| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.313798 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.211041 |
| VIM | vimentin | 0.177007 |
| FAM107B | family with sequence similarity 107, member B | 0.113619 |
| RPS6 | ribosomal protein S6 | 0.112739 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.107489 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.103166 |
| EFNA5 | ephrin-A5 | 0.103125 |
| EGFR | epidermal growth factor receptor | 0.100907 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0965163 |
| RPS3 | ribosomal protein S3 | 0.0911018 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0874155 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.086888 |
| STC1 | stanniocalcin 1 | 0.0859187 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0847267 |
| TMSB10 | thymosin beta 10 | 0.0835195 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0830185 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.080316 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0781515 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0766453 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0722424 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0713601 |
| LDHA | lactate dehydrogenase A | 0.0695608 |
| MT2A | metallothionein 2A | 0.0683739 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0671134 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0643219 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0615822 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0588783 |
| NDRG1 | N-myc downstream regulated 1 | 0.0560645 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0555666 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0547592 |
| ASPH | aspartate beta-hydroxylase | 0.0547273 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0541389 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.052944 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0495163 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0488409 |
| PDE10A | phosphodiesterase 10A | 0.0488184 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0483047 |
| GOLGB1 | golgin B1 | 0.0482208 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0480338 |
| RPS19 | ribosomal protein S19 | 0.0479704 |
| PTMA | prothymosin, alpha | 0.0469145 |
| LMO7 | LIM domain 7 | 0.046808 |
| AUTS2 | autism susceptibility candidate 2 | 0.0467989 |
| RPS12 | ribosomal protein S12 | 0.046555 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0461865 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0460798 |
| CCDC88A | coiled-coil domain containing 88A | 0.0458105 |
| RPL26 | ribosomal protein L26 | 0.0457933 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.045625 |
| AHNAK | AHNAK nucleoprotein | 0.0454411 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.04528 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0449805 |
| DSTN | destrin (actin depolymerizing factor) | 0.0442258 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0441663 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0435239 |
| MCL1 | myeloid cell leukemia 1 | 0.0431755 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0429226 |
| RPS8 | ribosomal protein S8 | 0.0417387 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0415092 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0414402 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0412858 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0411722 |
| CD44 | CD44 molecule (Indian blood group) | 0.0411326 |
| HMGA2 | high mobility group AT-hook 2 | 0.0410774 |
| RPS17 | ribosomal protein S17 | 0.0406733 |
| FLNB | filamin B, beta | 0.0398301 |
| FMNL2 | formin-like 2 | 0.039702 |
| RPL18 | ribosomal protein L18 | 0.0390308 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0388035 |
| RPS2 | ribosomal protein S2 | 0.0383217 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0378846 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0378015 |
| MYO1E | myosin IE | 0.0377151 |
| PCBP2 | poly(rC) binding protein 2 | 0.0374189 |
| MYO10 | myosin X | 0.0373368 |
| GPATCH2L | G patch domain containing 2-like | 0.0363075 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0362965 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0361896 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0361339 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0359028 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0358516 |
| ACTG1 | actin gamma 1 | 0.0358033 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0355192 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0336249 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0331541 |
| LAMC2 | laminin, gamma 2 | 0.0331184 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0328331 |
| RPL19 | ribosomal protein L19 | 0.0328198 |
| HDGF | hepatoma-derived growth factor | 0.0326335 |
| AXL | AXL receptor tyrosine kinase | 0.0325973 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0325284 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0324818 |
| RPL37A | ribosomal protein L37a | 0.031793 |
| TPM3 | tropomyosin 3 | 0.0316482 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0314789 |
| POTEF | POTE ankyrin domain family, member F | 0.0311675 |
| NRG1 | neuregulin 1 | 0.0310042 |
| ST6GAL2 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 | 0.0309286 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0307613 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.0681431 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0678893 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0594964 |
| TXNRD1 | thioredoxin reductase 1 | -0.0531081 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0503538 |
| OSMR | oncostatin M receptor | -0.0494666 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0458716 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0439742 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0412135 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.039497 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0351585 |
| NCOA7 | nuclear receptor coactivator 7 | -0.034445 |
| MT1X | metallothionein 1X | -0.0330856 |
| RPLP1 | ribosomal protein, large, P1 | -0.0326488 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0324222 |
| USP3 | ubiquitin specific peptidase 3 | -0.032146 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0315911 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0290376 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0278287 |
| SPAG9 | sperm associated antigen 9 | -0.0278124 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0264516 |
| RPS24 | ribosomal protein S24 | -0.0248612 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0245618 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0238731 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0234952 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0234939 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0232572 |
| RNF213 | ring finger protein 213 | -0.021327 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0211846 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.020766 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.0197842 |
| NRP1 | neuropilin 1 | -0.0189603 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0184854 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0182671 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0181631 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0180793 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0179909 |
| PTGR1 | prostaglandin reductase 1 | -0.0177602 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0176781 |
| CEP95 | centrosomal protein 95kDa | -0.0175827 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.017582 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0172975 |
| OGA | O-GlcNAcase | -0.0171949 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0171206 |
| KIFC3 | kinesin family member C3 | -0.0170693 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0170319 |
| DENND4C | DENN/MADD domain containing 4C | -0.016684 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0164611 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0162074 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0161308 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0160923 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.0160704 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0158379 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0157186 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0153436 |
| GLIS3 | GLIS family zinc finger 3 | -0.015281 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0149198 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.014861 |
| ITGAV | integrin, alpha V | -0.0146811 |
| RIGI | RNA sensor RIG-I | -0.0146447 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.0145962 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0143037 |
| ACTN4 | actinin, alpha 4 | -0.0140522 |
| HELZ | helicase with zinc finger | -0.0140374 |
| AOPEP | aminopeptidase O (putative) | -0.0139687 |
| NF1 | neurofibromin 1 | -0.0139136 |
| WDR45B | WD repeat domain 45B | -0.013581 |
| PON2 | paraoxonase 2 | -0.0135495 |
| NEMF | nuclear export mediator factor | -0.0134231 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | -0.0133322 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | -0.0132579 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0131661 |
| TKT | transketolase | -0.0131642 |
| FOXK2 | forkhead box K2 | -0.0129836 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0129433 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0129131 |
| BMERB1 | bMERB domain containing 1 | -0.0128509 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0128333 |
| CDK17 | cyclin-dependent kinase 17 | -0.0128085 |
| CP | ceruloplasmin (ferroxidase) | -0.0127923 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.012737 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.012706 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0126279 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0126204 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0125665 |
| OLA1 | Obg-like ATPase 1 | -0.0124568 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0123818 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0123789 |
| EVA1C | eva-1 homolog C (C. elegans) | -0.0123344 |
| TNS3 | tensin 3 | -0.0122921 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.01222 |
| FAR1 | fatty acyl CoA reductase 1 | -0.012208 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0121303 |
| KIAA1217 | KIAA1217 | -0.0119919 |
| GPRIN3 | GPRIN family member 3 | -0.0115922 |
| PCNX1 | pecanex 1 | -0.0115336 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0114595 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0114368 |
| NUP214 | nucleoporin 214kDa | -0.0114041 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0113348 |
