822
ABHD15 abhydrolase domain containing 15 -2.47822
BHLHE41 basic helix-loop-helix family, member e41 -2.47822
TBC1D3L TBC1 domain family, member 3L -2.47822
HTRA3 HtrA serine peptidase 3 -2.47822
AANAT aralkylamine N-acetyltransferase -2.47822
CHPF2 chondroitin polymerizing factor 2 -2.47822
FAM43A family with sequence similarity 43, member A -2.47822
CLDN1 claudin 1 -2.47822
AKAP14 A kinase (PRKA) anchor protein 14 -2.47822
SIX1 SIX homeobox 1 -2.47822
KNDC1 kinase non-catalytic C-lobe domain (KIND) containing 1 -2.47822
LOC390937 Ets2 repressor factor-like -2.47822
LIPA lipase A, lysosomal acid, cholesterol esterase -2.47822
ZNF436 zinc finger protein 436 -2.47822
PCDHA2 protocadherin alpha 2 -2.47822
PCDHB14 protocadherin beta 14 -2.47822
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.47822
ADAM20 ADAM metallopeptidase domain 20 -2.47822
FRMPD3 FERM and PDZ domain containing 3 -2.47822
MAP6 microtubule-associated protein 6 -2.47822
SMAD9 SMAD family member 9 -2.47822
CHI3L2 chitinase 3-like 2 -2.47822
HSCB HscB mitochondrial iron-sulfur cluster co-chaperone -2.47822
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein -2.47822
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -2.47822
FAM209B family with sequence similarity 209, member B -2.47822
EDN3 endothelin 3 -2.47822
ANKRD6 ankyrin repeat domain 6 -2.47822
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 -2.47822
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 -2.47822
IL21R interleukin 21 receptor -2.47822
TMEM132B transmembrane protein 132B -2.47822
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 -2.47822
RAD9B RAD9 homolog B (S. pombe) -2.47822
EIF3CL eukaryotic translation initiation factor 3, subunit C-like -2.47822
LRRC38 leucine rich repeat containing 38 -2.47822
SOBP sine oculis binding protein homolog (Drosophila) -2.47822
OPTC opticin -2.47822
ADAP1 ArfGAP with dual PH domains 1 -2.47822
ACKR3 atypical chemokine receptor 3 -2.47822
STRC stereocilin -2.47822
WDR70 WD repeat domain 70 -2.47822
KCTD13 potassium channel tetramerization domain containing 13 -2.47822
ZNF497 zinc finger protein 497 -2.47822
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing -2.47275
THOC6 THO complex 6 -2.4633
NINL ninein-like -2.44713
FAM3A family with sequence similarity 3, member A -2.44233
MRPS22 mitochondrial ribosomal protein S22 -2.44064
IFT74 intraflagellar transport 74 -2.43493
APP-DT APP divergent transcript -2.43493
GSTM3 glutathione S-transferase mu 3 (brain) -2.38206
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.379
ANAPC1 anaphase promoting complex subunit 1 -2.34887
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.34887
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 -2.32711
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -2.32301
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 -2.31892
NHLH2 nescient helix loop helix 2 -2.28806
CLUL1 clusterin-like 1 (retinal) -2.28806
PCGF1 polycomb group ring finger 1 -2.28806
TCL1B T-cell leukemia/lymphoma 1B -2.27041
FHL1 four and a half LIM domains 1 -2.25204
DIPK2A divergent protein kinase domain 2A -2.24084
NOS2 nitric oxide synthase 2, inducible -2.23836
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.2247
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 -2.2247
PLAAT3 phospholipase A and acyltransferase 3 -2.20365
GCN1 GCN1 activator of EIF2AK4 -2.16574
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.15684
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) -2.12849
CPNE5 copine V -2.12849
GPR146 G protein-coupled receptor 146 -2.12849
DCP1A decapping mRNA 1A -2.12692
H1-5 H1.5 linker histone, cluster member -2.11809
TMLHE trimethyllysine hydroxylase, epsilon -2.1054
AK3 adenylate kinase 3 -2.08851
STX5 syntaxin 5 -2.08851
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 -2.08851
DEPDC5 DEP domain containing 5 -2.08851
MDM4 MDM4, p53 regulator -2.08851
PLAG1 pleiomorphic adenoma gene 1 -2.08851
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -2.08851
CFAP144 cilia and flagella associated protein 144 -2.08851
UNC13A unc-13 homolog A (C. elegans) -2.08851
ARHGAP30 Rho GTPase activating protein 30 -2.08275
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -2.08275
PTP4A3 protein tyrosine phosphatase type IVA, member 3 -2.07611
SWI5 SWI5 recombination repair homolog (yeast) -2.07152
SIRT2 sirtuin 2 -2.06763
BAMBI BMP and activin membrane-bound inhibitor -2.063
FSTL1 follistatin-like 1 -2.05315
ACTN3 actinin, alpha 3 (gene/pseudogene) -2.04663
UCKL1 uridine-cytidine kinase 1-like 1 -2.04471
FNDC10 fibronectin type III domain containing 10 -2.03658
MATN2 matrilin 2 -2.02149
IRF4 interferon regulatory factor 4 -2.01528
DCK deoxycytidine kinase -2.01528
DEUP1 deuterosome assembly protein 1 -2.01528
ZNF707 zinc finger protein 707 -2.01528