AXIN2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description axin 2|The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8313)
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Genes

297 genes differentially expressed following the AXIN2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
RXRG retinoid X receptor, gamma 2.64663
CXORF65 chromosome X open reading frame 65 2.64663
OSR2 odd-skipped related transciption factor 2 2.64663
SLC25A41 solute carrier family 25, member 41 2.64663
PDZD9 PDZ domain containing 9 2.64663
ADRB2 adrenoceptor beta 2, surface 2.64663
TMEM176A transmembrane protein 176A 2.64663
OR51A7 olfactory receptor, family 51, subfamily A, member 7 2.64663
NAPSA napsin A aspartic peptidase 2.64663
AGTR1 angiotensin II receptor, type 1 2.64663
CD274 CD274 molecule 2.64663
RNF17 ring finger protein 17 2.64663
TPBGL trophoblast glycoprotein-like 2.64663
MEP1A meprin A, alpha (PABA peptide hydrolase) 2.64663
FOXD1 forkhead box D1 2.64663
FOSL1 FOS-like antigen 1 2.64663
AMBP alpha-1-microglobulin/bikunin precursor 2.64663
ARHGAP8 Rho GTPase activating protein 8 2.64663
CABS1 calcium-binding protein, spermatid-specific 1 2.64663
GJB1 gap junction protein, beta 1, 32kDa 2.64663
APOA2 apolipoprotein A-II 2.64663
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.64663
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 2.64663
MYL7 myosin, light chain 7, regulatory 2.64663
SPACA5 sperm acrosome associated 5 2.64663
BMP3 bone morphogenetic protein 3 2.64663
PRDM12 PR domain containing 12 2.64663
TRPC5OS TRPC5 opposite strand 2.64663
MUC22 mucin 22 2.64663
S100A5 S100 calcium binding protein A5 2.64663
LGI1 leucine-rich, glioma inactivated 1 2.64663
KIF2B kinesin family member 2B 2.64663
TTLL8 tubulin tyrosine ligase-like family member 8 2.64663
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.64663
RGPD3 RANBP2-like and GRIP domain containing 3 2.64663
GLRA3 glycine receptor, alpha 3 2.64663
TMEM72 transmembrane protein 72 2.64663
PTGER3 prostaglandin E receptor 3 (subtype EP3) 2.64663
NPIPB9 nuclear pore complex interacting protein family, member B9 2.64663
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 2.64663
OVOL3 ovo-like zinc finger 3 2.64663
FMO2 flavin containing monooxygenase 2 (non-functional) 2.64663
SPRR2A small proline-rich protein 2A 2.64663
KRT80 keratin 80, type II 2.64663
DUSP8 dual specificity phosphatase 8 2.64663
PNLIPRP2 pancreatic lipase-related protein 2 2.64663
MCHR1 melanin-concentrating hormone receptor 1 2.64663
HAO2 hydroxyacid oxidase 2 (long chain) 2.64663
STYXL2 serine/threonine/tyrosine interacting like 2 2.64663
ANKRD40CL ANKRD40 C-terminal like 2.64663
CFAP157 cilia and flagella associated protein 157 2.64663
DIPK1C divergent protein kinase domain 1C 2.64663
ACP4 acid phosphatase 4 2.64663
LHFPL7 LHFPL tetraspan subfamily member 7 2.64663
GREP1 glycine rich extracellular protein 1 2.64663
SRARP steroid receptor associated and regulated protein 2.64663
MAP3K4-AS1 MAP3K4 antisense RNA 1 2.64663
PNMA6F PNMA family member 6F 2.64663
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.64663
TBC1D3B TBC1 domain family, member 3B 2.64663
ZNF729 zinc finger protein 729 2.64663
BHLHA9 basic helix-loop-helix family, member a9 2.64663
ZNF24 zinc finger protein 24 2.64663
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 2.64663
TBX3 T-box 3 2.64663
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 2.64663
PLD4 phospholipase D family, member 4 2.64663
C9 complement component 9 2.64663
CAPN8 calpain 8 2.64663
STARD6 StAR-related lipid transfer (START) domain containing 6 2.64663
HAL histidine ammonia-lyase 2.64663
ZAR1L zygote arrest 1-like 2.64663
