ATR Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description ATR serine/threonine kinase|The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 545)
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Genes

100 substrates of the kinase ATR from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
MCM2 minichromosome maintenance complex component 2
MAP7D1 MAP7 domain containing 1
PDLIM5 PDZ and LIM domain 5
LYST lysosomal trafficking regulator
PITPNM3 PITPNM family member 3
EPS8L2 EPS8-like 2
CROCC ciliary rootlet coiled-coil, rootletin
PLIN5 perilipin 5
N4BP2 NEDD4 binding protein 2
XAF1 XIAP associated factor 1
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
OSBPL2 oxysterol binding protein-like 2
TTN titin
APOBR apolipoprotein B receptor
TNS1 tensin 1
TJP1 tight junction protein 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
PDE3A phosphodiesterase 3A, cGMP-inhibited
DTX3L deltex 3 like, E3 ubiquitin ligase
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
RBM6 RNA binding motif protein 6
ACIN1 apoptotic chromatin condensation inducer 1
EP300 E1A binding protein p300
IMMT inner membrane protein, mitochondrial
DNM1L dynamin 1-like
HCFC1 host cell factor C1
AIM1 absent in melanoma 1
DOK7 docking protein 7
ZNF609 zinc finger protein 609
CREBBP CREB binding protein
SF3B1 splicing factor 3b, subunit 1, 155kDa
STMN2 stathmin 2
RAD17 RAD17 homolog (S. pombe)
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
HPS5 Hermansky-Pudlak syndrome 5
RECQL4 RecQ protein-like 4
RECQL5 RecQ protein-like 5
PPAPDC3 phosphatidic acid phosphatase type 2 domain containing 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
CRY1 cryptochrome circadian clock 1
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
RBM34 RNA binding motif protein 34
SIN3A SIN3 transcription regulator family member A
MEX3C mex-3 RNA binding family member C
CDK6 cyclin-dependent kinase 6
CGNL1 cingulin-like 1
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
PHACTR4 phosphatase and actin regulator 4
KLC4 kinesin light chain 4
CAMSAP1 calmodulin regulated spectrin-associated protein 1
FBXO46 F-box protein 46
NBN nibrin
SIAH1 siah E3 ubiquitin protein ligase 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
KRTCAP3 keratinocyte associated protein 3
NIPBL Nipped-B homolog (Drosophila)
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1
TAGAP T-cell activation RhoGTPase activating protein
FAM188B family with sequence similarity 188, member B
RIF1 replication timing regulatory factor 1
PHACTR2 phosphatase and actin regulator 2
SH3KBP1 SH3-domain kinase binding protein 1
TMEM164 transmembrane protein 164
COBLL1 cordon-bleu WH2 repeat protein-like 1
PDE11A phosphodiesterase 11A
FKBP15 FK506 binding protein 15, 133kDa
EPB41L2 erythrocyte membrane protein band 4.1-like 2
CSNK1G1 casein kinase 1, gamma 1
SSRP1 structure specific recognition protein 1
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
TMEM201 transmembrane protein 201
RIMS1 regulating synaptic membrane exocytosis 1
PPL periplakin
SZT2 seizure threshold 2 homolog (mouse)
PTPN7 protein tyrosine phosphatase, non-receptor type 7
FOXO3 forkhead box O3
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
TSC1 tuberous sclerosis 1
SCLT1 sodium channel and clathrin linker 1
FLNB filamin B, beta
DEF6 differentially expressed in FDCP 6 homolog (mouse)
OSBPL11 oxysterol binding protein-like 11
CEP72 centrosomal protein 72kDa
LSR lipolysis stimulated lipoprotein receptor
LMF2 lipase maturation factor 2
RIMS2 regulating synaptic membrane exocytosis 2
RIMS3 regulating synaptic membrane exocytosis 3
CNOT12 CCR4-NOT transcription complex subunit 12
TP53BP1 tumor protein p53 binding protein 1
TESPA1 thymocyte expressed, positive selection associated 1
RARG retinoic acid receptor, gamma
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
RSBN1 round spermatid basic protein 1
RND3 Rho family GTPase 3
CIZ1 CDKN1A interacting zinc finger protein 1