AZD-7648_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-7648 perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-7648_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.126804
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.122001
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.110325
SVIL supervillin 0.0837928
SPTBN1 spectrin, beta, non-erythrocytic 1 0.083481
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0823902
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0583095
TIMP1 TIMP metallopeptidase inhibitor 1 0.0549235
APOB apolipoprotein B 0.053414
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0472497
IGFBP1 insulin-like growth factor binding protein 1 0.0437147
C3 complement component 3 0.0434974
SAMD4A sterile alpha motif domain containing 4A 0.0430758
PAWR PRKC, apoptosis, WT1, regulator 0.040514
AFDN afadin, adherens junction formation factor 0.0392358
FOXP1 forkhead box P1 0.0386326
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0380194
MACF1 microtubule-actin crosslinking factor 1 0.0364201
MYH9 myosin, heavy chain 9, non-muscle 0.0362365
DSPP dentin sialophosphoprotein 0.0349258
FAM107B family with sequence similarity 107, member B 0.0341115
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0334036
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0290445
RAI14 retinoic acid induced 14 0.029026
DST dystonin 0.0271339
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0265961
ELL2 elongation factor, RNA polymerase II, 2 0.0259995
BHLHE40 basic helix-loop-helix family, member e40 0.025458
CEMIP2 cell migration inducing hyaluronidase 2 0.0252683
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0250314
NRIP1 nuclear receptor interacting protein 1 0.0247746
ARHGAP9 Rho GTPase activating protein 9 0.0244235
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0243981
RUNX1 runt-related transcription factor 1 0.024276
FAT1 FAT atypical cadherin 1 0.0242653
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0240897
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0232038
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0230826
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0230204
GRB10 growth factor receptor-bound protein 10 0.0222841
ANO6 anoctamin 6 0.0221329
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0218036
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0213316
MALT1 MALT1 paracaspase 0.0204542
DOCK4 dedicator of cytokinesis 4 0.0204209
APLP2 amyloid beta (A4) precursor-like protein 2 0.020305
ABTB3 ankyrin repeat and BTB domain containing 3 0.0201166
CORO1C coronin, actin binding protein, 1C 0.0200721
KYNU kynureninase 0.0196576
RASA2 RAS p21 protein activator 2 0.0196364
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0196323
NKD1 naked cuticle homolog 1 (Drosophila) 0.0195676
QKI QKI, KH domain containing, RNA binding 0.019507
SMAD3 SMAD family member 3 0.0194755
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0192662
FNDC3B fibronectin type III domain containing 3B 0.0191253
AFF1 AF4/FMR2 family, member 1 0.0184621
DIAPH1 diaphanous-related formin 1 0.0183474
KLF6 Kruppel-like factor 6 0.018295
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0182701
TMEM181 transmembrane protein 181 0.0178554
RB1CC1 RB1-inducible coiled-coil 1 0.0177648
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0175469
DSCAM Down syndrome cell adhesion molecule 0.0171989
TOP1 topoisomerase (DNA) I 0.0170817
SHB Src homology 2 domain containing adaptor protein B 0.0170711
FRMD5 FERM domain containing 5 0.0170459
JMJD1C jumonji domain containing 1C 0.0170055
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0168632
DOCK5 dedicator of cytokinesis 5 0.0168409
SIK3 SIK family kinase 3 0.016784
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0167831
HSPA8 heat shock 70kDa protein 8 0.0167088
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0166377
CTNND1 catenin (cadherin-associated protein), delta 1 0.0166214
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0165284
FNIP1 folliculin interacting protein 1 0.0162597
EIF4B eukaryotic translation initiation factor 4B 0.01621
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0159885
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0157424
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0156704
TNS1 tensin 1 0.0154911
RBM39 RNA binding motif protein 39 0.0153518
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.015336
FBF1 Fas (TNFRSF6) binding factor 1 0.0153061
VMP1 vacuole membrane protein 1 0.0153045
SOX9 SRY (sex determining region Y)-box 9 0.0152471
NPTN neuroplastin 0.0151876
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.014892
RTN4 reticulon 4 0.0148712
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0148072
TPM1 tropomyosin 1 (alpha) 0.0147627
BZW1 basic leucine zipper and W2 domains 1 0.0145721
