| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL19 | ribosomal protein L19 | 0.113868 |
| FNDC3A | fibronectin type III domain containing 3A | 0.102241 |
| VMP1 | vacuole membrane protein 1 | 0.101955 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0993505 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0912451 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0837168 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0771585 |
| CLTC | clathrin, heavy chain (Hc) | 0.0726232 |
| INTS6 | integrator complex subunit 6 | 0.0708598 |
| EXT1 | exostosin glycosyltransferase 1 | 0.067961 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0612109 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0602854 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0585562 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0585123 |
| MT2A | metallothionein 2A | 0.0581484 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0578547 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0578434 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0577935 |
| RPS3 | ribosomal protein S3 | 0.055976 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0554585 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0552064 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0541072 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0531141 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0467726 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0446766 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0437729 |
| DUSP16 | dual specificity phosphatase 16 | 0.0429439 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0427664 |
| CWC25 | CWC25 spliceosome-associated protein homolog (S. cerevisiae) | 0.0415029 |
| PNN | pinin, desmosome associated protein | 0.041498 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0413774 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0410092 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0409046 |
| SEPTIN9 | septin 9 | 0.0405714 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0400415 |
| BRD4 | bromodomain containing 4 | 0.0394552 |
| VCP | valosin containing protein | 0.0390229 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0386435 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0380789 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0378277 |
| FGB | fibrinogen beta chain | 0.0356388 |
| BRD2 | bromodomain containing 2 | 0.0346201 |
| ATXN1 | ataxin 1 | 0.0336817 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0333959 |
| SET | SET nuclear proto-oncogene | 0.0332374 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0326004 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0323146 |
| MYO1D | myosin ID | 0.0319362 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0316909 |
| RPL23 | ribosomal protein L23 | 0.0316732 |
| B2M | beta-2-microglobulin | 0.0312785 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0310829 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0307998 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0303648 |
| ANKRD36C | ankyrin repeat domain 36C | 0.030086 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0300831 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0299948 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0297494 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0297181 |
| SMYD3 | SET and MYND domain containing 3 | 0.0294574 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0293231 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0291688 |
| RPS6 | ribosomal protein S6 | 0.0290708 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0290028 |
| USP47 | ubiquitin specific peptidase 47 | 0.0287737 |
| RPS6KB1 | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 0.0285764 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0284015 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0282266 |
| PLK2 | polo-like kinase 2 | 0.02796 |
| RCOR1 | REST corepressor 1 | 0.027686 |
| FAM168A | family with sequence similarity 168, member A | 0.0276769 |
| MYOF | myoferlin | 0.0276095 |
| SP100 | SP100 nuclear antigen | 0.0271338 |
| STXBP4 | syntaxin binding protein 4 | 0.0269703 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0269585 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0268939 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0268739 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | 0.0265778 |
| MED13L | mediator complex subunit 13-like | 0.0262036 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0260493 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0259379 |
| FAM219A | family with sequence similarity 219, member A | 0.0258663 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.025745 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0256852 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0255005 |
| FAM107B | family with sequence similarity 107, member B | 0.0250448 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0249923 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0249565 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0248363 |
| FNBP1 | formin binding protein 1 | 0.0248239 |
| TNIK | TRAF2 and NCK interacting kinase | 0.0245271 |
| CUL3 | cullin 3 | 0.0244345 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0243226 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.024196 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0240965 |
| PAPOLA | poly(A) polymerase alpha | 0.0240251 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0238766 |
| RPL18 | ribosomal protein L18 | 0.0237967 |
