AXIN1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description axin 1|This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2010] (NCBI Entrez Gene Database, 8312)
External Link http://www.ncbi.nlm.nih.gov/gene/8312
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400 interacting proteins for AXIN1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTB actin, beta
ACTG1 actin gamma 1
ACTN1 actinin, alpha 1
ACTN4 actinin, alpha 4
ADGRV1 adhesion G protein-coupled receptor V1
AHNAK AHNAK nucleoprotein
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKAP11 A kinase (PRKA) anchor protein 11
AKAP9 A kinase (PRKA) anchor protein 9
AMER1 APC membrane recruitment protein 1
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA11 annexin A11
ANXA2 annexin A2
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP3D1 adaptor-related protein complex 3, delta 1 subunit
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APC adenomatous polyposis coli
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARF1 ADP-ribosylation factor 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL2 ADP-ribosylation factor-like 2
ARRB1 arrestin, beta 1
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
AXIN2 axin 2
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BANF1 barrier to autointegration factor 1
BBS9 Bardet-Biedl syndrome 9
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C11ORF48
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3
CAND1 cullin-associated and neddylation-dissociated 1
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CARM1 coactivator-associated arginine methyltransferase 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC77 coiled-coil domain containing 77
CCNT1 cyclin T1
CD46 CD46 molecule, complement regulatory protein
CD9 CD9 molecule
CDC14A cell division cycle 14A
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK17 cyclin-dependent kinase 17
CDK5 cyclin-dependent kinase 5
CELF1 CUGBP, Elav-like family member 1
CELF2 CUGBP, Elav-like family member 2
CFL1 cofilin 1 (non-muscle)
CHMP2A charged multivesicular body protein 2A
CLASP2 cytoplasmic linker associated protein 2
CLTC clathrin, heavy chain (Hc)
COMMD5 COMM domain containing 5
COPB1 coatomer protein complex, subunit beta 1
COPZ1 coatomer protein complex, subunit zeta 1
CRMP1 collapsin response mediator protein 1
CROCC ciliary rootlet coiled-coil, rootletin
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSK c-src tyrosine kinase
CSNK1A1 casein kinase 1, alpha 1
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CSNK1G1 casein kinase 1, gamma 1
CSNK1G2 casein kinase 1, gamma 2
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYFIP1 cytoplasmic FMR1 interacting protein 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAB2IP DAB2 interacting protein
DACT1 dishevelled-binding antagonist of beta-catenin 1
DAXX death-domain associated protein
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DIAPH3 diaphanous-related formin 3
DIXDC1 DIX domain containing 1
DLG1 discs, large homolog 1 (Drosophila)
DNM1L dynamin 1-like
DNM2 dynamin 2
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNLL1 dynein, light chain, LC8-type 1
DYNLL2 dynein, light chain, LC8-type 2
EDNRA endothelin receptor type A
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EHD1 EH-domain containing 1
EHD4 EH-domain containing 4
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ELAVL1 ELAV like RNA binding protein 1
ENKD1 enkurin domain containing 1
ENO1 enolase 1, (alpha)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERI2 ERI1 exoribonuclease family member 2
EZR ezrin
FAM110B family with sequence similarity 110, member B
FAM64A family with sequence similarity 64, member A
FBXW11 F-box and WD repeat domain containing 11
FLII flightless I homolog (Drosophila)
FLNA filamin A, alpha
FLNB filamin B, beta
FLNC filamin C, gamma
FNTA farnesyltransferase, CAAX box, alpha
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
FRG1 FSHD region gene 1
FUK fucokinase
FYTTD1 forty-two-three domain containing 1
FZD5 frizzled class receptor 5
FZD6 frizzled class receptor 6
GAK cyclin G associated kinase
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GIPC1 GIPC PDZ domain containing family, member 1
GLIS2 GLIS family zinc finger 2
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GPA33 glycoprotein A33 (transmembrane)
GRIA4 glutamate receptor, ionotropic, AMPA 4
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSKIP GSK3B interacting protein
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HIPK2 homeodomain interacting protein kinase 2
HIRA histone cell cycle regulator
HIST1H1E histone cluster 1, H1e
HLTF helicase-like transcription factor
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1B heat shock 70kDa protein 1B
HSPB1 heat shock 27kDa protein 1
HTT huntingtin
IFRD1 interferon-related developmental regulator 1
IPO5 importin 5
IQCB1 IQ motif containing B1
IQGAP1 IQ motif containing GTPase activating protein 1
IQGAP2 IQ motif containing GTPase activating protein 2
IQGAP3 IQ motif containing GTPase activating protein 3
JUP junction plakoglobin
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIF5B kinesin family member 5B
KLC1 kinesin light chain 1
KLHL40 kelch-like family member 40
KPNB1 karyopherin (importin) beta 1
LAGE3 L antigen family, member 3
LARS leucyl-tRNA synthetase
LASP1 LIM and SH3 protein 1
LDHA lactate dehydrogenase A
LDHB lactate dehydrogenase B
LGALS4 lectin, galactoside-binding, soluble, 4
LMO2 LIM domain only 2 (rhombotin-like 1)
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MAP2 microtubule-associated protein 2
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MATR3 matrin 3
MAX MYC associated factor X
MSH6 mutS homolog 6
MSN moesin
MX1 MX dynamin-like GTPase 1
