AZD-7648_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-7648 perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-7648_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.164788
CXCL8 chemokine (C-X-C motif) ligand 8 0.148554
MT2A metallothionein 2A 0.139486
RPS3 ribosomal protein S3 0.110964
SLTM SAFB-like, transcription modulator 0.0922938
GRAMD1B GRAM domain containing 1B 0.0921824
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0844125
STC1 stanniocalcin 1 0.0695882
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0676259
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0663757
ELL2 elongation factor, RNA polymerase II, 2 0.0661263
THSD4 thrombospondin, type I, domain containing 4 0.0603315
CEMIP cell migration inducing protein, hyaluronan binding 0.0591092
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0575102
HSPA8 heat shock 70kDa protein 8 0.0562218
AKAP12 A kinase (PRKA) anchor protein 12 0.0547244
ERRFI1 ERBB receptor feedback inhibitor 1 0.0536596
AREG amphiregulin 0.0505501
SEC61G Sec61 gamma subunit 0.0501135
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0497265
TOP1 topoisomerase (DNA) I 0.0484143
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.048272
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0480844
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0476189
RPS6 ribosomal protein S6 0.0466735
LOC102724023 ES1 protein homolog, mitochondrial 0.0459233
LMO7 LIM domain 7 0.0456968
TBC1D22A TBC1 domain family, member 22A 0.0449156
SON SON DNA binding protein 0.0445573
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0437876
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0430246
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0425528
PRRC2C proline-rich coiled-coil 2C 0.0423261
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0404665
PTMA prothymosin, alpha 0.0396206
MYH9 myosin, heavy chain 9, non-muscle 0.0391847
SAMD4A sterile alpha motif domain containing 4A 0.0389764
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0389073
RPL37A ribosomal protein L37a 0.0383671
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0378646
RPS12 ribosomal protein S12 0.0375262
GOLGB1 golgin B1 0.0373804
LAMA4 laminin, alpha 4 0.0372909
SIK3 SIK family kinase 3 0.0365658
SRRM2 serine/arginine repetitive matrix 2 0.0364878
LDHA lactate dehydrogenase A 0.0364673
PM20D1 peptidase M20 domain containing 1 0.0356838
DSCAM Down syndrome cell adhesion molecule 0.0350267
NSUN6 NOP2/Sun domain family, member 6 0.0342568
ENO1 enolase 1, (alpha) 0.0342094
APLP2 amyloid beta (A4) precursor-like protein 2 0.0336388
EXT1 exostosin glycosyltransferase 1 0.0331115
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0329176
MKI67 marker of proliferation Ki-67 0.0326823
BCAR3 breast cancer anti-estrogen resistance 3 0.0326465
BRD2 bromodomain containing 2 0.0323221
MAP7 microtubule-associated protein 7 0.0322541
SMYD3 SET and MYND domain containing 3 0.0314419
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0310831
IGFBP3 insulin-like growth factor binding protein 3 0.030716
YBX3 Y box binding protein 3 0.0306546
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0306256
MCL1 myeloid cell leukemia 1 0.0304421
TRIP12 thyroid hormone receptor interactor 12 0.0302608
CHMP1B charged multivesicular body protein 1B 0.030081
RUNX1 runt-related transcription factor 1 0.030003
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0299606
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0299462
TPM3 tropomyosin 3 0.0294383
ANKRD11 ankyrin repeat domain 11 0.0294064
CDCP1 CUB domain containing protein 1 0.0293479
EPAS1 endothelial PAS domain protein 1 0.0291714
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.02909
NTSR1 neurotensin receptor 1 (high affinity) 0.0287989
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0285826
LOC112694756 uncharaterized LOC112694756 0.0282594
KTN1 kinectin 1 (kinesin receptor) 0.0281752
DOCK1 dedicator of cytokinesis 1 0.0278949
RPS8 ribosomal protein S8 0.0278398
ATP11A ATPase, class VI, type 11A 0.0276545
BMP6 bone morphogenetic protein 6 0.0274281
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0271855
CPE carboxypeptidase E 0.0271584
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0270058
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0268565
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0266467
MSN moesin 0.0266303
MYOF myoferlin 0.0264101
C15ORF48 chromosome 15 open reading frame 48 0.0263212
EIF4A2 eukaryotic translation initiation factor 4A2 0.0261128
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0260585
FAM107B family with sequence similarity 107, member B 0.0260288
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0257586
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.025603
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0250218
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0247671
MACF1 microtubule-actin crosslinking factor 1 0.0245
HOMER1 homer scaffolding protein 1 0.0244984
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 0.0243639
RACK1 receptor for activated C kinase 1 0.0241876

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.264541
