AZD-7648_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-7648 perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-7648_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.144951
LDHA lactate dehydrogenase A 0.135457
LMO7 LIM domain 7 0.131841
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.120235
HSPA8 heat shock 70kDa protein 8 0.116439
RPS6 ribosomal protein S6 0.113274
MYO1E myosin IE 0.097005
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0946
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0939175
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0911098
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0877188
EZR ezrin 0.0858247
FAT1 FAT atypical cadherin 1 0.0853837
KRT18 keratin 18, type I 0.0849818
ITPRID2 ITPR interacting domain containing 2 0.0810648
RACK1 receptor for activated C kinase 1 0.0768348
RPL4 ribosomal protein L4 0.0766174
PGK1 phosphoglycerate kinase 1 0.0765223
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0748252
POTEF POTE ankyrin domain family, member F 0.0742004
LOC112694756 uncharaterized LOC112694756 0.0709793
RPS12 ribosomal protein S12 0.0696916
KLF5 Kruppel-like factor 5 (intestinal) 0.0657903
EIF4A2 eukaryotic translation initiation factor 4A2 0.0657315
ENO1 enolase 1, (alpha) 0.0657084
TPT1 tumor protein, translationally-controlled 1 0.0652894
ACTG1 actin gamma 1 0.0633432
OXSR1 oxidative stress responsive 1 0.0631322
RIMKLB ribosomal modification protein rimK-like family member B 0.0616628
PKM pyruvate kinase, muscle 0.0599162
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0592078
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0591638
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0582572
DSG2 desmoglein 2 0.0575333
ASPH aspartate beta-hydroxylase 0.0554295
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0536783
DST dystonin 0.0533922
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0530371
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0518508
KTN1 kinectin 1 (kinesin receptor) 0.0511391
DSPP dentin sialophosphoprotein 0.0510522
KRT8 keratin 8, type II 0.0509744
SLTM SAFB-like, transcription modulator 0.0509133
CANX calnexin 0.0501481
BRD2 bromodomain containing 2 0.0491479
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0488246
RPS8 ribosomal protein S8 0.0487001
LOC105378220 macrophage receptor MARCO-like 0.048192
RPS3 ribosomal protein S3 0.0474881
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0470649
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0468431
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0458207
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0456852
ESYT2 extended synaptotagmin-like protein 2 0.0450451
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0444866
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.04447
EEF1G eukaryotic translation elongation factor 1 gamma 0.0442279
UBC ubiquitin C 0.0439991
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0439172
CXCL8 chemokine (C-X-C motif) ligand 8 0.0436666
RPL34 ribosomal protein L34 0.0435911
TJP1 tight junction protein 1 0.0425871
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0416325
ALCAM activated leukocyte cell adhesion molecule 0.0415994
RPL14 ribosomal protein L14 0.0412831
SQSTM1 sequestosome 1 0.040596
FRMD5 FERM domain containing 5 0.040121
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0391784
HLA-B major histocompatibility complex, class I, B 0.039136
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0389101
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0388171
MYH9 myosin, heavy chain 9, non-muscle 0.0385456
MUC13 mucin 13, cell surface associated 0.0380015
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0378218
ARRDC3 arrestin domain containing 3 0.0377886
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0363014
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0360841
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0355283
AHNAK AHNAK nucleoprotein 0.0352317
PLK2 polo-like kinase 2 0.0352226
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0351915
LOC102724023 ES1 protein homolog, mitochondrial 0.0348527
APOL1 apolipoprotein L, 1 0.0345906
ADAR adenosine deaminase, RNA-specific 0.0343227
SLK STE20-like kinase 0.0342146
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0329947
TMSB10 thymosin beta 10 0.0328071
TPI1 triosephosphate isomerase 1 0.0320384
BHLHE40 basic helix-loop-helix family, member e40 0.0316661
PDZD8 PDZ domain containing 8 0.031597
NDRG1 N-myc downstream regulated 1 0.0312923
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0312169
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0311984
SRRM2 serine/arginine repetitive matrix 2 0.031185
RPL37 ribosomal protein L37 0.030786
RPS17 ribosomal protein S17 0.0307032
DSC3 desmocollin 3 0.0306549
EXT1 exostosin glycosyltransferase 1 0.0303551
RPS2 ribosomal protein S2 0.0298871
SLC38A2 solute carrier family 38, member 2 0.0298169

decreased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.113197
