| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.298151 |
| MT2A | metallothionein 2A | 0.265141 |
| VIM | vimentin | 0.227505 |
| NDRG1 | N-myc downstream regulated 1 | 0.181575 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.1321 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.1252 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.114991 |
| TMSB10 | thymosin beta 10 | 0.11131 |
| STC1 | stanniocalcin 1 | 0.0981586 |
| RPS8 | ribosomal protein S8 | 0.0928955 |
| RPS6 | ribosomal protein S6 | 0.0928544 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0906397 |
| VEGFA | vascular endothelial growth factor A | 0.0895837 |
| CD44 | CD44 molecule (Indian blood group) | 0.0772106 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0702636 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0676801 |
| LDHA | lactate dehydrogenase A | 0.0660651 |
| RPS3 | ribosomal protein S3 | 0.0656111 |
| PTMA | prothymosin, alpha | 0.0607549 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0596793 |
| CALR | calreticulin | 0.0593428 |
| ENO1 | enolase 1, (alpha) | 0.0593076 |
| INHBA | inhibin, beta A | 0.0590517 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0533508 |
| B2M | beta-2-microglobulin | 0.052629 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.05194 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.05191 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0511157 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0507067 |
| GOLGA4 | golgin A4 | 0.0505833 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0498828 |
| GOLGB1 | golgin B1 | 0.0495558 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0487923 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0486537 |
| RPL35A | ribosomal protein L35a | 0.0481663 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0481407 |
| RACK1 | receptor for activated C kinase 1 | 0.0480795 |
| RPS19 | ribosomal protein S19 | 0.0472011 |
| RPL26 | ribosomal protein L26 | 0.0469063 |
| YBX1 | Y box binding protein 1 | 0.0460886 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0458174 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0457982 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0440338 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0438684 |
| RPL37A | ribosomal protein L37a | 0.0436386 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0435192 |
| RPL5 | ribosomal protein L5 | 0.0431688 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0425215 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0411267 |
| FAM107B | family with sequence similarity 107, member B | 0.0403781 |
| MTDH | metadherin | 0.0402846 |
| RPL7 | ribosomal protein L7 | 0.0397869 |
| RPL36 | ribosomal protein L36 | 0.0395343 |
| RPL11 | ribosomal protein L11 | 0.0389977 |
| RPL19 | ribosomal protein L19 | 0.0389345 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0385903 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.038056 |
| RPS12 | ribosomal protein S12 | 0.0380114 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0379993 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0375143 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0369732 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0368027 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0364827 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0362199 |
| TAPBP | TAP binding protein (tapasin) | 0.0354075 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0351338 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0348368 |
| RPL8 | ribosomal protein L8 | 0.034279 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0342433 |
| HLA-B | major histocompatibility complex, class I, B | 0.0341973 |
| RPL12 | ribosomal protein L12 | 0.0340623 |
| RPS2 | ribosomal protein S2 | 0.0338163 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0336324 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0335745 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0326168 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.032257 |
| RPL32 | ribosomal protein L32 | 0.031914 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0318205 |
| RND3 | Rho family GTPase 3 | 0.0317357 |
| S100A9 | S100 calcium binding protein A9 | 0.0315614 |
| HDLBP | high density lipoprotein binding protein | 0.0315436 |
| RPL37 | ribosomal protein L37 | 0.0309525 |
| EGR1 | early growth response 1 | 0.030866 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0304651 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0303429 |
| ARRDC3 | arrestin domain containing 3 | 0.0302573 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0298289 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0296136 |
| RPL23 | ribosomal protein L23 | 0.0294048 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | 0.0293382 |
| ADM | adrenomedullin | 0.0291799 |
| TMF1 | TATA element modulatory factor 1 | 0.0291376 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.028354 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0283218 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0281509 |
| SFTPA2 | surfactant protein A2 | 0.028135 |
| RPL18 | ribosomal protein L18 | 0.0277166 |
| IER3 | immediate early response 3 | 0.0275742 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0274601 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0272445 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.113019 |
