AZD-7648_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-7648 perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-7648_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.532903
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.092415
AKAP12 A kinase (PRKA) anchor protein 12 0.0894588
IGFBP3 insulin-like growth factor binding protein 3 0.0769423
EIF1 eukaryotic translation initiation factor 1 0.0749522
RPS8 ribosomal protein S8 0.0748897
RPS6 ribosomal protein S6 0.074027
HLA-B major histocompatibility complex, class I, B 0.0632157
RPS3 ribosomal protein S3 0.0576905
RPL37A ribosomal protein L37a 0.0575641
B2M beta-2-microglobulin 0.0489604
HLA-A major histocompatibility complex, class I, A 0.0468985
FAM107B family with sequence similarity 107, member B 0.0467735
RPL35A ribosomal protein L35a 0.0444925
C15ORF48 chromosome 15 open reading frame 48 0.0444278
RPS17 ribosomal protein S17 0.0441233
LOC102724023 ES1 protein homolog, mitochondrial 0.0432631
RPL19 ribosomal protein L19 0.0428956
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0426724
FTL ferritin, light polypeptide 0.0417671
RPS12 ribosomal protein S12 0.0406572
RPS19 ribosomal protein S19 0.0400024
RPL36 ribosomal protein L36 0.0397005
RPS27 ribosomal protein S27 0.0380772
KTN1 kinectin 1 (kinesin receptor) 0.0379327
NDRG1 N-myc downstream regulated 1 0.0366333
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.034786
LDHA lactate dehydrogenase A 0.0338807
RPL31 ribosomal protein L31 0.0330163
STC1 stanniocalcin 1 0.03133
RPS21 ribosomal protein S21 0.0312091
RPL37 ribosomal protein L37 0.0305788
GOLGB1 golgin B1 0.0291447
ASTN2 astrotactin 2 0.0291325
BRD2 bromodomain containing 2 0.0289254
RPS29 ribosomal protein S29 0.0282185
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0281452
GOLGA4 golgin A4 0.0277874
TPI1 triosephosphate isomerase 1 0.0276612
RUNX1 runt-related transcription factor 1 0.0273628
ANGPTL4 angiopoietin-like 4 0.027305
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0266008
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0263764
RPL26 ribosomal protein L26 0.0260033
CCL5 chemokine (C-C motif) ligand 5 0.0259816
RPL34 ribosomal protein L34 0.0259163
LGALS1 lectin, galactoside-binding, soluble, 1 0.0258473
RPS2 ribosomal protein S2 0.0255881
TAPBP TAP binding protein (tapasin) 0.0249579
S100A11 S100 calcium binding protein A11 0.0247731
CAVIN1 caveolae associated protein 1 0.0246199
RPS13 ribosomal protein S13 0.0243578
PRRC2C proline-rich coiled-coil 2C 0.0242398
RPS10 ribosomal protein S10 0.0241116
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0238572
TIMP1 TIMP metallopeptidase inhibitor 1 0.0234615
RPL32 ribosomal protein L32 0.0229669
FTH1 ferritin, heavy polypeptide 1 0.022939
APLP2 amyloid beta (A4) precursor-like protein 2 0.0229344
RPL11 ribosomal protein L11 0.0228202
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0226963
PYGL phosphorylase, glycogen, liver 0.0225608
RPL13A ribosomal protein L13a 0.0223563
RPL18 ribosomal protein L18 0.0221078
DHRS7 dehydrogenase/reductase (SDR family) member 7 0.0216078
RACK1 receptor for activated C kinase 1 0.0212143
VIM vimentin 0.0211003
PFN1 profilin 1 0.0208415
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0207394
SFTPA2 surfactant protein A2 0.0207111
CDCP1 CUB domain containing protein 1 0.0205552
IL6 interleukin 6 0.0203815
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 0.0202581
RPL12 ribosomal protein L12 0.0199826
RPS23 ribosomal protein S23 0.0198135
ARHGAP26 Rho GTPase activating protein 26 0.0194938
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.01914
MT1F metallothionein 1F 0.0188094
RPL28 ribosomal protein L28 0.0184263
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0182898
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0182766
RPL7 ribosomal protein L7 0.0181549
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.0180963
ATF4 activating transcription factor 4 0.0180939
MSN moesin 0.0178817
BASP1 brain abundant, membrane attached signal protein 1 0.0176637
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0176087
SRGN serglycin 0.0175502
RPL27 ribosomal protein L27 0.0174055
IFITM3 interferon induced transmembrane protein 3 0.0170169
TMED9 transmembrane emp24 protein transport domain containing 9 0.017003
STC2 stanniocalcin 2 0.0169698
CLU clusterin 0.0169413
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0169061
MORF4L2 mortality factor 4 like 2 0.0168184
EFNA1 ephrin-A1 0.0168137
INHBA inhibin, beta A 0.0167591
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0164972
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0164616
RPS14 ribosomal protein S14 0.0160937

decreased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B -0.158181
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.138179
TXNRD1 thioredoxin reductase 1 -0.0884331
