| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.192277 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.137995 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.127215 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.111455 |
| RPS3 | ribosomal protein S3 | 0.106876 |
| GDA | guanine deaminase | 0.10014 |
| MYOF | myoferlin | 0.0733844 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0670882 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0663522 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0656913 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0636727 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0616207 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0601121 |
| DSPP | dentin sialophosphoprotein | 0.054888 |
| RPS6 | ribosomal protein S6 | 0.0548429 |
| EZR | ezrin | 0.0523325 |
| GOLGB1 | golgin B1 | 0.0502151 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0497854 |
| TMC5 | transmembrane channel-like 5 | 0.0478501 |
| TJP1 | tight junction protein 1 | 0.0475984 |
| DSTN | destrin (actin depolymerizing factor) | 0.045904 |
| RPL18 | ribosomal protein L18 | 0.04434 |
| RPS12 | ribosomal protein S12 | 0.0438481 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0432351 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0419339 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0416137 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0399615 |
| SEPTIN9 | septin 9 | 0.0398738 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0393682 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | 0.0373671 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.037063 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0361293 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0355352 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0355108 |
| SLC38A2 | solute carrier family 38, member 2 | 0.034286 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.033682 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0335228 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0329469 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0328538 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.0327789 |
| TAPBP | TAP binding protein (tapasin) | 0.0320003 |
| RPL26 | ribosomal protein L26 | 0.0308855 |
| LIMA1 | LIM domain and actin binding 1 | 0.030443 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0302901 |
| ATP11A | ATPase, class VI, type 11A | 0.0294741 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0287244 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0286465 |
| RBM47 | RNA binding motif protein 47 | 0.0280109 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0278498 |
| TMF1 | TATA element modulatory factor 1 | 0.0278169 |
| DST | dystonin | 0.0277506 |
| MCU | mitochondrial calcium uniporter | 0.0267545 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0264081 |
| KLF6 | Kruppel-like factor 6 | 0.0263018 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | 0.0260425 |
| AHR | aryl hydrocarbon receptor | 0.0257376 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.025518 |
| BRD2 | bromodomain containing 2 | 0.0252198 |
| AREG | amphiregulin | 0.0250165 |
| RPS2 | ribosomal protein S2 | 0.0243572 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0243213 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0241918 |
| SGMS2 | sphingomyelin synthase 2 | 0.0241791 |
| SLTM | SAFB-like, transcription modulator | 0.0235234 |
| ASPH | aspartate beta-hydroxylase | 0.023482 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0234593 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0231839 |
| TMSB4X | thymosin beta 4, X-linked | 0.0227381 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0226778 |
| ATF3 | activating transcription factor 3 | 0.0226096 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0222 |
| LCN2 | lipocalin 2 | 0.0219322 |
| PMM2 | phosphomannomutase 2 | 0.0218681 |
| RPL14 | ribosomal protein L14 | 0.0217709 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0216691 |
| SON | SON DNA binding protein | 0.0212447 |
| AGR3 | anterior gradient 3 | 0.0211282 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0208001 |
| MYO1E | myosin IE | 0.0206275 |
| PDAP1 | PDGFA associated protein 1 | 0.0205879 |
| UGT1A6 | UDP glucuronosyltransferase 1 family, polypeptide A6 | 0.0205305 |
| ANXA1 | annexin A1 | 0.0202832 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0199139 |
| TMA7 | translation machinery associated 7 homolog (S. cerevisiae) | 0.0198968 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0197428 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0192537 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0190034 |
| FYTTD1 | forty-two-three domain containing 1 | 0.0189603 |
| XAF1 | XIAP associated factor 1 | 0.0188348 |
| RPL19 | ribosomal protein L19 | 0.0187615 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0187545 |
| GOLGA4 | golgin A4 | 0.0186069 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0185399 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 0.0184722 |
| LMNA | lamin A/C | 0.0184151 |
| SET | SET nuclear proto-oncogene | 0.0182109 |
| SP100 | SP100 nuclear antigen | 0.0179344 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.017793 |
| TPM3 | tropomyosin 3 | 0.0177609 |
| SPATA13 | spermatogenesis associated 13 | 0.0177161 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.222652 |
