| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.206268 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.137172 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0996081 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0887903 |
| RPS3 | ribosomal protein S3 | 0.0789836 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0777888 |
| RPS6 | ribosomal protein S6 | 0.0717701 |
| AREG | amphiregulin | 0.0621604 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0612751 |
| MKI67 | marker of proliferation Ki-67 | 0.0595364 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.05716 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0562227 |
| DST | dystonin | 0.0554995 |
| HMGA2 | high mobility group AT-hook 2 | 0.0550692 |
| RPS12 | ribosomal protein S12 | 0.0508895 |
| GOLGB1 | golgin B1 | 0.0491269 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0488137 |
| CENPF | centromere protein F, 350/400kDa | 0.0464323 |
| RPS2 | ribosomal protein S2 | 0.0463102 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0454238 |
| RPS8 | ribosomal protein S8 | 0.0445935 |
| ANXA1 | annexin A1 | 0.0435317 |
| RPL37A | ribosomal protein L37a | 0.039208 |
| PCDH7 | protocadherin 7 | 0.0378293 |
| BRD2 | bromodomain containing 2 | 0.035247 |
| TAPBP | TAP binding protein (tapasin) | 0.0346985 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0337423 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | 0.0333529 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0324718 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0311825 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0307905 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0303071 |
| YBX3 | Y box binding protein 3 | 0.0297819 |
| RPL26 | ribosomal protein L26 | 0.0295517 |
| TPM3 | tropomyosin 3 | 0.0294709 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0292026 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0288178 |
| INTS6 | integrator complex subunit 6 | 0.0277159 |
| RRM2 | ribonucleotide reductase M2 | 0.0274632 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0271821 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0268582 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0266136 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0261223 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0257824 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0255552 |
| UBXN4 | UBX domain protein 4 | 0.0255286 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0253745 |
| CCDC88A | coiled-coil domain containing 88A | 0.0250941 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0250313 |
| RPL36 | ribosomal protein L36 | 0.0245891 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0245378 |
| RPL13A | ribosomal protein L13a | 0.0242659 |
| GOLGA4 | golgin A4 | 0.0241302 |
| TPR | translocated promoter region, nuclear basket protein | 0.0236853 |
| LMO7 | LIM domain 7 | 0.0236753 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0226802 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0224347 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.0224157 |
| RPS19 | ribosomal protein S19 | 0.0216743 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0215787 |
| RACK1 | receptor for activated C kinase 1 | 0.0215244 |
| WBP11 | WW domain binding protein 11 | 0.0212616 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.021217 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0211112 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0209079 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0207755 |
| KIF5B | kinesin family member 5B | 0.0205871 |
| RBBP6 | retinoblastoma binding protein 6 | 0.0204763 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0204544 |
| CAVIN1 | caveolae associated protein 1 | 0.0204326 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0203259 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0200431 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0198787 |
| RPS7 | ribosomal protein S7 | 0.0197809 |
| MORF4L2 | mortality factor 4 like 2 | 0.0197445 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.019695 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0196655 |
| RPL18 | ribosomal protein L18 | 0.0196357 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.019526 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.019374 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0193486 |
| SON | SON DNA binding protein | 0.0190894 |
| TPI1 | triosephosphate isomerase 1 | 0.0190617 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0190115 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0187729 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0187302 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0185496 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.018461 |
| RAD50 | RAD50 homolog (S. cerevisiae) | 0.01837 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0183518 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0183053 |
| RPS17 | ribosomal protein S17 | 0.0180754 |
| KLF6 | Kruppel-like factor 6 | 0.0179357 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0179013 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | 0.0178063 |
| DSPP | dentin sialophosphoprotein | 0.0178058 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0178055 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0177362 |
| BRD4 | bromodomain containing 4 | 0.0174384 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.017335 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.17945 |
