| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.160692 |
| LMO7 | LIM domain 7 | 0.155628 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.115364 |
| CD44 | CD44 molecule (Indian blood group) | 0.107634 |
| MT2A | metallothionein 2A | 0.0999542 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0933324 |
| RPS6 | ribosomal protein S6 | 0.0926224 |
| RAI14 | retinoic acid induced 14 | 0.0884601 |
| NDRG1 | N-myc downstream regulated 1 | 0.077275 |
| MTSS1 | metastasis suppressor 1 | 0.076811 |
| TXNIP | thioredoxin interacting protein | 0.0708709 |
| B2M | beta-2-microglobulin | 0.0672796 |
| RPS8 | ribosomal protein S8 | 0.065538 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0650921 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0643951 |
| RPS3 | ribosomal protein S3 | 0.0630117 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0616622 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0608961 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0552605 |
| MSN | moesin | 0.0552064 |
| ASPH | aspartate beta-hydroxylase | 0.0522971 |
| RPL37 | ribosomal protein L37 | 0.0509676 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0495931 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0493332 |
| GOLGB1 | golgin B1 | 0.0492386 |
| RPS12 | ribosomal protein S12 | 0.0490699 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0484161 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.048041 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0474651 |
| ITGA6 | integrin, alpha 6 | 0.0474625 |
| ANGPTL4 | angiopoietin-like 4 | 0.04574 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0456866 |
| RPL37A | ribosomal protein L37a | 0.0445993 |
| TPM3 | tropomyosin 3 | 0.0435151 |
| MYOF | myoferlin | 0.0431506 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0422148 |
| CALB1 | calbindin 1, 28kDa | 0.042152 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.041818 |
| MKI67 | marker of proliferation Ki-67 | 0.0407249 |
| FAM107B | family with sequence similarity 107, member B | 0.0407051 |
| CSTB | cystatin B (stefin B) | 0.0402932 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0401943 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.04014 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0396905 |
| TGM2 | transglutaminase 2 | 0.0392569 |
| RPS19 | ribosomal protein S19 | 0.038655 |
| LDHA | lactate dehydrogenase A | 0.0382559 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0376332 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0375854 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.037463 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0371744 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0357964 |
| RPL36 | ribosomal protein L36 | 0.0357226 |
| CDCP1 | CUB domain containing protein 1 | 0.0354651 |
| DOK5 | docking protein 5 | 0.0352986 |
| LAMC2 | laminin, gamma 2 | 0.0352975 |
| RPS17 | ribosomal protein S17 | 0.0351478 |
| SIK3 | SIK family kinase 3 | 0.0348534 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0345006 |
| TPR | translocated promoter region, nuclear basket protein | 0.0340329 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0339241 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0335625 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0335556 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.033523 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0333337 |
| TAPBP | TAP binding protein (tapasin) | 0.0333172 |
| TMF1 | TATA element modulatory factor 1 | 0.0331119 |
| DST | dystonin | 0.032797 |
| ENO1 | enolase 1, (alpha) | 0.0325383 |
| EZR | ezrin | 0.0321539 |
| PRRC2C | proline-rich coiled-coil 2C | 0.031534 |
| MEGF6 | multiple EGF-like-domains 6 | 0.0314903 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0313262 |
| RPS2 | ribosomal protein S2 | 0.0313235 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0311953 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0311381 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.03063 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0301325 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0301284 |
| VEGFA | vascular endothelial growth factor A | 0.0300797 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0298342 |
| CTSB | cathepsin B | 0.0296065 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0295452 |
| RPS27 | ribosomal protein S27 | 0.0295035 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0294664 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0294599 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0293004 |
| HLA-B | major histocompatibility complex, class I, B | 0.0292988 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0292482 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0290346 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0290307 |
| CENPF | centromere protein F, 350/400kDa | 0.0289416 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0281493 |
| FNIP1 | folliculin interacting protein 1 | 0.0278055 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0277892 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0277394 |
| RPL5 | ribosomal protein L5 | 0.0275649 |
| ATF4 | activating transcription factor 4 | 0.0275203 |
| IFI44L | interferon-induced protein 44-like | 0.027465 |
| RPL23 | ribosomal protein L23 | 0.0273497 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | -0.089677 |
