| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.122381 |
| MT2A | metallothionein 2A | 0.116299 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.091052 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.088205 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0805101 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0797781 |
| TLE4 | transducin-like enhancer of split 4 | 0.0709857 |
| CENPF | centromere protein F, 350/400kDa | 0.0639315 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0619327 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0616787 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0612403 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0593122 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0562513 |
| FRMD4A | FERM domain containing 4A | 0.0541156 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0531715 |
| ASPH | aspartate beta-hydroxylase | 0.0523761 |
| SETBP1 | SET binding protein 1 | 0.0509874 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.047169 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0469115 |
| GOLGB1 | golgin B1 | 0.0453048 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0447676 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0432401 |
| RPS3 | ribosomal protein S3 | 0.0424423 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0416242 |
| PDLIM5 | PDZ and LIM domain 5 | 0.040202 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0400234 |
| BRD2 | bromodomain containing 2 | 0.0393533 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0389962 |
| FMN1 | formin 1 | 0.0384917 |
| RPS6 | ribosomal protein S6 | 0.0372974 |
| SFTPA2 | surfactant protein A2 | 0.0366932 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0365431 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0359976 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0359268 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0357744 |
| MSN | moesin | 0.0355218 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0352711 |
| EGR1 | early growth response 1 | 0.0346981 |
| INTS6 | integrator complex subunit 6 | 0.034509 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | 0.0344298 |
| LDHA | lactate dehydrogenase A | 0.0334535 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0334361 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0329185 |
| NAV1 | neuron navigator 1 | 0.0328516 |
| ZFP36 | ZFP36 ring finger protein | 0.0323602 |
| GPC6 | glypican 6 | 0.0317775 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.031772 |
| EXOC4 | exocyst complex component 4 | 0.0315762 |
| EFCAB13 | EF-hand calcium binding domain 13 | 0.0309644 |
| RPS12 | ribosomal protein S12 | 0.0309104 |
| SHISA5 | shisa family member 5 | 0.0305614 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0304902 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0292394 |
| ACTN1 | actinin, alpha 1 | 0.0284122 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0280941 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0279894 |
| TPR | translocated promoter region, nuclear basket protein | 0.027978 |
| DST | dystonin | 0.0276738 |
| RPL19 | ribosomal protein L19 | 0.0270316 |
| CTTNBP2 | cortactin binding protein 2 | 0.0269692 |
| TMF1 | TATA element modulatory factor 1 | 0.0262055 |
| TMEM178B | transmembrane protein 178B | 0.0258952 |
| B2M | beta-2-microglobulin | 0.0258924 |
| SEPTIN9 | septin 9 | 0.0255164 |
| USP53 | ubiquitin specific peptidase 53 | 0.0254889 |
| RPS2 | ribosomal protein S2 | 0.0254531 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0254349 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0253454 |
| RPL37A | ribosomal protein L37a | 0.0253102 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0250999 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.025054 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0247443 |
| LMNA | lamin A/C | 0.0246846 |
| MORF4L2 | mortality factor 4 like 2 | 0.0245311 |
| RPL36 | ribosomal protein L36 | 0.0245135 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0243429 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0242958 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0242029 |
| RPL12 | ribosomal protein L12 | 0.0239186 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0236163 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0236014 |
| TBC1D4 | TBC1 domain family, member 4 | 0.0233729 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0230019 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0229341 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0227959 |
| FLNB | filamin B, beta | 0.0226999 |
| ARRDC3 | arrestin domain containing 3 | 0.0226113 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0225583 |
| ATXN1 | ataxin 1 | 0.0224762 |
| SMYD3 | SET and MYND domain containing 3 | 0.0224634 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | 0.0223627 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0221254 |
| RGS2 | regulator of G-protein signaling 2 | 0.0221162 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0218799 |
| UTRN | utrophin | 0.0218407 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.021735 |
| RPL18 | ribosomal protein L18 | 0.0216331 |
| ZFYVE28 | zinc finger, FYVE domain containing 28 | 0.0215919 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0213236 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0213133 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.289203 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.151126 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.130541 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.096553 |