| VIM | vimentin | -0.161306 |
| UBC | ubiquitin C | -0.0891075 |
| RPS27A | ribosomal protein S27a | -0.0813348 |
| TMSB10 | thymosin beta 10 | -0.0792619 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0786474 |
| PCBP2 | poly(rC) binding protein 2 | -0.059973 |
| RPLP1 | ribosomal protein, large, P1 | -0.0539662 |
| RPS24 | ribosomal protein S24 | -0.0489136 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0484439 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0469867 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0459091 |
| RPL23 | ribosomal protein L23 | -0.0454346 |
| MMP12 | matrix metallopeptidase 12 | -0.0451507 |
| USP34 | ubiquitin specific peptidase 34 | -0.0416022 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0409549 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0376998 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0374176 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0373205 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0369151 |
| FBXO11 | F-box protein 11 | -0.0365638 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0354366 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0353975 |
| HMGA1 | high mobility group AT-hook 1 | -0.0353814 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0352398 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0344935 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.034433 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0340371 |
| MGAT4C | MGAT4 family, member C | -0.0338513 |
| MED13L | mediator complex subunit 13-like | -0.0338061 |
| TMEM123 | transmembrane protein 123 | -0.0334352 |
| S100A6 | S100 calcium binding protein A6 | -0.033183 |
| TUBA1B | tubulin, alpha 1b | -0.0330285 |
| ZNF207 | zinc finger protein 207 | -0.0327856 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.031844 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0314748 |
| RPS16 | ribosomal protein S16 | -0.0308082 |
| CEP192 | centrosomal protein 192kDa | -0.0306738 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0305794 |
| RPL36A | ribosomal protein L36a | -0.0303198 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0299956 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0294301 |
| CDK17 | cyclin-dependent kinase 17 | -0.0294161 |
| TMEM131 | transmembrane protein 131 | -0.0290458 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0288189 |
| XPO1 | exportin 1 | -0.0287045 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0283785 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0283683 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0280014 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.027733 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.02765 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0271286 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0266648 |
| NEK7 | NIMA-related kinase 7 | -0.0265657 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.025624 |
| TMEM41B | transmembrane protein 41B | -0.0254941 |
| PGK1 | phosphoglycerate kinase 1 | -0.0251651 |
| RPLP0 | ribosomal protein, large, P0 | -0.0250611 |
| YAP1 | Yes-associated protein 1 | -0.024957 |
| NHSL1 | NHS-like 1 | -0.0247871 |
| RPLP2 | ribosomal protein, large, P2 | -0.024399 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0241027 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0239816 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0239304 |
| GSK3B | glycogen synthase kinase 3 beta | -0.023819 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0232564 |
| TUBA1C | tubulin, alpha 1c | -0.0231605 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0231524 |
| RPL15 | ribosomal protein L15 | -0.0226907 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0226878 |
| TFG | TRK-fused gene | -0.0225428 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0224649 |
| VMP1 | vacuole membrane protein 1 | -0.0222585 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0220067 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0217464 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0216962 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0216787 |
| YEATS2 | YEATS domain containing 2 | -0.0215517 |
| NF1 | neurofibromin 1 | -0.0213507 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0213327 |
| RPL27A | ribosomal protein L27a | -0.0211584 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0211116 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0203505 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0202717 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0199912 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0198352 |
| HELB | helicase (DNA) B | -0.0198114 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.01981 |
| CEP95 | centrosomal protein 95kDa | -0.0195014 |
| CPOX | coproporphyrinogen oxidase | -0.0192532 |
| FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | -0.0192314 |
| NUP58 | nucleoporin 58 | -0.0191583 |
| HLA-A | major histocompatibility complex, class I, A | -0.0189487 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0189026 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0187414 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0187102 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0186714 |
| RPS25 | ribosomal protein S25 | -0.0185308 |
| MED13 | mediator complex subunit 13 | -0.0184533 |
| GNAS | GNAS complex locus | -0.0184178 |
