| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.115447 |
| MT2A | metallothionein 2A | 0.102114 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0943 |
| CD44 | CD44 molecule (Indian blood group) | 0.0758443 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0730002 |
| AHNAK | AHNAK nucleoprotein | 0.0502999 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0489266 |
| ZNF841 | zinc finger protein 841 | 0.0438597 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0435699 |
| PODXL | podocalyxin-like | 0.0428782 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0418637 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0393133 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0391972 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0379217 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0375616 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0366911 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0352306 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0334815 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0331935 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0329777 |
| MKI67 | marker of proliferation Ki-67 | 0.0328713 |
| FLNB | filamin B, beta | 0.0325846 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0319636 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0313831 |
| SMAD3 | SMAD family member 3 | 0.0289126 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0283543 |
| PTK2 | protein tyrosine kinase 2 | 0.0283492 |
| DST | dystonin | 0.0277009 |
| FAM107B | family with sequence similarity 107, member B | 0.0266907 |
| H1-4 | H1.4 linker histone, cluster member | 0.0262944 |
| LMO7 | LIM domain 7 | 0.0261923 |
| FUS | FUS RNA binding protein | 0.0254929 |
| MSN | moesin | 0.0250075 |
| CORO1C | coronin, actin binding protein, 1C | 0.0247654 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.024745 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0232206 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0230071 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0229278 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0228686 |
| TPM3 | tropomyosin 3 | 0.0225027 |
| RPS3 | ribosomal protein S3 | 0.022472 |
| TAPBP | TAP binding protein (tapasin) | 0.0224117 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0219809 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0217654 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0217341 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0217043 |
| NAV2 | neuron navigator 2 | 0.0214947 |
| SMYD3 | SET and MYND domain containing 3 | 0.0214644 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0213556 |
| HMGB2 | high mobility group box 2 | 0.0212107 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0210249 |
| CENPF | centromere protein F, 350/400kDa | 0.0209377 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0208344 |
| TOP1 | topoisomerase (DNA) I | 0.0207398 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0203348 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.019975 |
| RPL14 | ribosomal protein L14 | 0.019938 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0198032 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0195979 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0195874 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0194284 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0192889 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0190696 |
| MT1X | metallothionein 1X | 0.0188491 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0188185 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.018616 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0184942 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0184802 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0183777 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0182162 |
| GOLGB1 | golgin B1 | 0.0181917 |
| H1-2 | H1.2 linker histone, cluster member | 0.0180869 |
| CAVIN1 | caveolae associated protein 1 | 0.0180621 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.017982 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0178959 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0178652 |
| CLIC4 | chloride intracellular channel 4 | 0.0173289 |
| APP | amyloid beta (A4) precursor protein | 0.0172278 |
| EZR | ezrin | 0.0169381 |
| SEPTIN9 | septin 9 | 0.0167619 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0164331 |
| ERBIN | erbb2 interacting protein | 0.0163559 |
| JAK1 | Janus kinase 1 | 0.016123 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.015834 |
| VMP1 | vacuole membrane protein 1 | 0.0158006 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0157888 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0157742 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0157676 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0157143 |
| CALD1 | caldesmon 1 | 0.0155913 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0155222 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0155094 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0154805 |
| HEG1 | heart development protein with EGF-like domains 1 | 0.0154469 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.015425 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0153675 |
| SDC4 | syndecan 4 | 0.0153088 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0152935 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0152272 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0151709 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.2905 |
| FTL | ferritin, light polypeptide | -0.170857 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.165537 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.164746 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.15438 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.144844 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.107843 |
| HLA-B | major histocompatibility complex, class I, B | -0.103324 |
| NDRG1 | N-myc downstream regulated 1 | -0.0988298 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0947879 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0799106 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0728833 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.071372 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0689484 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0669207 |
| PLIN2 | perilipin 2 | -0.0605601 |
| PKM | pyruvate kinase, muscle | -0.0604912 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0559979 |
| VIM | vimentin | -0.0533335 |
| CTSD | cathepsin D | -0.048666 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0452375 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0429237 |
| POSTN | periostin, osteoblast specific factor | -0.0428779 |
| POTEF | POTE ankyrin domain family, member F | -0.0426827 |
| MMP12 | matrix metallopeptidase 12 | -0.0419696 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.040901 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0406061 |
| HLA-A | major histocompatibility complex, class I, A | -0.0380407 |
| PLCB4 | phospholipase C, beta 4 | -0.0378279 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0371629 |
| TPM4 | tropomyosin 4 | -0.0368463 |
| TMSB10 | thymosin beta 10 | -0.0346927 |
| S100A6 | S100 calcium binding protein A6 | -0.0336034 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0336 |
| DEK | DEK proto-oncogene | -0.0333755 |
| DTNA | dystrobrevin, alpha | -0.0333101 |
| ADM | adrenomedullin | -0.0332027 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.031957 |
| CCBE1 | collagen and calcium binding EGF domains 1 | -0.0316887 |
| GLIS3 | GLIS family zinc finger 3 | -0.029951 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0281462 |
| ENO1 | enolase 1, (alpha) | -0.0273443 |
| MAP1B | microtubule-associated protein 1B | -0.027283 |
| KRT7 | keratin 7, type II | -0.0270235 |
| GNAS | GNAS complex locus | -0.0268822 |
| SBF2 | SET binding factor 2 | -0.0265082 |
| CCDC80 | coiled-coil domain containing 80 | -0.0264199 |
| SULF1 | sulfatase 1 | -0.0259611 |
| LOX | lysyl oxidase | -0.0257198 |
| FAM162A | family with sequence similarity 162, member A | -0.0248419 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0248135 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.023394 |
| RPL35A | ribosomal protein L35a | -0.0233925 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0231983 |
| PTMA | prothymosin, alpha | -0.0231891 |
| TRAM1 | translocation associated membrane protein 1 | -0.0229314 |
| HMGA1 | high mobility group AT-hook 1 | -0.0228524 |
| COL5A2 | collagen, type V, alpha 2 | -0.0227714 |
| PFN1 | profilin 1 | -0.0225929 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0225261 |
| RAI14 | retinoic acid induced 14 | -0.0224819 |
| TUBA1B | tubulin, alpha 1b | -0.0224186 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0216726 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0213338 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0209985 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0207708 |
| RPLP2 | ribosomal protein, large, P2 | -0.0205983 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0205018 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0204916 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0202319 |
| CALR | calreticulin | -0.020141 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0200924 |
| TUBB | tubulin, beta class I | -0.0200384 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0196369 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0196049 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0193348 |
| MAP4 | microtubule-associated protein 4 | -0.0192784 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.019229 |
| RPLP1 | ribosomal protein, large, P1 | -0.0191235 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0190749 |
| TMEM165 | transmembrane protein 165 | -0.0190476 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0190078 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0189299 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.018858 |
| TOX | thymocyte selection-associated high mobility group box | -0.0185913 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.018579 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0185649 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0185409 |
| CADM1 | cell adhesion molecule 1 | -0.0184805 |
| DIPK2A | divergent protein kinase domain 2A | -0.0183871 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0182979 |
| HMGB1 | high mobility group box 1 | -0.0182238 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0182071 |
| RPS20 | ribosomal protein S20 | -0.0181554 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0180997 |
| L1CAM | L1 cell adhesion molecule | -0.0179223 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0179041 |
| NUP58 | nucleoporin 58 | -0.0178411 |
| PDE10A | phosphodiesterase 10A | -0.0177418 |
| RPL7A | ribosomal protein L7a | -0.0176461 |
