ATR signaling pathway Gene Set

Dataset PID Pathways
Category structural or functional annotations
Type pathway
Description The ATM and Rad3-related (ATR) serine/threonine kinase mediated signaling responds to several kinds of DNA damage, of which single-stranded DNA (ssDNA) exerts a key role. ssDNAs are induced by stressed replication forks. ATR acting on its substrates prevents the cell from erroneous mitotic entry, plays a key role in interstrand cross link (ICL) repair pathway and also exerts important regulatory roles in homologous recombination pathway of double-strand break repair. (Pathway Ontology, PW_0001362)
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39 proteins participating in the ATR signaling pathway pathway from the PID Pathways dataset.

Symbol Name
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
BRCA2 breast cancer 2, early onset
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC25C cell division cycle 25C
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CEP164 centrosomal protein 164kDa
CHEK1 checkpoint kinase 1
CLSPN claspin
FANCD2 Fanconi anemia, complementation group D2
FBXW11 F-box and WD repeat domain containing 11
HUS1 HUS1 checkpoint homolog (S. pombe)
MCM2 minichromosome maintenance complex component 2
MCM7 minichromosome maintenance complex component 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
NBN nibrin
PLK1 polo-like kinase 1
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
RAD1 RAD1 checkpoint DNA exonuclease
RAD17 RAD17 homolog (S. pombe)
RAD51 RAD51 recombinase
RAD9A RAD9 homolog A (S. pombe)
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SSPO SCO-spondin
TIMELESS timeless circadian clock
TIPIN TIMELESS interacting protein
TOPBP1 topoisomerase (DNA) II binding protein 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta