AXIN1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description axin 1|This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2010] (NCBI Entrez Gene Database, 8312)
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Genes

274 genes differentially expressed following the AXIN1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CCDC42 coiled-coil domain containing 42 4.40158
PXDC1 PX domain containing 1 4.40158
TCEA3 transcription elongation factor A (SII), 3 4.40158
KLK6 kallikrein-related peptidase 6 4.40158
ZNF324B zinc finger protein 324B 4.40158
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 4.40158
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 4.40158
S100A14 S100 calcium binding protein A14 4.40158
TBX20 T-box 20 4.40158
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 4.40158
LRRC36 leucine rich repeat containing 36 4.40158
MEIOSIN meiosis initiator 4.40158
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 4.40158
CXORF58 chromosome X open reading frame 58 4.40158
LHX6 LIM homeobox 6 4.40158
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 4.40158
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 4.39929
SLC30A4 solute carrier family 30 (zinc transporter), member 4 4.39929
LRRC55 leucine rich repeat containing 55 4.39929
FGD2 FYVE, RhoGEF and PH domain containing 2 4.39929
DUXA double homeobox A 4.39929
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 4.39929
SLC25A45 solute carrier family 25, member 45 4.39929
TMEM176B transmembrane protein 176B 4.39929
OR2A42 olfactory receptor, family 2, subfamily A, member 42 4.39929
PRSS41 protease, serine, 41 4.39929
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 4.39929
SLC23A3 solute carrier family 23, member 3 4.39929
TCAF2 TRPM8 channel-associated factor 2 4.39929
OIT3 oncoprotein induced transcript 3 4.39929
CRYAA crystallin, alpha A 4.39929
LUZP4 leucine zipper protein 4 4.39929
CPLX3 complexin 3 4.39929
BMP5 bone morphogenetic protein 5 4.39929
IL2RA interleukin 2 receptor, alpha 4.39929
FAM216B family with sequence similarity 216, member B 4.39929
MUC22 mucin 22 4.39929
NPIPA8 nuclear pore complex interacting protein family, member A8 4.39929
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 4.39929
KCNIP3 Kv channel interacting protein 3, calsenilin 4.39929
ZNF556 zinc finger protein 556 4.39929
RGPD4 RANBP2-like and GRIP domain containing 4 4.39929
PCDH8 protocadherin 8 4.39929
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 4.39929
SLC9C2 solute carrier family 9, member C2 (putative) 4.39929
THEMIS thymocyte selection associated 4.39929
NKAPL NFKB activating protein-like 4.39929
UTS2 urotensin 2 4.39929
PGA5 pepsinogen 5, group I (pepsinogen A) 4.39929
IL7R interleukin 7 receptor 4.39929
FGFBP2 fibroblast growth factor binding protein 2 4.39929
LTF lactotransferrin 4.39929
WDR64 WD repeat domain 64 4.39929
TMPRSS6 transmembrane protease, serine 6 4.39929
PKD2L1 polycystic kidney disease 2-like 1 4.39929
FIMP1 fertilization-influencing membrane protein 1 4.39929
VN1R1 vomeronasal 1 receptor 1 4.39929
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 4.39929
GBP3 guanylate binding protein 3 4.39929
SQOR sulfide quinone oxidoreductase 4.39929
DYNLT4 dynein light chain Tctex-type 4 4.39929
MAP3K4-AS1 MAP3K4 antisense RNA 1 4.39929
PNMA6F PNMA family member 6F 4.39929
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 4.39929
EXOC3L1 exocyst complex component 3-like 1 4.39929
SLCO1B3 solute carrier organic anion transporter family, member 1B3 4.39929
WEE2 WEE1 homolog 2 (S. pombe) 4.39929
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 4.39929
TBX21 T-box 21 4.39929
FPR3 formyl peptide receptor 3 4.39929
PVRIG poliovirus receptor related immunoglobulin domain containing 4.39929
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 4.39929
DEFB1 defensin, beta 1 4.39929
TRIM60 tripartite motif containing 60 4.39929
EDAR ectodysplasin A receptor 4.39929
CBLN2 cerebellin 2 precursor 4.39929
AMHR2 anti-Mullerian hormone receptor, type II 4.39929
OR2A12 olfactory receptor, family 2, subfamily A, member 12 4.39929
C1QL2 complement component 1, q subcomponent-like 2 4.39929
INSRR insulin receptor-related receptor 4.39929
NPFF neuropeptide FF-amide peptide precursor 4.39929
SPMIP9 sperm microtubule inner protein 9 4.39929
AQP7 aquaporin 7 4.39929
VCX3A variable charge, X-linked 3A 4.39929
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 4.39929
CATIP ciliogenesis associated TTC17 interacting protein 4.39929
NOX1 NADPH oxidase 1 4.39929
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 4.39929
