| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in CFPAC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.136135 |
| MT2A | metallothionein 2A | 0.128686 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0752814 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.070893 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0699469 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0659502 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0619214 |
| EFNA5 | ephrin-A5 | 0.0607143 |
| TAPBP | TAP binding protein (tapasin) | 0.0559316 |
| FAM107B | family with sequence similarity 107, member B | 0.0492846 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0489683 |
| RPS3 | ribosomal protein S3 | 0.0476796 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.046821 |
| PHF3 | PHD finger protein 3 | 0.0461373 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0447348 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0446752 |
| GOLGB1 | golgin B1 | 0.0446355 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0435078 |
| SMAD3 | SMAD family member 3 | 0.043327 |
| BRD2 | bromodomain containing 2 | 0.0422463 |
| TGM2 | transglutaminase 2 | 0.0397667 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0393877 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.038694 |
| MYOF | myoferlin | 0.0384935 |
| BICC1 | BicC family RNA binding protein 1 | 0.037816 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0348435 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0347559 |
| SGMS2 | sphingomyelin synthase 2 | 0.0344731 |
| ARRDC3 | arrestin domain containing 3 | 0.0340667 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0339379 |
| NRG3 | neuregulin 3 | 0.0333998 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.031783 |
| RUNX1 | runt-related transcription factor 1 | 0.0313706 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0312011 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0309484 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0307373 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0303036 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0295463 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0287603 |
| KYNU | kynureninase | 0.0283751 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0279308 |
| RAD51B | RAD51 paralog B | 0.0277095 |
| ATF3 | activating transcription factor 3 | 0.0272127 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0263916 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0263653 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0258976 |
| APP | amyloid beta (A4) precursor protein | 0.025772 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0255904 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0252696 |
| PRELID2 | PRELI domain containing 2 | 0.0247437 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0241189 |
| FAM3C | family with sequence similarity 3, member C | 0.0236215 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0233768 |
| HDAC9 | histone deacetylase 9 | 0.0233354 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0226901 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0226721 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0226431 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0225321 |
| AREG | amphiregulin | 0.0223766 |
| APOL1 | apolipoprotein L, 1 | 0.0222079 |
| NTN4 | netrin 4 | 0.0220843 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.0215621 |
| JAK1 | Janus kinase 1 | 0.0214172 |
| FAAH2 | fatty acid amide hydrolase 2 | 0.0213832 |
| NOTCH2 | notch 2 | 0.0206049 |
| HKDC1 | hexokinase domain containing 1 | 0.0205393 |
| TMEM51 | transmembrane protein 51 | 0.0202345 |
| RPS2 | ribosomal protein S2 | 0.0201067 |
| HOMER2 | homer scaffolding protein 2 | 0.0198999 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.019755 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0196671 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0196474 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0196173 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0196116 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0191011 |
| TMC5 | transmembrane channel-like 5 | 0.019008 |
| IRF1 | interferon regulatory factor 1 | 0.0183131 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0183119 |
| MT1E | metallothionein 1E | 0.018295 |
| PNN | pinin, desmosome associated protein | 0.0181178 |
| DSPP | dentin sialophosphoprotein | 0.0178997 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0178198 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0177426 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.0175892 |
| FHIT | fragile histidine triad | 0.017535 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0175008 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0173359 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0172716 |
| SHROOM3 | shroom family member 3 | 0.0170766 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0170457 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0169434 |
| ZFP36 | ZFP36 ring finger protein | 0.0169122 |
| ZNF638 | zinc finger protein 638 | 0.0166434 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0165542 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.016483 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | 0.0162681 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | 0.0162604 |
| ANO6 | anoctamin 6 | 0.0161976 |
