AURKA Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description aurora kinase A|The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6790)
External Link https://ncbi.nlm.nih.gov/gene/6790
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Genes

499 genes differentially expressed following the AURKA gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
XIC X chromosome inactivation center 0.0126727
KRT19 keratin 19, type I 0.0123429
FRS2 fibroblast growth factor receptor substrate 2 0.0119122
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0115925
CA2 carbonic anhydrase II 0.0115642
PLK2 polo-like kinase 2 0.0111653
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 0.0110781
S100A8 S100 calcium binding protein A8 0.0110681
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.0110358
YBX3 Y box binding protein 3 0.0108019
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.0106653
CRISP3 cysteine-rich secretory protein 3 0.0106643
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 0.0105886
RNF128 ring finger protein 128, E3 ubiquitin protein ligase 0.0105524
IGLL1 immunoglobulin lambda-like polypeptide 1 0.0103516
GPNMB glycoprotein (transmembrane) nmb 0.0103385
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 0.0102818
TGFA transforming growth factor, alpha 0.0101646
CPA3 carboxypeptidase A3 (mast cell) 0.0101582
PERP PERP, TP53 apoptosis effector 0.010096
PLAAT3 phospholipase A and acyltransferase 3 0.00992598
PCNA proliferating cell nuclear antigen 0.0097973
SSBP2 single-stranded DNA binding protein 2 0.00972434
HIST1H2AC histone cluster 1, H2ac 0.00971102
TFPI2 tissue factor pathway inhibitor 2 0.00948321
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 0.00946418
SCGB2A1 secretoglobin, family 2A, member 1 0.00943899
PCDH9 protocadherin 9 0.00939225
G0S2 G0/G1 switch 2 0.00934917
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.00933773
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 0.00924027
SCGB1D2 secretoglobin, family 1D, member 2 0.00919248
TPD52L1 tumor protein D52-like 1 0.0091837
ALB albumin 0.00913127
CD9 CD9 molecule 0.00896308
FAM3C family with sequence similarity 3, member C 0.00893764
SCPEP1 serine carboxypeptidase 1 0.00892106
POU2AF1 POU class 2 associating factor 1 0.00882509
DEFA4 defensin, alpha 4, corticostatin 0.00881525
CFD complement factor D (adipsin) 0.00880546
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 0.00880157
GADD45A growth arrest and DNA-damage-inducible, alpha 0.00875312
HMGN3 high mobility group nucleosomal binding domain 3 0.00867105
STK26 serine/threonine protein kinase 26 0.00853397
CLC Charcot-Leyden crystal galectin 0.0085049
CSTA cystatin A (stefin A) 0.00848002
AUTS2 autism susceptibility candidate 2 0.0084674
BLNK B-cell linker 0.0084462
TXN thioredoxin 0.00841783
CRYBG1 crystallin beta-gamma domain containing 1 0.00840197
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0083852
AKAP9 A kinase (PRKA) anchor protein 9 0.00827623
CLEC2B C-type lectin domain family 2, member B 0.00826178
FN1 fibronectin 1 0.00825918
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.00822792
NTS neurotensin 0.00818816
H1-2 H1.2 linker histone, cluster member 0.00812506
TRIB2 tribbles pseudokinase 2 0.00810675
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.00804418
S100A9 S100 calcium binding protein A9 0.00802615
ANXA4 annexin A4 0.00801815
ECM1 extracellular matrix protein 1 0.00801306
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.00800293
STEAP3 STEAP family member 3, metalloreductase 0.00799633
GREM1 gremlin 1, DAN family BMP antagonist 0.00799347
RALB v-ral simian leukemia viral oncogene homolog B 0.00791936
