| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/16747683 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in AZD-5438 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TP53 | tumor protein p53 | 3.43 |
| FN1 | fibronectin 1 | 1.42 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 1.39 |
| FGA | fibrinogen alpha chain | 1.36 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 1.36 |
| PRG4 | proteoglycan 4 | 1.29 |
| COL14A1 | collagen, type XIV, alpha 1 | 1.26 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 1.24 |
| BHLHA15 | basic helix-loop-helix family, member a15 | 1.22 |
| CPN1 | carboxypeptidase N, polypeptide 1 | 1.15 |
| F13A1 | coagulation factor XIII, A1 polypeptide | 1.12 |
| TMUB1 | transmembrane and ubiquitin-like domain containing 1 | 1.11 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | 1.08 |
| ITM2C | integral membrane protein 2C | 1.07 |
| F2 | coagulation factor II (thrombin) | 1.06 |
| TMEM106C | transmembrane protein 106C | 1.05 |
| FAM199X | family with sequence similarity 199, X-linked | 1.03 |
| PNKP | polynucleotide kinase 3'-phosphatase | 1.02 |
| BTBD3 | BTB (POZ) domain containing 3 | 1.01 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | 1.01 |
| VTN | vitronectin | 1.0 |
| RNASE4 | ribonuclease, RNase A family, 4 | 1.0 |
| CHRD | chordin | 1.0 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 0.97 |
| TAGLN | transgelin | 0.95 |
| CCN2 | cellular communication network factor 2 | 0.95 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.94 |
| AOC1 | amine oxidase, copper containing 1 | 0.94 |
| APOE | apolipoprotein E | 0.93 |
| INHBA | inhibin, beta A | 0.91 |
| FTL | ferritin, light polypeptide | 0.9 |
| GSTO2 | glutathione S-transferase omega 2 | 0.89 |
| DOCK11 | dedicator of cytokinesis 11 | 0.89 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.87 |
| MARCKSL1 | MARCKS-like 1 | 0.87 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 0.86 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.86 |
| TSPAN4 | tetraspanin 4 | 0.86 |
| GPN3 | GPN-loop GTPase 3 | 0.85 |
| HIPK3 | homeodomain interacting protein kinase 3 | 0.85 |
| ALG6 | ALG6, alpha-1,3-glucosyltransferase | 0.85 |
| CPVL | carboxypeptidase, vitellogenic-like | 0.85 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.85 |
| CCDC158 | coiled-coil domain containing 158 | 0.84 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.83 |
| PNPLA6 | patatin-like phospholipase domain containing 6 | 0.83 |
| PRR11 | proline rich 11 | 0.81 |
| FAM122B | family with sequence similarity 122B | 0.79 |
| CHMP3 | charged multivesicular body protein 3 | 0.79 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | 0.79 |
| HDGF | hepatoma-derived growth factor | 0.78 |
| AXL | AXL receptor tyrosine kinase | 0.78 |
| THBS1 | thrombospondin 1 | 0.77 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | 0.77 |
| STMN1 | stathmin 1 | 0.77 |
| LAMP1 | lysosomal-associated membrane protein 1 | 0.77 |
| FBXL16 | F-box and leucine-rich repeat protein 16 | 0.77 |
| CDC37 | cell division cycle 37 | 0.76 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.75 |
| TCOF1 | Treacher Collins-Franceschetti syndrome 1 | 0.75 |
| GDA | guanine deaminase | 0.75 |
| GLUL | glutamate-ammonia ligase | 0.75 |
| CAMK1 | calcium/calmodulin-dependent protein kinase I | 0.74 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 0.74 |
| CDK6 | cyclin-dependent kinase 6 | 0.73 |
| ICAM5 | intercellular adhesion molecule 5, telencephalin | 0.73 |