CDRT15L2 CMT1A duplicated region transcript 15-like 2 4.39929
RGR retinal G protein coupled receptor 4.39929
GH1 growth hormone 1 4.39929
ZNF534 zinc finger protein 534 4.39929
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) 4.39929
GCM1 glial cells missing homolog 1 (Drosophila) 4.39929
VWA7 von Willebrand factor A domain containing 7 4.39929
ENDOU endonuclease, polyU-specific 4.39929
MYF6 myogenic factor 6 (herculin) 4.39929
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 4.39929
HCRT hypocretin (orexin) neuropeptide precursor 4.39929
C18ORF63 chromosome 18 open reading frame 63 4.39929
CALHM1 calcium homeostasis modulator 1 4.39929
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 4.39929
TPSB2 tryptase beta 2 (gene/pseudogene) 4.39929
IGFBP1 insulin-like growth factor binding protein 1 4.39929
AKR1B15 aldo-keto reductase family 1, member B15 4.39929
NIPAL4 NIPA-like domain containing 4 4.39929
SPATA4 spermatogenesis associated 4 4.39929
COX7B2 cytochrome c oxidase subunit VIIb2 4.39929
SAMD7 sterile alpha motif domain containing 7 4.39929
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 4.39929
GCM2 glial cells missing homolog 2 (Drosophila) 4.39929
IL33 interleukin 33 4.39929
BCL2L15 BCL2-like 15 4.39929
RASA4 RAS p21 protein activator 4 4.39929
GPR17 G protein-coupled receptor 17 4.39929
TMEM88 transmembrane protein 88 4.39929
SPINT4 serine peptidase inhibitor, Kunitz type 4 4.39929
GOLGA8H golgin A8 family, member H 4.39929
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 4.39929
CTAG2 cancer/testis antigen 2 4.39929
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 4.39929
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 4.39929
MMP10 matrix metallopeptidase 10 4.39929
GPRC5D G protein-coupled receptor, class C, group 5, member D 4.39929
CD8A CD8a molecule 4.39929
CHAD chondroadherin 4.39929
PGR progesterone receptor 4.39929
PRR35 proline rich 35 4.39929
DUOXA1 dual oxidase maturation factor 1 4.39929
IFNE interferon, epsilon 4.39929
CSF1R colony stimulating factor 1 receptor 4.39929
C1ORF105 chromosome 1 open reading frame 105 4.39929
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 4.39929
CD27 CD27 molecule 4.39929
MON1B MON1 secretory trafficking family member B 3.83709
TRIM68 tripartite motif containing 68 3.32534
THSD8 thrombospondin type 1 domain containing 8 3.32534
HAPLN1 hyaluronan and proteoglycan link protein 1 3.32534
IL17D interleukin 17D 3.32534
TTBK1 tau tubulin kinase 1 3.32534
HDGF hepatoma-derived growth factor 3.27869
AK4 adenylate kinase 4 3.08609
ATAT1 alpha tubulin acetyltransferase 1 3.05661
CCNT1 cyclin T1 2.99985
MOG myelin oligodendrocyte glycoprotein 2.9018
GJA1 gap junction protein, alpha 1, 43kDa 2.79313
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2.78967
ADRA1D adrenoceptor alpha 1D 2.76906
CD79B CD79b molecule, immunoglobulin-associated beta 2.76906
FGD4 FYVE, RhoGEF and PH domain containing 4 2.72362
BTN2A1 butyrophilin, subfamily 2, member A1 2.64176
WASF2 WAS protein family, member 2 2.58965
CXXC5 CXXC finger protein 5 2.58965
TSPAN12 tetraspanin 12 2.58387
XBP1 X-box binding protein 1 2.55003
NQO2 NAD(P)H dehydrogenase, quinone 2 2.54169
TBRG4 transforming growth factor beta regulator 4 2.54169
SMC5 structural maintenance of chromosomes 5 2.53521
NAP1L1 nucleosome assembly protein 1-like 1 2.49609
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.46814
TGFBI transforming growth factor, beta-induced, 68kDa 2.43445
CHUK conserved helix-loop-helix ubiquitous kinase 2.354
MYO10 myosin X 2.34712
HCRTR2 hypocretin (orexin) receptor 2 2.30095
KLF11 Kruppel-like factor 11 2.30095
ANKRD7 ankyrin repeat domain 7 2.30095
NMBR neuromedin B receptor 2.30095
MFAP1 microfibrillar-associated protein 1 2.28478
NUP54 nucleoporin 54kDa 2.2768
TET1 tet methylcytosine dioxygenase 1 2.27071
LRRC24 leucine rich repeat containing 24 2.24126
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 2.23037
THAP8 THAP domain containing 8 2.19801
PRRT4 proline-rich transmembrane protein 4 2.19801
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 2.17395
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 2.14385
ATP7A ATPase, Cu++ transporting, alpha polypeptide 2.0983
RETREG2 reticulophagy regulator family member 2 2.09328
GRB2 growth factor receptor-bound protein 2 2.05441
TUBB2A tubulin, beta 2A class IIa 2.03515
IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) 2.03515
C8ORF88 chromosome 8 open reading frame 88 2.02279
GULP1 GULP, engulfment adaptor PTB domain containing 1 2.01407

decreased expression

Symbol Name Standardized Value
