AXL Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description AXL receptor tyrosine kinase|The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 558)
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Genes

322 genes differentially expressed following the AXL gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GPR4 G protein-coupled receptor 4 3.49863
PCDHB1 protocadherin beta 1 3.49863
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 3.49863
SOX14 SRY (sex determining region Y)-box 14 3.49863
CCNB3 cyclin B3 3.49863
OR10A2 olfactory receptor, family 10, subfamily A, member 2 3.49863
SH2D6 SH2 domain containing 6 3.49863
TKTL1 transketolase-like 1 3.49863
FFAR4 free fatty acid receptor 4 3.49863
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 3.49863
NANOS3 nanos homolog 3 (Drosophila) 3.49863
NDRG1 N-myc downstream regulated 1 3.49863
SBK3 SH3 domain binding kinase family, member 3 3.49863
GPR75 G protein-coupled receptor 75 3.49863
CEMP1 cementum protein 1 3.49863
FGD2 FYVE, RhoGEF and PH domain containing 2 3.49863
CD14 CD14 molecule 3.49863
CELF6 CUGBP, Elav-like family member 6 3.49863
SPINK7 serine peptidase inhibitor, Kazal type 7 (putative) 3.49863
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 3.49863
SCNN1G sodium channel, non voltage gated 1 gamma subunit 3.49863
SLC30A4 solute carrier family 30 (zinc transporter), member 4 3.49863
OR5V1 olfactory receptor, family 5, subfamily V, member 1 3.49863
MISP mitotic spindle positioning 3.49863
CRYGA crystallin, gamma A 3.49863
RTP3 receptor (chemosensory) transporter protein 3 3.49863
ZNF804B zinc finger protein 804B 3.49863
HRG histidine-rich glycoprotein 3.49863
NRSN1 neurensin 1 3.49863
CD226 CD226 molecule 3.49863
EIF1 eukaryotic translation initiation factor 1 3.49863
S100A7 S100 calcium binding protein A7 3.49863
NEU4 sialidase 4 3.49863
C19ORF67 chromosome 19 open reading frame 67 3.49863
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 3.49863
TRPV3 transient receptor potential cation channel, subfamily V, member 3 3.49863
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.49863
UMODL1 uromodulin-like 1 3.49863
CELA1 chymotrypsin-like elastase family, member 1 3.49863
COPZ2 coatomer protein complex, subunit zeta 2 3.49863
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 3.49863
HNF4A hepatocyte nuclear factor 4, alpha 3.49863
REELD1 reeler domain containing 1 3.49863
HTD2 hydroxyacyl-thioester dehydratase type 2 3.49863
GBP4 guanylate binding protein 4 3.49863
OPRM1 opioid receptor, mu 1 3.49863
PNLIPRP3 pancreatic lipase-related protein 3 3.49863
RD3 retinal degeneration 3 3.49863
GC group-specific component (vitamin D binding protein) 3.49863
OR52E4 olfactory receptor, family 52, subfamily E, member 4 3.49863
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 3.49863
DEPP1 DEPP autophagy regulator 1 3.49863
PLAAT4 phospholipase A and acyltransferase 4 3.49863
NOTCH2NLB notch 2 N-terminal like B 3.49863
PRRT1B proline rich transmembrane protein 1B 3.49863
CIMAP1D CIMAP1 family member D 3.49863
SMIM35 small integral membrane protein 35 3.49863
CLEC20A C-type lectin domain containing 20A 3.49863
CFAP276 cilia and flagella associated protein 276 3.49863
DYNLT4 dynein light chain Tctex-type 4 3.49863
CABCOCO1 ciliary associated calcium binding coiled-coil 1 3.49863
GATA3 GATA binding protein 3 3.49863
DLK1 delta-like 1 homolog (Drosophila) 3.49863
SAMD11 sterile alpha motif domain containing 11 3.49863
DSG1 desmoglein 1 3.49863
CLEC3A C-type lectin domain family 3, member A 3.49863
NXPE1 neurexophilin and PC-esterase domain family, member 1 3.49863
IRF5 interferon regulatory factor 5 3.49863
PCDHB11 protocadherin beta 11 3.49863
FPR1 formyl peptide receptor 1 3.49863
RAET1E retinoic acid early transcript 1E 3.49863
TAS2R9 taste receptor, type 2, member 9 3.49863
LIX1 Lix1 homolog (chicken) 3.49863
CBLN3 cerebellin 3 precursor 3.49863
GTSF1 gametocyte specific factor 1 3.49863
