ATR Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description ATR serine/threonine kinase|The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 545)
External Link http://www.ncbi.nlm.nih.gov/gene/545
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Genes

59 substrates of the kinase ATR from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
BLM Bloom syndrome, RecQ helicase-like
BORA bora, aurora kinase A activator
BRCA1 breast cancer 1, early onset
CCAR2 cell cycle and apoptosis regulator 2
CCDC82 coiled-coil domain containing 82
CDKN2A cyclin-dependent kinase inhibitor 2A
CGGBP1 CGG triplet repeat binding protein 1
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
CNOT2 CCR4-NOT transcription complex, subunit 2
CREB1 cAMP responsive element binding protein 1
CUX1 cut-like homeobox 1
DAXX death-domain associated protein
DBF4 DBF4 zinc finger
DCLRE1C DNA cross-link repair 1C
E2F1 E2F transcription factor 1
EWSR1 EWS RNA-binding protein 1
FANCA Fanconi anemia, complementation group A
FANCD2 Fanconi anemia, complementation group D2
FARSA phenylalanyl-tRNA synthetase, alpha subunit
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPS1 G protein pathway suppressor 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IRS1 insulin receptor substrate 1
KMT2A lysine (K)-specific methyltransferase 2A
MARCKSL1 MARCKS-like 1
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MLH1 mutL homolog 1
NBN nibrin
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PHF14 PHD finger protein 14
POLH polymerase (DNA directed), eta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAD17 RAD17 homolog (S. pombe)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBBP8 retinoblastoma binding protein 8
RPA2 replication protein A2, 32kDa
SIAH1 siah E3 ubiquitin protein ligase 1
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMC1A structural maintenance of chromosomes 1A
SP1 Sp1 transcription factor
SUGP2 SURP and G patch domain containing 2
SUN2 Sad1 and UNC84 domain containing 2
TP53 tumor protein p53
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UIMC1 ubiquitin interaction motif containing 1
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VCP valosin containing protein
XPA xeroderma pigmentosum, complementation group A
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZSCAN5A zinc finger and SCAN domain containing 5A