INAVA innate immunity activator 0.00791678
PRAME preferentially expressed antigen in melanoma 0.00790747
TRIP6 thyroid hormone receptor interactor 6 0.00783894
SALL1 spalt-like transcription factor 1 0.00782551
ACSL1 acyl-CoA synthetase long-chain family member 1 0.00781341
S100A12 S100 calcium binding protein A12 0.00781064
SCGB2A2 secretoglobin, family 2A, member 2 0.00778354
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.00775863
CRABP2 cellular retinoic acid binding protein 2 0.00769772
OGA O-GlcNAcase 0.00763397
SORBS2 sorbin and SH3 domain containing 2 0.00763246
RND3 Rho family GTPase 3 0.00758982
S100A10 S100 calcium binding protein A10 0.00758894
SCAF4 SR-related CTD-associated factor 4 0.00758651
CHP1 calcineurin-like EF-hand protein 1 0.00758528
ALOX5 arachidonate 5-lipoxygenase 0.00754296
HIST1H2BD histone cluster 1, H2bd 0.00752637
NCF1C neutrophil cytosolic factor 1C pseudogene 0.00751246
PDZK1 PDZ domain containing 1 0.00745051
AHNAK2 AHNAK nucleoprotein 2 0.00744297
ZDHHC11 zinc finger, DHHC-type containing 11 0.00736336
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 0.00734536
GSDMB gasdermin B 0.00732347
ELANE elastase, neutrophil expressed 0.00731836
SEC14L1 SEC14-like 1 (S. cerevisiae) 0.00730258
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.00728894
CAST calpastatin 0.00725777
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.00724402
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.00722253
PAX5 paired box 5 0.00718873
RHOB ras homolog family member B 0.00717517
S100P S100 calcium binding protein P 0.00716374
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 0.00713154
PLA1A phospholipase A1 member A 0.0071188
FGG fibrinogen gamma chain 0.00711874
FLRT3 fibronectin leucine rich transmembrane protein 3 0.00710169
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 0.00706283
CTBP2 C-terminal binding protein 2 0.00703239
KRT6A keratin 6A, type II 0.00702487
SIRPA signal-regulatory protein alpha 0.00701168
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.00700328
IL1B interleukin 1, beta 0.00697238
PPP1R3C protein phosphatase 1, regulatory subunit 3C 0.00696919
FHOD3 formin homology 2 domain containing 3 0.00692544
DTX4 deltex 4, E3 ubiquitin ligase 0.00692123
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.00690064
RSRP1 arginine/serine-rich protein 1 0.00688006
IL1RN interleukin 1 receptor antagonist 0.00685801
MT1X metallothionein 1X 0.00682871
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.00682297
TCL1A T-cell leukemia/lymphoma 1A 0.00680009
TXLNA taxilin alpha 0.00678828
SH3BP4 SH3-domain binding protein 4 0.00676727
IPO13 importin 13 0.00676576
KRT13 keratin 13, type I 0.00676504
GAB2 GRB2-associated binding protein 2 0.0067546
HIST1H2BH histone cluster 1, H2bh 0.00675091
HK2 hexokinase 2 0.00674738
MET MET proto-oncogene, receptor tyrosine kinase 0.00674305
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 0.00674062
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.00672864
POSTN periostin, osteoblast specific factor 0.00670951
FNDC3B fibronectin type III domain containing 3B 0.00670907
RRAGD Ras-related GTP binding D 0.00667321
KRT7 keratin 7, type II 0.00664072
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 0.0066302
KIAA0226L KIAA0226-like 0.00662827
ASXL2 additional sex combs like transcriptional regulator 2 0.00660439
GLUL glutamate-ammonia ligase 0.00659301
CCNG2 cyclin G2 0.00657728
ADM adrenomedullin 0.0065747
VEGFA vascular endothelial growth factor A 0.00657006
ENAH enabled homolog (Drosophila) 0.00656569
JCHAIN joining chain of multimeric IgA and IgM 0.00655355
MXRA5 matrix-remodelling associated 5 0.0065391
PDZD8 PDZ domain containing 8 0.00653049
