| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.116379 |
| INTS6 | integrator complex subunit 6 | 0.0812786 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0760638 |
| RPS3 | ribosomal protein S3 | 0.0675818 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0650421 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0572516 |
| LRRC23 | leucine rich repeat containing 23 | 0.0545746 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0501878 |
| RPS8 | ribosomal protein S8 | 0.0485874 |
| EGR1 | early growth response 1 | 0.0475454 |
| RPS6 | ribosomal protein S6 | 0.0468566 |
| RPS12 | ribosomal protein S12 | 0.0463563 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0453846 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0453615 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0421894 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0410308 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0373348 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0350597 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0342134 |
| RPL37A | ribosomal protein L37a | 0.0333856 |
| GOLGB1 | golgin B1 | 0.0330401 |
| BRD2 | bromodomain containing 2 | 0.0326933 |
| HOMER1 | homer scaffolding protein 1 | 0.0313302 |
| POTEF | POTE ankyrin domain family, member F | 0.0309315 |
| RPS2 | ribosomal protein S2 | 0.0299636 |
| RACK1 | receptor for activated C kinase 1 | 0.0282157 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.0281993 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0281172 |
| RPL26 | ribosomal protein L26 | 0.0273489 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0268624 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0267777 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0263954 |
| SFTPA2 | surfactant protein A2 | 0.0260386 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0260117 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.025704 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | 0.0253514 |
| AREG | amphiregulin | 0.0250349 |
| RPL18 | ribosomal protein L18 | 0.0242473 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0241446 |
| RPL36 | ribosomal protein L36 | 0.0238359 |
| JUN | jun proto-oncogene | 0.0236369 |
| AEBP2 | AE binding protein 2 | 0.0225284 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0221858 |
| MACROD2 | MACRO domain containing 2 | 0.0220006 |
| TAPBP | TAP binding protein (tapasin) | 0.0218765 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.021847 |
| RPL7 | ribosomal protein L7 | 0.0216593 |
| RPS17 | ribosomal protein S17 | 0.0213763 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0213449 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.020729 |
| ASPH | aspartate beta-hydroxylase | 0.0206862 |
| TGFB1 | transforming growth factor, beta 1 | 0.0206171 |
| RPS27 | ribosomal protein S27 | 0.0206103 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0205462 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0204737 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0199483 |
| ZFP36 | ZFP36 ring finger protein | 0.0199098 |
| IER2 | immediate early response 2 | 0.0197254 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.019598 |
| RPS18 | ribosomal protein S18 | 0.0193968 |
| UTRN | utrophin | 0.0185718 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0184774 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0184591 |
| TPM3 | tropomyosin 3 | 0.0182675 |
| HLA-B | major histocompatibility complex, class I, B | 0.0182338 |
| DST | dystonin | 0.0182248 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0181689 |
| MCL1 | myeloid cell leukemia 1 | 0.0181208 |
| NABP1 | nucleic acid binding protein 1 | 0.0180876 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0180364 |
| VCL | vinculin | 0.0179763 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.017942 |
| FAM107B | family with sequence similarity 107, member B | 0.0178489 |
| VIM | vimentin | 0.0178116 |
| TLN1 | talin 1 | 0.0176187 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0172846 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0172706 |
| PRKCA | protein kinase C, alpha | 0.0171561 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0170541 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0168743 |
| POU2F2 | POU class 2 homeobox 2 | 0.0167786 |
| BAIAP2 | BAI1-associated protein 2 | 0.0167721 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0166919 |
| SGMS2 | sphingomyelin synthase 2 | 0.0166592 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0165544 |
| TUFT1 | tuftelin 1 | 0.016423 |
| RPL37 | ribosomal protein L37 | 0.0164145 |
| TRIM72 | tripartite motif containing 72, E3 ubiquitin protein ligase | 0.0163564 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0161608 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0160566 |
| H1-4 | H1.4 linker histone, cluster member | 0.0159881 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0159285 |
| EFNB2 | ephrin-B2 | 0.0157558 |
| PNN | pinin, desmosome associated protein | 0.0155249 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.01549 |
| SQSTM1 | sequestosome 1 | 0.015433 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | 0.0154314 |
| TMA7 | translation machinery associated 7 homolog (S. cerevisiae) | 0.0153317 |
| CLU | clusterin | 0.0152948 |
| POLN | polymerase (DNA directed) nu | 0.0152897 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FAT1 | FAT atypical cadherin 1 | -0.206738 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.203707 |
