| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | axin 2|The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8313) |
| External Link | https://ncbi.nlm.nih.gov/gene/8313 |
| Similar Terms | |
| Downloads & Tools |
500 genes differentially expressed following the AXIN2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 0.0156776 |
| CD69 | CD69 molecule | 0.0121633 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.0113671 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.0110259 |
| CLEC2B | C-type lectin domain family 2, member B | 0.0106098 |
| ASS1 | argininosuccinate synthase 1 | 0.0102424 |
| GCH1 | GTP cyclohydrolase 1 | 0.00989895 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.00977007 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.00964837 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.00931342 |
| ORM1 | orosomucoid 1 | 0.00924879 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.00919331 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.00909308 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.00840876 |
| FGG | fibrinogen gamma chain | 0.00839333 |
| CFB | complement factor B | 0.0081166 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00804301 |
| CCL8 | chemokine (C-C motif) ligand 8 | 0.00796853 |
| STK26 | serine/threonine protein kinase 26 | 0.00787953 |
| APOB | apolipoprotein B | 0.00777026 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | 0.00772333 |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 | 0.00771895 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | 0.00766892 |
| HSPB1 | heat shock 27kDa protein 1 | 0.00761324 |
| WT1 | Wilms tumor 1 | 0.0075924 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.00746226 |
| ATF3 | activating transcription factor 3 | 0.00739131 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.0072655 |
| MOSPD1 | motile sperm domain containing 1 | 0.00718774 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.00716992 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.00714501 |
| ALB | albumin | 0.00710992 |
| STC2 | stanniocalcin 2 | 0.00706024 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | 0.00699051 |
| H1-0 | H1.0 linker histone | 0.00695923 |
| PRKCB | protein kinase C, beta | 0.00693104 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | 0.00691768 |
| SIRT3 | sirtuin 3 | 0.00689203 |
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | 0.00687565 |
| TGFB1 | transforming growth factor, beta 1 | 0.00684145 |
| SNAP23 | synaptosomal-associated protein, 23kDa | 0.00672821 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | 0.00671887 |
| GIMAP6 | GTPase, IMAP family member 6 | 0.00667158 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 0.00662908 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.00661094 |
| ASPN | asporin | 0.00659271 |
| PEG10 | paternally expressed 10 | 0.00653386 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | 0.00651321 |
| NPY1R | neuropeptide Y receptor Y1 | 0.00645008 |
| C1QA | complement component 1, q subcomponent, A chain | 0.00644893 |
| LUM | lumican | 0.00640718 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.00636284 |
| IFITM2 | interferon induced transmembrane protein 2 | 0.00635085 |
| TMEM135 | transmembrane protein 135 | 0.00630635 |
| CTH | cystathionine gamma-lyase | 0.00627512 |
| RIPOR2 | RHO family interacting cell polarization regulator 2 | 0.00626698 |
| CD19 | CD19 molecule | 0.00626148 |
| LAPTM4B | lysosomal protein transmembrane 4 beta | 0.00622279 |
| POLR2D | polymerase (RNA) II (DNA directed) polypeptide D | 0.00619582 |
| LY96 | lymphocyte antigen 96 | 0.00619218 |
| PRSS23 | protease, serine, 23 | 0.00617874 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.00617351 |
| FRZB | frizzled-related protein | 0.00612776 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.00612687 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.00604908 |
| CCL4 | chemokine (C-C motif) ligand 4 | 0.0060474 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.00599368 |
| DCN | decorin | 0.00598632 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | 0.00593493 |