CDK14 cyclin-dependent kinase 14 0.00652098
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.00649032
C14ORF132 chromosome 14 open reading frame 132 0.00648049
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 0.0064768
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.00643735
CA12 carbonic anhydrase XII 0.00643654
VPREB1 pre-B lymphocyte 1 0.00643393
TOB1 transducer of ERBB2, 1 0.00643369
ALDOB aldolase B, fructose-bisphosphate 0.00642314
ZNF83 zinc finger protein 83 0.00642267
LGALS4 lectin, galactoside-binding, soluble, 4 0.00641583
HBD hemoglobin, delta 0.00640118
RABEP2 rabaptin, RAB GTPase binding effector protein 2 0.00639861
RGS5 regulator of G-protein signaling 5 0.00639407
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.0063927
PRNP prion protein 0.00637104
CCDC88A coiled-coil domain containing 88A 0.00635753
CD44 CD44 molecule (Indian blood group) 0.0063209
DMTF1 cyclin D binding myb-like transcription factor 1 0.00631154
ZNF43 zinc finger protein 43 0.00630407
UBA6 ubiquitin-like modifier activating enzyme 6 0.00630022
DSTN destrin (actin depolymerizing factor) 0.00627656
RARRES3 retinoic acid receptor responder (tazarotene induced) 3 0.00625216
ADAM28 ADAM metallopeptidase domain 28 0.0062389
RGCC regulator of cell cycle 0.00621766
FKBP11 FK506 binding protein 11, 19 kDa 0.00620841
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.00620462
BTG1 B-cell translocation gene 1, anti-proliferative 0.00620367
FGB fibrinogen beta chain 0.00620097
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.00620082
GBAP1 glucosidase, beta, acid pseudogene 1 0.00620075
PBX3 pre-B-cell leukemia homeobox 3 0.00619166
SLC30A1 solute carrier family 30 (zinc transporter), member 1 0.00617513
AZU1 azurocidin 1 0.00611934
MXD1 MAX dimerization protein 1 0.006114
BEX1 brain expressed, X-linked 1 0.00611357
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 0.00610836
PPP4R3A protein phosphatase 4 regulatory subunit 3A 0.00607823
MTMR3 myotubularin related protein 3 0.00607533
PPP1R16B protein phosphatase 1, regulatory subunit 16B 0.00607516
PLCB4 phospholipase C, beta 4 0.00607031
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 0.0060575
HRK harakiri, BCL2 interacting protein 0.0060559
PHIP pleckstrin homology domain interacting protein 0.00605049
GOLGA8H golgin A8 family, member H 0.00604579
MAP7 microtubule-associated protein 7 0.00604414
BTF3P11 basic transcription factor 3 pseudogene 11 0.00603431
PSCA prostate stem cell antigen 0.00601567
CNOT4 CCR4-NOT transcription complex, subunit 4 0.00598946
KRT15 keratin 15, type I 0.00598665
RBM34 RNA binding motif protein 34 0.00598035
IFI16 interferon, gamma-inducible protein 16 0.0059683
SLCO4C1 solute carrier organic anion transporter family, member 4C1 0.00595961
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.0059585
SLC38A2 solute carrier family 38, member 2 0.00594158
ELMO1 engulfment and cell motility 1 0.00592574
NBPF10 neuroblastoma breakpoint family, member 10 0.00591711
FAM46C family with sequence similarity 46, member C 0.00591159
YBX1 Y box binding protein 1 0.00587127
MGAM maltase-glucoamylase 0.00587035
S100A11 S100 calcium binding protein A11 0.00585983
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.00585861
ADIRF adipogenesis regulatory factor 0.00585555
LEF1 lymphoid enhancer-binding factor 1 0.00585158
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 0.00584683
EHD3 EH-domain containing 3 0.005846
MZB1 marginal zone B and B1 cell-specific protein 0.00584572
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.0058392
PRODH proline dehydrogenase (oxidase) 1 0.00583834
PDZK1IP1 PDZK1 interacting protein 1 0.00581652
