| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/44137675 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in AZD 6482 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 1.77 |
| NOVA1 | neuro-oncological ventral antigen 1 | 1.43 |
| ITGB8 | integrin, beta 8 | 1.21 |
| FAM122B | family with sequence similarity 122B | 1.19 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 1.19 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 1.15 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 1.1 |
| ABTB1 | ankyrin repeat and BTB (POZ) domain containing 1 | 1.06 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | 1.02 |
| IRS2 | insulin receptor substrate 2 | 0.94 |
| DUSP6 | dual specificity phosphatase 6 | 0.93 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.92 |
| COQ8A | coenzyme Q8A | 0.91 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | 0.89 |
| WNT16 | wingless-type MMTV integration site family, member 16 | 0.89 |
| BLOC1S3 | biogenesis of lysosomal organelles complex-1, subunit 3 | 0.86 |
| TRIB1 | tribbles pseudokinase 1 | 0.85 |
| RTN2 | reticulon 2 | 0.83 |
| DAP | death-associated protein | 0.83 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | 0.82 |
| PAIP2 | poly(A) binding protein interacting protein 2 | 0.81 |
| XBP1 | X-box binding protein 1 | 0.81 |
| METTL7A | methyltransferase like 7A | 0.81 |
| GRB7 | growth factor receptor-bound protein 7 | 0.79 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.77 |
| ZG16B | zymogen granule protein 16B | 0.76 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 | 0.72 |
| CYBRD1 | cytochrome b reductase 1 | 0.71 |
| MT-ND5 | NADH dehydrogenase, subunit 5 (complex I) | 0.7 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.69 |
| PDLIM5 | PDZ and LIM domain 5 | 0.68 |
| SPOP | speckle-type POZ protein | 0.67 |
| SARDH | sarcosine dehydrogenase | 0.66 |
| IRF9 | interferon regulatory factor 9 | 0.66 |
| NR1D1 | nuclear receptor subfamily 1, group D, member 1 | 0.65 |
| UNG | uracil-DNA glycosylase | 0.65 |
| CLDN3 | claudin 3 | 0.65 |
| CASTOR2 | cytosolic arginine sensor for mTORC1 subunit 2 | 0.64 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.64 |
| TCTN2 | tectonic family member 2 | 0.64 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.63 |
| ZNF428 | zinc finger protein 428 | 0.63 |
| RBL2 | retinoblastoma-like 2 | 0.62 |
| LYRM1 | LYR motif containing 1 | 0.62 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.62 |
| HECA | headcase homolog (Drosophila) | 0.62 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | 0.61 |
| PTMA | prothymosin, alpha | 0.61 |
| ELF1 | E74-like factor 1 (ets domain transcription factor) | 0.61 |
| KIAA1107 | KIAA1107 | 0.61 |
| PPL | periplakin | 0.6 |
| ZNF446 | zinc finger protein 446 | 0.6 |
| MAGI1 | membrane associated guanylate kinase, WW and PDZ domain containing 1 | 0.6 |
| MT2A | metallothionein 2A | 0.59 |
| SGSM1 | small G protein signaling modulator 1 | 0.59 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.58 |
| RCN2 | reticulocalbin 2, EF-hand calcium binding domain | 0.58 |
| DENND3 | DENN/MADD domain containing 3 | 0.58 |
| RAB26 | RAB26, member RAS oncogene family | 0.56 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | 0.56 |
| EVPL | envoplakin | 0.56 |
| TRAPPC6A | trafficking protein particle complex 6A | 0.56 |
| LDHD | lactate dehydrogenase D | 0.55 |
| GRN | granulin | 0.55 |
| FZD1 | frizzled class receptor 1 | 0.55 |
| PTMS | parathymosin | 0.54 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 0.54 |
| ITGB4 | integrin, beta 4 | 0.53 |
| LINGO1 | leucine rich repeat and Ig domain containing 1 | 0.53 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.53 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.53 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | 0.53 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.53 |
| TM7SF2 | transmembrane 7 superfamily member 2 | 0.53 |
| OPTN | optineurin | 0.53 |
| TST | thiosulfate sulfurtransferase (rhodanese) | 0.53 |
| DNAH1 | dynein, axonemal, heavy chain 1 | 0.53 |
| DHTKD1 | dehydrogenase E1 and transketolase domain containing 1 | 0.53 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.52 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 0.52 |
| WDR19 | WD repeat domain 19 | 0.52 |
| NDRG1 | N-myc downstream regulated 1 | 0.52 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | 0.52 |
| CD109 | CD109 molecule | 0.52 |
| MFSD6 | major facilitator superfamily domain containing 6 | 0.52 |
| ZC3H6 | zinc finger CCCH-type containing 6 | 0.52 |
| ELMO3 | engulfment and cell motility 3 | 0.52 |
| WRB | tryptophan rich basic protein | 0.51 |
| R3HDM2 | R3H domain containing 2 | 0.51 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.51 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.51 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.51 |
| APPL2 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 | 0.51 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | 0.51 |
| ENPP5 | ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) | 0.5 |
| CRAT | carnitine O-acetyltransferase | 0.5 |
| ABHD3 | abhydrolase domain containing 3 | 0.5 |
| GSDME | gasdermin E | 0.5 |
| DOCK4 | dedicator of cytokinesis 4 | 0.5 |