GDF7 growth differentiation factor 7 2.64663
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.64663
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 2.64663
LY6K lymphocyte antigen 6 complex, locus K 2.64663
DOK7 docking protein 7 2.64663
WDR64 WD repeat domain 64 2.64663
CIMIP7 ciliary microtubule inner protein 7 2.64663
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 2.64663
SOSTDC1 sclerostin domain containing 1 2.64663
A3GALT2 alpha 1,3-galactosyltransferase 2 2.64663
OR6X1 olfactory receptor, family 6, subfamily X, member 1 2.64663
ERMN ermin, ERM-like protein 2.64663
CPO carboxypeptidase O 2.64663
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.64663
ANKRD62 ankyrin repeat domain 62 2.64663
PRSS57 protease, serine, 57 2.64663
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.64663
ETV3L ets variant 3-like 2.64663
ECM1 extracellular matrix protein 1 2.64663
TTC24 tetratricopeptide repeat domain 24 2.64663
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.64663
TBC1D21 TBC1 domain family, member 21 2.64663
TBC1D26 TBC1 domain family, member 26 2.64663
LOXHD1 lipoxygenase homology domains 1 2.64663
BTNL2 butyrophilin-like 2 2.64663
AQP6 aquaporin 6, kidney specific 2.64663
UTS2B urotensin 2B 2.64663
EGR3 early growth response 3 2.64663
CD27 CD27 molecule 2.64663
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.64663
THBD thrombomodulin 2.64663
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.64663
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 2.64663
CLEC4D C-type lectin domain family 4, member D 2.64663
DMRT1 doublesex and mab-3 related transcription factor 1 2.64663
TPSB2 tryptase beta 2 (gene/pseudogene) 2.64663
F2RL2 coagulation factor II (thrombin) receptor-like 2 2.64663
GLT1D1 glycosyltransferase 1 domain containing 1 2.64663
KLHL41 kelch-like family member 41 2.64663
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.64663
WDFY4 WDFY family member 4 2.64663
LPAR5 lysophosphatidic acid receptor 5 2.64663
APOL6 apolipoprotein L, 6 2.64663
CRTAM cytotoxic and regulatory T cell molecule 2.64663
PRSS22 protease, serine, 22 2.64663
DCST1 DC-STAMP domain containing 1 2.64663
CD80 CD80 molecule 2.64663
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.64663
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.64663
MYLK2 myosin light chain kinase 2 2.64663
AGBL3 ATP/GTP binding protein-like 3 2.64663
TMPRSS15 transmembrane protease, serine 15 2.64663
CD226 CD226 molecule 2.64663
RNASE6 ribonuclease, RNase A family, k6 2.64663
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.64663
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 2.64663
NUTM2B NUT family member 2B 2.64663
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.64663
ACKR2 atypical chemokine receptor 2 2.64663
CLCA1 chloride channel accessory 1 2.64663
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.64663
OR11G2 olfactory receptor, family 11, subfamily G, member 2 2.64663
ZNF831 zinc finger protein 831 2.64663
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.64663
TXNDC9 thioredoxin domain containing 9 2.57553
MYO1D myosin ID 2.52416
CEP85L centrosomal protein 85kDa-like 2.52227
TM7SF2 transmembrane 7 superfamily member 2 2.47328
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 2.47103
NLE1 notchless homolog 1 (Drosophila) 2.4312
RFC3 replication factor C (activator 1) 3, 38kDa 2.41821
ZNRD2 zinc ribbon domain containing 2 2.40827
COX4I1 cytochrome c oxidase subunit IV isoform 1 2.38842
FMO1 flavin containing monooxygenase 1 2.37317
DYNAP dynactin associated protein 2.37254
KIF1C-AS1 KIF1C antisense RNA 1 2.37254
ESRP1 epithelial splicing regulatory protein 1 2.36507