TSPAN1 tetraspanin 1 0.00581398
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 0.00581128
MIS18BP1 MIS18 binding protein 1 0.00580804
IGF2R insulin-like growth factor 2 receptor 0.00579332
LXN latexin 0.00578444
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.00575902
RAB38 RAB38, member RAS oncogene family 0.0057468
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0057454
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.00572897
TGIF1 TGFB-induced factor homeobox 1 0.0057262
DDIT3 DNA-damage-inducible transcript 3 0.00571913
HSPA2 heat shock 70kDa protein 2 0.00571044
PTK2B protein tyrosine kinase 2 beta 0.00570702
OCRL oculocerebrorenal syndrome of Lowe 0.0057026
ADAM10 ADAM metallopeptidase domain 10 0.00569933
NCOA3 nuclear receptor coactivator 3 0.00569622
THAP9-AS1 THAP9 antisense RNA 1 0.00568934
PRTN3 proteinase 3 0.00568657
ZNF638 zinc finger protein 638 0.00567898
MAGED1 melanoma antigen family D1 0.00567384
CXADR coxsackie virus and adenovirus receptor 0.00566631
GNAS GNAS complex locus 0.00565486
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 0.00565383
ADCY1 adenylate cyclase 1 (brain) 0.00561633
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1 0.00560776
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.00558982
RSF1 remodeling and spacing factor 1 0.00558578
MME membrane metallo-endopeptidase 0.00556559
REG1A regenerating islet-derived 1 alpha 0.0055535
ISYNA1 inositol-3-phosphate synthase 1 0.00555158
KIF5B kinesin family member 5B 0.00554804
SPRR3 small proline-rich protein 3 0.00554408
KDM7A lysine (K)-specific demethylase 7A 0.0055438
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.00553489
OFD1 oral-facial-digital syndrome 1 0.00551827
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) 0.00551766
SPINK1 serine peptidase inhibitor, Kazal type 1 0.00551744
DENND1B DENN/MADD domain containing 1B 0.00551319

decreased expression

Symbol Name Standardized Value
PRMT1 protein arginine methyltransferase 1 -0.0127036
MYBPC1 myosin binding protein C, slow type -0.0122332
BST2 bone marrow stromal cell antigen 2 -0.0121175
GPC3 glypican 3 -0.0111855
RNF167 ring finger protein 167 -0.0111437
XPO7 exportin 7 -0.0111024
DLK1 delta-like 1 homolog (Drosophila) -0.0110468
PUF60 poly-U binding splicing factor 60KDa -0.0103306
C8ORF4 chromosome 8 open reading frame 4 -0.00985674
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) -0.00984887
STXBP2 syntaxin binding protein 2 -0.00967037
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.00950823
CD34 CD34 molecule -0.0094501
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.00926755
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 -0.00893334
ARID4A AT rich interactive domain 4A (RBP1-like) -0.00875871
PDLIM2 PDZ and LIM domain 2 (mystique) -0.00868533
F2R coagulation factor II (thrombin) receptor -0.0086105
CST3 cystatin C -0.00860825
CDCA4 cell division cycle associated 4 -0.00860054
ISLR immunoglobulin superfamily containing leucine-rich repeat -0.00847459
PDGFRL platelet-derived growth factor receptor-like -0.00840554
WDR61 WD repeat domain 61 -0.00838859
ACTL6A actin-like 6A -0.00821423
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.00809199
TMOD1 tropomodulin 1 -0.00801688
C7 complement component 7 -0.00799326
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.00798275
IFITM1 interferon induced transmembrane protein 1 -0.0077811
LYRM4 LYR motif containing 4 -0.00773151
OXA1L oxidase (cytochrome c) assembly 1-like -0.00772231
CDC42 cell division cycle 42 -0.00765842
IGF1 insulin-like growth factor 1 (somatomedin C) -0.00759553
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -0.00759272
RAD23B RAD23 homolog B (S. cerevisiae) -0.00756942
