| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.10941 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0974424 |
| FAT1 | FAT atypical cadherin 1 | 0.0778856 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0634748 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0549767 |
| LMO7 | LIM domain 7 | 0.0482351 |
| ONECUT3 | one cut homeobox 3 | 0.0446274 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0438822 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0429519 |
| ASPH | aspartate beta-hydroxylase | 0.0375631 |
| AHNAK | AHNAK nucleoprotein | 0.036706 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0358199 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0335358 |
| FHIT | fragile histidine triad | 0.0298786 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0297535 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.029527 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0291906 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0277564 |
| H1-0 | H1.0 linker histone | 0.0276935 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0270295 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0270144 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0262579 |
| NEBL | nebulette | 0.0255205 |
| PDE10A | phosphodiesterase 10A | 0.0254467 |
| MYO1E | myosin IE | 0.0254081 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0251182 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0251139 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0248125 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0245634 |
| RPS3 | ribosomal protein S3 | 0.0241916 |
| RPL14 | ribosomal protein L14 | 0.0232355 |
| H1-4 | H1.4 linker histone, cluster member | 0.023106 |
| DUSP4 | dual specificity phosphatase 4 | 0.0229803 |
| TRIM2 | tripartite motif containing 2 | 0.0218804 |
| EGFR | epidermal growth factor receptor | 0.0215218 |
| ECT2 | epithelial cell transforming 2 | 0.0215206 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0211192 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0208523 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.020257 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0200414 |
| SMAD2 | SMAD family member 2 | 0.0200078 |
| MT2A | metallothionein 2A | 0.0191911 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0186554 |
| SIK3 | SIK family kinase 3 | 0.0184142 |
| CENPF | centromere protein F, 350/400kDa | 0.0183397 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0181795 |
| RPL18 | ribosomal protein L18 | 0.0180363 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0180016 |
| RPS2 | ribosomal protein S2 | 0.0178327 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0175839 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0172609 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0171797 |
| SEPTIN9 | septin 9 | 0.017056 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0167484 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0167201 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0164967 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0164917 |
| SMYD3 | SET and MYND domain containing 3 | 0.0164417 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0163918 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0162092 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0158592 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.0158488 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0157964 |
| RPL4 | ribosomal protein L4 | 0.0157795 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0153427 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0151978 |
| HMGB2 | high mobility group box 2 | 0.0151895 |
| LDHA | lactate dehydrogenase A | 0.015097 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0150144 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0147599 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0145084 |
| INTS6 | integrator complex subunit 6 | 0.0142674 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0142286 |
| RAD51B | RAD51 paralog B | 0.0141209 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0140994 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0139393 |
| MACROD2 | MACRO domain containing 2 | 0.0138856 |
| H1-2 | H1.2 linker histone, cluster member | 0.013851 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.0137062 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0137062 |
| BRD2 | bromodomain containing 2 | 0.0133774 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0133411 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0133311 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0130631 |
| CCND1 | cyclin D1 | 0.0130028 |
| EXPH5 | exophilin 5 | 0.012964 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0128955 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0127798 |
| RUNX1 | runt-related transcription factor 1 | 0.0126361 |
| FAM107B | family with sequence similarity 107, member B | 0.0125484 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 0.0125219 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0125059 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | 0.0124899 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0123167 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0122966 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0122298 |
| RPS8 | ribosomal protein S8 | 0.0121726 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0121129 |
| CEP128 | centrosomal protein 128kDa | 0.0120571 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0120367 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.133867 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.118412 |
| NPSR1 | neuropeptide S receptor 1 | -0.105901 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.100959 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0898463 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0738627 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0648719 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0643028 |
| ITGA6 | integrin, alpha 6 | -0.0622159 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0620717 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.061196 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.06083 |
| NDRG1 | N-myc downstream regulated 1 | -0.0599814 |
| GOLGA4 | golgin A4 | -0.0568366 |
| FAM13A | family with sequence similarity 13, member A | -0.0551596 |
| CALB1 | calbindin 1, 28kDa | -0.0530102 |
| MUC17 | mucin 17, cell surface associated | -0.0514649 |
| PTEN | phosphatase and tensin homolog | -0.0506793 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0493382 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0482014 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.046274 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0456572 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.0440774 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0424754 |
| ANXA2 | annexin A2 | -0.0420382 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0419976 |
| S100A6 | S100 calcium binding protein A6 | -0.0417168 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0416223 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0413312 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0402182 |
| ACTN4 | actinin, alpha 4 | -0.0400489 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0398817 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0394989 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0389514 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0389207 |
| TXNIP | thioredoxin interacting protein | -0.038029 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0376457 |
| HMGA1 | high mobility group AT-hook 1 | -0.0375936 |
| WDR45B | WD repeat domain 45B | -0.0375084 |
| FNBP1L | formin binding protein 1-like | -0.0374098 |
| SBF2 | SET binding factor 2 | -0.0372631 |
| RNF145 | ring finger protein 145 | -0.0360076 |
| FLNB | filamin B, beta | -0.0357642 |
| GDF15 | growth differentiation factor 15 | -0.0355221 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0352488 |
| EZR | ezrin | -0.0352357 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0348443 |
| CD2AP | CD2-associated protein | -0.0348042 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0347526 |
| MED13L | mediator complex subunit 13-like | -0.0341871 |
| CCNY | cyclin Y | -0.0341461 |
| KRT19 | keratin 19, type I | -0.0340594 |
| EMP1 | epithelial membrane protein 1 | -0.0335084 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0331385 |
| ITGB4 | integrin, beta 4 | -0.0331318 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0330716 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0323962 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0322377 |
| SETD5 | SET domain containing 5 | -0.0318989 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0315696 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0309784 |
| SHROOM3 | shroom family member 3 | -0.0303363 |
| EXOC1 | exocyst complex component 1 | -0.0302952 |
| ZNF292 | zinc finger protein 292 | -0.0302117 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0298216 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0297801 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0297435 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0295272 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0294092 |
| RREB1 | ras responsive element binding protein 1 | -0.0290641 |
| FHL2 | four and a half LIM domains 2 | -0.0289555 |
| GLG1 | golgi glycoprotein 1 | -0.0287681 |
| FTL | ferritin, light polypeptide | -0.0285463 |
| PERP | PERP, TP53 apoptosis effector | -0.0284742 |
| SPAG9 | sperm associated antigen 9 | -0.0282973 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.028249 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0282265 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0281267 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0280281 |
| USP34 | ubiquitin specific peptidase 34 | -0.0279938 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0279702 |
| EPCAM | epithelial cell adhesion molecule | -0.0278582 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0275016 |
| CACNB2 | calcium channel, voltage-dependent, beta 2 subunit | -0.0274604 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0272741 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0269281 |
| DNM2 | dynamin 2 | -0.0268499 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0267552 |
| EREG | epiregulin | -0.0267509 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | -0.0266334 |
| NFIA | nuclear factor I/A | -0.026558 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0262951 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0262749 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | -0.026149 |
| DERA | deoxyribose-phosphate aldolase (putative) | -0.0260907 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | -0.026072 |
| VCL | vinculin | -0.0259373 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0257546 |
| TMSB10 | thymosin beta 10 | -0.0257297 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0256841 |
