| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in AN3 CA cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.167032 |
| MEST | mesoderm specific transcript | 0.120778 |
| MGP | matrix Gla protein | 0.118774 |
| VEGFA | vascular endothelial growth factor A | 0.114402 |
| VIM | vimentin | 0.110373 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0735674 |
| MYOF | myoferlin | 0.0714226 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0703614 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0682071 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0664004 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.066075 |
| FNIP1 | folliculin interacting protein 1 | 0.0635907 |
| RPS6 | ribosomal protein S6 | 0.0626581 |
| IER3 | immediate early response 3 | 0.062511 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0602478 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0597771 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0579194 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0574755 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0556205 |
| RPS3 | ribosomal protein S3 | 0.0551973 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0528792 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0515419 |
| BRD2 | bromodomain containing 2 | 0.0506927 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0504471 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0452809 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0448651 |
| ANO6 | anoctamin 6 | 0.0441253 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0438032 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0436034 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0430083 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0419497 |
| EGR1 | early growth response 1 | 0.041897 |
| LDHA | lactate dehydrogenase A | 0.0418499 |
| EZR | ezrin | 0.0411649 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0402074 |
| ENO1 | enolase 1, (alpha) | 0.0386218 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0384593 |
| FRMD6 | FERM domain containing 6 | 0.0379678 |
| RPS2 | ribosomal protein S2 | 0.0376985 |
| SFTPA2 | surfactant protein A2 | 0.0355853 |
| FLNB | filamin B, beta | 0.0354762 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0341145 |
| INTS6 | integrator complex subunit 6 | 0.0334519 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0331663 |
| POTEF | POTE ankyrin domain family, member F | 0.0325446 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.0318622 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0315223 |
| ZNF516 | zinc finger protein 516 | 0.0313607 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0312603 |
| SIK3 | SIK family kinase 3 | 0.0311458 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0308546 |
| ADM | adrenomedullin | 0.0306746 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0296337 |
| SET | SET nuclear proto-oncogene | 0.029437 |
| ATP6V1C1 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 | 0.0292791 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0287173 |
| CTBP2 | C-terminal binding protein 2 | 0.0285862 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0282939 |
| KIDINS220 | kinase D-interacting substrate, 220kDa | 0.0281416 |
| AFF4 | AF4/FMR2 family, member 4 | 0.027546 |
| PAPOLA | poly(A) polymerase alpha | 0.0272326 |
| RPL14 | ribosomal protein L14 | 0.0272029 |
| NDRG1 | N-myc downstream regulated 1 | 0.0272016 |
| AHNAK | AHNAK nucleoprotein | 0.0268089 |
| ARRDC3 | arrestin domain containing 3 | 0.0268043 |
| SPAG9 | sperm associated antigen 9 | 0.0266399 |
| SNX14 | sorting nexin 14 | 0.0262658 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0262635 |
| IGF2 | insulin-like growth factor 2 | 0.0262149 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0258438 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.0253716 |
| PCBP2 | poly(rC) binding protein 2 | 0.0251077 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.0248019 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0244294 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0243203 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0242 |
| RPL7 | ribosomal protein L7 | 0.0241905 |
| RPL3 | ribosomal protein L3 | 0.0241801 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.0239082 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0238718 |
| SERTAD2 | SERTA domain containing 2 | 0.0237819 |
| GOLGA4 | golgin A4 | 0.0237228 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0236075 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0234771 |
| MXI1 | MAX interactor 1, dimerization protein | 0.023364 |
| ACTG1 | actin gamma 1 | 0.0233581 |
| CREBRF | CREB3 regulatory factor | 0.0233416 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0230232 |
| USP28 | ubiquitin specific peptidase 28 | 0.0226321 |
| RPS8 | ribosomal protein S8 | 0.0224845 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0218959 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0218209 |
| RCOR1 | REST corepressor 1 | 0.0217183 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0216772 |
| IPO7 | importin 7 | 0.0216623 |
| RPL18 | ribosomal protein L18 | 0.0216351 |
| RPS12 | ribosomal protein S12 | 0.0216108 |
| JUN | jun proto-oncogene | 0.0214583 |
| PHF3 | PHD finger protein 3 | 0.0212916 |
| SQSTM1 | sequestosome 1 | 0.0212905 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MEOX2 | mesenchyme homeobox 2 | -0.138863 |
| TPK1 | thiamin pyrophosphokinase 1 | -0.10444 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0896328 |
