AZD-7648_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-7648 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-7648_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.319769
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.148211
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.132556
ERRFI1 ERBB receptor feedback inhibitor 1 0.132475
PTMA prothymosin, alpha 0.131532
VIM vimentin 0.117423
TMSB10 thymosin beta 10 0.109523
TM4SF1 transmembrane 4 L six family member 1 0.10776
CD44 CD44 molecule (Indian blood group) 0.105534
CAPRIN2 caprin family member 2 0.103117
RPS6 ribosomal protein S6 0.0873134
WWTR1 WW domain containing transcription regulator 1 0.0866428
BCAR3 breast cancer anti-estrogen resistance 3 0.0781857
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0771438
PSD3 pleckstrin and Sec7 domain containing 3 0.0765889
RPS8 ribosomal protein S8 0.0717032
TMSB4X thymosin beta 4, X-linked 0.0660811
RACK1 receptor for activated C kinase 1 0.0652424
RPS3 ribosomal protein S3 0.0629014
KMT2E lysine (K)-specific methyltransferase 2E 0.0600595
ARHGAP5 Rho GTPase activating protein 5 0.0582379
RPL36 ribosomal protein L36 0.0570271
CXCL8 chemokine (C-X-C motif) ligand 8 0.055787
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0556441
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0528037
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0511518
RPL12 ribosomal protein L12 0.0505606
VCL vinculin 0.048948
RPL23 ribosomal protein L23 0.0485378
HSPA8 heat shock 70kDa protein 8 0.0484675
NT5E 5'-nucleotidase, ecto (CD73) 0.046597
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0463854
ANGPTL4 angiopoietin-like 4 0.0461666
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0453786
MT1X metallothionein 1X 0.0450122
RPL26 ribosomal protein L26 0.0449771
KLF6 Kruppel-like factor 6 0.0448756
EREG epiregulin 0.0446759
RPS19 ribosomal protein S19 0.0441164
GCLM glutamate-cysteine ligase, modifier subunit 0.0430782
POTEF POTE ankyrin domain family, member F 0.0413815
RPL19 ribosomal protein L19 0.040477
NPAS2 neuronal PAS domain protein 2 0.0400655
MT1E metallothionein 1E 0.039965
RPL35 ribosomal protein L35 0.038286
ZBTB38 zinc finger and BTB domain containing 38 0.0381811
BIRC3 baculoviral IAP repeat containing 3 0.0376614
RPL35A ribosomal protein L35a 0.0357911
TPT1 tumor protein, translationally-controlled 1 0.0355861
PDE10A phosphodiesterase 10A 0.0349322
LOC102724023 ES1 protein homolog, mitochondrial 0.0344241
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0341778
RUNX1 runt-related transcription factor 1 0.0339591
RPL18 ribosomal protein L18 0.0331894
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0331557
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0329535
EMP1 epithelial membrane protein 1 0.0318436
AREG amphiregulin 0.0316812
EGR1 early growth response 1 0.0316008
FMNL2 formin-like 2 0.0315118
RPL5 ribosomal protein L5 0.0312354
CFLAR CASP8 and FADD-like apoptosis regulator 0.0307644
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0306278
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0300135
HOMER1 homer scaffolding protein 1 0.0299218
TGM2 transglutaminase 2 0.0297287
SRRM2 serine/arginine repetitive matrix 2 0.029681
APLP2 amyloid beta (A4) precursor-like protein 2 0.0293518
HDAC9 histone deacetylase 9 0.0293334
RPL10A ribosomal protein L10a 0.0292814
LOC112694756 uncharaterized LOC112694756 0.0291988
S100A6 S100 calcium binding protein A6 0.0291358
RPS4X ribosomal protein S4, X-linked 0.029051
EIF4A2 eukaryotic translation initiation factor 4A2 0.0289841
EZR ezrin 0.0288065
BIRC2 baculoviral IAP repeat containing 2 0.0287088
SPAG9 sperm associated antigen 9 0.0277426
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0275723
RAB7A RAB7A, member RAS oncogene family 0.0274373
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.027168
SRGN serglycin 0.0268235
RPS12 ribosomal protein S12 0.0265464
EEF1G eukaryotic translation elongation factor 1 gamma 0.0262191
MACF1 microtubule-actin crosslinking factor 1 0.0261961
SET SET nuclear proto-oncogene 0.0261644
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0261108
ENO1 enolase 1, (alpha) 0.0260672
RPL32 ribosomal protein L32 0.0259953
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0259787
F2R coagulation factor II (thrombin) receptor 0.0259528
SON SON DNA binding protein 0.0256627
RPS27A ribosomal protein S27a 0.0256072
RPS17 ribosomal protein S17 0.0255857
GOLGB1 golgin B1 0.0251392
ZDHHC14 zinc finger, DHHC-type containing 14 0.02511
PRDX1 peroxiredoxin 1 0.0250283
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0248754
RPS27 ribosomal protein S27 0.0248373
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0248123
RPS21 ribosomal protein S21 0.0247916

decreased expression

Symbol Name Standardized Value
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0898107
COL5A2 collagen, type V, alpha 2 -0.062731
TNS3 tensin 3 -0.0602667
DLG1 discs, large homolog 1 (Drosophila) -0.058423