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -0.00754672
SFRP1 secreted frizzled-related protein 1 -0.00752897
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon -0.00752239
TMEM100 transmembrane protein 100 -0.00749592
ANXA6 annexin A6 -0.0074909
TMEM204 transmembrane protein 204 -0.00743723
IKZF1 IKAROS family zinc finger 1 (Ikaros) -0.0073993
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -0.00737646
TMED3 transmembrane emp24 protein transport domain containing 3 -0.007343
FKBP10 FK506 binding protein 10, 65 kDa -0.00732613
TNNC1 troponin C type 1 (slow) -0.00730984
SPARCL1 SPARC-like 1 (hevin) -0.00730651
PDLIM3 PDZ and LIM domain 3 -0.00729623
IFRD2 interferon-related developmental regulator 2 -0.00720653
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 -0.00717723
DCTPP1 dCTP pyrophosphatase 1 -0.00716422
LAMP5 lysosomal-associated membrane protein family, member 5 -0.00712373
RNASEH2A ribonuclease H2, subunit A -0.00711163
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -0.00710952
SLC26A3 solute carrier family 26 (anion exchanger), member 3 -0.0070484
DACH1 dachshund family transcription factor 1 -0.00702813
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0070196
AGR2 anterior gradient 2 -0.00695355
FBN1 fibrillin 1 -0.00689477
MRPS16 mitochondrial ribosomal protein S16 -0.00687241
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta -0.00685882
FKBP14 FK506 binding protein 14, 22 kDa -0.00676522
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.00676438
ITM2A integral membrane protein 2A -0.00674658
COL3A1 collagen, type III, alpha 1 -0.00672534
IQGAP2 IQ motif containing GTPase activating protein 2 -0.00672031
SCG5 secretogranin V -0.00671009
H1-0 H1.0 linker histone -0.00667872
KLHL23 kelch-like family member 23 -0.00667868
SPTSSA serine palmitoyltransferase, small subunit A -0.00665592
DIO2 deiodinase, iodothyronine, type II -0.0066515
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -0.00664292
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -0.00664142
ICAM2 intercellular adhesion molecule 2 -0.00662699
JAM2 junctional adhesion molecule 2 -0.00660973
CPVL carboxypeptidase, vitellogenic-like -0.00659601
LOX lysyl oxidase -0.00659269
RFC2 replication factor C (activator 1) 2, 40kDa -0.00657519
RPA3 replication protein A3, 14kDa -0.00655586
TRAPPC3 trafficking protein particle complex 3 -0.00653332
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -0.00652361
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) -0.00651505
RSL1D1 ribosomal L1 domain containing 1 -0.00649846
BAX BCL2-associated X protein -0.00648021
CARHSP1 calcium regulated heat stable protein 1, 24kDa -0.00647486
TSPYL5 TSPY-like 5 -0.00645943
CD2 CD2 molecule -0.00643513
MEF2C myocyte enhancer factor 2C -0.00642353
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) -0.00642046
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.006396
SLIT2 slit homolog 2 (Drosophila) -0.00637944
FABP7 fatty acid binding protein 7, brain -0.00637421
VCAM1 vascular cell adhesion molecule 1 -0.00637027
SLN sarcolipin -0.00632934
PLPBP pyridoxal phosphate binding protein -0.00631936
CHMP6 charged multivesicular body protein 6 -0.00628088
DMD dystrophin -0.0062795
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0062768
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -0.00627472
SFRP4 secreted frizzled-related protein 4 -0.00623906
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -0.00623896
PRKCQ protein kinase C, theta -0.00622058
PRF1 perforin 1 (pore forming protein) -0.00621387
DAD1 defender against cell death 1 -0.00621357
GYG1 glycogenin 1 -0.00620887
AURKA aurora kinase A -0.0062054