SDC4 syndecan 4 0.0145086
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0144616
ZBTB38 zinc finger and BTB domain containing 38 0.0144581
RBM25 RNA binding motif protein 25 0.0144523
NFE2L1 nuclear factor, erythroid 2-like 1 0.0144254
CCL20 chemokine (C-C motif) ligand 20 0.0143324
KAT6A K(lysine) acetyltransferase 6A 0.014017

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.714125
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.136851
APOA2 apolipoprotein A-II -0.10374
TPT1 tumor protein, translationally-controlled 1 -0.0836171
FTL ferritin, light polypeptide -0.0770446
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0751099
PLIN2 perilipin 2 -0.0745165
HMGA1 high mobility group AT-hook 1 -0.0629952
RPS24 ribosomal protein S24 -0.0578581
RPLP1 ribosomal protein, large, P1 -0.0537564
ENO1 enolase 1, (alpha) -0.0521666
RPL35A ribosomal protein L35a -0.0459533
CP ceruloplasmin (ferroxidase) -0.0455714
RPL37A ribosomal protein L37a -0.0443137
RPS8 ribosomal protein S8 -0.0437345
ISG15 ISG15 ubiquitin-like modifier -0.0434475
AHSG alpha-2-HS-glycoprotein -0.0401757
NPAS2 neuronal PAS domain protein 2 -0.0392307
RPL23 ribosomal protein L23 -0.0385914
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0384117
EGR1 early growth response 1 -0.038382
RPS25 ribosomal protein S25 -0.0382035
TMSB10 thymosin beta 10 -0.0381963
TPM4 tropomyosin 4 -0.0358532
SOS1 son of sevenless homolog 1 (Drosophila) -0.0350483
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0346063
RPL31 ribosomal protein L31 -0.034409
RPS27A ribosomal protein S27a -0.0337641
RPS13 ribosomal protein S13 -0.0327274
RPS19 ribosomal protein S19 -0.0319911
GMDS GDP-mannose 4,6-dehydratase -0.0314738
PTMA prothymosin, alpha -0.0306938
PKM pyruvate kinase, muscle -0.0303323
RPS23 ribosomal protein S23 -0.0301616
RPS29 ribosomal protein S29 -0.0299304
APOA1 apolipoprotein A-I -0.0297062
RPL9 ribosomal protein L9 -0.0294452
RPL11 ribosomal protein L11 -0.0293645
APOE apolipoprotein E -0.0293631
RPL12 ribosomal protein L12 -0.0293624
MCL1 myeloid cell leukemia 1 -0.0293288
RNF213 ring finger protein 213 -0.0291104
IFI6 interferon, alpha-inducible protein 6 -0.0279198
NDRG1 N-myc downstream regulated 1 -0.0276699
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0272495
ACTG1 actin gamma 1 -0.0265911
RPLP2 ribosomal protein, large, P2 -0.0261463
TMEM123 transmembrane protein 123 -0.0261289
RPLP0 ribosomal protein, large, P0 -0.0259612
TM4SF1 transmembrane 4 L six family member 1 -0.0255927
S100A9 S100 calcium binding protein A9 -0.02506
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0246845
EHBP1 EH domain binding protein 1 -0.0244089
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0243275
IER3 immediate early response 3 -0.024095
RPL34 ribosomal protein L34 -0.0240483
PERP PERP, TP53 apoptosis effector -0.0239042
RPL28 ribosomal protein L28 -0.0238317
RPS21 ribosomal protein S21 -0.0238313
LYZ lysozyme -0.0237972
GK glycerol kinase -0.0233804
RPS11 ribosomal protein S11 -0.0232241
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0226588
IFITM1 interferon induced transmembrane protein 1 -0.0223946
RPS16 ribosomal protein S16 -0.0220468
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0219216
IFI27 interferon, alpha-inducible protein 27 -0.0217823
SOX5 SRY (sex determining region Y)-box 5 -0.0210905
RPS10 ribosomal protein S10 -0.02108
RPS14 ribosomal protein S14 -0.0209645
HLA-A major histocompatibility complex, class I, A -0.0204302
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0203121
RPL27A ribosomal protein L27a -0.0201003
APOC1 apolipoprotein C-I -0.0198589
P4HB prolyl 4-hydroxylase, beta polypeptide -0.019713
CTSD cathepsin D -0.0192148
HLA-B major histocompatibility complex, class I, B -0.0190109
RPS5 ribosomal protein S5 -0.018717
IFITM3 interferon induced transmembrane protein 3 -0.0185896
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0184344
ARFGEF3 ARFGEF family member 3 -0.0181422
CALR calreticulin -0.0179646
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0179505
RPL38 ribosomal protein L38 -0.0177472
ZHX2 zinc fingers and homeoboxes 2 -0.0176633
GNAS GNAS complex locus -0.0175692
RPL36A ribosomal protein L36a -0.0173
PDIA3 protein disulfide isomerase family A, member 3 -0.0172055
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0171596
S100A6 S100 calcium binding protein A6 -0.0171335
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0170471
CST3 cystatin C -0.0165745
GPC6 glypican 6 -0.0164949
EML4 echinoderm microtubule associated protein like 4 -0.0163809
RPL27 ribosomal protein L27 -0.0163795
ETFB electron-transfer-flavoprotein, beta polypeptide -0.016243
AMBP alpha-1-microglobulin/bikunin precursor -0.0162089
RPL7A ribosomal protein L7a -0.0160535
MAML2 mastermind-like 2 (Drosophila) -0.0159908
MX2 MX dynamin-like GTPase 2 -0.0159517