CFB complement factor B -0.0566039
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0547321
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0544798
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0491455
EPHA4 EPH receptor A4 -0.0476755
WARS1 tryptophanyl-tRNA synthetase 1 -0.0463252
ANXA1 annexin A1 -0.0420139
TP63 tumor protein p63 -0.0356644
EHBP1 EH domain binding protein 1 -0.0348
EFNA5 ephrin-A5 -0.0326847
MBNL2 muscleblind-like splicing regulator 2 -0.0324411
APOLD1 apolipoprotein L domain containing 1 -0.0317563
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0312224
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0310149
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0278272
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0269409
EGFR epidermal growth factor receptor -0.0266313
CFAP299 cilia and flagella associated protein 299 -0.0255758
RNF213 ring finger protein 213 -0.0249647
YEATS2 YEATS domain containing 2 -0.0238555
ISG15 ISG15 ubiquitin-like modifier -0.0235237
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0224416
WSB1 WD repeat and SOCS box containing 1 -0.0223208
ZMYND8 zinc finger, MYND-type containing 8 -0.0219756
BIRC6 baculoviral IAP repeat containing 6 -0.0216106
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0215294
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0204978
ZNF292 zinc finger protein 292 -0.02039
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 -0.0201896
ANKRD28 ankyrin repeat domain 28 -0.0200159
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0199229
ARHGAP12 Rho GTPase activating protein 12 -0.0198289
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0197829
TMEM123 transmembrane protein 123 -0.0192125
PIAS2 protein inhibitor of activated STAT, 2 -0.0187923
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0183189
RCAN1 regulator of calcineurin 1 -0.0181281
MAP4 microtubule-associated protein 4 -0.0178693
BRWD1 bromodomain and WD repeat domain containing 1 -0.0177049
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0173811
DPYD dihydropyrimidine dehydrogenase -0.0172873
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0171921
EXOC4 exocyst complex component 4 -0.0171819
SOD2 superoxide dismutase 2, mitochondrial -0.0171366
APP amyloid beta (A4) precursor protein -0.0170333
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0168848
AMBRA1 autophagy/beclin-1 regulator 1 -0.0167671
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0161789
RAI1 retinoic acid induced 1 -0.0161118
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0161068
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0160817
FNDC3B fibronectin type III domain containing 3B -0.015523
ZMYM2 zinc finger, MYM-type 2 -0.0152215
DENND5B DENN/MADD domain containing 5B -0.0150651
WASF2 WAS protein family, member 2 -0.0150608
EPB41 erythrocyte membrane protein band 4.1 -0.0150203
MTCL1 microtubule crosslinking factor 1 -0.0147366
CDK19 cyclin-dependent kinase 19 -0.0145506
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0145231
ZFAND3 zinc finger, AN1-type domain 3 -0.0144785
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -0.0144286
CHI3L2 chitinase 3-like 2 -0.0144193
BABAM2 BRISC and BRCA1 A complex member 2 -0.0142471
SAA2 serum amyloid A2 -0.0141293
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0140609
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0140596
CANX calnexin -0.0140482
ANKRD50 ankyrin repeat domain 50 -0.0140015
CADM2 cell adhesion molecule 2 -0.0139966
LPP LIM domain containing preferred translocation partner in lipoma -0.0138369
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0137892
CD109 CD109 molecule -0.0137875
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0137226
SAA2-SAA4 SAA2-SAA4 readthrough -0.0136932
SPIRE1 spire-type actin nucleation factor 1 -0.0134929
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0134017
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0133536
FAM162A family with sequence similarity 162, member A -0.0133465
TXNRD1 thioredoxin reductase 1 -0.0133246
TNRC6B trinucleotide repeat containing 6B -0.0131586
PARD3 par-3 family cell polarity regulator -0.013007
SFTPA2 surfactant protein A2 -0.0129423
LMAN1 lectin, mannose-binding, 1 -0.0129004
SRP54 signal recognition particle 54kDa -0.0128501
SLC39A10 solute carrier family 39 (zinc transporter), member 10 -0.0127436
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0125645
TAOK1 TAO kinase 1 -0.0124969
STRN3 striatin, calmodulin binding protein 3 -0.0124889
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0123831
IFI6 interferon, alpha-inducible protein 6 -0.0123783
RHOA ras homolog family member A -0.012315
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0122794
TMEM135 transmembrane protein 135 -0.0122695
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0121694
XPO1 exportin 1 -0.0120775
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0120421