PDE2A phosphodiesterase 2A, cGMP-stimulated -0.0062012
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -0.00618091
HAUS4 HAUS augmin-like complex, subunit 4 -0.00618022
PRMT5 protein arginine methyltransferase 5 -0.00616532
DENND2B DENN domain containing 2B -0.00609982
LAPTM4B lysosomal protein transmembrane 4 beta -0.00609274
FPGS folylpolyglutamate synthase -0.00607644
MAGT1 magnesium transporter 1 -0.00607536
FXYD6 FXYD domain containing ion transport regulator 6 -0.00602941
PLAT plasminogen activator, tissue -0.00600407
BIRC5 baculoviral IAP repeat containing 5 -0.00600236
GSTA4 glutathione S-transferase alpha 4 -0.00598308
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.00597429
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.00596501
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 -0.00595921
FILIP1L filamin A interacting protein 1-like -0.00595723
ANKRD10 ankyrin repeat domain 10 -0.00594843
ZW10 zw10 kinetochore protein -0.00594189
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.00593059
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 -0.00592917
THYN1 thymocyte nuclear protein 1 -0.00592374
DET1 de-etiolated homolog 1 (Arabidopsis) -0.00588024
COQ8A coenzyme Q8A -0.00586103
PLAGL1 pleiomorphic adenoma gene-like 1 -0.00585259
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -0.00584916
CNPY3 canopy FGF signaling regulator 3 -0.00584527
TMED9 transmembrane emp24 protein transport domain containing 9 -0.0058317
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.00581416
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0058094
IL32 interleukin 32 -0.0058087
SPRED2 sprouty-related, EVH1 domain containing 2 -0.00580461
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -0.0057953
IL2RB interleukin 2 receptor, beta -0.00578668
TMEM106C transmembrane protein 106C -0.0057828
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -0.00577234
PCGF2 polycomb group ring finger 2 -0.00576553
HACD1 3-hydroxyacyl-CoA dehydratase 1 -0.00576075
CD1C CD1c molecule -0.00575989
SRC SRC proto-oncogene, non-receptor tyrosine kinase -0.00574829
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.00574311
ERAP2 endoplasmic reticulum aminopeptidase 2 -0.00573972
ABHD4 abhydrolase domain containing 4 -0.00572563
FHL3 four and a half LIM domains 3 -0.00569111
PCYOX1L prenylcysteine oxidase 1 like -0.00566073
CD320 CD320 molecule -0.00565646
ARL1 ADP-ribosylation factor-like 1 -0.00565541
RELN reelin -0.00564474
MEOX1 mesenchyme homeobox 1 -0.00564438
OTULINL OTU deubiquitinase with linear linkage specificity like -0.00561722
NSL1 NSL1, MIS12 kinetochore complex component -0.00561044
CHEK2 checkpoint kinase 2 -0.00560803
PBK PDZ binding kinase -0.00558038
BMP6 bone morphogenetic protein 6 -0.00556932
CLCA1 chloride channel accessory 1 -0.00556325
MCTS1 malignant T cell amplified sequence 1 -0.0055611
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0055578
PTGIS prostaglandin I2 (prostacyclin) synthase -0.00554601
MEIS2 Meis homeobox 2 -0.00553101
THBS4 thrombospondin 4 -0.00552296
EPHB2 EPH receptor B2 -0.00551912
GIMAP5 GTPase, IMAP family member 5 -0.00551685
PRPF19 pre-mRNA processing factor 19 -0.00551156
TNNT1 troponin T type 1 (skeletal, slow) -0.00550351
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit -0.00549952
MAL mal, T-cell differentiation protein -0.0054987
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) -0.00548178
PYCR1 pyrroline-5-carboxylate reductase 1 -0.00548112
BANF1 barrier to autointegration factor 1 -0.00547279
MYL1 myosin, light chain 1, alkali; skeletal, fast -0.00547065
KLHDC3 kelch domain containing 3 -0.00546383
UQCRC1 ubiquinol-cytochrome c reductase core protein I -0.00543848
