| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD44 | CD44 molecule (Indian blood group) | 0.134498 |
| ASPH | aspartate beta-hydroxylase | 0.130321 |
| MT2A | metallothionein 2A | 0.0949174 |
| B2M | beta-2-microglobulin | 0.0947341 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0884842 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0863414 |
| RPS6 | ribosomal protein S6 | 0.0785893 |
| GOLGB1 | golgin B1 | 0.0774927 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0768232 |
| TPM3 | tropomyosin 3 | 0.0731929 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0609673 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0596912 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0572925 |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.0553868 |
| MSN | moesin | 0.0553607 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0538393 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0536004 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0530688 |
| RND3 | Rho family GTPase 3 | 0.0512267 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0511733 |
| CDCP1 | CUB domain containing protein 1 | 0.0510985 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0485833 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0483432 |
| RPS8 | ribosomal protein S8 | 0.0477678 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0476134 |
| RPS3 | ribosomal protein S3 | 0.0462123 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0457303 |
| RPL37A | ribosomal protein L37a | 0.0434003 |
| SEPTIN9 | septin 9 | 0.0427289 |
| TLN1 | talin 1 | 0.0416699 |
| MKI67 | marker of proliferation Ki-67 | 0.0415932 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0398477 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0397543 |
| RPS2 | ribosomal protein S2 | 0.0396304 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0395211 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0394233 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0394195 |
| SFTPA2 | surfactant protein A2 | 0.0378841 |
| LDHA | lactate dehydrogenase A | 0.037513 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0369237 |
| TAPBP | TAP binding protein (tapasin) | 0.0368383 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0367472 |
| CENPF | centromere protein F, 350/400kDa | 0.0365187 |
| VEGFA | vascular endothelial growth factor A | 0.0359112 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0351899 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0351157 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0345659 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.034171 |
| S100A11 | S100 calcium binding protein A11 | 0.0338013 |
| OPTN | optineurin | 0.0337605 |
| RPS12 | ribosomal protein S12 | 0.0337364 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | 0.0336917 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0334356 |
| RPS17 | ribosomal protein S17 | 0.033232 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.032837 |
| EGFR | epidermal growth factor receptor | 0.0323482 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0312769 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0309766 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0307707 |
| IFI44L | interferon-induced protein 44-like | 0.0302344 |
| KYNU | kynureninase | 0.0301652 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0301589 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0300473 |
| ADAR | adenosine deaminase, RNA-specific | 0.0299221 |
| SON | SON DNA binding protein | 0.0295616 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0289576 |
| TXNRD1 | thioredoxin reductase 1 | 0.028918 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0287017 |
| TMF1 | TATA element modulatory factor 1 | 0.0286568 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0286085 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0282845 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0282007 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0281913 |
| HDAC9 | histone deacetylase 9 | 0.0281432 |
| RPS19 | ribosomal protein S19 | 0.0279659 |
| MYADM | myeloid-associated differentiation marker | 0.0278205 |
| NAV2 | neuron navigator 2 | 0.0275483 |
| HDGF | hepatoma-derived growth factor | 0.0271878 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0271195 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0269996 |
| RAI14 | retinoic acid induced 14 | 0.0268429 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0266297 |
| RBBP6 | retinoblastoma binding protein 6 | 0.0265739 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0264039 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0263747 |
| BRD2 | bromodomain containing 2 | 0.026043 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0260327 |
| SET | SET nuclear proto-oncogene | 0.0258409 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0257038 |
| MYOF | myoferlin | 0.0257008 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0251705 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0250195 |
| RPS4X | ribosomal protein S4, X-linked | 0.0247439 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0246311 |
| GPC5 | glypican 5 | 0.0245667 |
| ATF3 | activating transcription factor 3 | 0.0245358 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0244444 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0242021 |
| VIM | vimentin | 0.0241806 |
| MSH6 | mutS homolog 6 | 0.0240854 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FRMD4A | FERM domain containing 4A | -0.210512 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.159311 |
| GPC6 | glypican 6 | -0.155903 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.116494 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0846826 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0809213 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0766111 |
| RHEB | Ras homolog enriched in brain | -0.0667099 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0660777 |
| CP | ceruloplasmin (ferroxidase) | -0.0647501 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0593165 |
| RPS24 | ribosomal protein S24 | -0.0581153 |
| RAB10 | RAB10, member RAS oncogene family | -0.0578326 |
| SPAG9 | sperm associated antigen 9 | -0.0563333 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0548096 |
| CADM1 | cell adhesion molecule 1 | -0.054397 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0541655 |
| CTSD | cathepsin D | -0.0538742 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0537328 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0531741 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0518418 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0517569 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0515255 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0507855 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0499364 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0489711 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.048572 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0482807 |
| ATP13A3 | ATPase type 13A3 | -0.0479241 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0476248 |
| ARF1 | ADP-ribosylation factor 1 | -0.0472825 |
| DENND2B | DENN domain containing 2B | -0.0470699 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0469066 |
| GNAS | GNAS complex locus | -0.0460475 |
| G0S2 | G0/G1 switch 2 | -0.0456271 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0452889 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0451521 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0447616 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0442376 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.044009 |
| SDCBP | syndecan binding protein (syntenin) | -0.0427866 |
| GDF15 | growth differentiation factor 15 | -0.0420791 |
| USP3 | ubiquitin specific peptidase 3 | -0.0411611 |
| HYCC2 | hyccin PI4KA lipid kinase complex subunit 2 | -0.0408355 |
| CD70 | CD70 molecule | -0.0407276 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0398881 |
| ANKRD17 | ankyrin repeat domain 17 | -0.039607 |
| SRPK2 | SRSF protein kinase 2 | -0.0394291 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0391823 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0383636 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.038288 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0382593 |
| SCFD2 | sec1 family domain containing 2 | -0.0380787 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0365103 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | -0.0362539 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0359502 |
| INSIG1 | insulin induced gene 1 | -0.0358936 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0358341 |
| WAC | WW domain containing adaptor with coiled-coil | -0.03509 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0350346 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0346247 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | -0.0344286 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0342432 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0340055 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0336579 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0335353 |
| CDK13 | cyclin-dependent kinase 13 | -0.0333221 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.033132 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0331006 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | -0.0330186 |
| DENND4C | DENN/MADD domain containing 4C | -0.0326533 |
| FMNL2 | formin-like 2 | -0.0325761 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0325362 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0323487 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0322748 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0321204 |
| RPLP1 | ribosomal protein, large, P1 | -0.0318251 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | -0.0317088 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.03158 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0315322 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.031485 |
| ZNF207 | zinc finger protein 207 | -0.0311515 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.0311403 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0309472 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0308136 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0307105 |
| FN1 | fibronectin 1 | -0.0305406 |
| XPO1 | exportin 1 | -0.0304412 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0304306 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | -0.030101 |
| QKI | QKI, KH domain containing, RNA binding | -0.0300426 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0300368 |
| TFG | TRK-fused gene | -0.0298982 |
| TKT | transketolase | -0.0298189 |
| FTL | ferritin, light polypeptide | -0.0296215 |
| STK17A | serine/threonine kinase 17a | -0.0296137 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0295006 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.0293348 |
| OLA1 | Obg-like ATPase 1 | -0.0290854 |
| CD82 | CD82 molecule | -0.0290659 |