| CRISP3 | cysteine-rich secretory protein 3 | 0.00591631 |
| GMPR | guanosine monophosphate reductase | 0.00591304 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.00591106 |
| LRRC15 | leucine rich repeat containing 15 | 0.00589075 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.00586854 |
| ALG6 | ALG6, alpha-1,3-glucosyltransferase | 0.005867 |
| PLIN2 | perilipin 2 | 0.00584292 |
| ATP9A | ATPase, class II, type 9A | 0.00582214 |
| NPY | neuropeptide Y | 0.00581971 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.00577669 |
| VAMP5 | vesicle-associated membrane protein 5 | 0.0057756 |
| TSPAN13 | tetraspanin 13 | 0.00576637 |
| LGALS8 | lectin, galactoside-binding, soluble, 8 | 0.00574822 |
| GIMAP4 | GTPase, IMAP family member 4 | 0.00572436 |
| FGA | fibrinogen alpha chain | 0.00568322 |
| COL11A1 | collagen, type XI, alpha 1 | 0.0056788 |
| CLDN7 | claudin 7 | 0.0056532 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 0.00565101 |
| ALOX5 | arachidonate 5-lipoxygenase | 0.00564856 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.00559617 |
| SERPINH1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | 0.00557556 |
| SST | somatostatin | 0.00553913 |
| APOA1 | apolipoprotein A-I | 0.00553571 |
| CD52 | CD52 molecule | 0.00553371 |
| RND3 | Rho family GTPase 3 | 0.00553033 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.00552537 |
| WTAP | Wilms tumor 1 associated protein | 0.00552385 |
| S100P | S100 calcium binding protein P | 0.00551352 |
| IFRD1 | interferon-related developmental regulator 1 | 0.00546103 |
| CTSA | cathepsin A | 0.00544677 |
| PCP4 | Purkinje cell protein 4 | 0.00540868 |
| C11ORF58 | chromosome 11 open reading frame 58 | 0.0053965 |
| NFE2 | nuclear factor, erythroid 2 | 0.00536488 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.00536127 |
| TPP1 | tripeptidyl peptidase I | 0.00536002 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 0.00535624 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.00533864 |
| G0S2 | G0/G1 switch 2 | 0.00533336 |
| PALM | paralemmin | 0.00532892 |
| BMP4 | bone morphogenetic protein 4 | 0.00531351 |
| C1QB | complement component 1, q subcomponent, B chain | 0.00529891 |
| ADGRG2 | adhesion G protein-coupled receptor G2 | 0.0052831 |
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | 0.00527544 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | 0.00526746 |
| MAGEA3 | melanoma antigen family A3 | 0.00525848 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.00525563 |
| FOXO1 | forkhead box O1 | 0.0052209 |
| INHBA | inhibin, beta A | 0.00521776 |
| RAB8A | RAB8A, member RAS oncogene family | 0.00519291 |
| NR1H3 | nuclear receptor subfamily 1, group H, member 3 | 0.00518795 |
| PXDC1 | PX domain containing 1 | 0.00518668 |
| DCK | deoxycytidine kinase | 0.00516267 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.00514862 |
| MT2A | metallothionein 2A | 0.00514809 |
| RRAGC | Ras-related GTP binding C | 0.00513828 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.00513199 |
| PRSS8 | protease, serine, 8 | 0.00512171 |
| ABAT | 4-aminobutyrate aminotransferase | 0.00511678 |
| SAV1 | salvador family WW domain containing protein 1 | 0.00510268 |
| HBD | hemoglobin, delta | 0.00509004 |
| COL2A1 | collagen, type II, alpha 1 | 0.00508646 |
| YIPF6 | Yip1 domain family, member 6 | 0.00507393 |
| KCNS3 | potassium voltage-gated channel, modifier subfamily S, member 3 | 0.00504873 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.00504811 |
| BMP2K | BMP2 inducible kinase | 0.00504148 |
| GPNMB | glycoprotein (transmembrane) nmb | 0.00504135 |
| CCN2 | cellular communication network factor 2 | 0.00502734 |
| PSTPIP2 | proline-serine-threonine phosphatase interacting protein 2 | 0.00501598 |
| GEM | GTP binding protein overexpressed in skeletal muscle | 0.00499721 |
| PSMF1 | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | 0.00499258 |
| NPTN | neuroplastin | 0.00498128 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.00498099 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.00498098 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.00497124 |
| PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | 0.00496943 |
| SMCO4 | single-pass membrane protein with coiled-coil domains 4 | 0.00492754 |
| LYPD1 | LY6/PLAUR domain containing 1 | 0.00490909 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.00488761 |
| RHOB | ras homolog family member B | 0.004881 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.00487568 |
| TMEM126B | transmembrane protein 126B | 0.00486999 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | 0.00485889 |
| TNFSF4 | tumor necrosis factor (ligand) superfamily, member 4 | 0.00485447 |
| RARA | retinoic acid receptor, alpha | 0.00485168 |
| APOC3 | apolipoprotein C-III | 0.00482392 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0048178 |
| ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | 0.00480199 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | 0.00480007 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | 0.00479958 |
| HP | haptoglobin | 0.00479707 |
| RAB13 | RAB13, member RAS oncogene family | 0.0047851 |
| STK32B | serine/threonine kinase 32B | 0.00477013 |
| ATP6V1C1 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 | 0.00476417 |
| BMP2 | bone morphogenetic protein 2 | 0.00476042 |
| PPP1R1A | protein phosphatase 1, regulatory (inhibitor) subunit 1A | 0.00475259 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.00473487 |
| CD79B | CD79b molecule, immunoglobulin-associated beta | 0.00472738 |
| IL1RN | interleukin 1 receptor antagonist | 0.00470065 |
| GLRX2 | glutaredoxin 2 | 0.00469644 |
| ICAM2 | intercellular adhesion molecule 2 | 0.0046958 |
| GNPTAB | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | 0.00469479 |
| H1-2 | H1.2 linker histone, cluster member | 0.00468897 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.00468283 |
| MOB4 | MOB family member 4, phocein | 0.004678 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | 0.00465894 |
| PDCD10 | programmed cell death 10 | 0.00464966 |
| TNNT1 | troponin T type 1 (skeletal, slow) | 0.00464668 |
| TMEM176B | transmembrane protein 176B | 0.00463652 |
| EFNA1 | ephrin-A1 | 0.00463125 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | 0.0046253 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.00462361 |
| NDUFS4 | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) | 0.00461723 |
| TPST2 | tyrosylprotein sulfotransferase 2 | 0.00461228 |
| EIF1B | eukaryotic translation initiation factor 1B | 0.00460042 |
| ATP6V1E1 | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 | 0.00459873 |
| SNRPB2 | small nuclear ribonucleoprotein polypeptide B | 0.00458671 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.00458595 |
| NCAM1 | neural cell adhesion molecule 1 | 0.00458589 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.0045652 |
| HTR2B | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | 0.00456507 |
| SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 0.00456438 |
| PENK | proenkephalin | 0.00455738 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.00455724 |
| EDN1 | endothelin 1 | 0.00455042 |
| CSRNP2 | cysteine-serine-rich nuclear protein 2 | 0.00454748 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | 0.00454443 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.00453739 |
| ATP6V0E1 | ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 | 0.00453475 |
| SRPK2 | SRSF protein kinase 2 | 0.00452846 |
| AIM2 | absent in melanoma 2 | 0.00451866 |
| WASL | Wiskott-Aldrich syndrome-like | 0.00451821 |
| ECM1 | extracellular matrix protein 1 | 0.00450981 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.00450728 |
| UXS1 | UDP-glucuronate decarboxylase 1 | 0.00450601 |
| IGLL1 | immunoglobulin lambda-like polypeptide 1 | 0.00450445 |
| PLA1A | phospholipase A1 member A | 0.004487 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.00448676 |
| PTPN22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.00448226 |
| C3ORF14 | chromosome 3 open reading frame 14 | 0.0044743 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.00447051 |
| CST7 | cystatin F (leukocystatin) | 0.00445863 |
| MMP9 | matrix metallopeptidase 9 | 0.00445276 |
