| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the AZD-7648_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.149924 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.138644 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.12493 |
| RPS3 | ribosomal protein S3 | 0.100825 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0875313 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.083015 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0787336 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0780519 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0724829 |
| GOLGB1 | golgin B1 | 0.0715965 |
| GOLGA4 | golgin A4 | 0.0696617 |
| SET | SET nuclear proto-oncogene | 0.0673446 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0663016 |
| RPS6 | ribosomal protein S6 | 0.0590866 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0549893 |
| RPS2 | ribosomal protein S2 | 0.0545184 |
| RPS12 | ribosomal protein S12 | 0.0529823 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0518296 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0503275 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0482344 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0461179 |
| ECT2 | epithelial cell transforming 2 | 0.0459588 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0457822 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0455894 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0453639 |
| TAPBP | TAP binding protein (tapasin) | 0.0448818 |
| BRD2 | bromodomain containing 2 | 0.0415955 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0415263 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0411878 |
| SON | SON DNA binding protein | 0.040951 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0407825 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.039883 |
| CENPF | centromere protein F, 350/400kDa | 0.0395464 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0389015 |
| MKI67 | marker of proliferation Ki-67 | 0.0388775 |
| RPL14 | ribosomal protein L14 | 0.0385866 |
| RPL26 | ribosomal protein L26 | 0.0385791 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0383829 |
| TMF1 | TATA element modulatory factor 1 | 0.0382827 |
| TMA7 | translation machinery associated 7 homolog (S. cerevisiae) | 0.0380647 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0370893 |
| AFDN | afadin, adherens junction formation factor | 0.035847 |
| SMAD3 | SMAD family member 3 | 0.0352413 |
| FLNA | filamin A, alpha | 0.0350257 |
| PNN | pinin, desmosome associated protein | 0.0348511 |
| RPL18 | ribosomal protein L18 | 0.0346097 |
| ATXN1 | ataxin 1 | 0.0339506 |
| RPL37A | ribosomal protein L37a | 0.0334036 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0326837 |
| RND3 | Rho family GTPase 3 | 0.0321065 |
| KRT86 | keratin 86, type II | 0.0318267 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0315839 |
| RACK1 | receptor for activated C kinase 1 | 0.0314886 |
| RPS8 | ribosomal protein S8 | 0.0312935 |
| PHF3 | PHD finger protein 3 | 0.0312551 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0303078 |
| TPM3 | tropomyosin 3 | 0.0300021 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0299024 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0298756 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0298638 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0296583 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0296208 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0293351 |
| RUNX1 | runt-related transcription factor 1 | 0.0289544 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0284747 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0284507 |
| VMP1 | vacuole membrane protein 1 | 0.0284481 |
| BBX | bobby sox homolog (Drosophila) | 0.0281407 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0280086 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0277671 |
| RPS17 | ribosomal protein S17 | 0.0277122 |
| SFPQ | splicing factor proline/glutamine-rich | 0.027639 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0272118 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0268477 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0268134 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.0266059 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0262149 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 0.0261245 |
| H1-4 | H1.4 linker histone, cluster member | 0.0261091 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.025947 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.025935 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0256472 |
| ASPH | aspartate beta-hydroxylase | 0.0254628 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0253948 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0248771 |
| DSPP | dentin sialophosphoprotein | 0.0248279 |
| BICC1 | BicC family RNA binding protein 1 | 0.0244358 |
| RBM12 | RNA binding motif protein 12 | 0.0242331 |
| DSTN | destrin (actin depolymerizing factor) | 0.023955 |
| SVIL | supervillin | 0.0236482 |
| MYOF | myoferlin | 0.0236435 |
| NOTCH2 | notch 2 | 0.0234002 |
| FNIP1 | folliculin interacting protein 1 | 0.0232571 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0232401 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.0231375 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0229465 |
| APP | amyloid beta (A4) precursor protein | 0.0229239 |