GMDS GDP-mannose 4,6-dehydratase -0.0842428
THSD4 thrombospondin, type I, domain containing 4 -0.0818816
MON2 MON2 homolog (S. cerevisiae) -0.059778
PDE4D phosphodiesterase 4D, cAMP-specific -0.0502294
PLAC8 placenta-specific 8 -0.0455269
VCL vinculin -0.0405531
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0400244
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0391788
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0390321
COG5 component of oligomeric golgi complex 5 -0.0383311
FOXO1 forkhead box O1 -0.0382071
ZFAND3 zinc finger, AN1-type domain 3 -0.0381128
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0366144
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0354238
GOLGA4 golgin A4 -0.0344766
RAD51B RAD51 paralog B -0.033139
RBM25 RNA binding motif protein 25 -0.0320738
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0317567
ETNK1 ethanolamine kinase 1 -0.0314998
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0306718
PTEN phosphatase and tensin homolog -0.030276
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0301476
SMC4 structural maintenance of chromosomes 4 -0.0296541
MCU mitochondrial calcium uniporter -0.0292365
GDF15 growth differentiation factor 15 -0.0289974
SETD5 SET domain containing 5 -0.0289633
IARS1 isoleucyl-tRNA synthetase 1 -0.0288257
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0288189
ANO1 anoctamin 1, calcium activated chloride channel -0.0287282
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0283651
GARS1 glycyl-tRNA synthetase 1 -0.028204
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0280752
ANKRD11 ankyrin repeat domain 11 -0.0277498
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0275385
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0275325
AOPEP aminopeptidase O (putative) -0.0274689
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0274503
ZMYM2 zinc finger, MYM-type 2 -0.0272283
BACE2 beta-site APP-cleaving enzyme 2 -0.0268818
PTPRK protein tyrosine phosphatase, receptor type, K -0.0267027
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0265014
ZNF207 zinc finger protein 207 -0.0261496
ANKRD17 ankyrin repeat domain 17 -0.0258901
KLF3 Kruppel-like factor 3 (basic) -0.0254407
DENND1A DENN/MADD domain containing 1A -0.0254001
TAS2R14 taste receptor, type 2, member 14 -0.0253137
FBXO34 F-box protein 34 -0.0252742
CDK13 cyclin-dependent kinase 13 -0.025146
ARHGAP29 Rho GTPase activating protein 29 -0.0251266
COG6 component of oligomeric golgi complex 6 -0.0246456
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0236854
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0233501
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0230548
METTL15 methyltransferase like 15 -0.0229933
WARS1 tryptophanyl-tRNA synthetase 1 -0.0229715
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0228281
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0226513
ACTN4 actinin, alpha 4 -0.0225097
AKAP9 A kinase (PRKA) anchor protein 9 -0.0224196
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0223121
SBF2 SET binding factor 2 -0.0223106
MX1 MX dynamin-like GTPase 1 -0.0222544
OSBPL3 oxysterol binding protein-like 3 -0.0220521
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0220411
CLASP2 cytoplasmic linker associated protein 2 -0.0219689
TTC3 tetratricopeptide repeat domain 3 -0.0217829
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0217345
TRIM2 tripartite motif containing 2 -0.0216294
PIBF1 progesterone immunomodulatory binding factor 1 -0.0211028
MSI2 musashi RNA-binding protein 2 -0.0210301
HMGA1 high mobility group AT-hook 1 -0.0208423
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0208254
PPARG peroxisome proliferator-activated receptor gamma -0.0207977
P3H2 prolyl 3-hydroxylase 2 -0.020592
SEC31A SEC31 homolog A (S. cerevisiae) -0.0202893
RAP1B RAP1B, member of RAS oncogene family -0.0202507
STK17A serine/threonine kinase 17a -0.0201666
CDK19 cyclin-dependent kinase 19 -0.0201333
KLF12 Kruppel-like factor 12 -0.0201129
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0199791
ZNF609 zinc finger protein 609 -0.0199005
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.019768
SRP54 signal recognition particle 54kDa -0.0196852
PKP2 plakophilin 2 -0.019272
PIAS1 protein inhibitor of activated STAT, 1 -0.0190778
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0190447
NF1 neurofibromin 1 -0.0189396
CEP95 centrosomal protein 95kDa -0.018908
SFPQ splicing factor proline/glutamine-rich -0.0188114
ICA1 islet cell autoantigen 1, 69kDa -0.0187534
BTBD9 BTB (POZ) domain containing 9 -0.0187397
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -0.0186929
TMEM165 transmembrane protein 165 -0.0186382
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.0185474
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -0.0184872
SCFD1 sec1 family domain containing 1 -0.0184491
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0183953
DIAPH3 diaphanous-related formin 3 -0.0183403
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0183082