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 3.49863
S100G S100 calcium binding protein G 3.49863
PRR4 proline rich 4 (lacrimal) 3.49863
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 3.49863
SIM2 single-minded family bHLH transcription factor 2 3.49863
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 3.49863
CATSPER3 cation channel, sperm associated 3 3.49863
NRN1 neuritin 1 3.49863
KCNK9 potassium channel, two pore domain subfamily K, member 9 3.49863
BAHCC1 BAH domain and coiled-coil containing 1 3.49863
NUPR1 nuclear protein, transcriptional regulator, 1 3.49863
FZD1 frizzled class receptor 1 3.49863
IFITM5 interferon induced transmembrane protein 5 3.49863
C5AR2 complement component 5a receptor 2 3.49863
COX7B2 cytochrome c oxidase subunit VIIb2 3.49863
TAT tyrosine aminotransferase 3.49863
AMER2 APC membrane recruitment protein 2 3.49863
IL19 interleukin 19 3.49863
KISS1 KiSS-1 metastasis-suppressor 3.49863
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 3.49863
PCDHGA2 protocadherin gamma subfamily A, 2 3.49863
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.49863
ZSCAN4 zinc finger and SCAN domain containing 4 3.49863
EDN2 endothelin 2 3.49863
EDN3 endothelin 3 3.49863
VAX2 ventral anterior homeobox 2 3.49863
KLHL6 kelch-like family member 6 3.49863
GP1BB glycoprotein Ib (platelet), beta polypeptide 3.49863
KLF2 Kruppel-like factor 2 3.49863
HAVCR1 hepatitis A virus cellular receptor 1 3.49863
C10ORF120 chromosome 10 open reading frame 120 3.49863
ZNF474 zinc finger protein 474 3.49863
DHRS7C dehydrogenase/reductase (SDR family) member 7C 3.49863
THBD thrombomodulin 3.49863
FAM135B family with sequence similarity 135, member B 3.49863
AMDHD1 amidohydrolase domain containing 1 3.49863
PPP1R3G protein phosphatase 1, regulatory subunit 3G 3.49863
NR5A1 nuclear receptor subfamily 5, group A, member 1 3.49863
GPR142 G protein-coupled receptor 142 3.49863
TEX29 testis expressed 29 3.49863
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.49863
TAS2R46 taste receptor, type 2, member 46 3.49863
CDCP2 CUB domain containing protein 2 3.49863
ART1 ADP-ribosyltransferase 1 3.49863
ITGAD integrin, alpha D 3.49863
CRHBP corticotropin releasing hormone binding protein 3.49863
RPL7A ribosomal protein L7a 3.49863
SPHKAP SPHK1 interactor, AKAP domain containing 3.49863
KLK6 kallikrein-related peptidase 6 3.49863
FSHR follicle stimulating hormone receptor 3.49863
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.49863
RHAG Rh-associated glycoprotein 3.49863
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.49863
TPPP2 tubulin polymerization-promoting protein family member 2 3.49863
SYTL4 synaptotagmin-like 4 3.49863
ST18 suppression of tumorigenicity 18, zinc finger 3.49863
TGM3 transglutaminase 3 3.49863
C10ORF90 chromosome 10 open reading frame 90 3.49863
PXDN peroxidasin 3.2949
TUBA1B tubulin, alpha 1b 3.29367
ARL4D ADP-ribosylation factor-like 4D 3.28443
KCTD14 potassium channel tetramerization domain containing 14 3.22182
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 3.19987
ERO1B endoplasmic reticulum oxidoreductase 1 beta 3.19921
ERH enhancer of rudimentary homolog (Drosophila) 3.18711
C1ORF216 chromosome 1 open reading frame 216 3.02299
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 2.96238
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) 2.9153
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 2.77368
PTPN12 protein tyrosine phosphatase, non-receptor type 12 2.70597
SEPHS1 selenophosphate synthetase 1 2.68095
RPL29 ribosomal protein L29 2.67378
RPL13A ribosomal protein L13a 2.65611
PDE5A phosphodiesterase 5A, cGMP-specific 2.64017
BEX3 brain expressed X-linked 3 2.63117
LCK LCK proto-oncogene, Src family tyrosine kinase 2.62062
RTN2 reticulon 2 2.6092
THSD4 thrombospondin, type I, domain containing 4 2.59876
ODC1 ornithine decarboxylase 1 2.59485
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 2.5754
JPH2 junctophilin 2 2.5717
