AXIN2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description axin 2|The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8313)
External Link http://www.ncbi.nlm.nih.gov/gene/8313
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Genes

42 interacting proteins for AXIN2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AKAP11 A kinase (PRKA) anchor protein 11
AKAP9 A kinase (PRKA) anchor protein 9
AMER1 APC membrane recruitment protein 1
AMER3 APC membrane recruitment protein 3
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ANKRD6 ankyrin repeat domain 6
APC adenomatous polyposis coli
APC2 adenomatosis polyposis coli 2
AXIN1 axin 1
CDC20 cell division cycle 20
CLASP2 cytoplasmic linker associated protein 2
CSNK1A1 casein kinase 1, alpha 1
CSNK1E casein kinase 1, epsilon
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DLG1 discs, large homolog 1 (Drosophila)
DYNLL1 dynein, light chain, LC8-type 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSKIP GSK3B interacting protein
KDM5B lysine (K)-specific demethylase 5B
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRUNE prune exopolyphosphatase
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
RNF111 ring finger protein 111
RNF146 ring finger protein 146
RPS27A ribosomal protein S27a
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
UBC ubiquitin C
USP34 ubiquitin specific peptidase 34