| FGFR2 | fibroblast growth factor receptor 2 | -0.176086 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.153517 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.137736 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.126645 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.106011 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0936378 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0856704 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0818172 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0807563 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0766741 |
| S100A6 | S100 calcium binding protein A6 | -0.0760947 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0730749 |
| RPLP1 | ribosomal protein, large, P1 | -0.0699464 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0669494 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0658121 |
| TMSB10 | thymosin beta 10 | -0.0604708 |
| KRT18 | keratin 18, type I | -0.0558125 |
| RPS25 | ribosomal protein S25 | -0.0557082 |
| S100A10 | S100 calcium binding protein A10 | -0.0515965 |
| RPS24 | ribosomal protein S24 | -0.0512804 |
| ITGB4 | integrin, beta 4 | -0.0493737 |
| HLA-E | major histocompatibility complex, class I, E | -0.0483766 |
| WDR45B | WD repeat domain 45B | -0.0473194 |
| EMP1 | epithelial membrane protein 1 | -0.0458509 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.045476 |
| HLA-A | major histocompatibility complex, class I, A | -0.0440624 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0439869 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0436872 |
| UBC | ubiquitin C | -0.0426163 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0426037 |
| PTMA | prothymosin, alpha | -0.0417794 |
| LYZ | lysozyme | -0.0416712 |
| INSIG1 | insulin induced gene 1 | -0.0412717 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0411298 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | -0.0407688 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0407602 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0393663 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0390584 |
| NF1 | neurofibromin 1 | -0.0390005 |
| ANLN | anillin, actin binding protein | -0.0385774 |
| AGR2 | anterior gradient 2 | -0.036799 |
| KRT8 | keratin 8, type II | -0.0366213 |
| BCL2L1 | BCL2-like 1 | -0.0364072 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.0363229 |
| GNAS | GNAS complex locus | -0.0356157 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0355675 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0351757 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0349939 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0346634 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0344555 |
| PGK1 | phosphoglycerate kinase 1 | -0.0340159 |
| CALR | calreticulin | -0.0333706 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0332529 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0324291 |
| KRT7 | keratin 7, type II | -0.0323455 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0318839 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0316163 |
| PKM | pyruvate kinase, muscle | -0.0312326 |
| RPS27A | ribosomal protein S27a | -0.0309904 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0304263 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0303139 |
| TMEM123 | transmembrane protein 123 | -0.0302559 |
| RPS16 | ribosomal protein S16 | -0.0301731 |
| RPL36A | ribosomal protein L36a | -0.0300027 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | -0.0297791 |
| USP34 | ubiquitin specific peptidase 34 | -0.0297425 |
| KLHL29 | kelch-like family member 29 | -0.029437 |
| COG5 | component of oligomeric golgi complex 5 | -0.0293364 |
| FLNB | filamin B, beta | -0.029262 |
| MED13 | mediator complex subunit 13 | -0.0290118 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0289842 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0288001 |
| ANXA2 | annexin A2 | -0.0285431 |
| KLK10 | kallikrein-related peptidase 10 | -0.028489 |
| ZNF207 | zinc finger protein 207 | -0.0282406 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0280971 |
| CANX | calnexin | -0.02809 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0280092 |
| ZNF609 | zinc finger protein 609 | -0.0278389 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0278145 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | -0.0276788 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0276627 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.027592 |
| ACTG1 | actin gamma 1 | -0.0274096 |
| NDRG1 | N-myc downstream regulated 1 | -0.027407 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0273246 |
| AUTS2 | autism susceptibility candidate 2 | -0.0271822 |
| CCNY | cyclin Y | -0.0269415 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0268723 |
| RREB1 | ras responsive element binding protein 1 | -0.0268119 |
| RNF43 | ring finger protein 43 | -0.0266991 |
| EHBP1 | EH domain binding protein 1 | -0.0266877 |
| RPL39 | ribosomal protein L39 | -0.0264006 |
| PTK2 | protein tyrosine kinase 2 | -0.0262395 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0261378 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0261045 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0260942 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0260269 |
| HM13 | histocompatibility (minor) 13 | -0.0259172 |
