ATRX Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description alpha thalassemia/mental retardation syndrome X-linked|The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2013] (NCBI Entrez Gene Database, 546)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_ATRX
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Genes

211 co-expressed genes for ATRX from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ADCY3 adenylate cyclase 3
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGPS alkylglycerone phosphate synthase
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AQP5 aquaporin 5
ARHGAP12 Rho GTPase activating protein 12
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATRX alpha thalassemia/mental retardation syndrome X-linked
BAHD1 bromo adjacent homology domain containing 1
BCL2 B-cell CLL/lymphoma 2
BPHL biphenyl hydrolase-like (serine hydrolase)
BRCA1 breast cancer 1, early onset
BRD1 bromodomain containing 1
BTD biotinidase
C1ORF216 chromosome 1 open reading frame 216
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CDK13 cyclin-dependent kinase 13
CDYL chromodomain protein, Y-like
CEP135 centrosomal protein 135kDa
CEP350 centrosomal protein 350kDa
CETN3 centrin, EF-hand protein, 3
CHD3 chromodomain helicase DNA binding protein 3
CHD9 chromodomain helicase DNA binding protein 9
CLOCK clock circadian regulator
CLP1 cleavage and polyadenylation factor I subunit 1
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CMA1 chymase 1, mast cell
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CTAGE5 CTAGE family, member 5
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DNA2 DNA replication helicase/nuclease 2
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DPT dermatopontin
DTNA dystrobrevin, alpha
ECE2 endothelin converting enzyme 2
EIF5B eukaryotic translation initiation factor 5B
EP400 E1A binding protein p400
ERC1 ELKS/RAB6-interacting/CAST family member 1
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
EXTL3 exostosin-like glycosyltransferase 3
FAM189A2 family with sequence similarity 189, member A2
FAM8A1 family with sequence similarity 8, member A1
FANCG Fanconi anemia, complementation group G
FDXR ferredoxin reductase
FIG4 FIG4 phosphoinositide 5-phosphatase
FNTB farnesyltransferase, CAAX box, beta
FOSL1 FOS-like antigen 1
FRYL FRY-like
GCFC2 GC-rich sequence DNA-binding factor 2
GLE1 GLE1 RNA export mediator
GOLGA3 golgin A3
GPATCH8 G patch domain containing 8
GPR15 G protein-coupled receptor 15
GRIK5 glutamate receptor, ionotropic, kainate 5
GRIP2 glutamate receptor interacting protein 2
GSK3B glycogen synthase kinase 3 beta
GTSE1 G-2 and S-phase expressed 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOXD4 homeobox D4
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IGBP1 immunoglobulin (CD79A) binding protein 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL13 interleukin 13
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
INSIG2 insulin induced gene 2
IPCEF1 interaction protein for cytohesin exchange factors 1
IRF2 interferon regulatory factor 2
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
JRK Jrk homolog (mouse)
KANK2 KN motif and ankyrin repeat domains 2
KANK3 KN motif and ankyrin repeat domains 3
KAT8 K(lysine) acetyltransferase 8
KAZN kazrin, periplakin interacting protein
KDM3B lysine (K)-specific demethylase 3B
KIAA0195 KIAA0195
KIAA0586 KIAA0586
KLHDC10 kelch domain containing 10
KLHL18 kelch-like family member 18
KLHL20 kelch-like family member 20
KRT33A keratin 33A, type I
KRT86 keratin 86, type II
LEPROTL1 leptin receptor overlapping transcript-like 1
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LSM1 LSM1, U6 small nuclear RNA associated
LTBP4 latent transforming growth factor beta binding protein 4
LTN1 listerin E3 ubiquitin protein ligase 1
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MC5R melanocortin 5 receptor
MFN1 mitofusin 1
MGA MGA, MAX dimerization protein
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MLN motilin
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSH3 mutS homolog 3
MSL3 male-specific lethal 3 homolog (Drosophila)
MSX1 msh homeobox 1
MT4 metallothionein 4
MTX1 metaxin 1
MUTYH mutY homolog
NCKIPSD NCK interacting protein with SH3 domain
NEK9 NIMA-related kinase 9
NFRKB nuclear factor related to kappaB binding protein
NFX1 nuclear transcription factor, X-box binding 1
NFYB nuclear transcription factor Y, beta
NKRF NFKB repressing factor
NMT1 N-myristoyltransferase 1
NR2C1 nuclear receptor subfamily 2, group C, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRTN neurturin
NUMB numb homolog (Drosophila)
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PARN poly(A)-specific ribonuclease
PAX9 paired box 9
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCF11 PCF11 cleavage and polyadenylation factor subunit
PCGF1 polycomb group ring finger 1
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
PEX3 peroxisomal biogenesis factor 3
PHF10 PHD finger protein 10
PHF21A PHD finger protein 21A
PIAS2 protein inhibitor of activated STAT, 2
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PIGF phosphatidylinositol glycan anchor biosynthesis, class F
PIGR polymeric immunoglobulin receptor
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
POU6F2 POU class 6 homeobox 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PPP5C protein phosphatase 5, catalytic subunit
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RAP1A RAP1A, member of RAS oncogene family
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBBP8 retinoblastoma binding protein 8
RERE arginine-glutamic acid dipeptide (RE) repeats
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNF14 ring finger protein 14
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RSRP1 arginine/serine-rich protein 1
RUNX1 runt-related transcription factor 1
SCAMP1 secretory carrier membrane protein 1
SEC31A SEC31 homolog A (S. cerevisiae)
SEC62 SEC62 homolog (S. cerevisiae)
SEZ6L seizure related 6 homolog (mouse)-like
SH2B1 SH2B adaptor protein 1
SIK3 SIK family kinase 3
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SMC5 structural maintenance of chromosomes 5
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNX4 sorting nexin 4
SPAST spastin
SPEF1 sperm flagellar 1
SPRED2 sprouty-related, EVH1 domain containing 2
SS18 synovial sarcoma translocation, chromosome 18
SSTR5 somatostatin receptor 5
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SYNJ2 synaptojanin 2
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TBC1D22A TBC1 domain family, member 22A
TBCE tubulin folding cofactor E
TBX5 T-box 5
TCF12 transcription factor 12
TLN2 talin 2
TMCC1 transmembrane and coiled-coil domain family 1
TMEM11 transmembrane protein 11
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TPR translocated promoter region, nuclear basket protein
TRIM27 tripartite motif containing 27
TTI1 TELO2 interacting protein 1
TTLL5 tubulin tyrosine ligase-like family member 5
UBE4B ubiquitination factor E4B
UBR2 ubiquitin protein ligase E3 component n-recognin 2
UTRN utrophin
VAMP4 vesicle-associated membrane protein 4
WDR62 WD repeat domain 62
WIPF2 WAS/WASL interacting protein family, member 2
YAF2 YY1 associated factor 2
ZBTB22 zinc finger and BTB domain containing 22
ZNF133 zinc finger protein 133
ZNF271P zinc finger protein 271, pseudogene
ZNF292 zinc finger protein 292
ZNF32 zinc finger protein 32
ZNF500 zinc finger protein 500
ZNF592 zinc finger protein 592