MYBBP1A MYB binding protein (P160) 1a
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH14 myosin, heavy chain 14, non-muscle
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYH9 myosin, heavy chain 9, non-muscle
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MYOT myotilin
NARF nuclear prelamin A recognition factor
NCAPG non-SMC condensin I complex, subunit G
NCK2 NCK adaptor protein 2
NIN ninein (GSK3B interacting protein)
NOL8 nucleolar protein 8
NOTCH1 notch 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OTUD4 OTU deubiquitinase 4
PAPD7 PAP associated domain containing 7
PCM1 pericentriolar material 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PCNA proliferating cell nuclear antigen
PDCD10 programmed cell death 10
PDCD7 programmed cell death 7
PHF5A PHD finger protein 5A
PHF6 PHD finger protein 6
PHGDH phosphoglycerate dehydrogenase
PIAS1 protein inhibitor of activated STAT, 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKM pyruvate kinase, muscle
PLAA phospholipase A2-activating protein
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEC plectin
PML promyelocytic leukemia
PPIH peptidylprolyl isomerase H (cyclophilin H)
PPL periplakin
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PPP5C protein phosphatase 5, catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRMT1 protein arginine methyltransferase 1
PRPF3 pre-mRNA processing factor 3
PRUNE prune exopolyphosphatase
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PSME4 proteasome (prosome, macropain) activator subunit 4
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTBP1 polypyrimidine tract binding protein 1
PTBP2 polypyrimidine tract binding protein 2
PTBP3 polypyrimidine tract binding protein 3
PUF60 poly-U binding splicing factor 60KDa
PUM1 pumilio RNA-binding family member 1
RAB11A RAB11A, member RAS oncogene family
RAB15 RAB15, member RAS oncogene family
RAB5B RAB5B, member RAS oncogene family
RAB5C RAB5C, member RAS oncogene family
RAB7A RAB7A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RALY RALY heterogeneous nuclear ribonucleoprotein
RAN RAN, member RAS oncogene family
RANBP2 RAN binding protein 2
RB1CC1 RB1-inducible coiled-coil 1
RBM14 RNA binding motif protein 14
RBM4 RNA binding motif protein 4
RBMS1 RNA binding motif, single stranded interacting protein 1
RCC2 regulator of chromosome condensation 2
RDX radixin
RNF111 ring finger protein 111
RNF146 ring finger protein 146
RNPC3 RNA-binding region (RNP1, RRM) containing 3
RPS27A ribosomal protein S27a
RRP36 ribosomal RNA processing 36 homolog (S. cerevisiae)
RUNX2 runt-related transcription factor 2
SACK1D scaffolding CK1 anchoring protein D
SACK1H scaffolding CK1 anchoring protein H
SACS sacsin molecular chaperone
SART3 squamous cell carcinoma antigen recognized by T cells 3
SCN3A sodium channel, voltage gated, type III alpha subunit
SEC31A SEC31 homolog A (S. cerevisiae)
SELENBP1 selenium binding protein 1
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SEPT2 septin 2
SEPT7 septin 7
SEPT9 septin 9
SET SET nuclear proto-oncogene
SETD3 SET domain containing 3
SETX senataxin
SF3A1 splicing factor 3a, subunit 1, 120kDa
SF3B1 splicing factor 3b, subunit 1, 155kDa
SF3B2 splicing factor 3b, subunit 2, 145kDa
SH3GL1 SH3-domain GRB2-like 1
SH3GL2 SH3-domain GRB2-like 2
SKI SKI proto-oncogene
SKIL SKI-like proto-oncogene
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD6 SMAD family member 6
SMAD7 SMAD family member 7
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SMYD2 SET and MYND domain containing 2
SNRNP48 small nuclear ribonucleoprotein 48kDa (U11/U12)
SNX1 sorting nexin 1
SNX2 sorting nexin 2
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein)
SRP68 signal recognition particle 68kDa
SRP72 signal recognition particle 72kDa
SRRM1 serine/arginine repetitive matrix 1
STIP1 stress-induced phosphoprotein 1
STRAP serine/threonine kinase receptor associated protein
STX3 syntaxin 3
SUGP2 SURP and G patch domain containing 2
SUMO1 small ubiquitin-like modifier 1
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TARDBP TAR DNA binding protein
TCF20 transcription factor 20 (AR1)
TEX15 testis expressed 15
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TGFB3 transforming growth factor, beta 3
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TKFC triokinase/FMN cyclase
TLN1 talin 1
TMEM33 transmembrane protein 33
TMTC2 transmembrane and tetratricopeptide repeat containing 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TNPO1 transportin 1
TP53 tumor protein p53
TPM3 tropomyosin 3
TRIM21 tripartite motif containing 21
TRIM28 tripartite motif containing 28
TRIM29 tripartite motif containing 29
TRIM33 tripartite motif containing 33
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TUBG1 tubulin, gamma 1
UBC ubiquitin C
UBE2O ubiquitin-conjugating enzyme E2O
UBQLN1 ubiquilin 1
UBQLN2 ubiquilin 2
UBXN1 UBX domain protein 1
UNC45A unc-45 homolog A (C. elegans)
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
USO1 USO1 vesicle transport factor
USP34 ubiquitin specific peptidase 34
USP9X ubiquitin specific peptidase 9, X-linked
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
VPS33B vacuolar protein sorting 33 homolog B (yeast)
VSNL1 visinin-like 1
WISP1 WNT1 inducible signaling pathway protein 1
WNK1 WNK lysine deficient protein kinase 1
WNT3A wingless-type MMTV integration site family, member 3A
XIRP1 xin actin binding repeat containing 1
XPC xeroderma pigmentosum, complementation group C
XPO1 exportin 1
XPO4 exportin 4
XPO5 exportin 5
XPO7 exportin 7
XPOT exportin, tRNA
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YTHDC2 YTH domain containing 2
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZMAT5 zinc finger, matrin-type 5
ZNF318 zinc finger protein 318
ZWILCH zwilch kinetochore protein