| FN1 | fibronectin 1 | -0.102466 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0788626 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0475093 |
| PRELID2 | PRELI domain containing 2 | -0.0435803 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.041911 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.04152 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0397555 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0378174 |
| CALD1 | caldesmon 1 | -0.0310948 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0310383 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0308184 |
| FRMD4A | FERM domain containing 4A | -0.0286059 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.027971 |
| BNC2 | basonuclin 2 | -0.0276232 |
| CNTN5 | contactin 5 | -0.0274698 |
| SMYD3 | SET and MYND domain containing 3 | -0.0262071 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0249485 |
| VCL | vinculin | -0.0247685 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0244378 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0231342 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0229342 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0225923 |
| CLIC4 | chloride intracellular channel 4 | -0.0225471 |
| TENM1 | teneurin transmembrane protein 1 | -0.0225099 |
| SMAD3 | SMAD family member 3 | -0.0206297 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0199995 |
| EBF1 | early B-cell factor 1 | -0.0197661 |
| CADM1 | cell adhesion molecule 1 | -0.0195635 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0193777 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0190658 |
| NREP | neuronal regeneration related protein | -0.0188269 |
| TPM1 | tropomyosin 1 (alpha) | -0.0186175 |
| FBN1 | fibrillin 1 | -0.0182825 |
| ZFHX3 | zinc finger homeobox 3 | -0.0177815 |
| LOXL2 | lysyl oxidase-like 2 | -0.0176709 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0176656 |
| COL1A2 | collagen, type I, alpha 2 | -0.0174173 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0172445 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0172394 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0170202 |
| COL5A1 | collagen, type V, alpha 1 | -0.0166045 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | -0.0166003 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0164416 |
| TNS3 | tensin 3 | -0.0163411 |
| TRAM2 | translocation associated membrane protein 2 | -0.0163355 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0160111 |
| RNF220 | ring finger protein 220 | -0.0158026 |
| DST | dystonin | -0.0157542 |
| POSTN | periostin, osteoblast specific factor | -0.0154681 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0154017 |
| VEPH1 | ventricular zone expressed PH domain-containing 1 | -0.0153959 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0153714 |
| NABP1 | nucleic acid binding protein 1 | -0.015364 |
| EXOC4 | exocyst complex component 4 | -0.0150792 |
| ATP13A3 | ATPase type 13A3 | -0.015073 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.0150683 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0150509 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0150126 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0146483 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0146259 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0145282 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0145021 |
| NBEAL1 | neurobeachin-like 1 | -0.014423 |
| RUNX2 | runt-related transcription factor 2 | -0.0140425 |
| CHD6 | chromodomain helicase DNA binding protein 6 | -0.0139694 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0136537 |
| TENM3 | teneurin transmembrane protein 3 | -0.0135687 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0134402 |
| RBFOX1 | RNA binding protein, fox-1 homolog (C. elegans) 1 | -0.013431 |
| PRR16 | proline rich 16 | -0.0133491 |
| SULF1 | sulfatase 1 | -0.0133323 |
| EPHB1 | EPH receptor B1 | -0.0133002 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0132507 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0131882 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0131273 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0131267 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0130462 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.012943 |
| PFKP | phosphofructokinase, platelet | -0.0129271 |
| CEP95 | centrosomal protein 95kDa | -0.0128451 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0128316 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0127663 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0124583 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0124291 |
| CAPRIN1 | cell cycle associated protein 1 | -0.0124045 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0123863 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0123413 |
| KLF12 | Kruppel-like factor 12 | -0.0122059 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0121393 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0120995 |
| ZNF460 | zinc finger protein 460 | -0.0120557 |
| ACLY | ATP citrate lyase | -0.0119932 |
| GPC6 | glypican 6 | -0.0119715 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0119643 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0118272 |
| EHD2 | EH-domain containing 2 | -0.0115091 |
| NRG3 | neuregulin 3 | -0.011493 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0113794 |
| FAM20C | family with sequence similarity 20, member C | -0.0113606 |