IGBP1 immunoglobulin (CD79A) binding protein 1 -0.00543777
OAZ1 ornithine decarboxylase antizyme 1 -0.00543773
SNX17 sorting nexin 17 -0.00543554
MRPS28 mitochondrial ribosomal protein S28 -0.00542778
TSPAN31 tetraspanin 31 -0.00541974
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) -0.00541101
COL15A1 collagen, type XV, alpha 1 -0.00540513
PENK proenkephalin -0.00540288
CHODL chondrolectin -0.00540008
LGALS1 lectin, galactoside-binding, soluble, 1 -0.00539813
TYRP1 tyrosinase-related protein 1 -0.00538331
ECI2 enoyl-CoA delta isomerase 2 -0.00538269
IFT52 intraflagellar transport 52 -0.00537933
RFC5 replication factor C (activator 1) 5, 36.5kDa -0.00537435
COMMD4 COMM domain containing 4 -0.00536713
CD4 CD4 molecule -0.00536529
RPS5 ribosomal protein S5 -0.00535684
GEMIN2 gem (nuclear organelle) associated protein 2 -0.00534356
KYAT3 kynurenine aminotransferase 3 -0.00533604
PDE3B phosphodiesterase 3B, cGMP-inhibited -0.00532808
MPI mannose phosphate isomerase -0.00531623
ADGRE1 adhesion G protein-coupled receptor E1 -0.00531175
POGLUT2 protein O-glucosyltransferase 2 -0.00531126
CCL5 chemokine (C-C motif) ligand 5 -0.00530658
TRIP10 thyroid hormone receptor interactor 10 -0.00530269
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.00530045
CNOT7 CCR4-NOT transcription complex, subunit 7 -0.00528369
CHI3L2 chitinase 3-like 2 -0.0052829
KRT20 keratin 20, type I -0.00528243
EPAS1 endothelial PAS domain protein 1 -0.00527582
ADCY3 adenylate cyclase 3 -0.00526919
UBE2I ubiquitin-conjugating enzyme E2I -0.00526814
GET3 guided entry of tail-anchored proteins factor 3, ATPase -0.00525918
ILK integrin-linked kinase -0.00525528
ADSL adenylosuccinate lyase -0.0052525
SRPX2 sushi-repeat containing protein, X-linked 2 -0.00524454
ICAM3 intercellular adhesion molecule 3 -0.00523419
SPAG4 sperm associated antigen 4 -0.00522667
SIAH2 siah E3 ubiquitin protein ligase 2 -0.00522054
DIABLO diablo, IAP-binding mitochondrial protein -0.00521826
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog -0.00520459
NIPSNAP2 nipsnap homolog 2 -0.0052021
GCH1 GTP cyclohydrolase 1 -0.00519177
QPRT quinolinate phosphoribosyltransferase -0.00517117
METRN meteorin, glial cell differentiation regulator -0.00515107
ACOT9 acyl-CoA thioesterase 9 -0.00514474
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -0.00514386
GNG4 guanine nucleotide binding protein (G protein), gamma 4 -0.00514149
TCEAL1 transcription elongation factor A (SII)-like 1 -0.00514046
MRPL17 mitochondrial ribosomal protein L17 -0.00513985
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 -0.00512807
CRYL1 crystallin, lambda 1 -0.00511723
LMCD1 LIM and cysteine-rich domains 1 -0.0051071
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -0.00510226
BATF3 basic leucine zipper transcription factor, ATF-like 3 -0.00508297
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) -0.0050618
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -0.005028
WBP5 WW domain binding protein 5 -0.00502543
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.00501683
EGR3 early growth response 3 -0.00501524
RIOX2 ribosomal oxygenase 2 -0.00501063
ESD esterase D -0.00499295
TMEM38B transmembrane protein 38B -0.0049897
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C -0.0049858
GCHFR GTP cyclohydrolase I feedback regulator -0.00497814
EMC9 ER membrane protein complex subunit 9 -0.00497068
CLDN3 claudin 3 -0.00496862
MANSC1 MANSC domain containing 1 -0.00496667
ALDOA aldolase A, fructose-bisphosphate -0.00496047
VIPR1 vasoactive intestinal peptide receptor 1 -0.00495154
RPP40 ribonuclease P/MRP 40kDa subunit -0.00494438
RASIP1 Ras interacting protein 1 -0.00492332