| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.195053 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.122209 |
| SMAD3 | SMAD family member 3 | 0.0989968 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.094625 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0864354 |
| MT2A | metallothionein 2A | 0.0849953 |
| NDRG1 | N-myc downstream regulated 1 | 0.0806449 |
| CD44 | CD44 molecule (Indian blood group) | 0.0717288 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0697506 |
| PCBP2 | poly(rC) binding protein 2 | 0.0692933 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0629952 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.061535 |
| RPS6 | ribosomal protein S6 | 0.0595866 |
| RPS3 | ribosomal protein S3 | 0.0563757 |
| NAV2 | neuron navigator 2 | 0.0558497 |
| MYO10 | myosin X | 0.0535008 |
| FAM107B | family with sequence similarity 107, member B | 0.0531747 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0526236 |
| TAPBP | TAP binding protein (tapasin) | 0.0507231 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0506001 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0501149 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0494884 |
| RPS12 | ribosomal protein S12 | 0.0491539 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0483028 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0482818 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0449702 |
| LDHA | lactate dehydrogenase A | 0.0437139 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0436724 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0430677 |
| RUNX1 | runt-related transcription factor 1 | 0.0421182 |
| ANGPTL4 | angiopoietin-like 4 | 0.042082 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.042035 |
| B2M | beta-2-microglobulin | 0.0406098 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0405693 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0384156 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0381143 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0377669 |
| AADAC | arylacetamide deacetylase | 0.0367684 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0354828 |
| ECE1 | endothelin converting enzyme 1 | 0.0350548 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0348101 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0341378 |
| RPS8 | ribosomal protein S8 | 0.0337533 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0336607 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0335486 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0329631 |
| IL1R1 | interleukin 1 receptor, type I | 0.0328908 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0324052 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0318327 |
| RPL4 | ribosomal protein L4 | 0.0310249 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0307811 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0306945 |
| TGM2 | transglutaminase 2 | 0.0301575 |
| RPL36 | ribosomal protein L36 | 0.0297467 |
| RPS17 | ribosomal protein S17 | 0.0292625 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0292188 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0291548 |
| CDCP1 | CUB domain containing protein 1 | 0.0290023 |
| BRD2 | bromodomain containing 2 | 0.0284724 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0283942 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0280083 |
| VEGFA | vascular endothelial growth factor A | 0.0276627 |
| SFTPA2 | surfactant protein A2 | 0.0275667 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0272703 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0270314 |
| NTN4 | netrin 4 | 0.0267514 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0266041 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0262791 |
| RPL37A | ribosomal protein L37a | 0.0258248 |
| LOXL2 | lysyl oxidase-like 2 | 0.0255346 |
| IFI44L | interferon-induced protein 44-like | 0.0255315 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0252869 |
| INTS6 | integrator complex subunit 6 | 0.0249793 |
| RPL18 | ribosomal protein L18 | 0.0249448 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0247788 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0246382 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0245488 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0240967 |
| TNNC1 | troponin C type 1 (slow) | 0.0239991 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0239776 |
| RPS19 | ribosomal protein S19 | 0.0235484 |
| CORO1C | coronin, actin binding protein, 1C | 0.0235404 |
| CTDSP2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 | 0.023388 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0232635 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0231612 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | 0.0230439 |
| RPL32 | ribosomal protein L32 | 0.0229834 |
| GATA6 | GATA binding protein 6 | 0.0229513 |
| IFI44 | interferon-induced protein 44 | 0.0229133 |
| MSN | moesin | 0.0228743 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0227773 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.022334 |
| RPS2 | ribosomal protein S2 | 0.0223064 |
| KIAA1217 | KIAA1217 | 0.0222364 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0221058 |
| RPL5 | ribosomal protein L5 | 0.0217321 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.021631 |
| ATXN1 | ataxin 1 | 0.0214948 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0214421 |
| VIM | vimentin | 0.0213861 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.174555 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.134272 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.116861 |
| CDH13 | cadherin 13 | -0.101675 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.099057 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0981382 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0979578 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0958004 |
| NRG1 | neuregulin 1 | -0.0954399 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0911383 |
| USP34 | ubiquitin specific peptidase 34 | -0.0908827 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0877068 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0776256 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0764964 |
| OSMR | oncostatin M receptor | -0.0764404 |
| MTSS1 | metastasis suppressor 1 | -0.0744948 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0727852 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0718969 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0717716 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0673339 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0670366 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0651035 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0620089 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0619905 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0594898 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0587455 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0576995 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0573859 |
| ETV6 | ets variant 6 | -0.0555482 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0551052 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0547566 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0539089 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0538875 |
| MEF2A | myocyte enhancer factor 2A | -0.0513492 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0511459 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0507131 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0501111 |
| STC1 | stanniocalcin 1 | -0.0495877 |
| TMEM165 | transmembrane protein 165 | -0.0495067 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0490827 |
| LOX | lysyl oxidase | -0.0482603 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0480013 |
| ENOSF1 | enolase superfamily member 1 | -0.0477927 |
| TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | -0.0462379 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0459884 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0450607 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0447639 |
| MECOM | MDS1 and EVI1 complex locus | -0.0440949 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0436897 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0430952 |
| HMGA2 | high mobility group AT-hook 2 | -0.0429213 |
| DNER | delta/notch-like EGF repeat containing | -0.0409144 |
| AOPEP | aminopeptidase O (putative) | -0.0409112 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0408801 |
| CLMP | CXADR-like membrane protein | -0.040761 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0404966 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0401124 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0400921 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0392724 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0392656 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0388049 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0384492 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0383378 |
| DENND4A | DENN/MADD domain containing 4A | -0.0380804 |
| PYGL | phosphorylase, glycogen, liver | -0.0380638 |
| FBXO11 | F-box protein 11 | -0.0380296 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0378103 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0375931 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0375902 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0375141 |
| TMSB10 | thymosin beta 10 | -0.0373825 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0373705 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0371333 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0365508 |
| LRRC8C | leucine rich repeat containing 8 family, member C | -0.0362797 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0357505 |
| S100A6 | S100 calcium binding protein A6 | -0.0356526 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0354028 |
| OXR1 | oxidation resistance 1 | -0.0353616 |
| RUNX2 | runt-related transcription factor 2 | -0.0345857 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0341365 |
| GNAS | GNAS complex locus | -0.0337709 |
| ABCA6 | ATP-binding cassette, sub-family A (ABC1), member 6 | -0.0335786 |
| CLIC4 | chloride intracellular channel 4 | -0.033514 |
| PGK1 | phosphoglycerate kinase 1 | -0.0330681 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0329489 |
| HM13 | histocompatibility (minor) 13 | -0.0328153 |
| NF1 | neurofibromin 1 | -0.0327357 |
| RBM39 | RNA binding motif protein 39 | -0.0325593 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0325045 |
| ZNF609 | zinc finger protein 609 | -0.0319833 |
| RAI14 | retinoic acid induced 14 | -0.0318242 |
| DIAPH2 | diaphanous-related formin 2 | -0.0317866 |
| FAM20C | family with sequence similarity 20, member C | -0.031756 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | -0.0317078 |
| NUMB | numb homolog (Drosophila) | -0.0316384 |
| TMEM131 | transmembrane protein 131 | -0.0315365 |
| CP | ceruloplasmin (ferroxidase) | -0.031338 |
| CALU | calumenin | -0.0311633 |
| PRRX1 | paired related homeobox 1 | -0.0311424 |
