| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.260884 |
| RPS3 | ribosomal protein S3 | 0.10631 |
| RPS6 | ribosomal protein S6 | 0.103708 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0918636 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.079217 |
| RPS19 | ribosomal protein S19 | 0.0775939 |
| RPL18 | ribosomal protein L18 | 0.0766965 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0763567 |
| FAT1 | FAT atypical cadherin 1 | 0.0759183 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0748103 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0743583 |
| TMEM123 | transmembrane protein 123 | 0.070245 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0697778 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0675449 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0649019 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0636545 |
| PTMA | prothymosin, alpha | 0.0631482 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.062946 |
| PLK2 | polo-like kinase 2 | 0.0624988 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0617607 |
| SMAD3 | SMAD family member 3 | 0.0613853 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0609281 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0595565 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.0594052 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0585506 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0557806 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.055707 |
| TLE4 | transducin-like enhancer of split 4 | 0.0555788 |
| EXPH5 | exophilin 5 | 0.0546154 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0544892 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0542057 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0541718 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0540253 |
| DST | dystonin | 0.0531759 |
| TMSB10 | thymosin beta 10 | 0.0514355 |
| RPL23 | ribosomal protein L23 | 0.0504766 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0492159 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0483563 |
| RPS8 | ribosomal protein S8 | 0.0454746 |
| DPP4 | dipeptidyl-peptidase 4 | 0.0433819 |
| TJP1 | tight junction protein 1 | 0.0425291 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0411394 |
| LMNA | lamin A/C | 0.0401927 |
| MYOF | myoferlin | 0.0395781 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0389088 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0385955 |
| SGMS2 | sphingomyelin synthase 2 | 0.0369827 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0367591 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0364769 |
| GOLGA4 | golgin A4 | 0.0364672 |
| SET | SET nuclear proto-oncogene | 0.0359977 |
| CCNYL1 | cyclin Y-like 1 | 0.0357024 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0348757 |
| EPCAM | epithelial cell adhesion molecule | 0.0348063 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0343386 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0340677 |
| FLNB | filamin B, beta | 0.0338636 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0335492 |
| RPS2 | ribosomal protein S2 | 0.0333682 |
| GOLGB1 | golgin B1 | 0.0331727 |
| YBX1 | Y box binding protein 1 | 0.0330202 |
| MYZAP | myocardial zonula adherens protein | 0.0324578 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0320606 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0318667 |
| ATXN1 | ataxin 1 | 0.0317074 |
| KIF5B | kinesin family member 5B | 0.0315846 |
| GOLM1 | golgi membrane protein 1 | 0.0313418 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0304777 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0303924 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.030256 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0301373 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0298751 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0294634 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0291924 |
| HYOU1 | hypoxia up-regulated 1 | 0.0291587 |
| MEF2A | myocyte enhancer factor 2A | 0.0290279 |
| CBX3 | chromobox homolog 3 | 0.0287941 |
| RPL5 | ribosomal protein L5 | 0.0283972 |
| PDE10A | phosphodiesterase 10A | 0.0283581 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0283361 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0283311 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0283209 |
| FAM107B | family with sequence similarity 107, member B | 0.0282543 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0282232 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.0280884 |
| ANXA11 | annexin A11 | 0.0280056 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0279376 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0279251 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0277716 |
| RPLP2 | ribosomal protein, large, P2 | 0.0276966 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0276695 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0276048 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0275424 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0272522 |
| RPL7 | ribosomal protein L7 | 0.0271844 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.027045 |
| ZFP36 | ZFP36 ring finger protein | 0.0269196 |
| SIK3 | SIK family kinase 3 | 0.026708 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0265293 |