HAUS2 HAUS augmin-like complex, subunit 2 2.3615
REP15 RAB15 effector protein 2.30045
KDR kinase insert domain receptor 2.30045
ARTN artemin 2.2941
LOC124902694 uncharacterized LOC124902694 2.27996
MARCHF5 membrane associated ring-CH-type finger 5 2.27996
GOLT1A golgi transport 1A 2.2641
PATL1 protein associated with topoisomerase II homolog 1 (yeast) 2.25739
GPR135 G protein-coupled receptor 135 2.25185
ANO4 anoctamin 4 2.25185
ARF6 ADP-ribosylation factor 6 2.25185
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.21032
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 2.19953
NEURL1B neuralized E3 ubiquitin protein ligase 1B 2.19617
LRP1 low density lipoprotein receptor-related protein 1 2.18092
CDIN1 CDAN1 interacting nuclease 1 2.18086
DAAM2 dishevelled associated activator of morphogenesis 2 2.18086
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 2.18086
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 2.17191
MRPL14 mitochondrial ribosomal protein L14 2.17191
EIF4E3 eukaryotic translation initiation factor 4E family member 3 2.17191
PARP12 poly (ADP-ribose) polymerase family, member 12 2.17191
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 2.16606
RPS8 ribosomal protein S8 2.16486
RGPD2 RANBP2-like and GRIP domain containing 2 2.13739
ETNK2 ethanolamine kinase 2 2.13739
TMEM45A transmembrane protein 45A 2.13739
ELF1 E74-like factor 1 (ets domain transcription factor) 2.11863
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 2.10536
NPIPB13 nuclear pore complex interacting protein family, member B13 2.09717
INMT indolethylamine N-methyltransferase 2.09717
TIPRL TOR signaling pathway regulator 2.07401
PDE8A phosphodiesterase 8A 2.06872
MOB1B MOB kinase activator 1B 2.06142
NUTF2 nuclear transport factor 2 2.05471
UBE2D3 ubiquitin-conjugating enzyme E2D 3 2.05457
EPHX2 epoxide hydrolase 2, cytoplasmic 2.04669
CDC37 cell division cycle 37 2.03562
ILDR2 immunoglobulin-like domain containing receptor 2 2.03143
SNX6 sorting nexin 6 2.02914
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 2.02862
FZD6 frizzled class receptor 6 2.0
TLR5 toll-like receptor 5 2.0
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa 2.0
H4C9 H4 clustered histone 9 2.0

decreased expression

Symbol Name Standardized Value
TFF3 trefoil factor 3 (intestinal) -2.64663
KYNU kynureninase -2.64663
GPR82 G protein-coupled receptor 82 -2.64663
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 -2.64663
FAM216B family with sequence similarity 216, member B -2.64663
SPMIP8 sperm microtubule inner protein 8 -2.64663
PDE4DIP phosphodiesterase 4D interacting protein -2.64663
TMPRSS5 transmembrane protease, serine 5 -2.64663
FAM151A family with sequence similarity 151, member A -2.64663
ZNF225 zinc finger protein 225 -2.64663
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) -2.64663
FXYD2 FXYD domain containing ion transport regulator 2 -2.64663
DYDC2 DPY30 domain containing 2 -2.64663
SHISAL2A shisa like 2A -2.64663
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -2.64663
FAM162A family with sequence similarity 162, member A -2.64663
RPS11 ribosomal protein S11 -2.61041
SP6 Sp6 transcription factor -2.41821
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) -2.41821
PADI1 peptidyl arginine deiminase, type I -2.41821
FAM90A1 family with sequence similarity 90, member A1 -2.41821
MEIG1 meiosis/spermiogenesis associated 1 -2.41821
NKPD1 NTPase, KAP family P-loop domain containing 1 -2.41821
CTRL chymotrypsin-like -2.41821
LOX lysyl oxidase -2.41821
H4C14 H4 clustered histone 14 -2.41821
TARS1 threonyl-tRNA synthetase 1 -2.41821
SELENOK selenoprotein K -2.41821