| AHNAK | AHNAK nucleoprotein | -0.144201 |
| PTMA | prothymosin, alpha | -0.142196 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.123451 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.109919 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.10468 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.104559 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.091024 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0807729 |
| MKI67 | marker of proliferation Ki-67 | -0.0807675 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0787953 |
| MED13L | mediator complex subunit 13-like | -0.07124 |
| NF1 | neurofibromin 1 | -0.0701429 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0680346 |
| NDRG1 | N-myc downstream regulated 1 | -0.0676055 |
| TMSB10 | thymosin beta 10 | -0.0656282 |
| TPM4 | tropomyosin 4 | -0.0647829 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0606016 |
| RAD51B | RAD51 paralog B | -0.060523 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0600041 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0591712 |
| SERINC5 | serine incorporator 5 | -0.0577995 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.05619 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0553766 |
| MSI2 | musashi RNA-binding protein 2 | -0.0522762 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0515524 |
| SETD5 | SET domain containing 5 | -0.050915 |
| DIAPH3 | diaphanous-related formin 3 | -0.0508659 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0505802 |
| KRT18 | keratin 18, type I | -0.0491047 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0477923 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0474988 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0472058 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0471977 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0469177 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0468162 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.046457 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0462004 |
| JMJD1C | jumonji domain containing 1C | -0.0453828 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0452876 |
| RPS24 | ribosomal protein S24 | -0.0451519 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0450044 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0439519 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0436914 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0433875 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0428436 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0423933 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0420122 |
| ZNF292 | zinc finger protein 292 | -0.0414408 |
| TUBB | tubulin, beta class I | -0.0411382 |
| ZNF207 | zinc finger protein 207 | -0.041063 |
| XPO1 | exportin 1 | -0.0408459 |
| USP34 | ubiquitin specific peptidase 34 | -0.0407415 |
| PGK1 | phosphoglycerate kinase 1 | -0.040495 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0403236 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0398635 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0396907 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0396316 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0395664 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0391202 |
| WDR45B | WD repeat domain 45B | -0.0389403 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.0388707 |
| NUP58 | nucleoporin 58 | -0.0386987 |
| FDPS | farnesyl diphosphate synthase | -0.0385148 |
| CD2AP | CD2-associated protein | -0.0382078 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0378451 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0374815 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0373614 |
| ARF4 | ADP-ribosylation factor 4 | -0.0372023 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.03712 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0362308 |
| PRELID2 | PRELI domain containing 2 | -0.0356486 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0355923 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0355467 |
| OGA | O-GlcNAcase | -0.0355075 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0353544 |
| CENPF | centromere protein F, 350/400kDa | -0.0350004 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0348974 |
| TUBA1B | tubulin, alpha 1b | -0.0346828 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0346503 |
| RLF | rearranged L-myc fusion | -0.0345838 |
| HMGB2 | high mobility group box 2 | -0.0344354 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0343863 |
| OLA1 | Obg-like ATPase 1 | -0.033921 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0337507 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0336472 |
| PTK2 | protein tyrosine kinase 2 | -0.0334728 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0331818 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0330732 |
| SHROOM3 | shroom family member 3 | -0.0329373 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0328509 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0324534 |
| SRP54 | signal recognition particle 54kDa | -0.0323487 |
| FAM117B | family with sequence similarity 117, member B | -0.0322463 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0322439 |
| ANKRD11 | ankyrin repeat domain 11 | -0.031979 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0319726 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.031932 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.031841 |