TM4SF1 transmembrane 4 L six family member 1 -0.0728677
PM20D1 peptidase M20 domain containing 1 -0.0680171
PDE4D phosphodiesterase 4D, cAMP-specific -0.0665551
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0606299
TFPI2 tissue factor pathway inhibitor 2 -0.060042
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0592583
ZFAND3 zinc finger, AN1-type domain 3 -0.0576666
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0574345
FGB fibrinogen beta chain -0.05697
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0542283
RTN4 reticulon 4 -0.0530557
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0513239
THSD4 thrombospondin, type I, domain containing 4 -0.0500164
ERBIN erbb2 interacting protein -0.0461095
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0445321
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0441605
BICC1 BicC family RNA binding protein 1 -0.0421641
EEF2 eukaryotic translation elongation factor 2 -0.040916
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0407595
ZNF207 zinc finger protein 207 -0.0401339
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0400826
USP3 ubiquitin specific peptidase 3 -0.0397379
WDR43 WD repeat domain 43 -0.0393805
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.039163
CYRIB CYFIP related Rac1 interactor B -0.0386496
DENND4A DENN/MADD domain containing 4A -0.0384588
PTK2 protein tyrosine kinase 2 -0.0383301
RHEB Ras homolog enriched in brain -0.0381591
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0376308
UBC ubiquitin C -0.0372168
MAML3 mastermind-like 3 (Drosophila) -0.0368274
PKM pyruvate kinase, muscle -0.0350715
MCL1 myeloid cell leukemia 1 -0.0350589
ADGRG6 adhesion G protein-coupled receptor G6 -0.0343998
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0342484
RAD21 RAD21 homolog (S. pombe) -0.0340976
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.033756
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0335393
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0328687
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0326744
NEGR1 neuronal growth regulator 1 -0.032332
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0317489
PDE8A phosphodiesterase 8A -0.0316452
ANKRD28 ankyrin repeat domain 28 -0.0313245
ECT2 epithelial cell transforming 2 -0.031009
FBXO11 F-box protein 11 -0.0309962
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0309411
APP amyloid beta (A4) precursor protein -0.0304058
WWOX WW domain containing oxidoreductase -0.0302392
CHN1 chimerin 1 -0.0298182
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0296293
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0295886
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0295094
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.029442
USP34 ubiquitin specific peptidase 34 -0.029407
OLA1 Obg-like ATPase 1 -0.02922
DOCK4 dedicator of cytokinesis 4 -0.028959
TPD52 tumor protein D52 -0.0288971
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0287062
TNPO1 transportin 1 -0.0286661
AK1 adenylate kinase 1 -0.0286524
VMP1 vacuole membrane protein 1 -0.0283912
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0282201
PARD3 par-3 family cell polarity regulator -0.0281269
RASAL2 RAS protein activator like 2 -0.028113
TRIO trio Rho guanine nucleotide exchange factor -0.0279787
EFNA5 ephrin-A5 -0.0278259
COG5 component of oligomeric golgi complex 5 -0.0277266
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0276229
ZNF292 zinc finger protein 292 -0.0275021
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0272342
AHR aryl hydrocarbon receptor -0.0270619
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0270592
MBNL1 muscleblind-like splicing regulator 1 -0.0265857
THBS1 thrombospondin 1 -0.026212
YAP1 Yes-associated protein 1 -0.0260188
FAM168A family with sequence similarity 168, member A -0.0258341
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0257343
AHNAK AHNAK nucleoprotein -0.0255945
NAV3 neuron navigator 3 -0.0255022
MARCHF6 membrane associated ring-CH-type finger 6 -0.0254799
SPAG9 sperm associated antigen 9 -0.0252167
CMIP c-Maf inducing protein -0.0250209
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0248715
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0246982
PUM2 pumilio RNA-binding family member 2 -0.0246505
RPS27A ribosomal protein S27a -0.0246091
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0245763
TFG TRK-fused gene -0.0243264
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0242861
RBM39 RNA binding motif protein 39 -0.0239759
MIS18BP1 MIS18 binding protein 1 -0.0239491
TMEM131 transmembrane protein 131 -0.0237277
PUM1 pumilio RNA-binding family member 1 -0.0236485
YME1L1 YME1-like 1 ATPase -0.0236301
MORF4L1 mortality factor 4 like 1 -0.0233135
BIRC3 baculoviral IAP repeat containing 3 -0.0232977