AXL Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description AXL receptor tyrosine kinase|The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 558)
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100 substrates of the kinase AXL from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
KMT5A lysine methyltransferase 5A 100.0
KLC3 kinesin light chain 3 99.94
SH2D3C SH2 domain containing 3C 99.87
UNG uracil-DNA glycosylase 99.85
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 99.83
STING1 stimulator of interferon response cGAMP interactor 1 99.83
CNOT9 CCR4-NOT transcription complex subunit 9 99.74
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 99.71
ARRDC3 arrestin domain containing 3 99.67
WWP2 WW domain containing E3 ubiquitin protein ligase 2 99.59
FCHO1 FCH domain only 1 99.58
CMKLR1 chemerin chemokine-like receptor 1 99.52
SLC39A3 solute carrier family 39 (zinc transporter), member 3 99.45
MUC16 mucin 16, cell surface associated 99.41
FKBP6 FK506 binding protein 6, 36kDa 99.34
INVS inversin 99.32
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 99.3
DCAF13 DDB1 and CUL4 associated factor 13 99.26
FHIT fragile histidine triad 99.26
RIPOR3 RIPOR family member 3 99.23
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 99.1
SIPA1L1 signal-induced proliferation-associated 1 like 1 99.04
CNBD2 cyclic nucleotide binding domain containing 2 99.01
TAMALIN trafficking regulator and scaffold protein tamalin 98.8
PSME3IP1 proteasome activator subunit 3 interacting protein 1 98.69
GH1 growth hormone 1 98.67
PRPS2 phosphoribosyl pyrophosphate synthetase 2 98.67
CKS1B CDC28 protein kinase regulatory subunit 1B 98.6
SRCIN1 SRC kinase signaling inhibitor 1 98.585
NAXE NAD(P)HX epimerase 98.53
FPR2 formyl peptide receptor 2 98.49
PRPS1 phosphoribosyl pyrophosphate synthetase 1 98.45
RASGRP4 RAS guanyl releasing protein 4 98.32
FKBP5 FK506 binding protein 5 98.32
RPS10-NUDT3 RPS10-NUDT3 readthrough 98.31
RPS10 ribosomal protein S10 98.31
PTPRB protein tyrosine phosphatase, receptor type, B 98.25
MX2 MX dynamin-like GTPase 2 98.21
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) 98.14
UMPS uridine monophosphate synthetase 98.1
UBASH3A ubiquitin associated and SH3 domain containing A 98.05
TBL3 transducin (beta)-like 3 98.01
RFTN1 raftlin, lipid raft linker 1 97.99
MPZ myelin protein zero 97.97
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 97.94
CLMP CXADR-like membrane protein 97.88
DOK3 docking protein 3 97.75
PABPC3 poly(A) binding protein, cytoplasmic 3 97.68
PEBP1 phosphatidylethanolamine binding protein 1 97.625
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 97.55
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 97.53
COG3 component of oligomeric golgi complex 3 97.51
KTN1 kinectin 1 (kinesin receptor) 97.5
PADI2 peptidyl arginine deiminase, type II 97.48
GH2 growth hormone 2 97.44
TRIM25 tripartite motif containing 25 97.44
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3 97.31
GNL1 guanine nucleotide binding protein-like 1 97.31
GCHFR GTP cyclohydrolase I feedback regulator 97.27
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 97.22
GREB1 growth regulation by estrogen in breast cancer 1 97.18
KAT2A K(lysine) acetyltransferase 2A 97.16
IFITM2 interferon induced transmembrane protein 2 97.15
CAPN2 calpain 2, (m/II) large subunit 96.96
STYK1 serine/threonine/tyrosine kinase 1 96.94
HCST hematopoietic cell signal transducer 96.89
FAM168A family with sequence similarity 168, member A 96.78
NR1H4 nuclear receptor subfamily 1, group H, member 4 96.76
PLPPR4 phospholipid phosphatase related 4 96.67
JUN jun proto-oncogene 96.65
RPL8 ribosomal protein L8 96.59
FAF2 Fas associated factor family member 2 96.58
PHLDB3 pleckstrin homology-like domain, family B, member 3 96.48
KAT2B K(lysine) acetyltransferase 2B 96.41
KAZN kazrin, periplakin interacting protein 96.37
GATAD2B GATA zinc finger domain containing 2B 96.35
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 96.32
PHKB phosphorylase kinase, beta 96.26
LOC102725035 leukocyte immunoglobulin-like receptor subfamily B member 3 96.23
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 96.23
TWF1 twinfilin actin binding protein 1 96.19
RGS10 regulator of G-protein signaling 10 96.15
ANXA6 annexin A6 96.11
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2 96.1
CD300LB CD300 molecule-like family member b 96.06
RIOK1 RIO kinase 1 95.99
MKNK1 MAP kinase interacting serine/threonine kinase 1 95.97
ZNF512 zinc finger protein 512 95.95
DVL1 dishevelled segment polarity protein 1 95.93
FHOD1 formin homology 2 domain containing 1 95.89
STARD13 StAR-related lipid transfer (START) domain containing 13 95.88
UBE2E1 ubiquitin-conjugating enzyme E2E 1 95.8
UBE2E2 ubiquitin-conjugating enzyme E2E 2 95.8
UBE2E3 ubiquitin-conjugating enzyme E2E 3 95.8
ZCCHC3 zinc finger, CCHC domain containing 3 95.69
BTBD7 BTB (POZ) domain containing 7 95.67
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 95.67
ITSN1 intersectin 1 (SH3 domain protein) 95.6
RGS14 regulator of G-protein signaling 14 95.54
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 95.51