AKR1C1 aldo-keto reductase family 1, member C1 -0.100722
LRP1B low density lipoprotein receptor-related protein 1B -0.0680041
FTH1 ferritin, heavy polypeptide 1 -0.046762
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0440289
TMEM165 transmembrane protein 165 -0.038428
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0373697
TXNRD1 thioredoxin reductase 1 -0.0368591
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0357589
PTPRM protein tyrosine phosphatase, receptor type, M -0.0330567
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0318576
RNF213 ring finger protein 213 -0.0312087
CAV1 caveolin 1, caveolae protein, 22kDa -0.031175
PRDX1 peroxiredoxin 1 -0.0298607
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0294872
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0286356
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0274398
EGFR epidermal growth factor receptor -0.0273452
NCOA3 nuclear receptor coactivator 3 -0.0272985
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0263999
TNS3 tensin 3 -0.0257852
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0255725
ANKRD10 ankyrin repeat domain 10 -0.0253958
NRIP1 nuclear receptor interacting protein 1 -0.0241635
AGR2 anterior gradient 2 -0.0238749
MGAT4C MGAT4 family, member C -0.0222943
NCOA7 nuclear receptor coactivator 7 -0.0222282
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.021691
GM2A GM2 ganglioside activator -0.0215422
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0214768
FTL ferritin, light polypeptide -0.0214249
CP ceruloplasmin (ferroxidase) -0.0213265
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0211051
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0207892
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0205668
KRT7 keratin 7, type II -0.0204051
SBF2 SET binding factor 2 -0.019948
ANXA2 annexin A2 -0.0199148
KCMF1 potassium channel modulatory factor 1 -0.0199039
CAMTA1 calmodulin binding transcription activator 1 -0.0195204
TPD52 tumor protein D52 -0.0193811
ZMYND8 zinc finger, MYND-type containing 8 -0.019077
LIMCH1 LIM and calponin homology domains 1 -0.0183491
NT5C2 5'-nucleotidase, cytosolic II -0.0178003
AHNAK AHNAK nucleoprotein -0.017554
GCLM glutamate-cysteine ligase, modifier subunit -0.0172438
RPS24 ribosomal protein S24 -0.0171464
PATJ PATJ crumbs cell polarity complex component -0.0171431
SEC31A SEC31 homolog A (S. cerevisiae) -0.0171213
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0165171
OSMR oncostatin M receptor -0.0163409
BRWD1 bromodomain and WD repeat domain containing 1 -0.0162636
BIRC3 baculoviral IAP repeat containing 3 -0.016212
ZMYM2 zinc finger, MYM-type 2 -0.0158101
SOD2 superoxide dismutase 2, mitochondrial -0.0158021
SREBF2 sterol regulatory element binding transcription factor 2 -0.0156437
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0156271
GNAS GNAS complex locus -0.0155249
FBXO34 F-box protein 34 -0.0154865
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -0.0153988
MON2 MON2 homolog (S. cerevisiae) -0.0153629
PKM pyruvate kinase, muscle -0.0151786
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0150927
MCU mitochondrial calcium uniporter -0.0146045
NDE1 nudE neurodevelopment protein 1 -0.0144727
LPP LIM domain containing preferred translocation partner in lipoma -0.0143041
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0142645
TC2N tandem C2 domains, nuclear -0.0139073
NPC1 Niemann-Pick disease, type C1 -0.0136283
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0136172
HDLBP high density lipoprotein binding protein -0.0135721
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.013514
BRWD3 bromodomain and WD repeat domain containing 3 -0.0134804
NABP1 nucleic acid binding protein 1 -0.0133004
PERP PERP, TP53 apoptosis effector -0.0132977
EFNA5 ephrin-A5 -0.01316
PCED1B PC-esterase domain containing 1B -0.0129293
TKT transketolase -0.0128442
CATSPERB catsper channel auxiliary subunit beta -0.0128348
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0127499
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0126941
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0126823
TPT1 tumor protein, translationally-controlled 1 -0.0126202
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 -0.0121817
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0121689
WASF2 WAS protein family, member 2 -0.0121625
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0121064
S100A6 S100 calcium binding protein A6 -0.0120336
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0120132
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0118962
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0118674
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0116541
PTGR1 prostaglandin reductase 1 -0.0116211
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0115845
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0115822
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.011369
BMPR1B bone morphogenetic protein receptor, type IB -0.0113137
KIAA0319 KIAA0319 -0.011229
SPTSSA serine palmitoyltransferase, small subunit A -0.0111937
TMOD3 tropomodulin 3 (ubiquitous) -0.0111655