| PPP1R14B | protein phosphatase 1, regulatory (inhibitor) subunit 14B | 0.73 |
| TSPAN3 | tetraspanin 3 | 0.73 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | 0.72 |
| B3GALNT2 | beta-1,3-N-acetylgalactosaminyltransferase 2 | 0.72 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.72 |
| LPCAT3 | lysophosphatidylcholine acyltransferase 3 | 0.71 |
| ARHGEF37 | Rho guanine nucleotide exchange factor (GEF) 37 | 0.71 |
| CPNE7 | copine VII | 0.7 |
| GGT7 | gamma-glutamyltransferase 7 | 0.7 |
| PTPRS | protein tyrosine phosphatase, receptor type, S | 0.7 |
| MYDGF | myeloid-derived growth factor | 0.7 |
| NOC2L | nucleolar complex associated 2 homolog (S. cerevisiae) | 0.7 |
| RAB1B | RAB1B, member RAS oncogene family | 0.7 |
| SH3BGRL2 | SH3 domain binding glutamate-rich protein like 2 | 0.7 |
| TTN | titin | 0.7 |
| CAV2 | caveolin 2 | 0.69 |
| SCARB1 | scavenger receptor class B, member 1 | 0.69 |
| BCL2L12 | BCL2-like 12 (proline rich) | 0.68 |
| RCN1 | reticulocalbin 1, EF-hand calcium binding domain | 0.68 |
| GLB1L2 | galactosidase, beta 1-like 2 | 0.68 |
| HACD2 | 3-hydroxyacyl-CoA dehydratase 2 | 0.68 |
| ITFG2 | integrin alpha FG-GAP repeat containing 2 | 0.68 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.68 |
| QTRT1 | queuine tRNA-ribosyltransferase 1 | 0.68 |
| APEH | acylaminoacyl-peptide hydrolase | 0.67 |
| HPSE | heparanase | 0.67 |
| CLTA | clathrin, light chain A | 0.67 |
| GALNS | galactosamine (N-acetyl)-6-sulfatase | 0.67 |
| TNPO2 | transportin 2 | 0.67 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.66 |
| PSME1 | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 0.66 |
| MYO1G | myosin IG | 0.66 |
| NECTIN3 | nectin cell adhesion molecule 3 | 0.66 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMEM242 | transmembrane protein 242 | -7.23 |
| WSB1 | WD repeat and SOCS box containing 1 | -6.29 |
| NR1D1 | nuclear receptor subfamily 1, group D, member 1 | -6.19 |
| HSF2 | heat shock transcription factor 2 | -6.18 |
| ZFAND5 | zinc finger, AN1-type domain 5 | -5.56 |
| TRIB1 | tribbles pseudokinase 1 | -5.13 |
| WEE1 | WEE1 G2 checkpoint kinase | -4.73 |
| STK17A | serine/threonine kinase 17a | -4.56 |
| FAM110A | family with sequence similarity 110, member A | -4.55 |
| TGIF1 | TGFB-induced factor homeobox 1 | -4.5 |
| ZCCHC9 | zinc finger, CCHC domain containing 9 | -4.5 |
| DUSP6 | dual specificity phosphatase 6 | -4.35 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | -4.27 |
| CHTOP | chromatin target of PRMT1 | -4.23 |
| AMD1 | adenosylmethionine decarboxylase 1 | -4.23 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -4.09 |
| DUSP4 | dual specificity phosphatase 4 | -4.02 |
| GGNBP2 | gametogenetin binding protein 2 | -3.69 |
| DERPC | DERPC proline and glycine rich nuclear protein | -3.69 |
| PHF13 | PHD finger protein 13 | -3.68 |
| RESF1 | retroelement silencing factor 1 | -3.52 |
| FEM1A | fem-1 homolog a (C. elegans) | -3.51 |
| MYNN | myoneurin | -3.48 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -3.46 |
| FYTTD1 | forty-two-three domain containing 1 | -3.46 |
| FAM207A | family with sequence similarity 207, member A | -3.28 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -3.26 |
| CCDC137 | coiled-coil domain containing 137 | -3.19 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -3.19 |
| VWA1 | von Willebrand factor A domain containing 1 | -3.16 |
| POLDIP3 | polymerase (DNA-directed), delta interacting protein 3 | -3.11 |