| UXT | ubiquitously-expressed, prefoldin-like chaperone | 0.00445007 |
| TEX10 | testis expressed 10 | 0.00444757 |
| KLF9 | Kruppel-like factor 9 | 0.00444584 |
| MB | myoglobin | 0.00444189 |
| YPEL5 | yippee-like 5 (Drosophila) | 0.0044393 |
| SARS1 | seryl-tRNA synthetase 1 | 0.00443611 |
| ATG101 | autophagy related 101 | 0.00443235 |
| ARG2 | arginase 2 | 0.00442965 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.00442864 |
| BST2 | bone marrow stromal cell antigen 2 | 0.00442731 |
| STAB1 | stabilin 1 | 0.00440861 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.00440771 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.00440659 |
| TDO2 | tryptophan 2,3-dioxygenase | 0.00440002 |
| POLR3K | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa | 0.00439159 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.00438961 |
| CTBS | chitobiase, di-N-acetyl- | 0.00438624 |
| GNG10 | guanine nucleotide binding protein (G protein), gamma 10 | 0.0043796 |
| ARPP21 | cAMP-regulated phosphoprotein, 21kDa | 0.00437227 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 0.00437095 |
| DDA1 | DET1 and DDB1 associated 1 | 0.00436778 |
| TSG101 | tumor susceptibility 101 | 0.00436686 |
| ABHD3 | abhydrolase domain containing 3 | 0.00436565 |
| APOBEC3A | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A | 0.00436473 |
| EGFL7 | EGF-like-domain, multiple 7 | 0.00436323 |
| LYRM4 | LYR motif containing 4 | 0.00436131 |
| SNAP29 | synaptosomal-associated protein, 29kDa | 0.00435368 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | 0.00434262 |
| YME1L1 | YME1-like 1 ATPase | 0.00433276 |
| SDCBP | syndecan binding protein (syntenin) | 0.00432842 |
| IFI35 | interferon-induced protein 35 | 0.00430376 |
| NOX4 | NADPH oxidase 4 | 0.00429674 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.00428709 |
| VRK2 | vaccinia related kinase 2 | 0.00428427 |
| CLDND1 | claudin domain containing 1 | 0.00427679 |
| BSG | basigin (Ok blood group) | 0.004275 |
| CD72 | CD72 molecule | 0.00426965 |
| VTN | vitronectin | 0.00426586 |
| SLC25A24 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 | 0.00426407 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0199136 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.014812 |
| XPO7 | exportin 7 | -0.0118374 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.0107504 |
| BHLHE41 | basic helix-loop-helix family, member e41 | -0.0107132 |
| LRP4 | low density lipoprotein receptor-related protein 4 | -0.0104463 |
| TNC | tenascin C | -0.0100087 |
| MAP7 | microtubule-associated protein 7 | -0.00992732 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.00989894 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.00952359 |
| PNMA8A | PNMA family member 8A | -0.00930843 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.00928554 |
| IPO13 | importin 13 | -0.00886896 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.00844483 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00834725 |
| SFRP1 | secreted frizzled-related protein 1 | -0.00822057 |
| ZNF395 | zinc finger protein 395 | -0.00809528 |
| PER2 | period circadian clock 2 | -0.00793907 |
| MYH11 | myosin, heavy chain 11, smooth muscle | -0.00789681 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.00780143 |
| GPX2 | glutathione peroxidase 2 | -0.0077157 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.00761886 |
| SRPX | sushi-repeat containing protein, X-linked | -0.00759577 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | -0.0075442 |
| SPRY2 | sprouty homolog 2 (Drosophila) | -0.0074524 |
| FGFR3 | fibroblast growth factor receptor 3 | -0.00743849 |
| NRCAM | neuronal cell adhesion molecule | -0.00734237 |
| SDC1 | syndecan 1 | -0.00732004 |
| NPEPL1 | aminopeptidase-like 1 | -0.00729752 |
| IRF4 | interferon regulatory factor 4 | -0.00728094 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.00725683 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.00713917 |
| TMEM255A | transmembrane protein 255A | -0.00706549 |
| KCNJ15 | potassium channel, inwardly rectifying subfamily J, member 15 | -0.00700296 |
