AZD-7648_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-7648 perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-7648_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FMN1 formin 1 0.169948
VCL vinculin 0.167258
LSAMP limbic system-associated membrane protein 0.144423
SYT1 synaptotagmin I 0.12396
NALF1 NALCN channel auxiliary factor 1 0.120719
EXT1 exostosin glycosyltransferase 1 0.0987529
RPS6 ribosomal protein S6 0.0969614
ZSWIM6 zinc finger, SWIM-type containing 6 0.0892499
AKAP12 A kinase (PRKA) anchor protein 12 0.0883306
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0857308
PTPRD protein tyrosine phosphatase, receptor type, D 0.0850254
PRKCA protein kinase C, alpha 0.0836427
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0808831
ACTG1 actin gamma 1 0.0771289
RPL23 ribosomal protein L23 0.0749431
RPS3 ribosomal protein S3 0.0743896
BPTF bromodomain PHD finger transcription factor 0.07426
SLIT2 slit homolog 2 (Drosophila) 0.0732437
THSD4 thrombospondin, type I, domain containing 4 0.0711229
GREM2 gremlin 2, DAN family BMP antagonist 0.0692303
ZNF804A zinc finger protein 804A 0.067913
BCAS3 breast carcinoma amplified sequence 3 0.0675406
TLE4 transducin-like enhancer of split 4 0.0666381
TIMP3 TIMP metallopeptidase inhibitor 3 0.0659741
NRG1 neuregulin 1 0.0636147
ANTXR1 anthrax toxin receptor 1 0.0633775
RPL19 ribosomal protein L19 0.062715
NPAS2 neuronal PAS domain protein 2 0.0599797
TPM1 tropomyosin 1 (alpha) 0.0584623
LPIN1 lipin 1 0.0559373
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0541807
RPS12 ribosomal protein S12 0.0522398
CADM2 cell adhesion molecule 2 0.0516971
PTMA prothymosin, alpha 0.051562
ITGA1 integrin, alpha 1 0.0500377
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0499396
KLHL13 kelch-like family member 13 0.0497644
PRRC2C proline-rich coiled-coil 2C 0.0495714
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0487412
RPS17 ribosomal protein S17 0.0486096
DST dystonin 0.0479582
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0479566
RPL26 ribosomal protein L26 0.0468705
SP100 SP100 nuclear antigen 0.046816
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.046769
LOC102724023 ES1 protein homolog, mitochondrial 0.0464884
RPL37A ribosomal protein L37a 0.0458018
STK38L serine/threonine kinase 38 like 0.0452175
SLC38A2 solute carrier family 38, member 2 0.0446667
CALD1 caldesmon 1 0.0442725
RNF213 ring finger protein 213 0.0441138
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0440209
TRIO trio Rho guanine nucleotide exchange factor 0.0437382
VMP1 vacuole membrane protein 1 0.0429001
MYH9 myosin, heavy chain 9, non-muscle 0.0426866
COL1A1 collagen, type I, alpha 1 0.0422086
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0416313
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0410835
DNAH14 dynein, axonemal, heavy chain 14 0.0408553
HSPA8 heat shock 70kDa protein 8 0.04049
CRH corticotropin releasing hormone 0.0404522
B2M beta-2-microglobulin 0.0404123
RPL36 ribosomal protein L36 0.0403843
LPP LIM domain containing preferred translocation partner in lipoma 0.0398273
PBX1 pre-B-cell leukemia homeobox 1 0.0394321
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0393574
RIGI RNA sensor RIG-I 0.0385843
RPS19 ribosomal protein S19 0.0385634
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0382701
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0376649
GLCCI1 glucocorticoid induced 1 0.0369886
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0365739
LINGO2 leucine rich repeat and Ig domain containing 2 0.036314
TPST1 tyrosylprotein sulfotransferase 1 0.0363111
EGR1 early growth response 1 0.036175
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0361716
SIK2 salt-inducible kinase 2 0.0357303
EIF1 eukaryotic translation initiation factor 1 0.0357242
FAM107B family with sequence similarity 107, member B 0.0355421
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0354708
NAP1L1 nucleosome assembly protein 1-like 1 0.0353429
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0346764
DGKH diacylglycerol kinase, eta 0.0341665
RACK1 receptor for activated C kinase 1 0.0338332
EFNA5 ephrin-A5 0.033782
RPL34 ribosomal protein L34 0.0331068
NFE2L2 nuclear factor, erythroid 2-like 2 0.0323858
RPL27 ribosomal protein L27 0.0321536
ATXN1 ataxin 1 0.032086
IER3 immediate early response 3 0.031837
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0315481
FRMD4A FERM domain containing 4A 0.0313534
RPL32 ribosomal protein L32 0.0311168
PDLIM5 PDZ and LIM domain 5 0.031055
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0310144
RUNX1 runt-related transcription factor 1 0.0309803
MAPK10 mitogen-activated protein kinase 10 0.0308543
PCNX4 pecanex 4 0.0306621
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0304241
JUP junction plakoglobin 0.0303211

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.122735
HELZ helicase with zinc finger -0.0629596
WDR45B WD repeat domain 45B -0.0566534