| IFI44 | interferon-induced protein 44 | 0.0160365 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0159723 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.243383 |
| TMSB10 | thymosin beta 10 | -0.196019 |
| MMP7 | matrix metallopeptidase 7 | -0.177071 |
| S100A6 | S100 calcium binding protein A6 | -0.140072 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.127562 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.125074 |
| LAMB3 | laminin, beta 3 | -0.121226 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.112775 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.110771 |
| HMGA1 | high mobility group AT-hook 1 | -0.109367 |
| VIM | vimentin | -0.100117 |
| ACTG1 | actin gamma 1 | -0.0999646 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0973178 |
| ANXA2 | annexin A2 | -0.0940097 |
| KRT19 | keratin 19, type I | -0.0858949 |
| DTNA | dystrobrevin, alpha | -0.0780086 |
| PTMA | prothymosin, alpha | -0.0766348 |
| TPM4 | tropomyosin 4 | -0.0743891 |
| HLA-B | major histocompatibility complex, class I, B | -0.0715219 |
| PGK1 | phosphoglycerate kinase 1 | -0.0699892 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0695133 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0680786 |
| PKM | pyruvate kinase, muscle | -0.0670832 |
| HLA-A | major histocompatibility complex, class I, A | -0.0659446 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0641911 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0624957 |
| NDRG1 | N-myc downstream regulated 1 | -0.0608145 |
| S100A10 | S100 calcium binding protein A10 | -0.0605828 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.060578 |
| RCOR1 | REST corepressor 1 | -0.0593921 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0587673 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0584254 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0582168 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0572859 |
| ITGA6 | integrin, alpha 6 | -0.0563112 |
| CP | ceruloplasmin (ferroxidase) | -0.0562682 |
| PLAT | plasminogen activator, tissue | -0.0555701 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0553337 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0550692 |
| ENO1 | enolase 1, (alpha) | -0.0531447 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0527595 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0525928 |
| MAP1B | microtubule-associated protein 1B | -0.0522432 |
| UBC | ubiquitin C | -0.050938 |
| PLAU | plasminogen activator, urokinase | -0.0508076 |
| RPS24 | ribosomal protein S24 | -0.0495096 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0494391 |
| TMSB4X | thymosin beta 4, X-linked | -0.0492268 |
| RPLP1 | ribosomal protein, large, P1 | -0.0486837 |
| NCKAP5 | NCK-associated protein 5 | -0.0465732 |
| HMGA2 | high mobility group AT-hook 2 | -0.0465345 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.046205 |
| LAMC2 | laminin, gamma 2 | -0.0452629 |
| SPAG9 | sperm associated antigen 9 | -0.0443588 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0437236 |
| JUP | junction plakoglobin | -0.0436716 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0436131 |
| PARD3 | par-3 family cell polarity regulator | -0.0432024 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0431895 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0427321 |
| GNAS | GNAS complex locus | -0.0419261 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0410363 |
| ACTN4 | actinin, alpha 4 | -0.0402552 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0386866 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.038257 |
| MEF2A | myocyte enhancer factor 2A | -0.0379975 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.037932 |
| TMEM165 | transmembrane protein 165 | -0.0379098 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0379037 |
| LASP1 | LIM and SH3 protein 1 | -0.0378685 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0376628 |
| POTEF | POTE ankyrin domain family, member F | -0.0373977 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0366034 |
| RPL35A | ribosomal protein L35a | -0.0365738 |
| MCU | mitochondrial calcium uniporter | -0.0362131 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0357474 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0355641 |
| ITGB4 | integrin, beta 4 | -0.0355351 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0355322 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0354309 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0352405 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0351165 |
| NUMB | numb homolog (Drosophila) | -0.0348736 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0347462 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0345758 |
| PLS3 | plastin 3 | -0.0345304 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0343401 |
| VCL | vinculin | -0.0343365 |
| SEC24A | SEC24 family member A | -0.0341527 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0338448 |
| FTL | ferritin, light polypeptide | -0.0338332 |
| VDAC1 | voltage-dependent anion channel 1 | -0.033599 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.033379 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0332632 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0331624 |
| KRT18 | keratin 18, type I | -0.0330956 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0330564 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0329748 |
| RPL23 | ribosomal protein L23 | -0.032961 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0328102 |
