AZD-7648_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-7648 perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-7648_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.424522
MT2A metallothionein 2A 0.234082
TMSB10 thymosin beta 10 0.186483
ASPH aspartate beta-hydroxylase 0.150721
HMGA2 high mobility group AT-hook 2 0.140175
RPS6 ribosomal protein S6 0.130929
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.124598
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.11534
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.111542
EXT1 exostosin glycosyltransferase 1 0.109424
COL5A1 collagen, type V, alpha 1 0.106858
CD44 CD44 molecule (Indian blood group) 0.0981545
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0937497
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0928056
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0890755
RPS8 ribosomal protein S8 0.0889482
RPL12 ribosomal protein L12 0.0858042
NAV1 neuron navigator 1 0.0842065
AHNAK AHNAK nucleoprotein 0.080253
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0789366
CXCL8 chemokine (C-X-C motif) ligand 8 0.0783398
TPT1 tumor protein, translationally-controlled 1 0.0758025
ENO1 enolase 1, (alpha) 0.0749078
AKAP12 A kinase (PRKA) anchor protein 12 0.0715166
RPS3 ribosomal protein S3 0.0712704
CDH13 cadherin 13 0.0704093
INHBA inhibin, beta A 0.0680861
RAI14 retinoic acid induced 14 0.0654774
MYO10 myosin X 0.0653891
LAMB3 laminin, beta 3 0.0635162
PTMA prothymosin, alpha 0.0622899
ACTG1 actin gamma 1 0.0617917
IL1B interleukin 1, beta 0.0585053
RPS19 ribosomal protein S19 0.0565017
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0561063
EIF1 eukaryotic translation initiation factor 1 0.056028
NALF1 NALCN channel auxiliary factor 1 0.055854
RPL23 ribosomal protein L23 0.055774
DST dystonin 0.0553947
LOC102724023 ES1 protein homolog, mitochondrial 0.0552468
TIMP1 TIMP metallopeptidase inhibitor 1 0.0539035
RPL37A ribosomal protein L37a 0.051979
RPL35A ribosomal protein L35a 0.0513954
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0502012
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0496303
ANXA2 annexin A2 0.0485202
RPS12 ribosomal protein S12 0.0484854
RPL32 ribosomal protein L32 0.0479437
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0467088
TPI1 triosephosphate isomerase 1 0.0464693
MAP1B microtubule-associated protein 1B 0.0458685
RPL19 ribosomal protein L19 0.0454894
RPL31 ribosomal protein L31 0.0442279
RPL9 ribosomal protein L9 0.0433012
SEPTIN9 septin 9 0.041817
COL6A2 collagen, type VI, alpha 2 0.0417353
RPLP1 ribosomal protein, large, P1 0.0415462
RPLP2 ribosomal protein, large, P2 0.0412025
NAP1L1 nucleosome assembly protein 1-like 1 0.0400094
CAVIN1 caveolae associated protein 1 0.0398304
RPL26 ribosomal protein L26 0.0396888
RPL34 ribosomal protein L34 0.039529
RPL11 ribosomal protein L11 0.0389403
COL6A3 collagen, type VI, alpha 3 0.0389352
ANGPTL4 angiopoietin-like 4 0.0388513
RPL37 ribosomal protein L37 0.0384473
RPS27A ribosomal protein S27a 0.0383348
LDHA lactate dehydrogenase A 0.0381872
LMNA lamin A/C 0.0379322
RACK1 receptor for activated C kinase 1 0.0377645
PRSS23 protease, serine, 23 0.0376445
ANKRD11 ankyrin repeat domain 11 0.03744
G0S2 G0/G1 switch 2 0.0369263
ZBTB38 zinc finger and BTB domain containing 38 0.0365996
FN1 fibronectin 1 0.0363964
EGFR epidermal growth factor receptor 0.0363959
CAPN2 calpain 2, (m/II) large subunit 0.0363043
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0363001
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0362954
RPS17 ribosomal protein S17 0.0360647
CLMP CXADR-like membrane protein 0.0360522
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0359698
CCND1 cyclin D1 0.0356518
B2M beta-2-microglobulin 0.0356485
RPS4X ribosomal protein S4, X-linked 0.0354914
S100A10 S100 calcium binding protein A10 0.0350315
ANKRD12 ankyrin repeat domain 12 0.0349502
RPLP0 ribosomal protein, large, P0 0.0341465
RPS13 ribosomal protein S13 0.034051
PCBP3 poly(rC) binding protein 3 0.0337094
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0335904
RRBP1 ribosome binding protein 1 0.0335577
SH3KBP1 SH3-domain kinase binding protein 1 0.0333055
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0331842
HLA-B major histocompatibility complex, class I, B 0.0330888
BASP1 brain abundant, membrane attached signal protein 1 0.0325556
BICD1 bicaudal D homolog 1 (Drosophila) 0.0322815
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0321631
MYH9 myosin, heavy chain 9, non-muscle 0.0321277
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0319973

decreased expression

Symbol Name Standardized Value
ELL2 elongation factor, RNA polymerase II, 2 -0.0541
FNDC3B fibronectin type III domain containing 3B -0.0422093