| RPL19 | ribosomal protein L19 | 0.0264052 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH14 | myosin, heavy chain 14, non-muscle | -0.161873 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.150548 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.1247 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0975052 |
| NDRG1 | N-myc downstream regulated 1 | -0.0893089 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0845406 |
| RNF213 | ring finger protein 213 | -0.0758763 |
| SLC45A4 | solute carrier family 45, member 4 | -0.072699 |
| LAMA4 | laminin, alpha 4 | -0.0706614 |
| ANXA2 | annexin A2 | -0.0700164 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0695579 |
| FRY | furry homolog (Drosophila) | -0.0685307 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0640331 |
| FOXO3 | forkhead box O3 | -0.0635571 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0602498 |
| DIAPH2 | diaphanous-related formin 2 | -0.0593259 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | -0.0589721 |
| ACTG1 | actin gamma 1 | -0.0541776 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0524407 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0516163 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0514918 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0509219 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.050572 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0493318 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0480178 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0470887 |
| FTL | ferritin, light polypeptide | -0.0468973 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0465224 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0452775 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.045032 |
| KRT19 | keratin 19, type I | -0.0442287 |
| ACTN4 | actinin, alpha 4 | -0.0438228 |
| USP54 | ubiquitin specific peptidase 54 | -0.0407877 |
| LYZ | lysozyme | -0.0406906 |
| VCL | vinculin | -0.0402555 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.03948 |
| SQSTM1 | sequestosome 1 | -0.0393367 |
| HKDC1 | hexokinase domain containing 1 | -0.0392788 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0387005 |
| DGKH | diacylglycerol kinase, eta | -0.0384302 |
| JUN | jun proto-oncogene | -0.0375765 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.0375656 |
| RPS24 | ribosomal protein S24 | -0.0374884 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0370107 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0368508 |
| RDH13 | retinol dehydrogenase 13 (all-trans/9-cis) | -0.0367169 |
| PRELID2 | PRELI domain containing 2 | -0.0364497 |
| MECOM | MDS1 and EVI1 complex locus | -0.0362359 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0360979 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | -0.0360978 |
| RBM47 | RNA binding motif protein 47 | -0.0360458 |
| EGR1 | early growth response 1 | -0.0356222 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0337973 |
| MMP7 | matrix metallopeptidase 7 | -0.0331237 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0331137 |
| KRT20 | keratin 20, type I | -0.0330286 |
| S100A6 | S100 calcium binding protein A6 | -0.032786 |
| SDC4 | syndecan 4 | -0.032618 |
| MCL1 | myeloid cell leukemia 1 | -0.0320859 |
| GSN | gelsolin | -0.0318797 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0303616 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.029888 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0298529 |
| TM4SF4 | transmembrane 4 L six family member 4 | -0.0296146 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.029582 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0294754 |
| MUC13 | mucin 13, cell surface associated | -0.0293807 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0293566 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0290722 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0283537 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0282639 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0282587 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0279348 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.0277564 |
| CCNY | cyclin Y | -0.0275735 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0274833 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0272523 |
| WASF2 | WAS protein family, member 2 | -0.0268473 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0266876 |
| AGR2 | anterior gradient 2 | -0.0266151 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0262449 |
| STK24 | serine/threonine kinase 24 | -0.0259976 |
| INSIG1 | insulin induced gene 1 | -0.0255631 |
| PCED1B | PC-esterase domain containing 1B | -0.0253224 |
| NIBAN2 | niban apoptosis regulator 2 | -0.024054 |
| TRIB1 | tribbles pseudokinase 1 | -0.0239698 |
| CDK19 | cyclin-dependent kinase 19 | -0.0236404 |
| CD2AP | CD2-associated protein | -0.0236368 |
| PYGB | phosphorylase, glycogen; brain | -0.0233873 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0231705 |
| EXOC4 | exocyst complex component 4 | -0.0231593 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0231494 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0230502 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.0229183 |
| ADIPOR2 | adiponectin receptor 2 | -0.0228775 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.0226922 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0225851 |
| PERP | PERP, TP53 apoptosis effector | -0.0223869 |
| CTSD | cathepsin D | -0.0223261 |
| CD82 | CD82 molecule | -0.022248 |
