AXL Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description AXL receptor tyrosine kinase|The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 558)
External Link http://www.ncbi.nlm.nih.gov/gene/558
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Genes

151 interacting proteins for AXL from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABI1 abl-interactor 1
ABI2 abl-interactor 2
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACAD11 acyl-CoA dehydrogenase family, member 11
ACVR1 activin A receptor, type I
ADAM10 ADAM metallopeptidase domain 10
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALK anaplastic lymphoma receptor tyrosine kinase
AURKA aurora kinase A
AURKB aurora kinase B
AZI2 5-azacytidine induced 2
BAIAP2 BAI1-associated protein 2
BCR breakpoint cluster region
BMP2K BMP2 inducible kinase
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
BTK Bruton agammaglobulinemia tyrosine kinase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD247 CD247 molecule
CD28 CD28 molecule
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD80 CD80 molecule
CD86 CD86 molecule
CNTRL centriolin
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CSK c-src tyrosine kinase
CUX1 cut-like homeobox 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
ELAVL1 ELAV like RNA binding protein 1
EPHA2 EPH receptor A2
EPHB4 EPH receptor B4
ERRFI1 ERBB receptor feedback inhibitor 1
FBXO25 F-box protein 25
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FER fer (fps/fes related) tyrosine kinase
FGF1 fibroblast growth factor 1 (acidic)
FGF10 fibroblast growth factor 10
FGF16 fibroblast growth factor 16
FGF17 fibroblast growth factor 17
FGF18 fibroblast growth factor 18
FGF19 fibroblast growth factor 19
FGF2 fibroblast growth factor 2 (basic)
FGF20 fibroblast growth factor 20
FGF22 fibroblast growth factor 22
FGF23 fibroblast growth factor 23
FGF3 fibroblast growth factor 3
FGF4 fibroblast growth factor 4
FGF5 fibroblast growth factor 5
FGF6 fibroblast growth factor 6
FGF7 fibroblast growth factor 7
FGF8 fibroblast growth factor 8 (androgen-induced)
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
FGFR1OP FGFR1 oncogene partner
FGFR1OP2 FGFR1 oncogene partner 2
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GAS6 growth arrest-specific 6
GRAP2 GRB2-related adaptor protein 2
GRB2 growth factor receptor-bound protein 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker)
IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker)
IGHG4 immunoglobulin heavy constant gamma 4 (G4m marker)
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLC1 immunoglobulin lambda constant 1 (Mcg marker)
IGLC2 immunoglobulin lambda constant 2 (Kern-Oz- marker)
IGLC3 immunoglobulin lambda constant 3 (Kern-Oz+ marker)
IGLC6 immunoglobulin lambda constant 6 (Kern+Oz- marker, gene/pseudogene)
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL15RA interleukin 15 receptor, alpha
IL2RG interleukin 2 receptor, gamma
IRAK1 interleukin-1 receptor-associated kinase 1
ITK IL2-inducible T-cell kinase
JAK1 Janus kinase 1
KDR kinase insert domain receptor
KL klotho
KLB klotho beta
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIMK1 LIM domain kinase 1
LIMK2 LIM domain kinase 2
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MERTK MER proto-oncogene, tyrosine kinase
MST1R macrophage stimulating 1 receptor
MYO18A myosin XVIIIA
NCK2 NCK adaptor protein 2
NCKAP1 NCK-associated protein 1
NUAK1 NUAK family, SNF1-like kinase, 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRKD2 protein kinase D2
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RANBP9 RAN binding protein 9
RHOA ras homolog family member A
RIPK2 receptor-interacting serine-threonine kinase 2
SH2D2A SH2 domain containing 2A
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SLK STE20-like kinase
SOCS1 suppressor of cytokine signaling 1
SOS1 son of sevenless homolog 1 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STK4 serine/threonine kinase 4
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SYK spleen tyrosine kinase
TANK TRAF family member-associated NFKB activator
TBK1 TANK-binding kinase 1
TBKBP1 TBK1 binding protein 1
TEC tec protein tyrosine kinase
TNK2 tyrosine kinase, non-receptor, 2
TNS2 tensin 2
TRAF2 TNF receptor-associated factor 2
TRIM24 tripartite motif containing 24
TXK TXK tyrosine kinase
TYK2 tyrosine kinase 2
UBC ubiquitin C
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2
WASF3 WAS protein family, member 3
ZMYM2 zinc finger, MYM-type 2