| CADM2 | cell adhesion molecule 2 | -0.0892245 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0757269 |
| SEPTIN11 | septin 11 | -0.068932 |
| COL1A2 | collagen, type I, alpha 2 | -0.0663242 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0624902 |
| PDGFC | platelet derived growth factor C | -0.0609772 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0599865 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0580333 |
| KLHDC10 | kelch domain containing 10 | -0.0576478 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0529294 |
| RPS24 | ribosomal protein S24 | -0.0522535 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0496118 |
| RNF130 | ring finger protein 130 | -0.0484305 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0481483 |
| NFIA | nuclear factor I/A | -0.04701 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.045007 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0449346 |
| RANBP17 | RAN binding protein 17 | -0.0447749 |
| KAZN | kazrin, periplakin interacting protein | -0.0428481 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0425223 |
| HDAC8 | histone deacetylase 8 | -0.0423683 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0422485 |
| RFX7 | regulatory factor X, 7 | -0.0421848 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.040904 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0405993 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.040215 |
| RHEB | Ras homolog enriched in brain | -0.0394638 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0391977 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0389332 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0387588 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0387267 |
| RPLP0 | ribosomal protein, large, P0 | -0.0371809 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0369247 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0369035 |
| DIAPH3 | diaphanous-related formin 3 | -0.036568 |
| KIF20B | kinesin family member 20B | -0.0359198 |
| PTK2 | protein tyrosine kinase 2 | -0.0359073 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0358322 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0358068 |
| CENPE | centromere protein E, 312kDa | -0.0357465 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0348894 |
| VCL | vinculin | -0.0340737 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0337819 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.033606 |
| MATR3 | matrin 3 | -0.0333973 |
| PARD3 | par-3 family cell polarity regulator | -0.0331423 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0326029 |
| DEK | DEK proto-oncogene | -0.0324451 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -0.032235 |
| ITGAV | integrin, alpha V | -0.0319439 |
| QKI | QKI, KH domain containing, RNA binding | -0.0319188 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0318945 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0318643 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.031545 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0315035 |
| R3HDM1 | R3H domain containing 1 | -0.031317 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0311188 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0310727 |
| DEPDC1B | DEP domain containing 1B | -0.0309721 |
| TMSB10 | thymosin beta 10 | -0.0309537 |
| LYPD6 | LY6/PLAUR domain containing 6 | -0.030432 |
| WDR70 | WD repeat domain 70 | -0.0299538 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0299349 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0298021 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0296527 |
| CLASP2 | cytoplasmic linker associated protein 2 | -0.0293944 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | -0.0293815 |
| RNF216 | ring finger protein 216 | -0.0293804 |
| TENT2 | terminal nucleotidyltransferase 2 | -0.029177 |
| ZBTB35 | zinc finger and BTB domain containing 35 | -0.0288643 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0287724 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0286462 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.028596 |
| USP3 | ubiquitin specific peptidase 3 | -0.0284989 |
| CHD6 | chromodomain helicase DNA binding protein 6 | -0.028285 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0282001 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.028197 |
| AK1 | adenylate kinase 1 | -0.02811 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0280955 |
| PHF14 | PHD finger protein 14 | -0.0276055 |
| WTAP | Wilms tumor 1 associated protein | -0.0275318 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0275149 |
| SHROOM3 | shroom family member 3 | -0.0274698 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0269714 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0266607 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0264811 |
| SH3RF1 | SH3 domain containing ring finger 1 | -0.0262101 |
| MTAP | methylthioadenosine phosphorylase | -0.0261829 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0261758 |
| KIF18A | kinesin family member 18A | -0.0255895 |
| FBXW11 | F-box and WD repeat domain containing 11 | -0.0252305 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0250671 |
| MMS22L | MMS22-like, DNA repair protein | -0.0250468 |
| YTHDC2 | YTH domain containing 2 | -0.0248622 |
| ATAD2B | ATPase family, AAA domain containing 2B | -0.0247563 |
| MKI67 | marker of proliferation Ki-67 | -0.0247495 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0247463 |