| ANKRD11 | ankyrin repeat domain 11 | 0.023767 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.02374 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.271778 |
| LASP1 | LIM and SH3 protein 1 | -0.100058 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0849333 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0667073 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0652601 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0609809 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0542002 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0500533 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0450688 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0423357 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.042135 |
| TENM2 | teneurin transmembrane protein 2 | -0.0417789 |
| BCAS1 | breast carcinoma amplified sequence 1 | -0.0417686 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0389028 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.0387032 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.038248 |
| TMEM123 | transmembrane protein 123 | -0.0381198 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -0.0380508 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0369062 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0364326 |
| RPL35A | ribosomal protein L35a | -0.0355838 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0343365 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.0337374 |
| FASN | fatty acid synthase | -0.0336541 |
| FADS2 | fatty acid desaturase 2 | -0.0335785 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0331224 |
| ZFHX3 | zinc finger homeobox 3 | -0.0321978 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.031662 |
| SHROOM3 | shroom family member 3 | -0.030548 |
| TPM4 | tropomyosin 4 | -0.028797 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | -0.0282314 |
| NCOA6 | nuclear receptor coactivator 6 | -0.0268461 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | -0.0260136 |
| PRLR | prolactin receptor | -0.0258264 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.025285 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0252539 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0248295 |
| ZNF652 | zinc finger protein 652 | -0.0248178 |
| GRB7 | growth factor receptor-bound protein 7 | -0.0246371 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.0245097 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0242886 |
| FDPS | farnesyl diphosphate synthase | -0.0242193 |
| ENAH | enabled homolog (Drosophila) | -0.0241793 |
| TPM1 | tropomyosin 1 (alpha) | -0.0241012 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0241011 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0236635 |
| RPS24 | ribosomal protein S24 | -0.0231301 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0229335 |
| PTMA | prothymosin, alpha | -0.0227626 |
| RBM47 | RNA binding motif protein 47 | -0.0220813 |
| CCND1 | cyclin D1 | -0.0219535 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | -0.0214685 |
| CDH15 | cadherin 15, type 1, M-cadherin (myotubule) | -0.0214298 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0210245 |
| CEP250 | centrosomal protein 250kDa | -0.0207488 |
| KIAA1217 | KIAA1217 | -0.0202754 |
| DENND1B | DENN/MADD domain containing 1B | -0.0202517 |
| TMSB4X | thymosin beta 4, X-linked | -0.0200078 |
| NFIA | nuclear factor I/A | -0.0198295 |
| TNS3 | tensin 3 | -0.0193831 |
| TMC5 | transmembrane channel-like 5 | -0.0191946 |
| RPL27A | ribosomal protein L27a | -0.019168 |
| SIDT1 | SID1 transmembrane family, member 1 | -0.0189664 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0189174 |
| ALDH3B2 | aldehyde dehydrogenase 3 family, member B2 | -0.0189127 |
| GNAS | GNAS complex locus | -0.0186484 |
| GDPD1 | glycerophosphodiester phosphodiesterase domain containing 1 | -0.0186079 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.018424 |
| HMGB1 | high mobility group box 1 | -0.01822 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0181439 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0181186 |
| PARD3 | par-3 family cell polarity regulator | -0.0177259 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0176086 |
| GGNBP2 | gametogenetin binding protein 2 | -0.0175498 |
| RAB6A | RAB6A, member RAS oncogene family | -0.017437 |
| RPS25 | ribosomal protein S25 | -0.0173061 |
| RESF1 | retroelement silencing factor 1 | -0.0172785 |
| RAD51B | RAD51 paralog B | -0.017097 |
| XBP1 | X-box binding protein 1 | -0.0170264 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0169907 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0169724 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0168446 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0168131 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0166714 |
| MACROD2 | MACRO domain containing 2 | -0.0166399 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0166148 |
| MSI2 | musashi RNA-binding protein 2 | -0.016606 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0163823 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0163093 |
| FOXK1 | forkhead box K1 | -0.0160805 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0160337 |
| MACROD1 | MACRO domain containing 1 | -0.0159157 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0158164 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0158005 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | -0.0157887 |
| DENND1A | DENN/MADD domain containing 1A | -0.0156364 |
| GATA3 | GATA binding protein 3 | -0.0156186 |
| CD164 | CD164 molecule, sialomucin | -0.0154877 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0153776 |
| TOP6BL | TOP6B like initiator of meiotic double strand breaks | -0.0152928 |
