| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.207304 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.178639 |
| MT2A | metallothionein 2A | 0.175167 |
| STC1 | stanniocalcin 1 | 0.119139 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.114225 |
| RPS6 | ribosomal protein S6 | 0.0966141 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0945524 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0900804 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0874606 |
| VIM | vimentin | 0.0730668 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0620083 |
| LDHA | lactate dehydrogenase A | 0.0559298 |
| PTMA | prothymosin, alpha | 0.0537442 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0528286 |
| MSN | moesin | 0.0513722 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0511394 |
| B2M | beta-2-microglobulin | 0.0507615 |
| RACK1 | receptor for activated C kinase 1 | 0.050578 |
| CENPF | centromere protein F, 350/400kDa | 0.0501233 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.048944 |
| RPS8 | ribosomal protein S8 | 0.0477934 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0470276 |
| BRD2 | bromodomain containing 2 | 0.0460913 |
| NDRG1 | N-myc downstream regulated 1 | 0.0455315 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0454195 |
| CALR | calreticulin | 0.0439194 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0431752 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.043084 |
| ZNF395 | zinc finger protein 395 | 0.0426795 |
| FAM13A | family with sequence similarity 13, member A | 0.0426115 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0418289 |
| VEGFA | vascular endothelial growth factor A | 0.0401867 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0393069 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0378131 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0377986 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0377747 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0360903 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0359969 |
| MKI67 | marker of proliferation Ki-67 | 0.0358241 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0352315 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0352274 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0350816 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0347312 |
| TLN1 | talin 1 | 0.034727 |
| TAPBP | TAP binding protein (tapasin) | 0.0345636 |
| TXNIP | thioredoxin interacting protein | 0.033623 |
| INHBA | inhibin, beta A | 0.0334493 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0318832 |
| RPS3 | ribosomal protein S3 | 0.0311617 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0310961 |
| GOLGB1 | golgin B1 | 0.0302574 |
| RPL32 | ribosomal protein L32 | 0.0302187 |
| HYOU1 | hypoxia up-regulated 1 | 0.0301878 |
| SEC61G | Sec61 gamma subunit | 0.0301746 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | 0.0300571 |
| EGR1 | early growth response 1 | 0.0298464 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0294948 |
| TPI1 | triosephosphate isomerase 1 | 0.0294723 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0292964 |
| FOSL1 | FOS-like antigen 1 | 0.0291701 |
| RPL18 | ribosomal protein L18 | 0.0283101 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0278082 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.027774 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0273679 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.026906 |
| FAM107B | family with sequence similarity 107, member B | 0.0265145 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.026204 |
| YBX1 | Y box binding protein 1 | 0.0259494 |
| RPS12 | ribosomal protein S12 | 0.0255754 |
| H1-2 | H1.2 linker histone, cluster member | 0.0255341 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0249675 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0248607 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0248228 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0248011 |
| TPM3 | tropomyosin 3 | 0.0247131 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0246821 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0245543 |
| HELZ | helicase with zinc finger | 0.0245412 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0243445 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0242667 |
| PCBP3 | poly(rC) binding protein 3 | 0.0241053 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0240719 |
| TGFB1 | transforming growth factor, beta 1 | 0.0235821 |
| SEPTIN7 | septin 7 | 0.0235524 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0234895 |
| RPL36 | ribosomal protein L36 | 0.0233796 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0230314 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0229301 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0228498 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0224586 |
| CTSB | cathepsin B | 0.0223089 |
| CD44 | CD44 molecule (Indian blood group) | 0.0223053 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0220843 |
| FAM219A | family with sequence similarity 219, member A | 0.0218922 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0218596 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0218439 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0218319 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0217043 |
| ZNF292 | zinc finger protein 292 | 0.0213519 |
| CKAP5 | cytoskeleton associated protein 5 | 0.021214 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NALF1 | NALCN channel auxiliary factor 1 | -0.141623 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.112359 |
| FN1 | fibronectin 1 | -0.104273 |
| GRB10 | growth factor receptor-bound protein 10 | -0.101729 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0927365 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0819724 |
| TNS3 | tensin 3 | -0.0789174 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0788644 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0695782 |
| CADM1 | cell adhesion molecule 1 | -0.0687655 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0686834 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0653906 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0636979 |
| VCL | vinculin | -0.059018 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0554997 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0549194 |
| FTL | ferritin, light polypeptide | -0.0537827 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0532878 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0495614 |
| DST | dystonin | -0.0491872 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0491185 |
| LOX | lysyl oxidase | -0.0490575 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0478429 |
| SBF2 | SET binding factor 2 | -0.0470378 |
| OSMR | oncostatin M receptor | -0.0468526 |
| TPM4 | tropomyosin 4 | -0.0465037 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0452997 |
| AHNAK | AHNAK nucleoprotein | -0.0440567 |
| PTCHD4 | patched domain containing 4 | -0.0432852 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0424854 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0420506 |
| AUTS2 | autism susceptibility candidate 2 | -0.040792 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0401996 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0394061 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0393107 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0391625 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0388502 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0381533 |
| ATXN1 | ataxin 1 | -0.037631 |
| FAM20C | family with sequence similarity 20, member C | -0.0372539 |
| AHR | aryl hydrocarbon receptor | -0.0368151 |
| FBXO11 | F-box protein 11 | -0.0361528 |
| CDK13 | cyclin-dependent kinase 13 | -0.035993 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0358918 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0355634 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0355416 |
| NF1 | neurofibromin 1 | -0.0351326 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0347075 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.0341621 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0337257 |
| RPS24 | ribosomal protein S24 | -0.033665 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0333757 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0332549 |
| NAV3 | neuron navigator 3 | -0.0332287 |
| MAP4 | microtubule-associated protein 4 | -0.0330915 |
| ACTN4 | actinin, alpha 4 | -0.0330651 |
| IGF2 | insulin-like growth factor 2 | -0.0324544 |
| CDK14 | cyclin-dependent kinase 14 | -0.0324486 |
| ZNF804A | zinc finger protein 804A | -0.0320065 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0315932 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0314967 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0313577 |
| CUX1 | cut-like homeobox 1 | -0.0310947 |
| LYPD6B | LY6/PLAUR domain containing 6B | -0.0306735 |
| TENM3 | teneurin transmembrane protein 3 | -0.0302242 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0299583 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0294714 |
| SQSTM1 | sequestosome 1 | -0.0293691 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0292193 |
| GPC6 | glypican 6 | -0.0290309 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0285931 |
| HIP1 | huntingtin interacting protein 1 | -0.0285896 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0284197 |
| IL6ST | interleukin 6 signal transducer | -0.028308 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0282771 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0280218 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.0278705 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0277404 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0276994 |
| SPAG9 | sperm associated antigen 9 | -0.0273417 |
| HS6ST3 | heparan sulfate 6-O-sulfotransferase 3 | -0.0271568 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0269151 |
| BPTF | bromodomain PHD finger transcription factor | -0.0267218 |
| GDF15 | growth differentiation factor 15 | -0.0264923 |
| TNRC18 | trinucleotide repeat containing 18 | -0.0264363 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0264337 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0263313 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0263044 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0262927 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0261945 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0260286 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0259774 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.025863 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0256603 |
| ANK2 | ankyrin 2, neuronal | -0.0256337 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0256202 |
| USP34 | ubiquitin specific peptidase 34 | -0.025571 |
| SEC24D | SEC24 family member D | -0.0254781 |
| TNNC1 | troponin C type 1 (slow) | -0.0253682 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0251253 |
