| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the AZD-7648_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.199102 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.180161 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.172309 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.122175 |
| CD44 | CD44 molecule (Indian blood group) | 0.12094 |
| PODXL | podocalyxin-like | 0.111284 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.103664 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0993605 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0968 |
| PLAT | plasminogen activator, tissue | 0.0897096 |
| TPM3 | tropomyosin 3 | 0.0826957 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0778515 |
| ASPH | aspartate beta-hydroxylase | 0.0764923 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0727439 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0717271 |
| FLNB | filamin B, beta | 0.0699396 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0680373 |
| HDAC9 | histone deacetylase 9 | 0.0662145 |
| B2M | beta-2-microglobulin | 0.0640028 |
| RPS3 | ribosomal protein S3 | 0.0627684 |
| MSN | moesin | 0.0611005 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0584427 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0582085 |
| CENPF | centromere protein F, 350/400kDa | 0.0574223 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0561315 |
| DST | dystonin | 0.0553 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0535103 |
| LDHA | lactate dehydrogenase A | 0.0527575 |
| TAPBP | TAP binding protein (tapasin) | 0.0499984 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0498824 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0496207 |
| SET | SET nuclear proto-oncogene | 0.0487625 |
| TMSB4X | thymosin beta 4, X-linked | 0.0486415 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0485388 |
| SEPTIN9 | septin 9 | 0.0477586 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0477476 |
| FSTL1 | follistatin-like 1 | 0.0467042 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0460178 |
| CDH13 | cadherin 13 | 0.0449762 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0431207 |
| MAP1B | microtubule-associated protein 1B | 0.0423163 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.04147 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0413448 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0412404 |
| RPS6 | ribosomal protein S6 | 0.0404675 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0402842 |
| CDK6 | cyclin-dependent kinase 6 | 0.0397712 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | 0.0394786 |
| PFN1 | profilin 1 | 0.0393713 |
| RUNX1 | runt-related transcription factor 1 | 0.0392054 |
| FAM107B | family with sequence similarity 107, member B | 0.0386966 |
| HSPA8 | heat shock 70kDa protein 8 | 0.038566 |
| SMC4 | structural maintenance of chromosomes 4 | 0.036732 |
| RPL37A | ribosomal protein L37a | 0.0366403 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0362152 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0358339 |
| APP | amyloid beta (A4) precursor protein | 0.0357362 |
| RAI14 | retinoic acid induced 14 | 0.0356551 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.035619 |
| SON | SON DNA binding protein | 0.0353669 |
| TLN1 | talin 1 | 0.034458 |
| POTEF | POTE ankyrin domain family, member F | 0.0343073 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0338901 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0338627 |
| NDRG1 | N-myc downstream regulated 1 | 0.0335269 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0333559 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.033084 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0330825 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0329402 |
| EZR | ezrin | 0.0326294 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0322233 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0321184 |
| SQSTM1 | sequestosome 1 | 0.0321184 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0320127 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0319268 |
| GOLGB1 | golgin B1 | 0.0317791 |
| MB21D2 | Mab-21 domain containing 2 | 0.0315323 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0313988 |
| SMAD3 | SMAD family member 3 | 0.0313335 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0312724 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0311708 |
| DSPP | dentin sialophosphoprotein | 0.0309322 |
| FLNA | filamin A, alpha | 0.0308445 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0306722 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0305674 |
| MKI67 | marker of proliferation Ki-67 | 0.0305448 |
| RPS8 | ribosomal protein S8 | 0.0304838 |
| TLE4 | transducin-like enhancer of split 4 | 0.0304241 |
| RPS2 | ribosomal protein S2 | 0.03025 |
| RPL36 | ribosomal protein L36 | 0.0299758 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0298544 |
| ANO6 | anoctamin 6 | 0.0297177 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.0296465 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0295966 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0294585 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0294538 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0293495 |
| GLIS3 | GLIS family zinc finger 3 | 0.0290939 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0290418 |
| FAT1 | FAT atypical cadherin 1 | 0.0289263 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.232638 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.190801 |