| GRAMD2B | GRAM domain containing 2B | 0.5 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -2.18 |
| DIPK1B | divergent protein kinase domain 1B | -1.77 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -1.69 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -1.24 |
| SESN2 | sestrin 2 | -1.21 |
| AEN | apoptosis enhancing nuclease | -1.19 |
| CIAO2B | cytosolic iron-sulfur assembly component 2B | -1.13 |
| STC2 | stanniocalcin 2 | -1.08 |
| SLC26A11 | solute carrier family 26 (anion exchanger), member 11 | -0.97 |
| SLC7A6 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 | -0.95 |
| BHLHA15 | basic helix-loop-helix family, member a15 | -0.93 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -0.87 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | -0.87 |
| RGN | regucalcin | -0.86 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -0.86 |
| PSAT1 | phosphoserine aminotransferase 1 | -0.85 |
| PLK1 | polo-like kinase 1 | -0.81 |
| IFRD1 | interferon-related developmental regulator 1 | -0.8 |
| CCNB1 | cyclin B1 | -0.78 |
| CHST3 | carbohydrate (chondroitin 6) sulfotransferase 3 | -0.77 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -0.76 |
| MICOS10 | mitochondrial contact site and cristae organizing system subunit 10 | -0.75 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.75 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | -0.74 |
| TUBE1 | tubulin, epsilon 1 | -0.74 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 | -0.73 |
| CDC20 | cell division cycle 20 | -0.73 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | -0.72 |
| SMTN | smoothelin | -0.72 |
| SETDB2 | SET domain, bifurcated 2 | -0.7 |
| ZNF805 | zinc finger protein 805 | -0.67 |
| JUN | jun proto-oncogene | -0.67 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | -0.67 |
| UPP1 | uridine phosphorylase 1 | -0.67 |
| ZFP36 | ZFP36 ring finger protein | -0.66 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -0.66 |
| SHCBP1 | SHC SH2-domain binding protein 1 | -0.65 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | -0.65 |
| TMEM189 | transmembrane protein 189 | -0.65 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | -0.65 |
| KMT5A | lysine methyltransferase 5A | -0.64 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | -0.63 |
| SYTL3 | synaptotagmin-like 3 | -0.63 |
| MYO15A | myosin XVA | -0.62 |
| SQSTM1 | sequestosome 1 | -0.62 |
| BAIAP2 | BAI1-associated protein 2 | -0.62 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -0.62 |
| GTDC1 | glycosyltransferase-like domain containing 1 | -0.61 |
| RASA3 | RAS p21 protein activator 3 | -0.6 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.6 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | -0.59 |
| EREG | epiregulin | -0.59 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.58 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.58 |
| JDP2 | Jun dimerization protein 2 | -0.58 |
| UCK2 | uridine-cytidine kinase 2 | -0.57 |
| DES | desmin | -0.57 |
| PRELID3B | PRELI domain containing 3B | -0.56 |
| GRB10 | growth factor receptor-bound protein 10 | -0.56 |
| NOS3 | nitric oxide synthase 3 (endothelial cell) | -0.56 |
| PYROXD1 | pyridine nucleotide-disulphide oxidoreductase domain 1 | -0.55 |
| FOXO3 | forkhead box O3 | -0.55 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.55 |
| KIF2C | kinesin family member 2C | -0.55 |
| SRXN1 | sulfiredoxin 1 | -0.55 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.55 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -0.54 |
| ADIPOR1 | adiponectin receptor 1 | -0.54 |
| CD320 | CD320 molecule | -0.54 |
| CENPE | centromere protein E, 312kDa | -0.53 |
| MAGEA2 | melanoma antigen family A2 | -0.53 |
| ZUP1 | zinc finger containing ubiquitin peptidase 1 | -0.53 |
| MID1IP1 | MID1 interacting protein 1 | -0.53 |
| VPS37A | vacuolar protein sorting 37 homolog A (S. cerevisiae) | -0.53 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | -0.52 |
| KCTD5 | potassium channel tetramerization domain containing 5 | -0.52 |
| GRB2 | growth factor receptor-bound protein 2 | -0.52 |
| CLCN5 | chloride channel, voltage-sensitive 5 | -0.52 |
| DUOX1 | dual oxidase 1 | -0.51 |
| FDXACB1 | ferredoxin-fold anticodon binding domain containing 1 | -0.51 |
| TAF11 | TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa | -0.51 |
| CENPJ | centromere protein J | -0.51 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | -0.51 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.51 |
| ASB6 | ankyrin repeat and SOCS box containing 6 | -0.5 |
| AARS | alanyl-tRNA synthetase | -0.5 |
| TRIM16 | tripartite motif containing 16 | -0.5 |
| RCHY1 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | -0.5 |
| DCHS1 | dachsous cadherin-related 1 | -0.5 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.49 |
| NAT9 | N-acetyltransferase 9 (GCN5-related, putative) | -0.49 |
| VIM | vimentin | -0.49 |
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | -0.49 |
| SDC1 | syndecan 1 | -0.49 |
| FOXJ2 | forkhead box J2 | -0.49 |
| PBK | PDZ binding kinase | -0.49 |
| RPL35A | ribosomal protein L35a | -0.49 |
| CHAC2 | ChaC, cation transport regulator homolog 2 (E. coli) | -0.49 |
| ZFHX4 | zinc finger homeobox 4 | -0.49 |