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 -4.40158
SLC46A1 solute carrier family 46 (folate transporter), member 1 -4.40158
MGARP mitochondria-localized glutamic acid-rich protein -4.40158
FGF20 fibroblast growth factor 20 -4.40158
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 -4.40158
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 -4.40158
CRACDL CRACD like -4.40158
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 -4.39929
TMEM176A transmembrane protein 176A -4.39929
EBI3 Epstein-Barr virus induced 3 -4.39929
GALR3 galanin receptor 3 -4.39929
CD226 CD226 molecule -4.39929
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -4.39929
CATSPERT catsper channel auxiliary subunit tau -4.39929
PAX5 paired box 5 -4.39929
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 -4.39929
LOC124906010 uncharacterized LOC124906010 -4.39929
STYXL2 serine/threonine/tyrosine interacting like 2 -4.39929
FAM107A family with sequence similarity 107, member A -4.39929
CCR6 chemokine (C-C motif) receptor 6 -4.39929
PCDHA1 protocadherin alpha 1 -4.39929
IL11RA interleukin 11 receptor, alpha -4.39929
COLEC10 collectin sub-family member 10 (C-type lectin) -4.39929
IZUMO3 IZUMO family member 3 -4.39929
HEATR9 HEAT repeat containing 9 -4.39929
PGM5 phosphoglucomutase 5 -4.39929
SEZ6L seizure related 6 homolog (mouse)-like -4.39929
TIGD3 tigger transposable element derived 3 -4.39929
C22ORF42 chromosome 22 open reading frame 42 -4.39929
BATF2 basic leucine zipper transcription factor, ATF-like 2 -4.39929
TTC22 tetratricopeptide repeat domain 22 -4.39929
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -4.39929
GSDMA gasdermin A -4.39929
NALCN sodium leak channel, non selective -4.3023
LOC124902694 uncharacterized LOC124902694 -4.3023
RP9 retinitis pigmentosa 9 (autosomal dominant) -3.86056
TBC1D30 TBC1 domain family, member 30 -3.65297
BTBD18 BTB (POZ) domain containing 18 -3.223
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 -2.97153
PLXDC1 plexin domain containing 1 -2.89673
MTNR1A melatonin receptor 1A -2.78967
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C -2.71806
SFRP1 secreted frizzled-related protein 1 -2.62971
SPMIP4 sperm microtubule inner protein 4 -2.6199
SYTL1 synaptotagmin-like 1 -2.54169
SPDYE5 speedy/RINGO cell cycle regulator family member E5 -2.54169
TK2 thymidine kinase 2, mitochondrial -2.43337
C17ORF67 chromosome 17 open reading frame 67 -2.41057
P4HB prolyl 4-hydroxylase, beta polypeptide -2.36933
SMDT1 single-pass membrane protein with aspartate-rich tail 1 -2.354
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) -2.35114
ZNF564 zinc finger protein 564 -2.34895
NAGLU N-acetylglucosaminidase, alpha -2.34575
CD59 CD59 molecule, complement regulatory protein -2.31141
LOC102723564 uncharacterized LOC102723564 -2.30095
AMOT angiomotin -2.30095
ZXDC ZXD family zinc finger C -2.30095
MROH7 maestro heat-like repeat family member 7 -2.2768
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B -2.2768
CARF calcium responsive transcription factor -2.2768
CNR1 cannabinoid receptor 1 (brain) -2.2768
EPSTI1 epithelial stromal interaction 1 (breast) -2.27197
NAP1L5 nucleosome assembly protein 1-like 5 -2.27197
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 -2.26085
SPMIP8 sperm microtubule inner protein 8 -2.22932
MMP24OS MMP24 opposite strand -2.22629
KLF6 Kruppel-like factor 6 -2.22624
CATSPERE catsper channel auxiliary subunit epsilon -2.2222
NPIPA2 nuclear pore complex interacting protein family, member A2 -2.19801
CD164 CD164 molecule, sialomucin -2.18636
COL11A2 collagen, type XI, alpha 2 -2.15376
VSTM2L V-set and transmembrane domain containing 2 like -2.15147
C1ORF202 chromosome 1 open reading frame 202 -2.15147
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 -2.15147
DIABLO diablo, IAP-binding mitochondrial protein -2.14721
RIN2 Ras and Rab interactor 2 -2.13743
MAPRE1 microtubule-associated protein, RP/EB family, member 1 -2.11682
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) -2.11583
MPND MPN domain containing -2.1094
LDAF1 lipid droplet assembly factor 1 -2.10739
PEX14 peroxisomal biogenesis factor 14 -2.09798
EFHD2 EF-hand domain family, member D2 -2.07016
ASPN asporin -2.06226
MCEE methylmalonyl CoA epimerase -2.06226
PRRC1 proline-rich coiled-coil 1 -2.06212
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -2.05657
SH3GLB1 SH3-domain GRB2-like endophilin B1 -2.04946
GM2A GM2 ganglioside activator -2.04369
RER1 retention in endoplasmic reticulum sorting receptor 1 -2.03534
DMAP1 DNA methyltransferase 1 associated protein 1 -2.01343
SRP19 signal recognition particle 19kDa -2.0019