| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in LOX-IMVI cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS6 | ribosomal protein S6 | 0.206201 |
| RPS3 | ribosomal protein S3 | 0.168714 |
| EXT1 | exostosin glycosyltransferase 1 | 0.132283 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.11959 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.113684 |
| DTNA | dystrobrevin, alpha | 0.113173 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.109761 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0972439 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0943319 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0937331 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0918523 |
| ASPH | aspartate beta-hydroxylase | 0.0887343 |
| RPS12 | ribosomal protein S12 | 0.0878067 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0831067 |
| CALD1 | caldesmon 1 | 0.0813906 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0760585 |
| LIMA1 | LIM domain and actin binding 1 | 0.0755161 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.074581 |
| HDAC9 | histone deacetylase 9 | 0.0741299 |
| RPS8 | ribosomal protein S8 | 0.0702506 |
| RPL37A | ribosomal protein L37a | 0.0687967 |
| EFNA5 | ephrin-A5 | 0.0679257 |
| RPL12 | ribosomal protein L12 | 0.0646605 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.058548 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0577909 |
| LDHA | lactate dehydrogenase A | 0.0572125 |
| RPS2 | ribosomal protein S2 | 0.056864 |
| RPS17 | ribosomal protein S17 | 0.0555367 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0541487 |
| RPL5 | ribosomal protein L5 | 0.0541119 |
| RPL7 | ribosomal protein L7 | 0.05389 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0534692 |
| RACK1 | receptor for activated C kinase 1 | 0.0533599 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0520549 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0494153 |
| RPL26 | ribosomal protein L26 | 0.0492308 |
| NAV3 | neuron navigator 3 | 0.0483465 |
| INTS6 | integrator complex subunit 6 | 0.0477884 |
| MSN | moesin | 0.0476524 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0468435 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0467984 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0461043 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0460038 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0457726 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0452109 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0452062 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0444275 |
| MT2A | metallothionein 2A | 0.0442411 |
| PRKCE | protein kinase C, epsilon | 0.0436126 |
| BRD2 | bromodomain containing 2 | 0.0429782 |
| GOLGB1 | golgin B1 | 0.0396195 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0394947 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0391306 |
| HMGA2 | high mobility group AT-hook 2 | 0.0385899 |
| TPM3 | tropomyosin 3 | 0.0383122 |
| RPL36 | ribosomal protein L36 | 0.0379567 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0367792 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0363732 |
| RPS4X | ribosomal protein S4, X-linked | 0.0360335 |
| SON | SON DNA binding protein | 0.0358708 |
| RPL14 | ribosomal protein L14 | 0.0357209 |
| RPL9 | ribosomal protein L9 | 0.035502 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0354873 |
| RPS19 | ribosomal protein S19 | 0.0354753 |
| CDK6 | cyclin-dependent kinase 6 | 0.0354419 |
| SET | SET nuclear proto-oncogene | 0.0352951 |
| RPL18 | ribosomal protein L18 | 0.0346779 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0346244 |
| ADAM32 | ADAM metallopeptidase domain 32 | 0.034273 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0341359 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | 0.0337487 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0333842 |
| RPL32 | ribosomal protein L32 | 0.0324399 |
| TLN1 | talin 1 | 0.0323642 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0318745 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0315942 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0315854 |
| RPL4 | ribosomal protein L4 | 0.0311506 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.031049 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0309555 |
| RUNX1 | runt-related transcription factor 1 | 0.0308353 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0306823 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0306755 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0296203 |
| FLNA | filamin A, alpha | 0.0294123 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0287105 |
| RPLP2 | ribosomal protein, large, P2 | 0.028642 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0282295 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.028126 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0280029 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0279875 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0279107 |
| TRIM44 | tripartite motif containing 44 | 0.0276789 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0276054 |
| GPHN | gephyrin | 0.0275659 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0272971 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0272632 |
| GOLGA4 | golgin A4 | 0.026732 |
| RPL13A | ribosomal protein L13a | 0.0256703 |
| RPS27A | ribosomal protein S27a | 0.0256656 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MMP12 | matrix metallopeptidase 12 | -0.170958 |