| FCGBP | Fc fragment of IgG binding protein | -0.00696143 |
| PLAT | plasminogen activator, tissue | -0.00693293 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.00690353 |
| OLFM4 | olfactomedin 4 | -0.00689616 |
| PBK | PDZ binding kinase | -0.00688967 |
| SHCBP1 | SHC SH2-domain binding protein 1 | -0.00688303 |
| HBB | hemoglobin, beta | -0.00685396 |
| TUBB2A | tubulin, beta 2A class IIa | -0.00685039 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | -0.00682769 |
| HK1 | hexokinase 1 | -0.00681594 |
| TP63 | tumor protein p63 | -0.00677611 |
| PLK1 | polo-like kinase 1 | -0.00677423 |
| STC1 | stanniocalcin 1 | -0.00677294 |
| LEFTY1 | left-right determination factor 1 | -0.00677048 |
| VCAN | versican | -0.00671651 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0067119 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.00670048 |
| COQ8A | coenzyme Q8A | -0.0066686 |
| FABP7 | fatty acid binding protein 7, brain | -0.00663085 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.00656173 |
| PTCH1 | patched 1 | -0.00650716 |
| POPDC3 | popeye domain containing 3 | -0.00649304 |
| NCOR2 | nuclear receptor corepressor 2 | -0.00645471 |
| TXN | thioredoxin | -0.00644092 |
| DMD | dystrophin | -0.00638304 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | -0.00637534 |
| VIM | vimentin | -0.00635299 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.00630849 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0062886 |
| PDZRN3 | PDZ domain containing ring finger 3 | -0.00618693 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | -0.00612123 |
| MAOA | monoamine oxidase A | -0.0060916 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.00609038 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.00608934 |
| MPDZ | multiple PDZ domain protein | -0.0060645 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.006046 |
| LAMB1 | laminin, beta 1 | -0.00604096 |
| EDN3 | endothelin 3 | -0.00597579 |
| TRIM9 | tripartite motif containing 9 | -0.00595799 |
| MYCL | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog | -0.00593335 |
| VCP | valosin containing protein | -0.0059318 |
| ITGB4 | integrin, beta 4 | -0.0059313 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.00592012 |
| ASRGL1 | asparaginase like 1 | -0.00589768 |
| CTSZ | cathepsin Z | -0.00589389 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.00589357 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.00588938 |
| TRIM29 | tripartite motif containing 29 | -0.00580255 |
| RBBP4 | retinoblastoma binding protein 4 | -0.00580242 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | -0.00578236 |
| DACH1 | dachshund family transcription factor 1 | -0.00576029 |
| MMP3 | matrix metallopeptidase 3 | -0.00570938 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | -0.00570277 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.00564788 |
| CTSH | cathepsin H | -0.00564562 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.00563495 |
| PUF60 | poly-U binding splicing factor 60KDa | -0.00563031 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.00560869 |
| FJX1 | four jointed box 1 (Drosophila) | -0.0055968 |
| ADCY1 | adenylate cyclase 1 (brain) | -0.00558933 |
| PDGFD | platelet derived growth factor D | -0.00558212 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | -0.00555963 |
| MAB21L2 | mab-21-like 2 (C. elegans) | -0.00555575 |
| SMC1A | structural maintenance of chromosomes 1A | -0.00555419 |
| TNS3 | tensin 3 | -0.00554468 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.00552775 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | -0.00550604 |
| FBN2 | fibrillin 2 | -0.00548749 |
| PRPF4 | pre-mRNA processing factor 4 | -0.00547826 |
| HIP1 | huntingtin interacting protein 1 | -0.00547708 |
| S100A11 | S100 calcium binding protein A11 | -0.00547149 |
| CD302 | CD302 molecule | -0.00547028 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | -0.00546706 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | -0.00543715 |
| TYRP1 | tyrosinase-related protein 1 | -0.00543495 |