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0386251
FAM13A family with sequence similarity 13, member A -0.0303021
SPAG9 sperm associated antigen 9 -0.0283658
NUP58 nucleoporin 58 -0.0255182
USP3 ubiquitin specific peptidase 3 -0.0244966
RNMT RNA (guanine-7-) methyltransferase -0.0242821
ZNF292 zinc finger protein 292 -0.0237229
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0225386
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0220058
NGLY1 N-glycanase 1 -0.0214079
LCORL ligand dependent nuclear receptor corepressor-like -0.0212099
THBS1 thrombospondin 1 -0.0205762
SBF2 SET binding factor 2 -0.019377
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0180745
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0170542
HELZ helicase with zinc finger -0.0169531
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0157794
FOXO3 forkhead box O3 -0.0157405
KMT2E lysine (K)-specific methyltransferase 2E -0.0156183
WDR45B WD repeat domain 45B -0.0154877
NAMPT nicotinamide phosphoribosyltransferase -0.0154295
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.01537
ZNF207 zinc finger protein 207 -0.0153292
FOXJ3 forkhead box J3 -0.0153188
CD109 CD109 molecule -0.0152626
MIS18BP1 MIS18 binding protein 1 -0.0150287
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0150065
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.0148229
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -0.0143731
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0142886
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0142836
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.014192
KDM2A lysine (K)-specific demethylase 2A -0.0138804
ADAM17 ADAM metallopeptidase domain 17 -0.013715
POM121 POM121 transmembrane nucleoporin -0.0136754
SP3 Sp3 transcription factor -0.0134883
SRP54 signal recognition particle 54kDa -0.0132898
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0129786
TENT4A terminal nucleotidyltransferase 4A -0.0129556
SGO2 shugoshin 2 -0.0129544
SFXN1 sideroflexin 1 -0.0129146
HOOK2 hook microtubule-tethering protein 2 -0.0128669
CEP192 centrosomal protein 192kDa -0.0127916
OGA O-GlcNAcase -0.0127831
SEC24A SEC24 family member A -0.0127623
ZNF654 zinc finger protein 654 -0.0126225
RNF24 ring finger protein 24 -0.0124781
XPO1 exportin 1 -0.0124327
DEPP1 DEPP autophagy regulator 1 -0.0124196
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0124177
TGFBI transforming growth factor, beta-induced, 68kDa -0.0123427
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0122363
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0122078
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0120811
KDM3A lysine (K)-specific demethylase 3A -0.0120618
RLF rearranged L-myc fusion -0.0120134
TPX2 TPX2, microtubule-associated -0.0119925
ECT2 epithelial cell transforming 2 -0.0119919
KIF18A kinesin family member 18A -0.0119238
YEATS2 YEATS domain containing 2 -0.0119008
TFG TRK-fused gene -0.0117959
TSC22D2 TSC22 domain family, member 2 -0.0115939
LPIN2 lipin 2 -0.0115526
AFF4 AF4/FMR2 family, member 4 -0.0114937
FBXO42 F-box protein 42 -0.0114798
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -0.0113758
RFWD3 ring finger and WD repeat domain 3 -0.0111116
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.0110323
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0108714
CHSY1 chondroitin sulfate synthase 1 -0.0108629
RAB8B RAB8B, member RAS oncogene family -0.0107822
MIMS1 mitochondrial inner membrane scaffold 1 -0.0107518
UGCG UDP-glucose ceramide glucosyltransferase -0.0107153
GAS2L3 growth arrest-specific 2 like 3 -0.0105434
WDR26 WD repeat domain 26 -0.0104845
POM121C POM121 transmembrane nucleoporin C -0.0104034
ADAM9 ADAM metallopeptidase domain 9 -0.0103959
ETNK1 ethanolamine kinase 1 -0.010362
IQGAP3 IQ motif containing GTPase activating protein 3 -0.0103526
SEC23A Sec23 homolog A (S. cerevisiae) -0.0103389
ZNF148 zinc finger protein 148 -0.0103055
NUP153 nucleoporin 153kDa -0.0102574
ARRDC3 arrestin domain containing 3 -0.0102304
TBC1D23 TBC1 domain family, member 23 -0.0101571
CRLS1 cardiolipin synthase 1 -0.0099675
ATP13A3 ATPase type 13A3 -0.0099567
TAC4 tachykinin 4 (hemokinin) -0.00986271
CKAP2 cytoskeleton associated protein 2 -0.00985933
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.00985784
ZFC3H1 zinc finger, C3H1-type containing -0.00984661
MAP2K4 mitogen-activated protein kinase kinase 4 -0.00980901
INSIG2 insulin induced gene 2 -0.00978483
AKAP10 A kinase (PRKA) anchor protein 10 -0.00977327
AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae) -0.00954711
RAB6A RAB6A, member RAS oncogene family -0.00951301
SPRED1 sprouty-related, EVH1 domain containing 1 -0.00950933
TMEM39A transmembrane protein 39A -0.00950416
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.00949009