| CD109 | CD109 molecule | -0.0960358 |
| VGF | VGF nerve growth factor inducible | -0.0908089 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0860969 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0784379 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0782251 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0775603 |
| CHSY1 | chondroitin sulfate synthase 1 | -0.0725934 |
| NDRG1 | N-myc downstream regulated 1 | -0.0724707 |
| PGK1 | phosphoglycerate kinase 1 | -0.0701632 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0687341 |
| TMEM123 | transmembrane protein 123 | -0.0676815 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0670033 |
| CALU | calumenin | -0.065484 |
| DCT | dopachrome tautomerase | -0.0610595 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0604511 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0603582 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0597279 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0594685 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0590293 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0581667 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0580423 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.057142 |
| CERT1 | ceramide transporter 1 | -0.0555991 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0540449 |
| CDC73 | cell division cycle 73 | -0.0534914 |
| UBC | ubiquitin C | -0.0507907 |
| ZNF292 | zinc finger protein 292 | -0.0496775 |
| NBAS | neuroblastoma amplified sequence | -0.0488746 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0487342 |
| SRPK2 | SRSF protein kinase 2 | -0.0485246 |
| TAC4 | tachykinin 4 (hemokinin) | -0.047205 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0464968 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0462194 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.0450923 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0446951 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0432857 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0429796 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0427586 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0420911 |
| VIM | vimentin | -0.0416146 |
| WDR45B | WD repeat domain 45B | -0.0414061 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0401016 |
| RUNX1 | runt-related transcription factor 1 | -0.0396673 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0394833 |
| RNF24 | ring finger protein 24 | -0.039299 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0388874 |
| GRID1 | glutamate receptor, ionotropic, delta 1 | -0.038472 |
| ENO1 | enolase 1, (alpha) | -0.0384566 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0375466 |
| POM121 | POM121 transmembrane nucleoporin | -0.037446 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0371896 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0364528 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0362482 |
| COL19A1 | collagen, type XIX, alpha 1 | -0.035837 |
| FOXJ3 | forkhead box J3 | -0.0354973 |
| GDF15 | growth differentiation factor 15 | -0.0352899 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | -0.0351787 |
| XPO1 | exportin 1 | -0.0351225 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.0351017 |
| COG5 | component of oligomeric golgi complex 5 | -0.0348836 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | -0.0348803 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | -0.0334769 |
| SCFD2 | sec1 family domain containing 2 | -0.0331738 |
| EHBP1 | EH domain binding protein 1 | -0.0330104 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0328654 |
| GNAS | GNAS complex locus | -0.032798 |
| OGA | O-GlcNAcase | -0.0323856 |
| COPA | coatomer protein complex, subunit alpha | -0.0323725 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0323447 |
| RHEB | Ras homolog enriched in brain | -0.0322126 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.0321185 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0320234 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | -0.0319419 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0315566 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0315253 |
| AHR | aryl hydrocarbon receptor | -0.0300062 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.029705 |
| C1ORF21 | chromosome 1 open reading frame 21 | -0.0296549 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.028968 |
| OXR1 | oxidation resistance 1 | -0.0289513 |
| CTSD | cathepsin D | -0.0287933 |
| KLHDC10 | kelch domain containing 10 | -0.0286202 |
| CSNK1E | casein kinase 1, epsilon | -0.0282253 |
| NUP58 | nucleoporin 58 | -0.0280084 |
| RNF145 | ring finger protein 145 | -0.0275973 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0274225 |
| TNPO3 | transportin 3 | -0.0270894 |
| LAMB1 | laminin, beta 1 | -0.0265832 |
| COL1A2 | collagen, type I, alpha 2 | -0.0265111 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0261139 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0260191 |
| CDK19 | cyclin-dependent kinase 19 | -0.0258883 |
| LNPK | lunapark, ER junction formation factor | -0.0257965 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0256089 |
| PYGB | phosphorylase, glycogen; brain | -0.0255568 |
| TAGLN2 | transgelin 2 | -0.0254945 |
