AZD-7648_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-7648 perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-7648_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.128097
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.116449
APLP2 amyloid beta (A4) precursor-like protein 2 0.104319
HSPA8 heat shock 70kDa protein 8 0.0934277
EFNA5 ephrin-A5 0.0886928
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0858826
AKAP12 A kinase (PRKA) anchor protein 12 0.0810722
ZSWIM6 zinc finger, SWIM-type containing 6 0.0793494
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0751367
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0741885
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0741348
FLNB filamin B, beta 0.0721406
RPS3 ribosomal protein S3 0.0644081
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0567994
FAM107B family with sequence similarity 107, member B 0.0542617
ABTB3 ankyrin repeat and BTB domain containing 3 0.0528368
PMM2 phosphomannomutase 2 0.0511137
FMNL2 formin-like 2 0.0510112
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0499341
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0477616
SACK1A scaffolding CK1 anchoring protein A 0.0458631
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0423061
TPM3 tropomyosin 3 0.0420997
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0404312
PRRC2C proline-rich coiled-coil 2C 0.0396208
TGM2 transglutaminase 2 0.0395629
ERRFI1 ERBB receptor feedback inhibitor 1 0.0394633
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0391551
MPRIP myosin phosphatase Rho interacting protein 0.0391182
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0391149
INTS6 integrator complex subunit 6 0.0382308
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0379252
TLN1 talin 1 0.0377014
MSN moesin 0.03699
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0362381
EXT1 exostosin glycosyltransferase 1 0.0361919
SRRM2 serine/arginine repetitive matrix 2 0.0356175
KTN1 kinectin 1 (kinesin receptor) 0.0341349
GOLGB1 golgin B1 0.0337746
PPARD peroxisome proliferator-activated receptor delta 0.0332899
SEPTIN9 septin 9 0.0326856
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0325466
VIM vimentin 0.032533
RPS6 ribosomal protein S6 0.0324396
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0323745
EIF5B eukaryotic translation initiation factor 5B 0.0313836
SGMS2 sphingomyelin synthase 2 0.0310876
RPS8 ribosomal protein S8 0.0306582
MT2A metallothionein 2A 0.0300776
TRIO trio Rho guanine nucleotide exchange factor 0.0299167
CD44 CD44 molecule (Indian blood group) 0.0298067
SIK3 SIK family kinase 3 0.0294493
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.029339
BRD2 bromodomain containing 2 0.0290658
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0289622
MBNL1 muscleblind-like splicing regulator 1 0.0282819
RUNX1 runt-related transcription factor 1 0.0282469
RPS12 ribosomal protein S12 0.0281467
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0277181
PTPRF protein tyrosine phosphatase, receptor type, F 0.0276639
RPS2 ribosomal protein S2 0.0275269
DSPP dentin sialophosphoprotein 0.0274969
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0272203
MYH9 myosin, heavy chain 9, non-muscle 0.0270115
DIAPH1 diaphanous-related formin 1 0.0265653
GRB10 growth factor receptor-bound protein 10 0.0263144
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0262297
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0260165
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0260039
HSPH1 heat shock 105kDa/110kDa protein 1 0.0258321
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0258072
BMP6 bone morphogenetic protein 6 0.0257765
ZMIZ1 zinc finger, MIZ-type containing 1 0.0257678
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0255425
POTEF POTE ankyrin domain family, member F 0.0252385
LOC102724023 ES1 protein homolog, mitochondrial 0.0251135
CAPRIN2 caprin family member 2 0.0250167
HPCAL1 hippocalcin-like 1 0.0242367
HIPK2 homeodomain interacting protein kinase 2 0.0239276
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.023516
TMF1 TATA element modulatory factor 1 0.0230732
S100A11 S100 calcium binding protein A11 0.0230547
TRIP12 thyroid hormone receptor interactor 12 0.0226282
RAI14 retinoic acid induced 14 0.0225579
RPL37A ribosomal protein L37a 0.0224399
KIF5B kinesin family member 5B 0.0224214
VMP1 vacuole membrane protein 1 0.0223645
MYO5B myosin VB 0.0221332
RPL36 ribosomal protein L36 0.021931
RACK1 receptor for activated C kinase 1 0.0216313
GTDC1 glycosyltransferase-like domain containing 1 0.0216281
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0216216
HMGA2 high mobility group AT-hook 2 0.0215416
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0214464
EZR ezrin 0.0214085
SET SET nuclear proto-oncogene 0.020494
SON SON DNA binding protein 0.0204619
DOCK1 dedicator of cytokinesis 1 0.0201471
RIOK3 RIO kinase 3 0.0198113
FLNA filamin A, alpha 0.0196998

decreased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 -0.167058