| PAPOLA | poly(A) polymerase alpha | 0.0229142 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0219758 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0218717 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.215216 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.187869 |
| TMSB10 | thymosin beta 10 | -0.114517 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.11444 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.110741 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0998383 |
| HMGA1 | high mobility group AT-hook 1 | -0.092035 |
| TPM4 | tropomyosin 4 | -0.0873202 |
| FTL | ferritin, light polypeptide | -0.083444 |
| CCND1 | cyclin D1 | -0.0756607 |
| RPLP1 | ribosomal protein, large, P1 | -0.0744358 |
| NDRG1 | N-myc downstream regulated 1 | -0.0645011 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0644806 |
| MT2A | metallothionein 2A | -0.0630563 |
| RPS24 | ribosomal protein S24 | -0.0619249 |
| ACTG1 | actin gamma 1 | -0.0612104 |
| PKM | pyruvate kinase, muscle | -0.0594832 |
| ANXA2 | annexin A2 | -0.0588862 |
| KRT7 | keratin 7, type II | -0.0560173 |
| PGK1 | phosphoglycerate kinase 1 | -0.0554356 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0549904 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0540217 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0519033 |
| NF1 | neurofibromin 1 | -0.0502246 |
| TXNRD1 | thioredoxin reductase 1 | -0.0500961 |
| AHNAK | AHNAK nucleoprotein | -0.0489583 |
| GNAS | GNAS complex locus | -0.0482129 |
| RPLP0 | ribosomal protein, large, P0 | -0.0480477 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0466383 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.0459674 |
| S100A6 | S100 calcium binding protein A6 | -0.0453668 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0441556 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0419079 |
| HMGA2 | high mobility group AT-hook 2 | -0.0417183 |
| ENO1 | enolase 1, (alpha) | -0.0401576 |
| S100A10 | S100 calcium binding protein A10 | -0.0401252 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.0400817 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0383707 |
| CDCP1 | CUB domain containing protein 1 | -0.0375946 |
| CD44 | CD44 molecule (Indian blood group) | -0.0372871 |
| TUBB | tubulin, beta class I | -0.0369157 |
| ATG7 | autophagy related 7 | -0.0367287 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0362893 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0361175 |
| WDR45B | WD repeat domain 45B | -0.0360149 |
| EGR1 | early growth response 1 | -0.0353963 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0350215 |
| TUBA1B | tubulin, alpha 1b | -0.0345249 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0344004 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0341215 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0340031 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0338414 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0338249 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0334256 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0328579 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.032666 |
| MAP4 | microtubule-associated protein 4 | -0.0324608 |
| KRT18 | keratin 18, type I | -0.0324505 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0323622 |
| BPTF | bromodomain PHD finger transcription factor | -0.0321895 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0316943 |
| RPL27A | ribosomal protein L27a | -0.0316734 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0314745 |
| KRT19 | keratin 19, type I | -0.0314566 |
| RPS25 | ribosomal protein S25 | -0.0313382 |
| SEPTIN10 | septin 10 | -0.0311292 |
| RPS16 | ribosomal protein S16 | -0.031044 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0308586 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.030601 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0303067 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.030206 |
| PCED1B | PC-esterase domain containing 1B | -0.0301247 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0300331 |
| CLDN1 | claudin 1 | -0.0298386 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0296377 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0294997 |
| ARF1 | ADP-ribosylation factor 1 | -0.0294644 |
| SETD5 | SET domain containing 5 | -0.0289273 |
| LASP1 | LIM and SH3 protein 1 | -0.0286439 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0285295 |
| VCL | vinculin | -0.0281379 |
| HMGB1 | high mobility group box 1 | -0.0280087 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0279638 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.02775 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.027723 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0272284 |
| XPO1 | exportin 1 | -0.0271704 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0271311 |
| GRAMD2B | GRAM domain containing 2B | -0.0270595 |
| USP34 | ubiquitin specific peptidase 34 | -0.0267887 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0267722 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0267661 |
| ZNF609 | zinc finger protein 609 | -0.0267627 |
| TAOK1 | TAO kinase 1 | -0.0264328 |
| RPL34 | ribosomal protein L34 | -0.026271 |
| S100A4 | S100 calcium binding protein A4 | -0.0260869 |
| CAPNS1 | calpain, small subunit 1 | -0.0259665 |
| RPS5 | ribosomal protein S5 | -0.0258775 |
| TKT | transketolase | -0.025756 |
| RPL28 | ribosomal protein L28 | -0.0256572 |