ALX1 ALX homeobox 1 -2.41821
DNAJC30 DnaJ (Hsp40) homolog, subfamily C, member 30 -2.41821
GRAP GRB2-related adaptor protein -2.41821
SMTNL1 smoothelin-like 1 -2.41821
FAM131C family with sequence similarity 131, member C -2.41821
IRF5 interferon regulatory factor 5 -2.41821
H2BC8 H2B clustered histone 8 -2.41821
PCDHA3 protocadherin alpha 3 -2.41821
SULT4A1 sulfotransferase family 4A, member 1 -2.41821
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -2.41821
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 -2.41821
LMX1B LIM homeobox transcription factor 1, beta -2.41821
PPP1R27 protein phosphatase 1, regulatory subunit 27 -2.41821
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -2.41821
CRHR1 corticotropin releasing hormone receptor 1 -2.41821
CLEC4G C-type lectin domain family 4, member G -2.41821
RWDD2B RWD domain containing 2B -2.41821
CXORF58 chromosome X open reading frame 58 -2.41821
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -2.41821
BATF2 basic leucine zipper transcription factor, ATF-like 2 -2.41821
BHLHA15 basic helix-loop-helix family, member a15 -2.41821
CTSS cathepsin S -2.41821
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 -2.41821
ADAM12 ADAM metallopeptidase domain 12 -2.41821
FBXO38 F-box protein 38 -2.40341
COL9A3 collagen, type IX, alpha 3 -2.39554
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.37453
SLBP stem-loop binding protein -2.36035
ANKRD36 ankyrin repeat domain 36 -2.34722
NXPH4 neurexophilin 4 -2.34381
TUBB3 tubulin, beta 3 class III -2.34381
ANKRD63 ankyrin repeat domain 63 -2.34381
STIM2 stromal interaction molecule 2 -2.32359
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -2.31024
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) -2.301
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B -2.30045
TRMT5 tRNA methyltransferase 5 -2.30045
DNAI1 dynein, axonemal, intermediate chain 1 -2.30045
KIDINS220 kinase D-interacting substrate, 220kDa -2.27996
CUL4B cullin 4B -2.27996
SHROOM4 shroom family member 4 -2.26172
DOP1A DOP1 leucine zipper like protein A -2.25423
PTPDC1 protein tyrosine phosphatase domain containing 1 -2.24229
LARS2 leucyl-tRNA synthetase 2, mitochondrial -2.22379
FBXO36 F-box protein 36 -2.21627
TTYH2 tweety family member 2 -2.21032
TPCN1 two pore segment channel 1 -2.18086
P4HA3 prolyl 4-hydroxylase, alpha polypeptide III -2.18086
TMEM177 transmembrane protein 177 -2.17191
ATG10 autophagy related 10 -2.15178
ARRDC2 arrestin domain containing 2 -2.1515
CCDC194 coiled-coil domain containing 194 -2.13739
CDK5 cyclin-dependent kinase 5 -2.13232
TM9SF4 transmembrane 9 superfamily protein member 4 -2.12791
CYFIP2 cytoplasmic FMR1 interacting protein 2 -2.12376
GRK6 G protein-coupled receptor kinase 6 -2.11844
DCTN6 dynactin 6 -2.10536
PRICKLE1 prickle homolog 1 (Drosophila) -2.10536
AMMECR1L AMMECR1-like -2.09818
DDAH2 dimethylarginine dimethylaminohydrolase 2 -2.09789
TUBG1 tubulin, gamma 1 -2.09717
GAK cyclin G associated kinase -2.08713
KRT7 keratin 7, type II -2.07708
APLN apelin -2.07401
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 -2.07401
HMGN2 high mobility group nucleosomal binding domain 2 -2.05836
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) -2.05471
SLC25A51 solute carrier family 25, member 51 -2.04419
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -2.03176
PIGH phosphatidylinositol glycan anchor biosynthesis, class H -2.0139
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.01383
TMEM11 transmembrane protein 11 -2.01119
SLC39A7 solute carrier family 39 (zinc transporter), member 7 -2.00636
SETD4 SET domain containing 4 -2.0
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.0