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.13747
MUC17 mucin 17, cell surface associated -0.125998
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.122355
F3 coagulation factor III (thromboplastin, tissue factor) -0.121526
TXNRD1 thioredoxin reductase 1 -0.102475
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0989553
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0966943
FTH1 ferritin, heavy polypeptide 1 -0.0933419
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0903914
VCAN versican -0.0886742
PTPRR protein tyrosine phosphatase, receptor type, R -0.0827298
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0799556
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0796575
NPSR1 neuropeptide S receptor 1 -0.0771493
SKAP2 src kinase associated phosphoprotein 2 -0.0752016
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0749049
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0748362
LMTK2 lemur tyrosine kinase 2 -0.0735878
HMGA1 high mobility group AT-hook 1 -0.070571
PRSS3 protease, serine, 3 -0.0654601
TPT1 tumor protein, translationally-controlled 1 -0.0647573
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0586392
TPM4 tropomyosin 4 -0.055244
FOXO1 forkhead box O1 -0.0537098
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0526179
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0511067
CD2AP CD2-associated protein -0.0510095
TRRAP transformation/transcription domain-associated protein -0.0506017
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0484853
PLAUR plasminogen activator, urokinase receptor -0.048146
EGFR epidermal growth factor receptor -0.0479963
SPAG9 sperm associated antigen 9 -0.044825
PGK1 phosphoglycerate kinase 1 -0.04392
SLC35F3 solute carrier family 35, member F3 -0.0438184
PERP PERP, TP53 apoptosis effector -0.0431248
ZMYND8 zinc finger, MYND-type containing 8 -0.0426967
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0414898
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0410578
FOXO3 forkhead box O3 -0.0396693
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0391595
S100A4 S100 calcium binding protein A4 -0.0390656
LY6E lymphocyte antigen 6 complex, locus E -0.0388657
FERMT1 fermitin family member 1 -0.0388518
RNF213 ring finger protein 213 -0.0388114
LAMA4 laminin, alpha 4 -0.038725
VCL vinculin -0.0386593
TSC22D2 TSC22 domain family, member 2 -0.0384266
SLMAP sarcolemma associated protein -0.0381909
ANTXR2 anthrax toxin receptor 2 -0.0378483
CTNND1 catenin (cadherin-associated protein), delta 1 -0.03766
KRT18 keratin 18, type I -0.0375984
ADAM9 ADAM metallopeptidase domain 9 -0.0375171
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0364829
ITGB4 integrin, beta 4 -0.0358176
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0357441
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0355198
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0353881
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0351811
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.034986
DIAPH2 diaphanous-related formin 2 -0.034696
COL17A1 collagen, type XVII, alpha 1 -0.0346708
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0345903
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0344576
GNAS GNAS complex locus -0.0344233
RIGI RNA sensor RIG-I -0.0341611
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) -0.0335015
CDH17 cadherin 17, LI cadherin (liver-intestine) -0.0334497
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0327971
NPC1 Niemann-Pick disease, type C1 -0.0326778
RABGAP1L RAB GTPase activating protein 1-like -0.0325932
TAOK3 TAO kinase 3 -0.0324546
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0322614
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0309767
KRT8 keratin 8, type II -0.0309605
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0308766
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0307351
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0307156
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.0305777
IFI16 interferon, gamma-inducible protein 16 -0.0305369
AFF4 AF4/FMR2 family, member 4 -0.0303208
GREB1L growth regulation by estrogen in breast cancer-like -0.0299878
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0299413
NBEAL1 neurobeachin-like 1 -0.0296492
SBF2 SET binding factor 2 -0.0292301
RRBP1 ribosome binding protein 1 -0.029159
SQSTM1 sequestosome 1 -0.0288184
ANXA11 annexin A11 -0.0287378
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0287091
BIRC6 baculoviral IAP repeat containing 6 -0.0285912
NEK7 NIMA-related kinase 7 -0.028497
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0284
TM4SF1 transmembrane 4 L six family member 1 -0.0283705
MX1 MX dynamin-like GTPase 1 -0.0280555
NT5C2 5'-nucleotidase, cytosolic II -0.027947
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -0.027915
KDM3A lysine (K)-specific demethylase 3A -0.0275636
PRELID2 PRELI domain containing 2 -0.0272847
EMP1 epithelial membrane protein 1 -0.0272491
INPP5D inositol polyphosphate-5-phosphatase, 145kDa -0.0271227