| LOX | lysyl oxidase | -0.11261 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.102226 |
| VIM | vimentin | -0.0806553 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0794186 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0696505 |
| FN1 | fibronectin 1 | -0.0667656 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0640612 |
| THBS2 | thrombospondin 2 | -0.0608452 |
| FBN1 | fibrillin 1 | -0.0588266 |
| COL1A2 | collagen, type I, alpha 2 | -0.0515907 |
| S100A6 | S100 calcium binding protein A6 | -0.0500442 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0484037 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0477327 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0436472 |
| SUCNR1 | succinate receptor 1 | -0.0400085 |
| COL5A2 | collagen, type V, alpha 2 | -0.0386077 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0372727 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0369549 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0358227 |
| HLA-C | major histocompatibility complex, class I, C | -0.0355163 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0339175 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0322035 |
| INSIG1 | insulin induced gene 1 | -0.030419 |
| LOXL2 | lysyl oxidase-like 2 | -0.0298505 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0292985 |
| RPS24 | ribosomal protein S24 | -0.0277967 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.027789 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0272101 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0267755 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.026741 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0259623 |
| AUTS2 | autism susceptibility candidate 2 | -0.0257081 |
| SLC39A11 | solute carrier family 39, member 11 | -0.025419 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0247028 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0244573 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.024394 |
| CSTB | cystatin B (stefin B) | -0.0240746 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0238851 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0228106 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -0.0224229 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0222523 |
| CTSD | cathepsin D | -0.0222381 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0216923 |
| TNS3 | tensin 3 | -0.0214967 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0214293 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0212629 |
| BSG | basigin (Ok blood group) | -0.0210415 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0210117 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0206027 |
| TMEM123 | transmembrane protein 123 | -0.0197891 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0197049 |
| MMP12 | matrix metallopeptidase 12 | -0.0194894 |
| ZNF207 | zinc finger protein 207 | -0.0194596 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0194334 |
| OGA | O-GlcNAcase | -0.0190858 |
| MEIS2 | Meis homeobox 2 | -0.0190851 |
| CANX | calnexin | -0.0188069 |
| SLC38A1 | solute carrier family 38, member 1 | -0.018726 |
| TMSB10 | thymosin beta 10 | -0.0186805 |
| TUBB | tubulin, beta class I | -0.0186719 |
| KIFAP3 | kinesin-associated protein 3 | -0.0185231 |
| RHOQ | ras homolog family member Q | -0.0185113 |
| MSI2 | musashi RNA-binding protein 2 | -0.0182677 |
| HLA-B | major histocompatibility complex, class I, B | -0.0182271 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0181511 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0181435 |
| HLA-E | major histocompatibility complex, class I, E | -0.0179822 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0179781 |
| S100A4 | S100 calcium binding protein A4 | -0.0178122 |
| WDFY1 | WD repeat and FYVE domain containing 1 | -0.0176649 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.017509 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0173259 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0172858 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.017147 |
| CD109 | CD109 molecule | -0.0171447 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0169801 |
| SPAG9 | sperm associated antigen 9 | -0.0169691 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0169292 |
| VKORC1 | vitamin K epoxide reductase complex, subunit 1 | -0.0169016 |
| RNF216 | ring finger protein 216 | -0.0168129 |
| INVS | inversin | -0.0167793 |
| GNAS | GNAS complex locus | -0.0165506 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0163321 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0162237 |
| ARF1 | ADP-ribosylation factor 1 | -0.0162151 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.016192 |
| S100A10 | S100 calcium binding protein A10 | -0.0161303 |
| HM13 | histocompatibility (minor) 13 | -0.0160679 |
| FGF13 | fibroblast growth factor 13 | -0.0159445 |
| ZBTB7C | zinc finger and BTB domain containing 7C | -0.0158257 |
| PXDN | peroxidasin | -0.0158087 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0157189 |
| UBC | ubiquitin C | -0.015715 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0156832 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0156659 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0154471 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0154206 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | -0.0153574 |
