| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.291775 |
| LCN2 | lipocalin 2 | 0.192801 |
| B2M | beta-2-microglobulin | 0.151349 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.144567 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.114745 |
| SMAD3 | SMAD family member 3 | 0.104687 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0927921 |
| TSC22D1 | TSC22 domain family, member 1 | 0.092706 |
| AREG | amphiregulin | 0.0912909 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0908741 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0869098 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0818848 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0768592 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.073332 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0717241 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0682263 |
| ASPH | aspartate beta-hydroxylase | 0.0635197 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0620638 |
| RUNX1 | runt-related transcription factor 1 | 0.0593903 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.0561995 |
| ATP11A | ATPase, class VI, type 11A | 0.0542387 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.05316 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0530227 |
| RPS6 | ribosomal protein S6 | 0.0526265 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0514024 |
| FTL | ferritin, light polypeptide | 0.0506298 |
| FAT1 | FAT atypical cadherin 1 | 0.050103 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0498618 |
| EFNB2 | ephrin-B2 | 0.0479171 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0469424 |
| ZNF292 | zinc finger protein 292 | 0.0465896 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0463399 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0460467 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0448186 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0445602 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0434816 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.04332 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0426069 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.041425 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0412101 |
| MYO1E | myosin IE | 0.0408966 |
| ETV6 | ets variant 6 | 0.0399996 |
| TMC5 | transmembrane channel-like 5 | 0.0398496 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0395568 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0390856 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0383875 |
| C6ORF132 | chromosome 6 open reading frame 132 | 0.0381672 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0380241 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0380023 |
| DSTN | destrin (actin depolymerizing factor) | 0.037917 |
| LIMA1 | LIM domain and actin binding 1 | 0.0369923 |
| DST | dystonin | 0.0363378 |
| RPL7L1 | ribosomal protein L7-like 1 | 0.0363265 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0360872 |
| CTSB | cathepsin B | 0.0359814 |
| DIAPH1 | diaphanous-related formin 1 | 0.0351838 |
| SEPTIN9 | septin 9 | 0.0344453 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0344151 |
| RPS3 | ribosomal protein S3 | 0.0340004 |
| FNIP2 | folliculin interacting protein 2 | 0.0338793 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0338386 |
| IFNGR1 | interferon gamma receptor 1 | 0.0330725 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0326376 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0319676 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.031755 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0317356 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0316873 |
| KYNU | kynureninase | 0.0315922 |
| RPS8 | ribosomal protein S8 | 0.0309158 |
| DUSP16 | dual specificity phosphatase 16 | 0.0306726 |
| TMEM123 | transmembrane protein 123 | 0.0306049 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.030561 |
| SFTPA2 | surfactant protein A2 | 0.0304973 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0304367 |
| YAP1 | Yes-associated protein 1 | 0.0304196 |
| PTMA | prothymosin, alpha | 0.0303471 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0294948 |
| VMP1 | vacuole membrane protein 1 | 0.0291689 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0288528 |
| MLPH | melanophilin | 0.0287834 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0286957 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0285461 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.02849 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0283699 |
| ITGA6 | integrin, alpha 6 | 0.0281067 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0280788 |
| MYO5B | myosin VB | 0.0280257 |
| TOX3 | TOX high mobility group box family member 3 | 0.0275188 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0274855 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0271475 |
| RPL19 | ribosomal protein L19 | 0.0271176 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0268829 |
| HKDC1 | hexokinase domain containing 1 | 0.0268131 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0265958 |
| STK24 | serine/threonine kinase 24 | 0.0265062 |
| MSI2 | musashi RNA-binding protein 2 | 0.0257645 |
| RBM47 | RNA binding motif protein 47 | 0.0257278 |
| XDH | xanthine dehydrogenase | 0.0255395 |
| TRIM2 | tripartite motif containing 2 | 0.0253647 |
| DPP4 | dipeptidyl-peptidase 4 | 0.0253346 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.0759513 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0543736 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0502427 |