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0491827
NPEPPS aminopeptidase puromycin sensitive -0.0416661
FAM13A family with sequence similarity 13, member A -0.0384333
HILPDA hypoxia inducible lipid droplet-associated -0.03458
OGA O-GlcNAcase -0.034202
MARCHF6 membrane associated ring-CH-type finger 6 -0.0334729
USP3 ubiquitin specific peptidase 3 -0.031833
KDM3A lysine (K)-specific demethylase 3A -0.0314215
WSB1 WD repeat and SOCS box containing 1 -0.0313229
NAMPT nicotinamide phosphoribosyltransferase -0.031212
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.028626
TENT5A terminal nucleotidyltransferase 5A -0.0277288
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0277082
RAB6A RAB6A, member RAS oncogene family -0.0276101
CDC27 cell division cycle 27 -0.0255202
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0251773
LCORL ligand dependent nuclear receptor corepressor-like -0.0248747
ZNF292 zinc finger protein 292 -0.0247719
MIS18BP1 MIS18 binding protein 1 -0.024691
NDRG1 N-myc downstream regulated 1 -0.0245073
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0241906
KMT2C lysine (K)-specific methyltransferase 2C -0.0239195
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0238121
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0232494
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0231728
DTNA dystrobrevin, alpha -0.0228675
KLHL24 kelch-like family member 24 -0.0218617
ANXA2 annexin A2 -0.0216961
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0215567
UBA2 ubiquitin-like modifier activating enzyme 2 -0.0214943
RNF24 ring finger protein 24 -0.0211553
KMT2E lysine (K)-specific methyltransferase 2E -0.0207728
GOLGA4 golgin A4 -0.0205008
PRPF8 pre-mRNA processing factor 8 -0.0204214
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0199174
WAC WW domain containing adaptor with coiled-coil -0.0198668
ESYT2 extended synaptotagmin-like protein 2 -0.0198028
XPO1 exportin 1 -0.0197254
CEP95 centrosomal protein 95kDa -0.0196439
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0192873
RNMT RNA (guanine-7-) methyltransferase -0.0192579
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0189213
MXI1 MAX interactor 1, dimerization protein -0.0186858
ACBD3 acyl-CoA binding domain containing 3 -0.0186777
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0183586
TFG TRK-fused gene -0.0183306
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.0183187
SRP54 signal recognition particle 54kDa -0.0182826
SREBF2 sterol regulatory element binding transcription factor 2 -0.0182301
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0180124
LMAN1 lectin, mannose-binding, 1 -0.0179934
HMGB2 high mobility group box 2 -0.017778
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.017752
VDAC1 voltage-dependent anion channel 1 -0.0177408
FNDC3B fibronectin type III domain containing 3B -0.0177107
SSBP2 single-stranded DNA binding protein 2 -0.0177087
NEK7 NIMA-related kinase 7 -0.0176238
KDM2A lysine (K)-specific demethylase 2A -0.0175627
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0172965
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.0172308
ZNF654 zinc finger protein 654 -0.0170162
CERT1 ceramide transporter 1 -0.0170144
PREPL prolyl endopeptidase-like -0.0168483
RIOK3 RIO kinase 3 -0.0167825
HMGA1 high mobility group AT-hook 1 -0.0167757
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0165324
C1ORF21 chromosome 1 open reading frame 21 -0.0164793
RARA retinoic acid receptor, alpha -0.0164626
CCNY cyclin Y -0.0164317
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0163644
ARHGAP12 Rho GTPase activating protein 12 -0.0163093
BRWD1 bromodomain and WD repeat domain containing 1 -0.0163047
UBE2O ubiquitin-conjugating enzyme E2O -0.0162523
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0162421
CABIN1 calcineurin binding protein 1 -0.0160053
SPAG9 sperm associated antigen 9 -0.0160013
ZFR zinc finger RNA binding protein -0.015989
GARS1 glycyl-tRNA synthetase 1 -0.0158831
SUCO SUN domain containing ossification factor -0.0158697
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0158011
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0157904
NUP58 nucleoporin 58 -0.0157689
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0156772
DENND4C DENN/MADD domain containing 4C -0.0156439
NEMF nuclear export mediator factor -0.0155435
SETD5 SET domain containing 5 -0.0155366
HBP1 HMG-box transcription factor 1 -0.0154733
MON2 MON2 homolog (S. cerevisiae) -0.0153664
RTN4 reticulon 4 -0.0152622
AMBRA1 autophagy/beclin-1 regulator 1 -0.0149856
GNG2 guanine nucleotide binding protein (G protein), gamma 2 -0.0149473
KDM6A lysine (K)-specific demethylase 6A -0.0148746
SEPTIN2 septin 2 -0.0148512
TENT4A terminal nucleotidyltransferase 4A -0.0147585
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0146724
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0146671
HDAC2 histone deacetylase 2 -0.0145