| FLNB | filamin B, beta | -0.0868117 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0729928 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.067991 |
| KRT17 | keratin 17, type I | -0.0679642 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0659932 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0653745 |
| SULF1 | sulfatase 1 | -0.0653247 |
| ANXA2 | annexin A2 | -0.0629518 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0599674 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.059688 |
| PLAT | plasminogen activator, tissue | -0.0582749 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0564963 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.054328 |
| GNAS | GNAS complex locus | -0.0467995 |
| SPAG9 | sperm associated antigen 9 | -0.0462923 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0460386 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0422858 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0415564 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | -0.0400103 |
| KRT6A | keratin 6A, type II | -0.0392244 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0376444 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0370678 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0368771 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0361795 |
| LMNA | lamin A/C | -0.0348906 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0332586 |
| PODXL | podocalyxin-like | -0.03317 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0324208 |
| KIAA1217 | KIAA1217 | -0.0318415 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.03152 |
| MECOM | MDS1 and EVI1 complex locus | -0.0313432 |
| FN1 | fibronectin 1 | -0.0310599 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0309247 |
| THBD | thrombomodulin | -0.0306644 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0306496 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0303097 |
| ARF1 | ADP-ribosylation factor 1 | -0.0289895 |
| IGF2 | insulin-like growth factor 2 | -0.0284512 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0282125 |
| SMAD3 | SMAD family member 3 | -0.0280128 |
| EPHA2 | EPH receptor A2 | -0.0278751 |
| SERTAD2 | SERTA domain containing 2 | -0.0276352 |
| FOXO1 | forkhead box O1 | -0.0276168 |
| RPS24 | ribosomal protein S24 | -0.0272892 |
| CUL4B | cullin 4B | -0.0272035 |
| GRK5 | G protein-coupled receptor kinase 5 | -0.0271202 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0269707 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0266198 |
| BCL2L1 | BCL2-like 1 | -0.0265375 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0263314 |
| PALLD | palladin, cytoskeletal associated protein | -0.0262707 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | -0.0261308 |
| TMSB10 | thymosin beta 10 | -0.0259342 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0256021 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0254662 |
| RIGI | RNA sensor RIG-I | -0.0252569 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0252262 |
| TKT | transketolase | -0.0252115 |
| HYCC2 | hyccin PI4KA lipid kinase complex subunit 2 | -0.0252063 |
| IRF1 | interferon regulatory factor 1 | -0.0246185 |
| FLNA | filamin A, alpha | -0.0242058 |
| SLMAP | sarcolemma associated protein | -0.0241247 |
| OGA | O-GlcNAcase | -0.0239946 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0239695 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0238799 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0237067 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0233227 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0232094 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0230885 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0230505 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0225482 |
| IER3 | immediate early response 3 | -0.0223727 |
| COPA | coatomer protein complex, subunit alpha | -0.0222475 |
| COG5 | component of oligomeric golgi complex 5 | -0.0221255 |
| CLIC4 | chloride intracellular channel 4 | -0.0218251 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0216898 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0216009 |
| S100A4 | S100 calcium binding protein A4 | -0.0213917 |
| WASF2 | WAS protein family, member 2 | -0.0212629 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0212042 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.020938 |
| TMEM123 | transmembrane protein 123 | -0.0208631 |
| C4BPB | complement component 4 binding protein, beta | -0.0208412 |
| FOXK1 | forkhead box K1 | -0.0207336 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0207325 |
| SDCBP | syndecan binding protein (syntenin) | -0.0206265 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0205665 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0205255 |
| PTMA | prothymosin, alpha | -0.0200032 |
| FOXO3 | forkhead box O3 | -0.0198244 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0197901 |
| SDC4 | syndecan 4 | -0.0197161 |
| SERINC3 | serine incorporator 3 | -0.0197025 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.019569 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0193899 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0193566 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.019292 |
| PHF20 | PHD finger protein 20 | -0.0191184 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0190418 |