| CDT1 | chromatin licensing and DNA replication factor 1 | -3.04 |
| AEN | apoptosis enhancing nuclease | -3.0 |
| MT2A | metallothionein 2A | -2.91 |
| DEPDC7 | DEP domain containing 7 | -2.89 |
| RIOK2 | RIO kinase 2 | -2.88 |
| NSA2 | NSA2 ribosome biogenesis homolog (S. cerevisiae) | -2.87 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | -2.84 |
| SOX13 | SRY (sex determining region Y)-box 13 | -2.83 |
| CDC20 | cell division cycle 20 | -2.83 |
| KDM5B | lysine (K)-specific demethylase 5B | -2.82 |
| C6ORF62 | chromosome 6 open reading frame 62 | -2.81 |
| CDC25B | cell division cycle 25B | -2.8 |
| PRSS8 | protease, serine, 8 | -2.78 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -2.77 |
| RPS19BP1 | ribosomal protein S19 binding protein 1 | -2.74 |
| ZNF12 | zinc finger protein 12 | -2.74 |
| ZNF561 | zinc finger protein 561 | -2.73 |
| TIGD5 | tigger transposable element derived 5 | -2.71 |
| TNS4 | tensin 4 | -2.71 |
| RPF1 | ribosome production factor 1 homolog (S. cerevisiae) | -2.7 |
| APPBP2 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | -2.66 |
| TPGS1 | tubulin polyglutamylase complex subunit 1 | -2.65 |
| SPOP | speckle-type POZ protein | -2.63 |
| GPBP1 | GC-rich promoter binding protein 1 | -2.61 |
| JARID2 | jumonji, AT rich interactive domain 2 | -2.61 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | -2.59 |
| SGO2 | shugoshin 2 | -2.57 |
| CCNA2 | cyclin A2 | -2.57 |
| FBXL3 | F-box and leucine-rich repeat protein 3 | -2.56 |
| SURF6 | surfeit 6 | -2.54 |
| RNF145 | ring finger protein 145 | -2.53 |
| KMT5A | lysine methyltransferase 5A | -2.53 |
| PRELID3B | PRELI domain containing 3B | -2.52 |
| RRP36 | ribosomal RNA processing 36 homolog (S. cerevisiae) | -2.51 |
| AMOTL2 | angiomotin like 2 | -2.51 |
| ZNF724 | zinc finger protein 724 | -2.51 |
| APEX2 | APEX nuclease (apurinic/apyrimidinic endonuclease) 2 | -2.5 |
| MMADHC | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria | -2.5 |
| OBI1 | ORC ubiquitin ligase 1 | -2.47 |
| CCDC59 | coiled-coil domain containing 59 | -2.45 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -2.44 |
| TOB1 | transducer of ERBB2, 1 | -2.44 |
| SESN2 | sestrin 2 | -2.43 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -2.43 |
| C1ORF131 | chromosome 1 open reading frame 131 | -2.42 |
| STC2 | stanniocalcin 2 | -2.41 |
| THAP1 | THAP domain containing, apoptosis associated protein 1 | -2.4 |
| TRIM44 | tripartite motif containing 44 | -2.4 |
| MLPH | melanophilin | -2.39 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -2.39 |
| MCM10 | minichromosome maintenance complex component 10 | -2.36 |
| FAM53C | family with sequence similarity 53, member C | -2.35 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -2.33 |
| QKI | QKI, KH domain containing, RNA binding | -2.32 |
| SOX9 | SRY (sex determining region Y)-box 9 | -2.31 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -2.31 |
| ESCO2 | establishment of sister chromatid cohesion N-acetyltransferase 2 | -2.3 |
| PIMREG | PICALM interacting mitotic regulator | -2.29 |
| FOXO3 | forkhead box O3 | -2.28 |
| JAG1 | jagged 1 | -2.27 |
| ODC1 | ornithine decarboxylase 1 | -2.26 |
| TULP3 | tubby like protein 3 | -2.26 |
| KIAA0586 | KIAA0586 | -2.25 |
| TCF12 | transcription factor 12 | -2.25 |
| ZNF286A | zinc finger protein 286A | -2.23 |
| ZNF417 | zinc finger protein 417 | -2.23 |
| CDCA7 | cell division cycle associated 7 | -2.23 |
| TIMM17A | translocase of inner mitochondrial membrane 17 homolog A (yeast) | -2.22 |
