AURKA Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description aurora kinase A|The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6790)
External Link http://www.ncbi.nlm.nih.gov/gene/6790
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Genes

39 substrates of the kinase AURKA from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
AR androgen receptor
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
AURKA aurora kinase A
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BRCA1 breast cancer 1, early onset
CDC25B cell division cycle 25B
CENPA centromere protein A
CETN2 centrin, EF-hand protein, 2
CPEB1 cytoplasmic polyadenylation element binding protein 1
CRMP1 collapsin response mediator protein 1
DCTN1 dynactin 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ESR1 estrogen receptor 1
FADD Fas (TNFRSF6)-associated via death domain
FAF1 Fas (TNFRSF6) associated factor 1
GMNN geminin, DNA replication inhibitor
GSK3B glycogen synthase kinase 3 beta
HIST1H3A histone cluster 1, H3a
LATS2 large tumor suppressor kinase 2
LIMK2 LIM domain kinase 2
MAP9 microtubule-associated protein 9
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MBD3 methyl-CpG binding domain protein 3
MCM2 minichromosome maintenance complex component 2
MYBBP1A MYB binding protein (P160) 1a
NDEL1 nudE neurodevelopment protein 1-like 1
NEDD1 neural precursor cell expressed, developmentally down-regulated 1
NUMA1 nuclear mitotic apparatus protein 1
PARD3 par-3 family cell polarity regulator
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLK1 polo-like kinase 1
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
TACC3 transforming, acidic coiled-coil containing protein 3
TP53 tumor protein p53
TP73 tumor protein p73
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WWC1 WW and C2 domain containing 1