| GUCY2C | guanylate cyclase 2C | -0.0054238 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | -0.00541022 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.00539967 |
| PLCE1 | phospholipase C, epsilon 1 | -0.0053798 |
| LIG1 | ligase I, DNA, ATP-dependent | -0.00537932 |
| SYNM | synemin, intermediate filament protein | -0.00534665 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | -0.00533485 |
| MDFIC | MyoD family inhibitor domain containing | -0.00532014 |
| TRIP13 | thyroid hormone receptor interactor 13 | -0.0053092 |
| CD320 | CD320 molecule | -0.00529896 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | -0.00529359 |
| JPT2 | Jupiter microtubule associated homolog 2 | -0.00529093 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | -0.00528973 |
| FERMT1 | fermitin family member 1 | -0.00527164 |
| COL7A1 | collagen, type VII, alpha 1 | -0.00525741 |
| MGLL | monoglyceride lipase | -0.00524718 |
| DHCR24 | 24-dehydrocholesterol reductase | -0.00524278 |
| FGF1 | fibroblast growth factor 1 (acidic) | -0.00524269 |
| LPXN | leupaxin | -0.00523947 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | -0.00523572 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00523365 |
| ALAD | aminolevulinate dehydratase | -0.00522359 |
| HSD17B4 | hydroxysteroid (17-beta) dehydrogenase 4 | -0.00520998 |
| HNRNPA0 | heterogeneous nuclear ribonucleoprotein A0 | -0.00520661 |
| SLC6A15 | solute carrier family 6 (neutral amino acid transporter), member 15 | -0.00520334 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | -0.00519391 |
| SLC47A1 | solute carrier family 47 (multidrug and toxin extrusion), member 1 | -0.00518856 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.00515925 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.00515644 |
| RAMP3 | receptor (G protein-coupled) activity modifying protein 3 | -0.0051456 |
| FBP1 | fructose-1,6-bisphosphatase 1 | -0.00514383 |
| LY6D | lymphocyte antigen 6 complex, locus D | -0.00513665 |
| IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 | -0.00513445 |
| NELL1 | NEL-like 1 (chicken) | -0.00512049 |
| FOXN3 | forkhead box N3 | -0.00510751 |
| NCALD | neurocalcin delta | -0.00510479 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.00509708 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | -0.00509689 |
| BMP7 | bone morphogenetic protein 7 | -0.00509391 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | -0.00508043 |
| MATN2 | matrilin 2 | -0.00507651 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.00505631 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.00505585 |
| MFHAS1 | malignant fibrous histiocytoma amplified sequence 1 | -0.00505549 |
| KRT7 | keratin 7, type II | -0.00505477 |
| MKI67 | marker of proliferation Ki-67 | -0.00505171 |
| BTG2 | BTG family, member 2 | -0.00504644 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.00504028 |
| TBX3 | T-box 3 | -0.00503538 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | -0.00502073 |
| SVIL | supervillin | -0.00499071 |
| TUBB4B | tubulin, beta 4B class IVb | -0.00498939 |
| UBXN7 | UBX domain protein 7 | -0.00497626 |
| FRAT2 | frequently rearranged in advanced T-cell lymphomas 2 | -0.00496954 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | -0.0049646 |
| TNFRSF17 | tumor necrosis factor receptor superfamily, member 17 | -0.00494676 |
| LAMC2 | laminin, gamma 2 | -0.0049447 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.00494116 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.00493119 |
| PROM1 | prominin 1 | -0.0049212 |
| FDPS | farnesyl diphosphate synthase | -0.00491435 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.00491343 |
| GAS6 | growth arrest-specific 6 | -0.00490737 |
| NFASC | neurofascin | -0.00490321 |
| ALDOA | aldolase A, fructose-bisphosphate | -0.00489519 |
| KIF23 | kinesin family member 23 | -0.00489268 |
| TXLNA | taxilin alpha | -0.00488439 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.00488137 |
| CCNB1 | cyclin B1 | -0.00487653 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.00487473 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | -0.00487406 |
| BAX | BCL2-associated X protein | -0.00487385 |