GYPE glycophorin E (MNS blood group) 2.5717
ERFE erythroferrone 2.5717
TMEM225B transmembrane protein 225B 2.5717
GALT galactose-1-phosphate uridylyltransferase 2.5717
FDXR ferredoxin reductase 2.52381
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 2.49376
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 2.44319
TNNI1 troponin I type 1 (skeletal, slow) 2.42605
KRT17 keratin 17, type I 2.42605
PCSK1 proprotein convertase subtilisin/kexin type 1 2.39966
RNF187 ring finger protein 187 2.39013
PNPLA7 patatin-like phospholipase domain containing 7 2.37922
EDNRA endothelin receptor type A 2.37922
EIF3A eukaryotic translation initiation factor 3, subunit A 2.37922
PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 2.35452
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 2.32571
LDHA lactate dehydrogenase A 2.32571
CFAP20 cilia and flagella associated protein 20 2.32165
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 2.32165
HCRTR1 hypocretin (orexin) receptor 1 2.32165
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 2.32165
CUL3 cullin 3 2.3029
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 2.30108
COL17A1 collagen, type XVII, alpha 1 2.29598
MRPL22 mitochondrial ribosomal protein L22 2.29384
TP53I13 tumor protein p53 inducible protein 13 2.29176
RAB26 RAB26, member RAS oncogene family 2.28358
CFAP65 cilia and flagella associated protein 65 2.28358
ATAD2B ATPase family, AAA domain containing 2B 2.28358
HMGXB4 HMG box domain containing 4 2.28229
SRPRB signal recognition particle receptor, B subunit 2.27994
TMEM132A transmembrane protein 132A 2.27994
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 2.27994
NCS1 neuronal calcium sensor 1 2.25282
MAGOH mago-nashi homolog, proliferation-associated (Drosophila) 2.23026
FSTL3 follistatin-like 3 (secreted glycoprotein) 2.17967
RPL23A ribosomal protein L23a 2.16871
TNS3 tensin 3 2.1682
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 2.1682
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 2.14791
FDFT1 farnesyl-diphosphate farnesyltransferase 1 2.14791
MDC1 mediator of DNA-damage checkpoint 1 2.14791
CKS1B CDC28 protein kinase regulatory subunit 1B 2.14791
RPS25 ribosomal protein S25 2.13607
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 2.12339
ZNF791 zinc finger protein 791 2.10579
ARF1 ADP-ribosylation factor 1 2.10363
RPSA ribosomal protein SA 2.09465
GGPS1 geranylgeranyl diphosphate synthase 1 2.09465
MTX2 metaxin 2 2.08754
MVK mevalonate kinase 2.0873
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 2.08224
MARCHF8 membrane associated ring-CH-type finger 8 2.07986
H3C4 H3 clustered histone 4 2.07927
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 2.07927
CHGA chromogranin A 2.07472
SCYL1 SCY1-like 1 (S. cerevisiae) 2.05966
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 2.05445
ZNF888 zinc finger protein 888 2.03777
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 2.0217
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 2.0217
CD72 CD72 molecule 2.01769
XYLT1 xylosyltransferase I 2.01609
TRIT1 tRNA isopentenyltransferase 1 2.01609
CDNF cerebral dopamine neurotrophic factor 2.00229
WDR1 WD repeat domain 1 2.00138

decreased expression

Symbol Name Standardized Value
CCDC170 coiled-coil domain containing 170 -3.49863
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 -3.49863
SEC63 SEC63 homolog (S. cerevisiae) -3.49863
SNTN sentan, cilia apical structure protein -3.40386
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -3.40386
WFDC8 WAP four-disulfide core domain 8 -3.40386
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 -3.40386
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 -3.40386
C8ORF74 chromosome 8 open reading frame 74 -3.40386
GH2 growth hormone 2 -3.40386
TUBA8 tubulin, alpha 8 -3.40386
PRAP1 proline-rich acidic protein 1 -3.40386
LRRC32 leucine rich repeat containing 32 -3.40386
HIGD1C HIG1 hypoxia inducible domain family, member 1C -3.40386