| EZR | ezrin | -0.0464697 |
| MUC20 | mucin 20, cell surface associated | -0.0460345 |
| NPSR1 | neuropeptide S receptor 1 | -0.0444394 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.042254 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.041926 |
| SQSTM1 | sequestosome 1 | -0.038873 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0373834 |
| PLSCR1 | phospholipid scramblase 1 | -0.0365336 |
| LYZ | lysozyme | -0.0364118 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.03469 |
| TXNIP | thioredoxin interacting protein | -0.0341267 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0328574 |
| TNS4 | tensin 4 | -0.0303271 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0294599 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0293686 |
| ARF1 | ADP-ribosylation factor 1 | -0.0289012 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0283346 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0270859 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0247983 |
| HM13 | histocompatibility (minor) 13 | -0.0244117 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0235759 |
| COG6 | component of oligomeric golgi complex 6 | -0.0235231 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0232008 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0231008 |
| CALU | calumenin | -0.0230916 |
| PHF3 | PHD finger protein 3 | -0.0230798 |
| NDRG1 | N-myc downstream regulated 1 | -0.0226078 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0224797 |
| IRF1 | interferon regulatory factor 1 | -0.022402 |
| TM4SF19 | transmembrane 4 L six family member 19 | -0.0222134 |
| MCL1 | myeloid cell leukemia 1 | -0.0221313 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0221204 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | -0.0219593 |
| APOL6 | apolipoprotein L, 6 | -0.0218741 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.021859 |
| INTS6 | integrator complex subunit 6 | -0.0215826 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0214656 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0211882 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0211437 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0211125 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0209864 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0209301 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.020586 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0203234 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0201973 |
| LRRC8A | leucine rich repeat containing 8 family, member A | -0.0200847 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0198859 |
| STX5 | syntaxin 5 | -0.0193063 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0192578 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0191899 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | -0.0187855 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0187136 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0178697 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0176142 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0175045 |
| LDLR | low density lipoprotein receptor | -0.0173842 |
| COPA | coatomer protein complex, subunit alpha | -0.0173434 |
| EGR1 | early growth response 1 | -0.0173181 |
| SEC24D | SEC24 family member D | -0.0172241 |
| GOLPH3L | golgi phosphoprotein 3-like | -0.0171813 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0170699 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0165611 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0163681 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0163452 |
| ACTN4 | actinin, alpha 4 | -0.0163091 |
| DIAPH3 | diaphanous-related formin 3 | -0.0162194 |
| CEP95 | centrosomal protein 95kDa | -0.0161857 |
| SCFD1 | sec1 family domain containing 1 | -0.0161376 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0159902 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0159836 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0158266 |
| PRELID2 | PRELI domain containing 2 | -0.0158032 |
| ANXA2 | annexin A2 | -0.0157759 |
| HDLBP | high density lipoprotein binding protein | -0.0156541 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0155806 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.015479 |
| TFRC | transferrin receptor | -0.0154309 |
| S100A10 | S100 calcium binding protein A10 | -0.015369 |
| SEC24A | SEC24 family member A | -0.0153252 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0153017 |
| XRN1 | 5'-3' exoribonuclease 1 | -0.0152552 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.015243 |
| LNX2 | ligand of numb-protein X 2 | -0.015215 |
| SDCBP2 | syndecan binding protein (syntenin) 2 | -0.0151836 |
| ENSA | endosulfine alpha | -0.0151045 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0151005 |
| ATXN1 | ataxin 1 | -0.0150051 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0147853 |
| GOLGA3 | golgin A3 | -0.0147505 |
| SLC33A1 | solute carrier family 33 (acetyl-CoA transporter), member 1 | -0.0146855 |
| ZNF432 | zinc finger protein 432 | -0.014674 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0145425 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | -0.0143069 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0142902 |
| PTEN | phosphatase and tensin homolog | -0.0142467 |
| CDK19 | cyclin-dependent kinase 19 | -0.014242 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.01418 |