| RASA4 | RAS p21 protein activator 4 | -0.00486611 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | -0.0048658 |
| TOB1 | transducer of ERBB2, 1 | -0.00485257 |
| PCDH9 | protocadherin 9 | -0.00484403 |
| SNX1 | sorting nexin 1 | -0.00484103 |
| MAP2K6 | mitogen-activated protein kinase kinase 6 | -0.00483264 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.00482393 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | -0.00481565 |
| GPM6B | glycoprotein M6B | -0.00481546 |
| EIF3I | eukaryotic translation initiation factor 3, subunit I | -0.00478684 |
| TADA2A | transcriptional adaptor 2A | -0.00478514 |
| VCL | vinculin | -0.00477907 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.00476438 |
| FAM13A | family with sequence similarity 13, member A | -0.00476419 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.00475934 |
| NDRG1 | N-myc downstream regulated 1 | -0.00471201 |
| TACC1 | transforming, acidic coiled-coil containing protein 1 | -0.00470887 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | -0.00470653 |
| C8ORF33 | chromosome 8 open reading frame 33 | -0.00468592 |
| SLC23A2 | solute carrier family 23 (ascorbic acid transporter), member 2 | -0.00467958 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | -0.00467182 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | -0.00466829 |
| CRH | corticotropin releasing hormone | -0.0046665 |
| INAVA | innate immunity activator | -0.00466052 |
| MLXIP | MLX interacting protein | -0.00465933 |
| SATB2 | SATB homeobox 2 | -0.00465735 |
| PAMR1 | peptidase domain containing associated with muscle regeneration 1 | -0.00465522 |
| HELLS | helicase, lymphoid-specific | -0.00463485 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.00463383 |
| MUC4 | mucin 4, cell surface associated | -0.00463353 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | -0.00463076 |
| TFF1 | trefoil factor 1 | -0.00462734 |
| LAMA3 | laminin, alpha 3 | -0.00461845 |
| NFIB | nuclear factor I/B | -0.00461797 |
| CHST7 | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 | -0.00461256 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.00460563 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.00460356 |
| FAM168A | family with sequence similarity 168, member A | -0.00459629 |
| VWA8 | von Willebrand factor A domain containing 8 | -0.00459148 |
| NPRL2 | nitrogen permease regulator-like 2 (S. cerevisiae) | -0.00458824 |
| GLTP | glycolipid transfer protein | -0.00458749 |
| EXPH5 | exophilin 5 | -0.00457855 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.00457819 |
| KIF13B | kinesin family member 13B | -0.00457239 |
| BICC1 | BicC family RNA binding protein 1 | -0.00456002 |
| CNR1 | cannabinoid receptor 1 (brain) | -0.00454102 |
| S100A2 | S100 calcium binding protein A2 | -0.00453398 |
| ADAT1 | adenosine deaminase, tRNA-specific 1 | -0.00453114 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -0.00451899 |
| TPM2 | tropomyosin 2 (beta) | -0.00451426 |
| KLHDC8A | kelch domain containing 8A | -0.00450277 |
| PADI2 | peptidyl arginine deiminase, type II | -0.00449615 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.00449277 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.00449179 |
| TGFBR3 | transforming growth factor, beta receptor III | -0.00448096 |
| DZIP1 | DAZ interacting zinc finger protein 1 | -0.00447977 |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | -0.00447108 |
| THBD | thrombomodulin | -0.00446449 |
| COL21A1 | collagen, type XXI, alpha 1 | -0.00446358 |
| ECT2 | epithelial cell transforming 2 | -0.00445097 |
| GET1 | guided entry of tail-anchored proteins factor 1 | -0.00444631 |
| DLG5 | discs, large homolog 5 (Drosophila) | -0.00442788 |
| CXCL6 | chemokine (C-X-C motif) ligand 6 | -0.00442753 |
| ZNF185 | zinc finger protein 185 (LIM domain) | -0.00442561 |
| PRKD1 | protein kinase D1 | -0.00441847 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | -0.00440524 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | -0.00440118 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.00439879 |
| GPM6A | glycoprotein M6A | -0.00439823 |