| GPC6 | glypican 6 | -0.102372 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.10088 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.100032 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0971493 |
| CD109 | CD109 molecule | -0.0794315 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0778156 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0777177 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0770278 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0659893 |
| VCL | vinculin | -0.0650859 |
| FN1 | fibronectin 1 | -0.0627429 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0587495 |
| CDK17 | cyclin-dependent kinase 17 | -0.0551991 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.053351 |
| ZNF292 | zinc finger protein 292 | -0.0531989 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -0.0499317 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0498658 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0495613 |
| HAS2 | hyaluronan synthase 2 | -0.0492564 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0489516 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.047937 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0477205 |
| TNNC1 | troponin C type 1 (slow) | -0.0475604 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.046386 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0453224 |
| SPAG9 | sperm associated antigen 9 | -0.0431575 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0430145 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0426165 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0414082 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0403357 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0402969 |
| NUP58 | nucleoporin 58 | -0.0400086 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0398088 |
| BNC2 | basonuclin 2 | -0.0395779 |
| FOXP1 | forkhead box P1 | -0.0394266 |
| LSAMP | limbic system-associated membrane protein | -0.0394011 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0393386 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0387226 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0382283 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0379699 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0372608 |
| PTK2 | protein tyrosine kinase 2 | -0.0369203 |
| GNAS | GNAS complex locus | -0.0366359 |
| TPM4 | tropomyosin 4 | -0.0356441 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0355999 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0353993 |
| RLF | rearranged L-myc fusion | -0.0348221 |
| MED13L | mediator complex subunit 13-like | -0.0345282 |
| ZNF207 | zinc finger protein 207 | -0.0339075 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.033868 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0333568 |
| ANXA2 | annexin A2 | -0.0328941 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0323474 |
| NRP2 | neuropilin 2 | -0.0322759 |
| SMAD3 | SMAD family member 3 | -0.031538 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0308874 |
| RIGI | RNA sensor RIG-I | -0.0301622 |
| RBM39 | RNA binding motif protein 39 | -0.0300304 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0293375 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.029076 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0288194 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0287309 |
| RTN4 | reticulon 4 | -0.0279809 |
| NLGN1 | neuroligin 1 | -0.0279122 |
| MCL1 | myeloid cell leukemia 1 | -0.0278152 |
| ADAM19 | ADAM metallopeptidase domain 19 | -0.0276215 |
| DNER | delta/notch-like EGF repeat containing | -0.027604 |
| NUP153 | nucleoporin 153kDa | -0.0272675 |
| SETD5 | SET domain containing 5 | -0.0269737 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0269588 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.0268131 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.026469 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.0264226 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0263205 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.026011 |
| PTMA | prothymosin, alpha | -0.0257074 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0255953 |
| ERBIN | erbb2 interacting protein | -0.0255782 |
| ITGAV | integrin, alpha V | -0.025563 |
| CCNL1 | cyclin L1 | -0.0255336 |
| USP3 | ubiquitin specific peptidase 3 | -0.0254366 |
| TFG | TRK-fused gene | -0.0253304 |
| HMGA1 | high mobility group AT-hook 1 | -0.0251375 |
| ATP13A3 | ATPase type 13A3 | -0.0251253 |
| NTM | neurotrimin | -0.0248311 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0243145 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0242317 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0242149 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0241815 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0241799 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0241572 |
| TENM2 | teneurin transmembrane protein 2 | -0.0241229 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0240575 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0235767 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0235387 |
| GLMN | glomulin, FKBP associated protein | -0.023291 |
| CD44 | CD44 molecule (Indian blood group) | -0.023188 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0231854 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0230518 |