NKPD1 NTPase, KAP family P-loop domain containing 1 -3.40386
ANXA8 annexin A8 -3.40386
AGTR1 angiotensin II receptor, type 1 -3.40386
SIX1 SIX homeobox 1 -3.40386
OTOF otoferlin -3.40386
CLDN14 claudin 14 -3.40386
OTOS otospiralin -3.40386
SPATS1 spermatogenesis associated, serine-rich 1 -3.40386
ADAP1 ArfGAP with dual PH domains 1 -3.40386
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -3.40386
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 -3.40386
CBLIF cobalamin binding intrinsic factor -3.40386
LOC124900192 uncharacterized LOC124900192 -3.40386
OR2A7 olfactory receptor, family 2, subfamily A, member 7 -3.40386
PLVAP plasmalemma vesicle associated protein -3.40386
MUC12 mucin 12, cell surface associated -3.02299
AXL AXL receptor tyrosine kinase -3.00457
SF1 splicing factor 1 -2.9153
PRR14L proline rich 14-like -2.83524
IREB2 iron-responsive element binding protein 2 -2.81034
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -2.77368
STYK1 serine/threonine/tyrosine kinase 1 -2.72013
SYT4 synaptotagmin IV -2.71742
CDH9 cadherin 9, type 2 (T1-cadherin) -2.68894
KLK13 kallikrein-related peptidase 13 -2.68894
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) -2.59485
MKX mohawk homeobox -2.54744
FGFR3 fibroblast growth factor receptor 3 -2.54744
PIR pirin (iron-binding nuclear protein) -2.53494
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 -2.40062
LCORL ligand dependent nuclear receptor corepressor-like -2.39013
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) -2.38141
ZBTB3 zinc finger and BTB domain containing 3 -2.37155
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 -2.36766
TIMP3 TIMP metallopeptidase inhibitor 3 -2.35045
VDAC1 voltage-dependent anion channel 1 -2.35045
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 -2.35045
CAPN6 calpain 6 -2.34394
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -2.32571
CDCA7 cell division cycle associated 7 -2.32571
SMO smoothened, frizzled class receptor -2.32561
YBX2 Y box binding protein 2 -2.32238
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -2.32238
TMEM200A transmembrane protein 200A -2.32165
CARD19 caspase recruitment domain family member 19 -2.31713
ATP5MK ATP synthase membrane subunit k -2.31554
BEST2 bestrophin 2 -2.31247
SKIC8 SKI8 subunit of superkiller complex -2.30024
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.29794
RNF227 ring finger protein 227 -2.29385
KIF1C-AS1 KIF1C antisense RNA 1 -2.29385
TMIE transmembrane inner ear -2.29385
ANTXR2 anthrax toxin receptor 2 -2.29134
MARCHF4 membrane associated ring-CH-type finger 4 -2.28508
VCL vinculin -2.28508
CRYBA4 crystallin, beta A4 -2.28358
ANXA9 annexin A9 -2.28358
NNAT neuronatin -2.28358
BAZ1B bromodomain adjacent to zinc finger domain, 1B -2.28358
LRRC3 leucine rich repeat containing 3 -2.28085
SERINC5 serine incorporator 5 -2.27994
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -2.27994
SF3B3 splicing factor 3b, subunit 3, 130kDa -2.25716
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -2.25282
RHOXF2 Rhox homeobox family, member 2 -2.21816
TMEM236 transmembrane protein 236 -2.21816
TTC22 tetratricopeptide repeat domain 22 -2.21766
ANGPTL7 angiopoietin-like 7 -2.21766
EXT2 exostosin glycosyltransferase 2 -2.20327
REV1 REV1, polymerase (DNA directed) -2.19681
DNASE1L1 deoxyribonuclease I-like 1 -2.17754
JAZF1 JAZF zinc finger 1 -2.1737
RBM11 RNA binding motif protein 11 -2.16871
ARHGAP39 Rho GTPase activating protein 39 -2.16289
TRIM21 tripartite motif containing 21 -2.13796
TBC1D14 TBC1 domain family, member 14 -2.13614
ANKRD34B ankyrin repeat domain 34B -2.1251
KIF5C kinesin family member 5C -2.11612
ZNF33A zinc finger protein 33A -2.08672
IPO7 importin 7 -2.07927
SIL1 SIL1 nucleotide exchange factor -2.07472
CMC2 C-x(9)-C motif containing 2 -2.06189
CPNE2 copine II -2.05445
DAP death-associated protein -2.05248
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -2.04968
DAZL deleted in azoospermia-like -2.03471